{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:59:08Z","timestamp":1790765948210,"version":"4.1.0"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2027,9,23]],"date-time":"2027-09-23T00:00:00Z","timestamp":1821657600000},"content-version":"am","delay-in-days":630,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2640-B-038-001"],"award-info":[{"award-number":["NSTC 114-2640-B-038-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2221-E-007-026-MY2"],"award-info":[{"award-number":["NSTC 114-2221-E-007-026-MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>An integrated heart\u2013lung LabChip reveals immune-mediated cardiotoxicity, featuring dynamic flow-resistance-enhanced trapping of heart organoids and tumor\u2013T-cell co-culture to distinguish cardiotoxic effects of three anticancer drugs.<\/jats:p>","DOI":"10.1039\/d6lc00764c","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:03:11Z","timestamp":1790154191000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heart\u2013lung-on-a-chip featuring dynamic flow-resistance capture for drug-associated cardiac dysfunction assessment under tumor\u2013immune-conditioned drug exposure"],"prefix":"10.1039","author":[{"given":"He-Jhen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Chun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Lun","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yao","family":"Huang","sequence":"additional","affiliation":[{"name":"Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan, Republic of China"},{"name":"Division of Cardiology and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan, Republic of China"},{"name":"Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-3892","authenticated-orcid":false,"given":"Cheng-Hsien","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan, Republic of China"},{"name":"Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 300044, Taiwan, Republic of China"},{"name":"College of Semiconductor Research, National Tsing Hua University, Hsinchu 300044, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan, Republic of China"},{"name":"Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei 11696, Taiwan, Republic of China"},{"name":"Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan, Republic of China"},{"name":"TMU Research Center for Thoracic Medicine, Taipei Medical University, Taipei 11031, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6LC00764C\/cit1\/1","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"D6LC00764C\/cit2\/1","first-page":"563","volume":"14","author":"Lambert","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D6LC00764C\/cit3\/1","first-page":"253","volume":"60","author":"Lenihan","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"D6LC00764C\/cit4\/1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nrcardio.2015.65","volume":"12","author":"Ewer","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"D6LC00764C\/cit5\/1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.hfc.2011.03.008","volume":"7","author":"Pawlak","year":"2011","journal-title":"Heart Failure Clin."},{"key":"D6LC00764C\/cit6\/1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrm2236","volume":"8","author":"Pampaloni","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D6LC00764C\/cit7\/1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/ten.teb.2009.0352","volume":"16","author":"Vunjak-Novakovic","year":"2010","journal-title":"Tissue Eng., Part B"},{"key":"D6LC00764C\/cit8\/1","first-page":"101","volume":"8","author":"Heymann","year":"2015","journal-title":"Dis. Models Mech."},{"key":"D6LC00764C\/cit9\/1","first-page":"561","volume":"19","author":"Mak","year":"2014","journal-title":"Drug Discovery Today"},{"key":"D6LC00764C\/cit10\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1039\/c2ib00176d","volume":"4","author":"van der Meer","year":"2012","journal-title":"Integr. Biol."},{"key":"D6LC00764C\/cit11\/1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tcb.2011.09.005","volume":"21","author":"Huh","year":"2011","journal-title":"Trends Cell Biol."},{"key":"D6LC00764C\/cit12\/1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1039\/c3ib40049b","volume":"5","author":"Jang","year":"2013","journal-title":"Integr. Biol."},{"key":"D6LC00764C\/cit13\/1","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1039\/C5LC00392J","volume":"15","author":"Maschmeyer","year":"2015","journal-title":"Lab Chip"},{"key":"D6LC00764C\/cit14\/1","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.drudis.2016.07.003","volume":"21","author":"Skardal","year":"2016","journal-title":"Drug Discovery Today"},{"key":"D6LC00764C\/cit15\/1","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/cvr\/cvaa082","volume":"116","author":"McMullen","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"D6LC00764C\/cit16\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"Ca-Cancer J. Clin."},{"key":"D6LC00764C\/cit17\/1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","volume":"363","author":"Brahmer","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"D6LC00764C\/cit18\/1","first-page":"e447","volume":"17","author":"Johnson","year":"2016","journal-title":"Lancet Oncol."},{"key":"D6LC00764C\/cit19\/1","first-page":"828","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Immunol."},{"key":"D6LC00764C\/cit20\/1","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1093\/eurheartj\/eht210","volume":"34","author":"Caforio","year":"2013","journal-title":"Eur. Heart J."},{"key":"D6LC00764C\/cit21\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/d41573-021-00194-5","volume":"21","author":"Li","year":"2022","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6LC00764C\/cit22\/1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.stem.2018.02.011","volume":"22","author":"Ronaldson-Bouchard","year":"2018","journal-title":"Cell Stem Cell"},{"key":"D6LC00764C\/cit23\/1","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/bit.26235","volume":"114","author":"Mills","year":"2017","journal-title":"Biotechnol. Bioeng."},{"key":"D6LC00764C\/cit24\/1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tibtech.2014.04.010","volume":"32","author":"Luni","year":"2014","journal-title":"Trends Biotechnol."},{"key":"D6LC00764C\/cit25\/1","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1039\/c2lc40173h","volume":"12","author":"Zheng","year":"2012","journal-title":"Lab Chip"},{"key":"D6LC00764C\/cit26\/1","first-page":"114834","volume":"219","author":"Chen","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"D6LC00764C\/cit27\/1","first-page":"1319","volume":"25","author":"Kennedy","year":"2019","journal-title":"Nat. Med."},{"key":"D6LC00764C\/cit28\/1","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1021\/ac060541s","volume":"78","author":"Di Carlo","year":"2006","journal-title":"Anal. Chem."},{"key":"D6LC00764C\/cit29\/1","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1039\/C5LC01173F","volume":"16","author":"Nourmohammadzadeh","year":"2016","journal-title":"Lab Chip"},{"key":"D6LC00764C\/cit30\/1","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1039\/D0LC90109A","volume":"20","author":"de Boer","year":"2020","journal-title":"Lab Chip"},{"key":"D6LC00764C\/cit31\/1","first-page":"276","volume":"17","author":"van der Meer","year":"2017","journal-title":"Lab Chip"},{"key":"D6LC00764C\/cit32\/1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","volume":"6","author":"Davies","year":"2009","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"issue":"7","key":"D6LC00764C\/cit33\/1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1161\/CIRCRESAHA.124.325685","volume":"136","author":"Cheng","year":"2025","journal-title":"Circ. Res."},{"key":"D6LC00764C\/cit34\/1","doi-asserted-by":"crossref","first-page":"135409","DOI":"10.1016\/j.snb.2024.135409","volume":"406","author":"Chen","year":"2024","journal-title":"Sens. Actuators, B"},{"key":"D6LC00764C\/cit35\/1","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1038\/s41467-021-25329-5","volume":"12","author":"Lewis-Israeli","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/LC\/article-pdf\/doi\/10.1039\/D6LC00764C\/0\/D6LC00764C.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:05:19Z","timestamp":1790762719000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/LC\/article-lookup\/doi\/10.1039\/D6LC00764C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"URL":"https:\/\/doi.org\/10.1039\/d6lc00764c","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}