{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:10:15Z","timestamp":1787771415842,"version":"build-2784847793"},"reference-count":70,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2027,6,29]],"date-time":"2027-06-29T00:00:00Z","timestamp":1814227200000},"content-version":"am","delay-in-days":544,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","award":["2021KCXTD044"],"award-info":[{"award-number":["2021KCXTD044"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1212040016"],"award-info":[{"award-number":["2021B1212040016"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013069","name":"Leading Talents Program of Guangdong Province","doi-asserted-by":"publisher","award":["2024CX11L018"],"award-info":[{"award-number":["2024CX11L018"]}],"id":[{"id":"10.13039\/501100013069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>(1) AOSs were inhibitors on tyrosinase and elastase. Multi-spectroscopic and docking approaches revealed inhibition interaction of AOSs on tyrosinase and elastase. (2) AOSs displayed the ability of melanin inhibition and ROS clearance.<\/jats:p>","DOI":"10.1039\/d6md00183a","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:06:04Z","timestamp":1782738364000},"page":"3397-3409","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition effects and binding behavior of alginate oligosaccharides on tyrosinase and elastase: multi-spectroscopic approaches and zebrafish evaluation"],"prefix":"10.1039","volume":"17","author":[{"given":"Hangen","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyi","family":"Cen","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6919-948X","authenticated-orcid":false,"given":"Xuetao","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering & Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6MD00183A\/cit1\/1","doi-asserted-by":"crossref","first-page":"e70354","DOI":"10.1111\/jocd.70354","volume":"24","author":"Yang","year":"2025","journal-title":"J. Cosmet. Dermatol."},{"key":"D6MD00183A\/cit2\/1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.imbio.2014.02.008","volume":"219","author":"Badowski","year":"2014","journal-title":"Immunobiology"},{"key":"D6MD00183A\/cit3\/1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3934\/molsci.2016.2.269","volume":"3","author":"Qin","year":"2016","journal-title":"AIMS Mol. Sci."},{"key":"D6MD00183A\/cit4\/1","doi-asserted-by":"crossref","first-page":"1383255","DOI":"10.3389\/fimmu.2024.1383255","volume":"15","author":"Huang","year":"2024","journal-title":"Front. Immunol."},{"key":"D6MD00183A\/cit5\/1","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.3390\/molecules27206914","volume":"27","author":"Pintus","year":"2022","journal-title":"Molecules"},{"key":"D6MD00183A\/cit6\/1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.indcrop.2018.06.029","volume":"122","author":"Chiocchio","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"D6MD00183A\/cit7\/1","doi-asserted-by":"crossref","first-page":"17444","DOI":"10.1021\/acsomega.2c01841","volume":"7","author":"Mughal","year":"2022","journal-title":"ACS Omega"},{"key":"D6MD00183A\/cit8\/1","doi-asserted-by":"crossref","first-page":"131933","DOI":"10.1016\/j.molstruc.2021.131933","volume":"1251","author":"Alsantali","year":"2022","journal-title":"J. Mol. Struct."},{"key":"D6MD00183A\/cit9\/1","doi-asserted-by":"crossref","first-page":"22159","DOI":"10.1039\/D1RA03196A","volume":"11","author":"Obaid","year":"2021","journal-title":"RSC Adv."},{"key":"D6MD00183A\/cit10\/1","doi-asserted-by":"crossref","first-page":"148135","DOI":"10.1016\/j.foodchem.2026.148135","volume":"506","author":"Zhang","year":"2026","journal-title":"Food Chem."},{"key":"D6MD00183A\/cit11\/1","doi-asserted-by":"crossref","first-page":"146057","DOI":"10.1016\/j.foodchem.2025.146057","volume":"493","author":"Wang","year":"2025","journal-title":"Food Chem."},{"key":"D6MD00183A\/cit12\/1","doi-asserted-by":"crossref","first-page":"145632","DOI":"10.1016\/j.foodchem.2025.145632","volume":"492","author":"Zhang","year":"2025","journal-title":"Food Chem."},{"key":"D6MD00183A\/cit13\/1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ijbiomac.2019.12.119","volume":"146","author":"Sadeghi-Kaji","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"D6MD00183A\/cit14\/1","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1080\/14756366.2021.1960830","volume":"36","author":"Favas","year":"2021","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6MD00183A\/cit15\/1","doi-asserted-by":"crossref","first-page":"1703354","DOI":"10.3389\/fnut.2025.1703354","volume":"12","author":"Ozler","year":"2025","journal-title":"Front. Nutr."},{"key":"D6MD00183A\/cit16\/1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/cjoc.202200406","volume":"41","author":"Chen","year":"2023","journal-title":"Chin. J. Chem."},{"key":"D6MD00183A\/cit17\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.carbpol.2018.10.088","volume":"206","author":"Li","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"D6MD00183A\/cit18\/1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.bmcl.2019.04.009","volume":"29","author":"Wang","year":"2019","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6MD00183A\/cit19\/1","doi-asserted-by":"crossref","first-page":"114860","DOI":"10.1016\/j.ejmech.2022.114860","volume":"245","author":"Zhou","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00183A\/cit20\/1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bmcl.2018.12.065","volume":"29","author":"He","year":"2019","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6MD00183A\/cit21\/1","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1021\/acs.jmedchem.3c01093","volume":"67","author":"Qin","year":"2024","journal-title":"J. Med. Chem."},{"key":"D6MD00183A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/s11426-024-2325-2","volume":"68","author":"Yang","year":"2025","journal-title":"Sci. China: Chem."},{"key":"D6MD00183A\/cit23\/1","doi-asserted-by":"crossref","first-page":"116333","DOI":"10.1016\/j.ejmech.2024.116333","volume":"270","author":"Wei","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00183A\/cit24\/1","doi-asserted-by":"crossref","first-page":"125938","DOI":"10.1016\/j.talanta.2024.125938","volume":"273","author":"Peng","year":"2024","journal-title":"Talanta"},{"key":"D6MD00183A\/cit25\/1","first-page":"12345","volume":"97","author":"Fan","year":"2025","journal-title":"Anal. Chem."},{"key":"D6MD00183A\/cit26\/1","doi-asserted-by":"crossref","first-page":"140125","DOI":"10.1016\/j.molstruc.2024.140125","volume":"1321","author":"Zhu","year":"2025","journal-title":"J. Mol. Struct."},{"key":"D6MD00183A\/cit27\/1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.2147\/IDR.S505311","volume":"18","author":"Yang","year":"2025","journal-title":"Infect. Drug Resist."},{"key":"D6MD00183A\/cit28\/1","doi-asserted-by":"crossref","first-page":"1285052","DOI":"10.3389\/fimmu.2023.1285052","volume":"14","author":"Hassan","year":"2023","journal-title":"Front. Immunol."},{"key":"D6MD00183A\/cit29\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.carbpol.2018.09.068","volume":"205","author":"Lu","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"D6MD00183A\/cit30\/1","doi-asserted-by":"crossref","first-page":"123351","DOI":"10.1016\/j.carbpol.2025.123351","volume":"355","author":"Xu","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"D6MD00183A\/cit31\/1","doi-asserted-by":"crossref","first-page":"121565","DOI":"10.1016\/j.carbpol.2023.121565","volume":"325","author":"Cao","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"D6MD00183A\/cit32\/1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.carbpol.2018.11.062","volume":"206","author":"Xu","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"D6MD00183A\/cit33\/1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.carbpol.2018.06.076","volume":"198","author":"Wei","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"D6MD00183A\/cit34\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11274-023-03658-5","volume":"39","author":"Li","year":"2023","journal-title":"World J. Microbiol. Biotechnol."},{"key":"D6MD00183A\/cit35\/1","first-page":"e00218","volume":"91","author":"Wang","year":"2025","journal-title":"Appl. Environ. Microbiol."},{"key":"D6MD00183A\/cit36\/1","first-page":"103155","volume":"31","author":"Biney","year":"2025","journal-title":"Food Chem.: X"},{"key":"D6MD00183A\/cit37\/1","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.3390\/nu17121977","volume":"17","author":"Song","year":"2025","journal-title":"Nutrients"},{"key":"D6MD00183A\/cit38\/1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-026-11487-5","author":"Wen","year":"2025","journal-title":"Mol. Diversity"},{"key":"D6MD00183A\/cit39\/1","doi-asserted-by":"crossref","first-page":"1451452","DOI":"10.3389\/fphar.2024.1451452","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"D6MD00183A\/cit40\/1","doi-asserted-by":"crossref","first-page":"13420","DOI":"10.3390\/ijms241713420","volume":"24","author":"Aguilar-Toal\u00e1","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6MD00183A\/cit41\/1","doi-asserted-by":"crossref","first-page":"7470","DOI":"10.3390\/molecules28227470","volume":"28","author":"Lu","year":"2023","journal-title":"Molecules"},{"key":"D6MD00183A\/cit42\/1","doi-asserted-by":"crossref","first-page":"148135","DOI":"10.1016\/j.foodchem.2026.148135","volume":"506","author":"Zhang","year":"2026","journal-title":"Food Chem."},{"key":"D6MD00183A\/cit43\/1","doi-asserted-by":"crossref","first-page":"140722","DOI":"10.1016\/j.foodchem.2024.140722","volume":"460","author":"Zhang","year":"2024","journal-title":"Food Chem."},{"key":"D6MD00183A\/cit44\/1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s11030-024-10943-4","volume":"29","author":"Sun","year":"2025","journal-title":"Mol. Diversity"},{"key":"D6MD00183A\/cit45\/1","doi-asserted-by":"crossref","first-page":"140481","DOI":"10.1016\/j.molstruc.2024.140481","volume":"1322","author":"Liang","year":"2025","journal-title":"J. Mol. Struct."},{"key":"D6MD00183A\/cit46\/1","doi-asserted-by":"crossref","first-page":"148794","DOI":"10.1016\/j.ijbiomac.2025.148794","volume":"333","author":"Kou","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D6MD00183A\/cit47\/1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-025-11369-2","author":"Zhou","year":"2025","journal-title":"Mol. Diversity"},{"key":"D6MD00183A\/cit48\/1","doi-asserted-by":"crossref","first-page":"120437","DOI":"10.1016\/j.jlumin.2024.120437","volume":"269","author":"Min","year":"2024","journal-title":"J. Lumin."},{"key":"D6MD00183A\/cit49\/1","doi-asserted-by":"crossref","first-page":"116595","DOI":"10.1016\/j.ejmech.2024.116595","volume":"275","author":"Liang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00183A\/cit50\/1","doi-asserted-by":"crossref","first-page":"115957","DOI":"10.1016\/j.ejmech.2023.115957","volume":"264","author":"Hu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00183A\/cit51\/1","doi-asserted-by":"crossref","first-page":"138311","DOI":"10.1016\/j.molstruc.2024.138311","volume":"1310","author":"Feng","year":"2024","journal-title":"J. Mol. Struct."},{"key":"D6MD00183A\/cit52\/1","doi-asserted-by":"crossref","first-page":"135279","DOI":"10.1016\/j.molstruc.2023.135279","volume":"1283","author":"Lin","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D6MD00183A\/cit53\/1","doi-asserted-by":"crossref","first-page":"8406","DOI":"10.1021\/acs.jmedchem.4c00676","volume":"67","author":"Li","year":"2024","journal-title":"J. Med. Chem."},{"key":"D6MD00183A\/cit54\/1","doi-asserted-by":"crossref","first-page":"17319","DOI":"10.1021\/acs.jmedchem.4c01223","volume":"67","author":"Huang","year":"2024","journal-title":"J. Med. Chem."},{"key":"D6MD00183A\/cit55\/1","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1039\/D2SC06860E","volume":"14","author":"Liu","year":"2023","journal-title":"Chem. Sci."},{"key":"D6MD00183A\/cit56\/1","doi-asserted-by":"crossref","first-page":"113091","DOI":"10.1016\/j.ejmech.2020.113091","volume":"211","author":"Qiu","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00183A\/cit57\/1","doi-asserted-by":"crossref","first-page":"114846","DOI":"10.1016\/j.ejmech.2022.114846","volume":"244","author":"Ye","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00183A\/cit58\/1","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1021\/acs.jmedchem.0c02044","volume":"64","author":"Xu","year":"2021","journal-title":"J. Med. Chem."},{"key":"D6MD00183A\/cit59\/1","doi-asserted-by":"crossref","first-page":"135792","DOI":"10.1016\/j.snb.2024.135792","volume":"412","author":"Su","year":"2024","journal-title":"Sens. Actuators, B"},{"key":"D6MD00183A\/cit60\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13065-021-00741-6","volume":"15","author":"Guo","year":"2021","journal-title":"BMC Chem."},{"key":"D6MD00183A\/cit61\/1","doi-asserted-by":"crossref","first-page":"115939","DOI":"10.1016\/j.bios.2023.115939","volume":"247","author":"Ding","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"D6MD00183A\/cit62\/1","doi-asserted-by":"crossref","first-page":"130363","DOI":"10.1016\/j.snb.2021.130363","volume":"345","author":"Chang","year":"2021","journal-title":"Sens. Actuators, B"},{"key":"D6MD00183A\/cit63\/1","doi-asserted-by":"crossref","first-page":"109734","DOI":"10.1016\/j.cclet.2024.109734","volume":"36","author":"Zeng","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"D6MD00183A\/cit64\/1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.ijbiomac.2016.07.082","volume":"92","author":"Chen","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"D6MD00183A\/cit65\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.abb.2005.11.001","volume":"445","author":"Senni","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"D6MD00183A\/cit66\/1","first-page":"0499","volume":"34","author":"Benhniya","year":"2025","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"D6MD00183A\/cit67\/1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/07391102.2012.682211","volume":"30","author":"Wang","year":"2012","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D6MD00183A\/cit68\/1","doi-asserted-by":"crossref","first-page":"101790","DOI":"10.1016\/j.fbio.2022.101790","volume":"48","author":"Yu","year":"2022","journal-title":"Food Biosci."},{"key":"D6MD00183A\/cit69\/1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.foodres.2017.07.082","volume":"100","author":"Chai","year":"2017","journal-title":"Food Res. Int."},{"key":"D6MD00183A\/cit70\/1","doi-asserted-by":"crossref","first-page":"112587","DOI":"10.1016\/j.fct.2021.112587","volume":"157","author":"Fan","year":"2021","journal-title":"Food Chem. Toxicol."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/MD\/article-pdf\/doi\/10.1039\/D6MD00183A\/0\/D6MD00183A.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:12:59Z","timestamp":1784891579000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/MD\/article-lookup\/doi\/10.1039\/D6MD00183A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":70,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,24]]}},"URL":"https:\/\/doi.org\/10.1039\/d6md00183a","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}