{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:40:07Z","timestamp":1789058407583,"version":"build-2803163510"},"reference-count":33,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":132,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ak0101140"],"award-info":[{"award-number":["JP20ak0101140"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H05346"],"award-info":[{"award-number":["JP16H05346"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H03701"],"award-info":[{"award-number":["JP19H03701"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K19366"],"award-info":[{"award-number":["JP21K19366"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>Optimization of a measles virus HR2-derived fusion inhibitor yielded a short peptide with potent antiviral activity and revealed key residues governing interactions with HR1.<\/jats:p>","DOI":"10.1039\/d6md00211k","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:01:14Z","timestamp":1778655674000},"page":"3100-3114","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification and structure\u2013activity relationship analysis of minimal fusion inhibitors targeting measles virus F protein"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3974-6136","authenticated-orcid":false,"given":"Kazuya","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Itahara","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2870-9425","authenticated-orcid":false,"given":"Kazushige","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Tohoku University Hospital, Sendai 980-8574, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Aoki","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan"},{"name":"Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6664-8117","authenticated-orcid":false,"given":"Naoya","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-0040","authenticated-orcid":false,"given":"Hironori","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University, Sendai 980-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6622-2752","authenticated-orcid":false,"given":"Eiichi","family":"Kodama","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University, Sendai 980-8575, Japan"},{"name":"Department of Infectious Diseases, Graduate School of Medicine and Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2833-2539","authenticated-orcid":false,"given":"Shinya","family":"Oishi","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6MD00211K\/cit1\/1","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1099\/jgv.0.001328","volume":"100","author":"Rima","year":"2019","journal-title":"J. Gen. Virol."},{"key":"D6MD00211K\/cit2\/1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0140-6736(21)02004-3","volume":"399","author":"H\u00fcbschen","year":"2022","journal-title":"Lancet"},{"key":"D6MD00211K\/cit3\/1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/microorganisms8020276","volume":"8","author":"Misin","year":"2020","journal-title":"Microorganisms"},{"key":"D6MD00211K\/cit4\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1089\/vim.2017.0143","volume":"31","author":"Griffin","year":"2018","journal-title":"Viral Immunol."},{"key":"D6MD00211K\/cit5\/1","doi-asserted-by":"crossref","first-page":"102885","DOI":"10.1016\/j.tmaid.2025.102885","volume":"67","author":"Huits","year":"2025","journal-title":"Travel Med. Infect. Dis."},{"key":"D6MD00211K\/cit6\/1","doi-asserted-by":"crossref","first-page":"e2058","DOI":"10.1002\/rmv.2058","volume":"29","author":"Garg","year":"2019","journal-title":"Rev. Med. Virol."},{"key":"D6MD00211K\/cit7\/1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/v8040112","volume":"8","author":"Plattet","year":"2016","journal-title":"Viruses"},{"key":"D6MD00211K\/cit8\/1","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1074\/jbc.REV119.009961","volume":"295","author":"Navaratnarajah","year":"2020","journal-title":"J. Biol. Chem."},{"key":"D6MD00211K\/cit9\/1","doi-asserted-by":"crossref","first-page":"E3795","DOI":"10.1073\/pnas.1403609111","volume":"111","author":"Brindley","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6MD00211K\/cit10\/1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.coviro.2012.01.002","volume":"2","author":"Berkhout","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"D6MD00211K\/cit11\/1","doi-asserted-by":"crossref","first-page":"eaav4580","DOI":"10.1126\/sciadv.aav4580","volume":"5","author":"Xia","year":"2019","journal-title":"Sci. Adv."},{"key":"D6MD00211K\/cit12\/1","doi-asserted-by":"crossref","first-page":"12648","DOI":"10.1021\/jacs.9b04615","volume":"141","author":"Outlaw","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D6MD00211K\/cit13\/1","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1073\/pnas.93.5.2186","volume":"93","author":"Lambert","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6MD00211K\/cit14\/1","doi-asserted-by":"crossref","first-page":"13785","DOI":"10.1128\/JVI.02436-13","volume":"87","author":"Welsch","year":"2013","journal-title":"J. Virol."},{"key":"D6MD00211K\/cit15\/1","doi-asserted-by":"crossref","first-page":"e0162823","DOI":"10.1371\/journal.pone.0162823","volume":"11","author":"Watanabe","year":"2016","journal-title":"PLoS One"},{"key":"D6MD00211K\/cit16\/1","doi-asserted-by":"crossref","first-page":"e01554-16","DOI":"10.1128\/JVI.01554-16","volume":"91","author":"Figueira","year":"2017","journal-title":"J. Virol."},{"key":"D6MD00211K\/cit17\/1","doi-asserted-by":"crossref","first-page":"12794","DOI":"10.1021\/acsnano.1c02057","volume":"15","author":"Bovier","year":"2021","journal-title":"ACS Nano"},{"key":"D6MD00211K\/cit18\/1","doi-asserted-by":"crossref","first-page":"12178","DOI":"10.1016\/S0021-9258(19)38328-0","volume":"255","author":"Kelsey","year":"1990","journal-title":"J. Biol. Chem."},{"key":"D6MD00211K\/cit19\/1","first-page":"5160","volume":"64","author":"Malvoisin","year":"1990","journal-title":"J. Viol."},{"key":"D6MD00211K\/cit20\/1","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1073\/pnas.1718957115","volume":"115","author":"Hashiguchi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6MD00211K\/cit21\/1","doi-asserted-by":"crossref","first-page":"eadm8693","DOI":"10.1126\/science.adm8693","volume":"384","author":"Zyla","year":"2024","journal-title":"Science"},{"key":"D6MD00211K\/cit22\/1","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/1521-3773(20020816)41:16<2937::AID-ANIE2937>3.0.CO;2-J","volume":"41","author":"Otaka","year":"2002","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MD00211K\/cit23\/1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1021\/jm701109d","volume":"51","author":"Oishi","year":"2008","journal-title":"J. Med. Chem."},{"key":"D6MD00211K\/cit24\/1","doi-asserted-by":"crossref","first-page":"9184","DOI":"10.1016\/j.bmc.2008.09.018","volume":"16","author":"Nishikawa","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"D6MD00211K\/cit25\/1","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1021\/acs.jmedchem.4c02337","volume":"68","author":"Takahara","year":"2025","journal-title":"J. Med. Chem."},{"key":"D6MD00211K\/cit26\/1","doi-asserted-by":"crossref","first-page":"108961","DOI":"10.1016\/j.isci.2024.108961","volume":"27","author":"Hirata","year":"2024","journal-title":"iScience"},{"key":"D6MD00211K\/cit27\/1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0006-291X(02)02761-4","volume":"299","author":"Zhu","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D6MD00211K\/cit28\/1","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1074\/jbc.M807169200","volume":"284","author":"Izumi","year":"2009","journal-title":"J. Biol. Chem."},{"key":"D6MD00211K\/cit29\/1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jmb.2009.07.027","volume":"392","author":"Watabe","year":"2009","journal-title":"J. Mol. Biol."},{"key":"D6MD00211K\/cit30\/1","doi-asserted-by":"crossref","first-page":"11259","DOI":"10.1074\/jbc.M411141200","volume":"280","author":"Liu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"D6MD00211K\/cit31\/1","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1074\/jbc.M809269200","volume":"284","author":"Champagne","year":"2009","journal-title":"J. Biol. Chem."},{"key":"D6MD00211K\/cit32\/1","doi-asserted-by":"crossref","first-page":"e0068122","DOI":"10.1128\/jvi.00681-22","volume":"96","author":"Bi","year":"2022","journal-title":"J. Virol."},{"key":"D6MD00211K\/cit33\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.7883\/yoken.JJID.2020.481","volume":"74","author":"Hashimoto","year":"2021","journal-title":"Jpn. J. Infect. Dis."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/MD\/D6MD00211K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:48:34Z","timestamp":1782215314000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D6MD00211K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d6md00211k","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}