{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:02:53Z","timestamp":1785164573835,"version":"3.55.0"},"reference-count":152,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2027,7,27]],"date-time":"2027-07-27T00:00:00Z","timestamp":1816646400000},"content-version":"am","delay-in-days":572,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    PDCs include a payload conjugated to a suitable peptide, often\n                    <jats:italic>via<\/jats:italic>\n                    a cleavable linker, and were developed to address BBB limitations and hit specific sites in the brain, increasing drugs' therapeutic efficacy, and reducing off-target toxicity.\n                  <\/jats:p>","DOI":"10.1039\/d6md00420b","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:50:46Z","timestamp":1785163846000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peptide\u2013drug conjugation: a strategy to address blood\u2013brain barrier limitations in central nervous system diseases"],"prefix":"10.1039","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7775-8784","authenticated-orcid":false,"given":"Elvira","family":"Passalacqua","sequence":"first","affiliation":[{"name":"Medicinal Chemistry, Ri.MED Foundation, Via Filippo Marini 14, 90128, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1925-7119","authenticated-orcid":false,"given":"Giuseppe","family":"Barberi","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry, Ri.MED Foundation, Via Filippo Marini 14, 90128, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-2194","authenticated-orcid":false,"given":"Pietro","family":"Amico","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry, Ri.MED Foundation, Via Filippo Marini 14, 90128, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-751X","authenticated-orcid":false,"given":"Simona","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry, Ri.MED Foundation, Via Filippo Marini 14, 90128, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4087-2554","authenticated-orcid":false,"given":"Maria","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry, Ri.MED Foundation, Via Filippo Marini 14, 90128, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6MD00420B\/cit1\/1","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3390\/pharmaceutics13101542","volume":"13","author":"Neumaier","year":"2021","journal-title":"Pharmaceutics"},{"key":"D6MD00420B\/cit2\/1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"key":"D6MD00420B\/cit3\/1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3390\/pharmaceutics17081041","volume":"17","author":"Yang","year":"2025","journal-title":"Pharmaceutics"},{"key":"D6MD00420B\/cit4\/1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.addr.2014.01.008","volume":"72","author":"Aryal","year":"2014","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6MD00420B\/cit5\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1021\/bc025526i","volume":"14","author":"Zhang","year":"2003","journal-title":"Bioconjugate Chem."},{"key":"D6MD00420B\/cit6\/1","doi-asserted-by":"crossref","first-page":"e202300254","DOI":"10.1002\/cbic.202300254","volume":"24","author":"Bugatti","year":"2023","journal-title":"ChemBioChem"},{"key":"D6MD00420B\/cit7\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41571-023-00850-2","volume":"21","author":"Tsuchikama","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D6MD00420B\/cit8\/1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.apsb.2022.07.020","volume":"13","author":"Fu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"D6MD00420B\/cit9\/1","doi-asserted-by":"crossref","first-page":"e202500262","DOI":"10.1002\/cmdc.202500262","volume":"20","author":"Lei","year":"2025","journal-title":"ChemMedChem"},{"key":"D6MD00420B\/cit10\/1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3390\/ijms24010829","volume":"24","author":"Heh","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6MD00420B\/cit11\/1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fchem.2020.00571","volume":"8","author":"Hoppenz","year":"2020","journal-title":"Front. Chem."},{"key":"D6MD00420B\/cit12\/1","unstructured":"ANG1005 in Leptomeningeal Disease From Breast Cancer (ANGLeD),  https:\/\/clinicaltrials.gov\/study\/NCT03613181 , (accessed May 2026.)"},{"key":"D6MD00420B\/cit13\/1","unstructured":"BT1718 in Patients with Advanced Solid Tumours,  https:\/\/www.clinicaltrials.gov\/study\/NCT03486730 , (accessed May 2026.)"},{"key":"D6MD00420B\/cit14\/1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1021\/acs.jmedchem.1c02022","volume":"65","author":"Liu","year":"2022","journal-title":"J. Med. Chem."},{"key":"D6MD00420B\/cit15\/1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-024-02107-5","volume":"10","author":"Xiao","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"key":"D6MD00420B\/cit16\/1","doi-asserted-by":"crossref","first-page":"9037","DOI":"10.1021\/acs.jmedchem.5c00007","volume":"68","author":"Ma","year":"2025","journal-title":"J. Med. Chem."},{"key":"D6MD00420B\/cit17\/1","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.2174\/0929867324666170404142840","volume":"24","author":"Ma","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"D6MD00420B\/cit18\/1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1021\/acs.molpharmaceut.4c01327","volume":"22","author":"Prades","year":"2025","journal-title":"Mol. Pharmaceutics"},{"key":"D6MD00420B\/cit19\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12987-024-00545-5","volume":"21","author":"Cavaco","year":"2024","journal-title":"Fluids Barriers CNS"},{"key":"D6MD00420B\/cit20\/1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.tibs.2015.10.004","volume":"40","author":"Kauffman","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"D6MD00420B\/cit21\/1","doi-asserted-by":"crossref","first-page":"11923","DOI":"10.1073\/pnas.1811520115","volume":"115","author":"Allolio","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"D6MD00420B\/cit22\/1","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1021\/acs.molpharmaceut.2c00523","volume":"19","author":"Parrasia","year":"2022","journal-title":"Mol. Pharmaceutics"},{"key":"D6MD00420B\/cit23\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1096\/fsb2fasebj.12.1.67","volume":"12","author":"Pooga","year":"1998","journal-title":"FASEB J."},{"key":"D6MD00420B\/cit24\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/jac\/dkn436","volume":"63","author":"Park","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"D6MD00420B\/cit25\/1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jconrel.2003.12.023","volume":"95","author":"Gorodetsky","year":"2004","journal-title":"J. Controlled Release"},{"key":"D6MD00420B\/cit26\/1","first-page":"18","volume":"28","author":"Temsamani","year":"2010","journal-title":"Chim. Oggi"},{"key":"D6MD00420B\/cit27\/1","doi-asserted-by":"crossref","first-page":"101443","DOI":"10.1016\/j.mtbio.2025.101443","volume":"30","author":"Sun","year":"2025","journal-title":"Mater. Today Bio"},{"key":"D6MD00420B\/cit28\/1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0962-8924(98)80017-2","volume":"8","author":"Derossi","year":"1998","journal-title":"Trends Cell Biol."},{"key":"D6MD00420B\/cit29\/1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1124\/mol.119.117713","volume":"96","author":"Lebedev","year":"2019","journal-title":"Mol. Pharmacol."},{"key":"D6MD00420B\/cit30\/1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3390\/pharmaceutics14050907","volume":"14","author":"Szab\u00f3","year":"2022","journal-title":"Pharmaceutics"},{"key":"D6MD00420B\/cit31\/1","doi-asserted-by":"crossref","first-page":"e6800","DOI":"10.1002\/cam4.6800","volume":"13","author":"Javid","year":"2024","journal-title":"Cancer Med."},{"key":"D6MD00420B\/cit32\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrm.2017.132","volume":"19","author":"Kaksonen","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D6MD00420B\/cit33\/1","doi-asserted-by":"crossref","first-page":"109382","DOI":"10.1016\/j.bioorg.2025.109382","volume":"169","author":"Yun","year":"2026","journal-title":"Bioorg. Chem."},{"key":"D6MD00420B\/cit34\/1","doi-asserted-by":"crossref","first-page":"e12255","DOI":"10.1002\/jev2.12255","volume":"11","author":"Zhu","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"D6MD00420B\/cit35\/1","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.biomaterials.2009.02.051","volume":"30","author":"Liu","year":"2009","journal-title":"Biomaterials"},{"key":"D6MD00420B\/cit36\/1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jconrel.2019.11.009","volume":"317","author":"Kim","year":"2020","journal-title":"J. Controlled Release"},{"key":"D6MD00420B\/cit37\/1","doi-asserted-by":"crossref","first-page":"19228","DOI":"10.1021\/acsami.6b03166","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6MD00420B\/cit38\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2016.03.008","volume":"110\u2013111","author":"Ruoslahti","year":"2017","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6MD00420B\/cit39\/1","doi-asserted-by":"crossref","first-page":"415103","DOI":"10.1088\/0957-4484\/22\/41\/415103","volume":"22","author":"Yan","year":"2011","journal-title":"Nanotechnology"},{"key":"D6MD00420B\/cit40\/1","doi-asserted-by":"crossref","first-page":"106200","DOI":"10.1016\/j.bioorg.2022.106200","volume":"130","author":"Larue","year":"2023","journal-title":"Bioorg. Chem."},{"key":"D6MD00420B\/cit41\/1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.2174\/138920111796117373","volume":"12","author":"Angelo","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"key":"D6MD00420B\/cit42\/1","doi-asserted-by":"crossref","first-page":"119666","DOI":"10.1016\/j.biomaterials.2019.119666","volume":"230","author":"Lu","year":"2020","journal-title":"Biomaterials"},{"key":"D6MD00420B\/cit43\/1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1021\/acschemneuro.1c00117","volume":"12","author":"Consoli","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"D6MD00420B\/cit44\/1","doi-asserted-by":"crossref","first-page":"177274","DOI":"10.1016\/j.ejphar.2025.177274","volume":"990","author":"Bocchieri","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"D6MD00420B\/cit45\/1","doi-asserted-by":"crossref","first-page":"2102978","DOI":"10.1002\/adfm.202102978","volume":"31","author":"Zhang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"D6MD00420B\/cit46\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2017.02.006","volume":"250","author":"Dissanayake","year":"2017","journal-title":"J. Controlled Release"},{"key":"D6MD00420B\/cit47\/1","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1021\/acs.jmedchem.3c01835","volume":"67","author":"Dean","year":"2024","journal-title":"J. Med. Chem."},{"key":"D6MD00420B\/cit48\/1","doi-asserted-by":"crossref","first-page":"118510","DOI":"10.1016\/j.bmc.2025.118510","volume":"133","author":"Fajar","year":"2026","journal-title":"Bioorg. Med. Chem."},{"key":"D6MD00420B\/cit49\/1","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.1073\/pnas.96.12.6925","volume":"96","author":"Shabat","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6MD00420B\/cit50\/1","doi-asserted-by":"crossref","first-page":"14740","DOI":"10.1002\/chem.201903127","volume":"25","author":"Dal Corso","year":"2019","journal-title":"Chemistry"},{"key":"D6MD00420B\/cit51\/1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1021\/acsptsci.3c00269","volume":"7","author":"Rizvi","year":"2024","journal-title":"ACS Pharmacology & Translational Science"},{"key":"D6MD00420B\/cit52\/1","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1016\/j.apsb.2023.06.015","volume":"13","author":"Wang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"D6MD00420B\/cit53\/1","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.3390\/molecules27175429","volume":"27","author":"Stokke","year":"2022","journal-title":"Molecules"},{"key":"D6MD00420B\/cit54\/1","doi-asserted-by":"crossref","first-page":"113018","DOI":"10.1016\/j.ejmech.2020.113018","volume":"211","author":"Vrettos","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00420B\/cit55\/1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1039\/D0CS00556H","volume":"50","author":"Cooper","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D6MD00420B\/cit56\/1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3390\/ph12030114","volume":"12","author":"Hennrich","year":"2019","journal-title":"Pharmaceuticals"},{"key":"D6MD00420B\/cit57\/1","doi-asserted-by":"crossref","first-page":"e70040","DOI":"10.1002\/psc.70040","volume":"31","author":"Armstrong","year":"2025","journal-title":"J. Pept. Sci."},{"key":"D6MD00420B\/cit58\/1","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3390\/molecules24101855","volume":"24","author":"He","year":"2019","journal-title":"Molecules"},{"key":"D6MD00420B\/cit59\/1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/s12951-022-01610-7","volume":"20","author":"Mitusova","year":"2022","journal-title":"J. Nanobiotechnology"},{"key":"D6MD00420B\/cit60\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-024-00516-y","volume":"10","author":"Weller","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"D6MD00420B\/cit61\/1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s13311-017-0519-x","volume":"14","author":"Chen","year":"2017","journal-title":"Neurotherapeutics"},{"key":"D6MD00420B\/cit62\/1","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3390\/biomedicines13061298","volume":"13","author":"Rajakaruna","year":"2025","journal-title":"Biomedicines"},{"key":"D6MD00420B\/cit63\/1","doi-asserted-by":"crossref","first-page":"2001960","DOI":"10.1002\/advs.202001960","volume":"8","author":"Hua","year":"2021","journal-title":"Adv. Sci."},{"key":"D6MD00420B\/cit64\/1","doi-asserted-by":"crossref","first-page":"41889","DOI":"10.1021\/acsami.9b14046","volume":"11","author":"Chen","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6MD00420B\/cit65\/1","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1021\/acs.bioconjchem.7b00519","volume":"28","author":"Yu","year":"2017","journal-title":"Bioconjugate Chem."},{"key":"D6MD00420B\/cit66\/1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jconrel.2012.04.010","volume":"161","author":"Yang","year":"2012","journal-title":"J. Controlled Release"},{"key":"D6MD00420B\/cit67\/1","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3390\/ijms24021728","volume":"24","author":"Kauerov\u00e1","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6MD00420B\/cit68\/1","doi-asserted-by":"crossref","first-page":"117527","DOI":"10.1016\/j.ejmech.2025.117527","volume":"290","author":"Laila","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00420B\/cit69\/1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1021\/acs.jmedchem.0c01399","volume":"64","author":"Baranyai","year":"2021","journal-title":"J. Med. Chem."},{"key":"D6MD00420B\/cit70\/1","first-page":"16927","volume":"9","author":"Horv\u00e1th","year":"2024","journal-title":"ACS Omega"},{"key":"D6MD00420B\/cit71\/1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jconrel.2024.04.011","volume":"369","author":"Zhou","year":"2024","journal-title":"J. Controlled Release"},{"key":"D6MD00420B\/cit72\/1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1021\/acs.molpharmaceut.5b00631","volume":"13","author":"Song","year":"2016","journal-title":"Mol. Pharmaceutics"},{"key":"D6MD00420B\/cit73\/1","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.3390\/cells10112996","volume":"10","author":"Rai","year":"2021","journal-title":"Cell"},{"key":"D6MD00420B\/cit74\/1","doi-asserted-by":"crossref","first-page":"17902","DOI":"10.1021\/jacs.5c02731","volume":"147","author":"Zhang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6MD00420B\/cit75\/1","doi-asserted-by":"crossref","first-page":"9126","DOI":"10.1021\/acsnano.2c12217","volume":"17","author":"Fan","year":"2023","journal-title":"ACS Nano"},{"key":"D6MD00420B\/cit76\/1","first-page":"1253","volume":"13","author":"Israel","year":"2019","journal-title":"ACS Nano"},{"key":"D6MD00420B\/cit77\/1","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.biomaterials.2012.10.061","volume":"34","author":"Zhen","year":"2013","journal-title":"Biomaterials"},{"key":"D6MD00420B\/cit78\/1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/protein\/gzn028","volume":"21","author":"Jonsson","year":"2008","journal-title":"Protein Eng., Des. Sel."},{"key":"D6MD00420B\/cit79\/1","doi-asserted-by":"crossref","first-page":"120250","DOI":"10.1016\/j.biomaterials.2020.120250","volume":"257","author":"Lee","year":"2020","journal-title":"Biomaterials"},{"key":"D6MD00420B\/cit80\/1","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41467-023-37328-9","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"D6MD00420B\/cit81\/1","doi-asserted-by":"crossref","first-page":"eadr8841","DOI":"10.1126\/sciadv.adr8841","volume":"11","author":"Li","year":"2025","journal-title":"Sci. Adv."},{"key":"D6MD00420B\/cit82\/1","first-page":"1","volume":"8","author":"Kou","year":"2013","journal-title":"Asian J. Pharm. Sci."},{"key":"D6MD00420B\/cit83\/1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1021\/acs.bioconjchem.4c00485","volume":"35","author":"Tao","year":"2024","journal-title":"Bioconjugate Chem."},{"key":"D6MD00420B\/cit84\/1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10585-011-9440-6","volume":"29","author":"Sun","year":"2012","journal-title":"Clin. Exp. Metastasis"},{"key":"D6MD00420B\/cit85\/1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.3748\/wjg.v17.i7.932","volume":"17","author":"Yang","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"D6MD00420B\/cit86\/1","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/acsomega.3c07486","volume":"9","author":"Bataille Backer","year":"2024","journal-title":"ACS Omega"},{"key":"D6MD00420B\/cit87\/1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1021\/acs.molpharmaceut.8b00924","volume":"16","author":"Kim","year":"2019","journal-title":"Mol. Pharmaceutics"},{"key":"D6MD00420B\/cit88\/1","doi-asserted-by":"crossref","first-page":"12411","DOI":"10.3390\/ijms252212411","volume":"25","author":"O'Flaherty","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D6MD00420B\/cit89\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00232-011-9381-7","volume":"242","author":"Kampen","year":"2011","journal-title":"J. Membr. Biol."},{"key":"D6MD00420B\/cit90\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2014.05.002","volume":"351","author":"Wu","year":"2014","journal-title":"Cancer Lett."},{"key":"D6MD00420B\/cit91\/1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3390\/ijms17050701","volume":"17","author":"Reinhardt","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"D6MD00420B\/cit92\/1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fmicb.2013.00294","volume":"4","author":"Gaspar","year":"2013","journal-title":"Front. Microbiol."},{"key":"D6MD00420B\/cit93\/1","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1038\/s41598-017-08963-2","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"D6MD00420B\/cit94\/1","first-page":"2171","volume":"76","author":"Kalmouni","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"D6MD00420B\/cit95\/1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1021\/acs.jmedchem.0c01530","volume":"64","author":"Alas","year":"2021","journal-title":"J. Med. Chem."},{"key":"D6MD00420B\/cit96\/1","doi-asserted-by":"crossref","first-page":"8398","DOI":"10.1021\/acs.analchem.9b01250","volume":"91","author":"Li","year":"2019","journal-title":"Anal. Chem."},{"key":"D6MD00420B\/cit97\/1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1208\/s12248-014-9710-8","volume":"17","author":"McCombs","year":"2015","journal-title":"AAPS J."},{"key":"D6MD00420B\/cit98\/1","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1021\/acs.bioconjchem.5c00119","volume":"36","author":"Boas","year":"2025","journal-title":"Bioconjugate Chem."},{"key":"D6MD00420B\/cit99\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2018.08.014","volume":"287","author":"Su","year":"2018","journal-title":"J. Controlled Release"},{"key":"D6MD00420B\/cit100\/1","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1039\/C6PY00756B","volume":"7","author":"Son","year":"2016","journal-title":"Polym. Chem."},{"key":"D6MD00420B\/cit101\/1","first-page":"1","volume":"6","author":"Tarudji","year":"2023","journal-title":"Adv. Therap."},{"key":"D6MD00420B\/cit102\/1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1039\/C5PY01704A","volume":"7","author":"Das","year":"2016","journal-title":"Polym. Chem."},{"key":"D6MD00420B\/cit103\/1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3390\/cells14050347","volume":"14","author":"Calvo","year":"2025","journal-title":"Cell"},{"key":"D6MD00420B\/cit104\/1","doi-asserted-by":"crossref","first-page":"102357","DOI":"10.1016\/j.arr.2024.102357","volume":"99","author":"Gadhave","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"D6MD00420B\/cit105\/1","doi-asserted-by":"crossref","first-page":"04160","DOI":"10.7189\/jogh.13.04160","volume":"13","author":"Huang","year":"2023","journal-title":"J. Glob. Health"},{"key":"D6MD00420B\/cit106\/1","unstructured":"11 million lives lost each year: urgent action needed on neurological care,  https:\/\/www.who.int\/news\/item\/14-10-2025-11-million-lives-lost-each-year-urgent-action-needed-on-neurological-care#:~:text=News\/-,11%20million%20lives%20lost%20each%20year:%20urgent%20action%20needed%20on,high%20burden%20of%20these%20diseases , (accessed May 2026.)"},{"key":"D6MD00420B\/cit107\/1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41392-025-02145-7","volume":"10","author":"Jiang","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"key":"D6MD00420B\/cit108\/1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","volume":"23","author":"Collaborators","year":"2024","journal-title":"Lancet Neurol."},{"key":"D6MD00420B\/cit109\/1","doi-asserted-by":"crossref","first-page":"111575","DOI":"10.1016\/j.mad.2021.111575","volume":"200","author":"Blinkouskaya","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"D6MD00420B\/cit110\/1","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1007\/s00018-012-0962-0","volume":"69","author":"Salminen","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"D6MD00420B\/cit111\/1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3390\/antiox11020405","volume":"11","author":"Goldsteins","year":"2022","journal-title":"Antioxidants"},{"key":"D6MD00420B\/cit112\/1","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/j.nrl.2021.01.016","volume":"38","author":"Ghosh","year":"2023","journal-title":"Neurologia"},{"key":"D6MD00420B\/cit113\/1","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.3390\/pharmaceutics15112599","volume":"15","author":"Niazi","year":"2023","journal-title":"Pharmaceutics"},{"key":"D6MD00420B\/cit114\/1","doi-asserted-by":"crossref","first-page":"214474","DOI":"10.1016\/j.bioadv.2025.214474","volume":"178","author":"Majie","year":"2026","journal-title":"Biomater. Adv."},{"key":"D6MD00420B\/cit115\/1","doi-asserted-by":"crossref","first-page":"106816","DOI":"10.1016\/j.jddst.2025.106816","volume":"107","author":"Pancholi","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"D6MD00420B\/cit116\/1","doi-asserted-by":"crossref","first-page":"e12050","DOI":"10.1002\/trc2.12050","volume":"6","author":"Cummings","year":"2020","journal-title":"Alzheimer's Dement.: Transl. Res. Clin. Interv."},{"key":"D6MD00420B\/cit117\/1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jconrel.2025.01.019","volume":"379","author":"Shastri","year":"2025","journal-title":"J. Controlled Release"},{"key":"D6MD00420B\/cit118\/1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.nrl.2023.11.005","volume":"40","author":"Mondal","year":"2025","journal-title":"Neurologia"},{"key":"D6MD00420B\/cit119\/1","doi-asserted-by":"crossref","first-page":"102379","DOI":"10.1016\/j.arr.2024.102379","volume":"99","author":"Shastri","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"D6MD00420B\/cit120\/1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fneur.2020.00614","volume":"11","author":"Manzano","year":"2020","journal-title":"Front. Neurol."},{"key":"D6MD00420B\/cit121\/1","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1002\/anie.201916380","volume":"60","author":"Pan","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MD00420B\/cit122\/1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/asia.201601461","volume":"12","author":"Wang","year":"2017","journal-title":"Chem. \u2013 Asian J."},{"key":"D6MD00420B\/cit123\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41557-018-0164-y","volume":"11","author":"Xu","year":"2019","journal-title":"Nat. Chem."},{"key":"D6MD00420B\/cit124\/1","doi-asserted-by":"crossref","first-page":"8545","DOI":"10.1074\/jbc.271.15.8545","volume":"271","author":"Tjernberg","year":"1996","journal-title":"J. Biol. Chem."},{"key":"D6MD00420B\/cit125\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3389\/fncel.2015.00297","volume":"9","author":"Giuffrida","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"D6MD00420B\/cit126\/1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s41061-025-00502-2","volume":"383","author":"Di Martino","year":"2025","journal-title":"Top. Curr. Chem."},{"key":"D6MD00420B\/cit127\/1","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(21)00249-0","volume":"20","author":"Rascol","year":"2021","journal-title":"Lancet Neurol."},{"key":"D6MD00420B\/cit128\/1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1089\/neu.2013.2917","volume":"31","author":"Wang","year":"2014","journal-title":"J. Neurotrauma"},{"key":"D6MD00420B\/cit129\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/a-0970-9310","volume":"53","author":"Schaefer","year":"2020","journal-title":"Pharmacopsychiatry"},{"key":"D6MD00420B\/cit130\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/gps.4109","volume":"30","author":"Wesnes","year":"2015","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"D6MD00420B\/cit131\/1","doi-asserted-by":"crossref","first-page":"e0123289","DOI":"10.1371\/journal.pone.0123289","volume":"10","author":"Matsunaga","year":"2015","journal-title":"PLoS One"},{"key":"D6MD00420B\/cit132\/1","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1006\/jmbi.1999.3422","volume":"295","author":"Tenidis","year":"2000","journal-title":"J. Mol. Biol."},{"key":"D6MD00420B\/cit133\/1","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1021\/bi8000616","volume":"47","author":"Krysmann","year":"2008","journal-title":"Biochemistry"},{"key":"D6MD00420B\/cit134\/1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00253-007-1305-1","volume":"78","author":"Liu","year":"2008","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"D6MD00420B\/cit135\/1","first-page":"2905","volume":"142","author":"Panza","year":"2019","journal-title":"Brain"},{"key":"D6MD00420B\/cit136\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fnagi.2018.00224","volume":"10","author":"Fulop","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"D6MD00420B\/cit137\/1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12551-019-00526-1","volume":"11","author":"Shanmugam","year":"2019","journal-title":"Biophys. Rev."},{"key":"D6MD00420B\/cit138\/1","doi-asserted-by":"crossref","first-page":"S499","DOI":"10.3233\/JAD-2010-100504","volume":"20","author":"Reddy","year":"2010","journal-title":"J. Alzheimer's Dis."},{"key":"D6MD00420B\/cit139\/1","doi-asserted-by":"crossref","first-page":"117460","DOI":"10.1016\/j.ejmech.2025.117460","volume":"289","author":"Liu","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00420B\/cit140\/1","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1021\/acs.jmedchem.3c01979","volume":"67","author":"Lambona","year":"2024","journal-title":"J. Med. Chem."},{"key":"D6MD00420B\/cit141\/1","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.18632\/aging.101592","volume":"10","author":"Yin","year":"2018","journal-title":"Aging"},{"key":"D6MD00420B\/cit142\/1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3233\/JAD-180126","volume":"64","author":"Li","year":"2018","journal-title":"J. Alzheimer's Dis."},{"key":"D6MD00420B\/cit143\/1","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1021\/acschemneuro.3c00041","volume":"14","author":"Mann","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"D6MD00420B\/cit144\/1","doi-asserted-by":"crossref","first-page":"10343","DOI":"10.1039\/C9SC04387J","volume":"10","author":"Du","year":"2019","journal-title":"Chem. Sci."},{"key":"D6MD00420B\/cit145\/1","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1039\/C7SC01269A","volume":"8","author":"Jones","year":"2017","journal-title":"Chem. Sci."},{"key":"D6MD00420B\/cit146\/1","doi-asserted-by":"crossref","first-page":"106285","DOI":"10.1016\/j.nbd.2023.106285","volume":"186","author":"Leit\u00e3o","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"D6MD00420B\/cit147\/1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"D6MD00420B\/cit148\/1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1021\/acs.bioconjchem.8b00894","volume":"30","author":"Rusiecka","year":"2019","journal-title":"Bioconjugate Chem."},{"key":"D6MD00420B\/cit149\/1","first-page":"403039","volume":"2011","author":"Hisahara","year":"2011","journal-title":"Int. J. Med. Chem."},{"key":"D6MD00420B\/cit150\/1","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.peptides.2011.07.018","volume":"32","author":"Song","year":"2011","journal-title":"Peptides"},{"key":"D6MD00420B\/cit151\/1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/pharmaceutics16060778","volume":"16","author":"Rusiecka","year":"2024","journal-title":"Pharmaceutics"},{"key":"D6MD00420B\/cit152\/1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3389\/fphar.2018.01311","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Pharmacol."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/MD\/article-pdf\/doi\/10.1039\/D6MD00420B\/0\/D6MD00420B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:51:06Z","timestamp":1785163866000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/MD\/article-lookup\/doi\/10.1039\/D6MD00420B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":152,"URL":"https:\/\/doi.org\/10.1039\/d6md00420b","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}