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Lead compound 7di demonstrated potent activity, supported by\n                    <jats:italic>in silico<\/jats:italic>\n                    ,\n                    <jats:italic>in vitro<\/jats:italic>\n                    , and\n                    <jats:italic>in vivo<\/jats:italic>\n                    studies.\n                  <\/jats:p>","DOI":"10.1039\/d6md00218h","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:09:29Z","timestamp":1784034569000},"page":"3739-3755","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and biological evaluation of branched N\n                    <sup>1<\/sup>\n                    functionalized lophine\u2013pyrazole heptacycles as myeloperoxidase inhibitors and anti-inflammatory agents"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6858-1014","authenticated-orcid":false,"given":"Reshma","family":"Rajan","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology-Vellore, Tamilnadu-632014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vallabh","family":"Mulay","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology-Vellore, Tamilnadu-632014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenin","family":"N","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology-Vellore, Tamilnadu-632014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalakshmi","family":"Jagadeesan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology-Vellore, Tamilnadu-632014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logesh","family":"Mathivathanan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology-Vellore, Tamilnadu-632014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-8823","authenticated-orcid":false,"given":"Rajagopal","family":"Desikan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology-Vellore, Tamilnadu-632014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6MD00218H\/cit1\/1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cca.2019.02.022","volume":"493","author":"Ndrepepa","year":"2019","journal-title":"Clin. 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