{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:00:36Z","timestamp":1791198036953,"version":"4.1.0"},"reference-count":62,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["ICAO\/R1\/231073"],"award-info":[{"award-number":["ICAO\/R1\/231073"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["University Research Fellowship and Enhancement Award"],"award-info":[{"award-number":["University Research Fellowship and Enhancement Award"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC StG 949821"],"award-info":[{"award-number":["ERC StG 949821"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301881\/2025-1"],"award-info":[{"award-number":["301881\/2025-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    Quinones are well-established antiparasitic agents. Here we report a mild and direct method for the fluorination of amino quinones, which show enhanced\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity against\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1039\/d6md00631k","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:20:58Z","timestamp":1791195658000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fluorination of amino-quinones enhances anti-\n                    <i>Trypanosoma cruzi<\/i>\n                    activity"],"prefix":"10.1039","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-2166","authenticated-orcid":false,"given":"Zhenhao","family":"Zhong","sequence":"first","affiliation":[{"name":"School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-0487","authenticated-orcid":false,"given":"Renata G.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Exatas, Departamento de Qu\u00edmica, Universidade Federal de Minas Gerais, CEP 31270-901, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6208-1621","authenticated-orcid":false,"given":"Victor F. S.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Celular, IOC, FIOCRUZ, Rio de Janeiro, RJ, 21045-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7403-1471","authenticated-orcid":false,"given":"Andrew J.","family":"Lacey","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1352-0641","authenticated-orcid":false,"given":"Rubem F. S.","family":"Menna-Barreto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Celular, IOC, FIOCRUZ, Rio de Janeiro, RJ, 21045-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-3085","authenticated-orcid":false,"given":"Guilherme A. M.","family":"Jardim","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Exatas, Departamento de Qu\u00edmica, Universidade Federal de Minas Gerais, CEP 31270-901, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-5453","authenticated-orcid":false,"given":"Eufr\u00e2nio N.","family":"da Silva J\u00fanior","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Exatas, Departamento de Qu\u00edmica, Universidade Federal de Minas Gerais, CEP 31270-901, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-7421","authenticated-orcid":false,"given":"Alastair J. J.","family":"Lennox","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6MD00631K\/cit1a\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1039\/C7CS00553A","volume":"47","author":"Dias","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"D6MD00631K\/cit1b\/1","doi-asserted-by":"crossref","first-page":"6933","DOI":"10.1039\/D3RA00539A","volume":"13","author":"Valentini","year":"2023","journal-title":"RSC Adv."},{"key":"D6MD00631K\/cit1c\/1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.chempr.2016.09.004","volume":"1","author":"Ding","year":"2016","journal-title":"Chem"},{"key":"D6MD00631K\/cit2\/1","first-page":"1899","volume":"7","author":"Liu","year":"2016","journal-title":"Front. Plant Sci."},{"key":"D6MD00631K\/cit3\/1","doi-asserted-by":"crossref","first-page":"109444","DOI":"10.1016\/j.cbi.2021.109444","volume":"343","author":"de Almeida","year":"2021","journal-title":"Chem.-Biol. Interact."},{"key":"D6MD00631K\/cit4\/1","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.3390\/molecules24071437","volume":"24","author":"Ravichandiran","year":"2019","journal-title":"Molecules"},{"key":"D6MD00631K\/cit5\/1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1590\/0001-3765201820170815","volume":"90","author":"Futuro","year":"2018","journal-title":"An. Acad. Bras. Cienc."},{"key":"D6MD00631K\/cit6\/1","doi-asserted-by":"crossref","first-page":"113084","DOI":"10.1016\/j.ejmech.2020.113084","volume":"210","author":"Patel","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00631K\/cit7\/1","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.2174\/1568026621666210915121348","volume":"21","author":"Ort\u00edz-P\u00e9rez","year":"2021","journal-title":"Curr. Top. Med. Chem."},{"key":"D6MD00631K\/cit8a\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/acs.chemrestox.6b00256","volume":"30","author":"Bolton","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"D6MD00631K\/cit8b\/1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.freeradbiomed.2010.05.009","volume":"49","author":"Song","year":"2010","journal-title":"Free Radical Biol. Med."},{"key":"D6MD00631K\/cit9a\/1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2174\/092986711793979779","volume":"18","author":"Salas","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"D6MD00631K\/cit9b\/1","doi-asserted-by":"crossref","first-page":"e0243855","DOI":"10.1371\/journal.pone.0243855","volume":"16","author":"Nara","year":"2021","journal-title":"PLoS One"},{"key":"D6MD00631K\/cit10a\/1","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1021\/acsinfecdis.2c00123","volume":"8","author":"Mart\u00edn-Escolano","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"D6MD00631K\/cit10b\/1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fpubh.2019.00166","volume":"7","author":"Lidani","year":"2019","journal-title":"Front. Public Health"},{"key":"D6MD00631K\/cit10c\/1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.actatropica.2009.11.003","volume":"115","author":"Schmu\u00f1is","year":"2010","journal-title":"Acta Trop."},{"key":"D6MD00631K\/cit11a\/1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.4269\/ajtmh.16-0761","volume":"97","author":"Sales Junior","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"D6MD00631K\/cit11b\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2015.12.017","volume":"156","author":"Bermudez","year":"2016","journal-title":"Acta Trop."},{"key":"D6MD00631K\/cit11c\/1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/jac\/dkz473","volume":"75","author":"Jackson","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"D6MD00631K\/cit12\/1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2174\/0929867323666161227094049","volume":"24","author":"Beltr\u00e1n-Hortelano","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"D6MD00631K\/cit13a\/1","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.3390\/molecules14114570","volume":"14","author":"Pinto","year":"2009","journal-title":"Molecules"},{"key":"D6MD00631K\/cit13b\/1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fcimb.2019.00435","volume":"9","author":"Mes\u00edas","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D6MD00631K\/cit14a\/1","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1039\/C6SC00302H","volume":"7","author":"Jardim","year":"2016","journal-title":"Chem. Sci."},{"key":"D6MD00631K\/cit14b\/1","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1021\/acs.orglett.6b01586","volume":"18","author":"Jardim","year":"2016","journal-title":"Org. Lett."},{"key":"D6MD00631K\/cit15\/1","doi-asserted-by":"crossref","first-page":"e202400188","DOI":"10.1002\/anie.202400188","volume":"63","author":"de Carvalho","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MD00631K\/cit16\/1","doi-asserted-by":"crossref","first-page":"e202401050","DOI":"10.1002\/asia.202401050","volume":"19","author":"Guimar\u00e3es","year":"2024","journal-title":"Chem. \u2013 Asian J."},{"key":"D6MD00631K\/cit17a\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/pathogens15010017","volume":"15","author":"Duarte","year":"2026","journal-title":"Pathogens"},{"key":"D6MD00631K\/cit17b\/1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1039\/D4MD00558A","volume":"16","author":"Figueroa","year":"2025","journal-title":"RSC Med. Chem."},{"key":"D6MD00631K\/cit17c\/1","doi-asserted-by":"crossref","first-page":"37898","DOI":"10.1021\/acsomega.5c05006","volume":"10","author":"Tavares Junior","year":"2025","journal-title":"ACS Omega"},{"key":"D6MD00631K\/cit17d\/1","doi-asserted-by":"crossref","first-page":"e202400757","DOI":"10.1002\/asia.202400757","volume":"19","author":"de Oliveira","year":"2024","journal-title":"Chem. \u2013 Asian J."},{"key":"D6MD00631K\/cit17e\/1","doi-asserted-by":"crossref","first-page":"e202300506","DOI":"10.1002\/ejoc.202300506","volume":"26","author":"Diogo","year":"2023","journal-title":"Eur. J. Org. Chem."},{"key":"D6MD00631K\/cit18a\/1","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/j.ejmech.2010.02.009","volume":"45","author":"Zakharova","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"D6MD00631K\/cit18b\/1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jfluchem.2014.04.014","volume":"164","author":"Troshkova","year":"2014","journal-title":"J. Fluorine\nChem."},{"key":"D6MD00631K\/cit18c\/1","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1021\/jm9014857","volume":"53","author":"Nyland","year":"2010","journal-title":"J. Med. Chem."},{"key":"D6MD00631K\/cit19\/1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1039\/B610213C","volume":"37","author":"Purser","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"D6MD00631K\/cit20a\/1","doi-asserted-by":"crossref","first-page":"10633","DOI":"10.1021\/acsomega.0c00830","volume":"5","author":"Inoue","year":"2020","journal-title":"ACS Omega"},{"key":"D6MD00631K\/cit20b\/1","doi-asserted-by":"crossref","first-page":"13830","DOI":"10.1039\/D6RA01711H","volume":"16","author":"Mishra","year":"2026","journal-title":"RSC Adv."},{"key":"D6MD00631K\/cit21\/1","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1021\/acs.jmedchem.5b00258","volume":"58","author":"Gillis","year":"2015","journal-title":"J. Med. Chem."},{"key":"D6MD00631K\/cit22\/1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1126\/science.1131943","volume":"317","author":"M\u00fcller","year":"2007","journal-title":"Science"},{"key":"D6MD00631K\/cit23\/1","first-page":"614014","author":"Menna-Barreto","year":"2014","journal-title":"BioMed Res. Int."},{"key":"D6MD00631K\/cit24\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/14756360701425014","volume":"22","author":"Shah","year":"2007","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6MD00631K\/cit25\/1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1039\/B711844A","volume":"37","author":"O'Hagan","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"D6MD00631K\/cit26a\/1","doi-asserted-by":"crossref","first-page":"e202400751","DOI":"10.1002\/ajoc.202400751","volume":"14","author":"Kudryavtseva","year":"2025","journal-title":"Asian J. Org. Chem."},{"key":"D6MD00631K\/cit26b\/1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/00304948009458564","volume":"12","author":"Loeffler","year":"1980","journal-title":"Org. Prep. Proced. Int."},{"key":"D6MD00631K\/cit26c\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1149\/1.3010724","volume":"13","author":"Nishiguchi","year":"2008","journal-title":"ECS Trans."},{"key":"D6MD00631K\/cit26d\/1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0883-2889(88)90069-X","volume":"39","author":"Herscheid","year":"1988","journal-title":"Appl. Radiat. Isot."},{"key":"D6MD00631K\/cit26e\/1","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1016\/S0040-4039(01)81752-4","volume":"25","author":"Cameron","year":"1984","journal-title":"Tetrahedron Lett."},{"key":"D6MD00631K\/cit27a\/1","doi-asserted-by":"crossref","first-page":"9172","DOI":"10.1039\/D2OB01792J","volume":"20","author":"Bhuyan","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"D6MD00631K\/cit27b\/1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1080\/00397911.2025.2458625","volume":"55","author":"Gao","year":"2025","journal-title":"Synth. Commun."},{"key":"D6MD00631K\/cit28a\/1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/anie.201912119","volume":"59","author":"Doobary","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MD00631K\/cit28b\/1","doi-asserted-by":"crossref","first-page":"16095","DOI":"10.1021\/acs.joc.1c01946","volume":"86","author":"Doobary","year":"2021","journal-title":"J. Org. Chem."},{"key":"D6MD00631K\/cit28c\/1","doi-asserted-by":"crossref","first-page":"e202404666","DOI":"10.1002\/anie.202404666","volume":"63","author":"Dean","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MD00631K\/cit28d\/1","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1038\/s41557-024-01561-6","volume":"16","author":"Doobary","year":"2024","journal-title":"Nat. Chem."},{"key":"D6MD00631K\/cit29a\/1","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1016\/S0040-4039(00)79383-X","volume":"32","author":"Differding","year":"1991","journal-title":"Tetrahedron Lett."},{"key":"D6MD00631K\/cit29b\/1","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1016\/S0040-4039(00)79384-1","volume":"32","author":"Differring","year":"1991","journal-title":"Tetrahedron Lett."},{"key":"D6MD00631K\/cit29c\/1","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1002\/chem.201900029","volume":"25","author":"Wood","year":"2019","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6MD00631K\/cit30a\/1","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1021\/ol051281o","volume":"7","author":"Zhang","year":"2005","journal-title":"Org. Lett."},{"key":"D6MD00631K\/cit30b\/1","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1021\/jo060213s","volume":"71","author":"Kralj","year":"2006","journal-title":"J. Org. Chem."},{"key":"D6MD00631K\/cit30c\/1","doi-asserted-by":"crossref","first-page":"33385","DOI":"10.1039\/C4RA15202F","volume":"5","author":"Geng","year":"2015","journal-title":"RSC Adv."},{"key":"D6MD00631K\/cit31\/1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/anie.200400648","volume":"44","author":"Nyffeler","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MD00631K\/cit32\/1","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1021\/acs.joc.3c00620","volume":"89","author":"Trometer","year":"2024","journal-title":"J. Org. Chem."},{"key":"D6MD00631K\/cit33\/1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1021\/acs.accounts.1c00766","volume":"55","author":"Li","year":"2022","journal-title":"Acc. Chem. Res."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/MD\/article-pdf\/doi\/10.1039\/D6MD00631K\/0\/D6MD00631K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:21:06Z","timestamp":1791195666000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/MD\/article-lookup\/doi\/10.1039\/D6MD00631K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":62,"URL":"https:\/\/doi.org\/10.1039\/d6md00631k","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}