{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:38:47Z","timestamp":1792676327105,"version":"4.5.0"},"reference-count":40,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":252,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["10.54499\/2024.01432.BD"],"award-info":[{"award-number":["10.54499\/2024.01432.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["2024.01432.BD"],"award-info":[{"award-number":["2024.01432.BD"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>The strong \u03b1-glucosidase inhibitory activity exhibited by myricetin against both yeast-derived and human enzymes further substantiates the therapeutic potential of polyphenols in diabetes management.<\/jats:p>","DOI":"10.1039\/d6md00685j","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:18:00Z","timestamp":1789035480000},"page":"4838-4850","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavonoids and chalcones as selective \u03b1-glucosidase inhibitors: from enzymatic screening to validation using the human enzyme"],"prefix":"10.1039","volume":"17","author":[{"given":"Beatriz","family":"Vicente","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Amaro","sequence":"additional","affiliation":[{"name":"Associate Laboratory; i4HB-Institute for Health and Bioeconomy, University of Porto, 4050-346 Porto, Portugal"},{"name":"UCIBIO-Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-346 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-5700","authenticated-orcid":false,"given":"Paula","family":"Guedes de Pinho","sequence":"additional","affiliation":[{"name":"Associate Laboratory; i4HB-Institute for Health and Bioeconomy, University of Porto, 4050-346 Porto, Portugal"},{"name":"UCIBIO-Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-346 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Proen\u00e7a","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6332-3937","authenticated-orcid":false,"given":"M. Lu\u00edsa","family":"Corvo","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines, Faculdade de Farm\u00e1cia, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-0976","authenticated-orcid":false,"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9114-9967","authenticated-orcid":false,"given":"Marisa","family":"Freitas","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6MD00685J\/cit1\/1","doi-asserted-by":"publisher","first-page":"172625","DOI":"10.1016\/j.ejphar.2019.172625","volume":"862","author":"Khursheed","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"D6MD00685J\/cit2\/1","unstructured":"World Health Organization,  https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death , (accessed June 2026)"},{"key":"D6MD00685J\/cit3\/1","unstructured":"International Diabetes Federation,  https:\/\/diabetesatlas.org\/ , (accessed June 2026)"},{"key":"D6MD00685J\/cit4\/1","doi-asserted-by":"publisher","first-page":"806","DOI":"10.3390\/ph14080806","volume":"14","author":"Blahova","year":"2021","journal-title":"Pharmaceuticals"},{"key":"D6MD00685J\/cit5\/1","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1080\/13813455.2023.2262167","volume":"130","author":"Kumari","year":"2024","journal-title":"Arch. Physiol. Biochem."},{"key":"D6MD00685J\/cit6\/1","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.3390\/plants11202722","volume":"11","author":"Kashtoh","year":"2022","journal-title":"Plants"},{"key":"D6MD00685J\/cit7\/1","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.2147\/DDDT.S133453","volume":"11","author":"Patil","year":"2017","journal-title":"Drug Des., Dev. Ther."},{"key":"D6MD00685J\/cit8\/1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13007-019-0487-8","volume":"15","author":"Lankatillake","year":"2019","journal-title":"Plant Methods"},{"key":"D6MD00685J\/cit9\/1","doi-asserted-by":"publisher","first-page":"4799","DOI":"10.1007\/s00018-020-03564-1","volume":"77","author":"Elferink","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"D6MD00685J\/cit10\/1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.18433\/j35s3k","volume":"15","author":"Sales","year":"2012","journal-title":"J. Pharm. Pharm. Sci."},{"key":"D6MD00685J\/cit11\/1","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.jmb.2007.10.069","volume":"375","author":"Sim","year":"2008","journal-title":"J. Mol. Biol."},{"key":"D6MD00685J\/cit12\/1","doi-asserted-by":"publisher","first-page":"3873","DOI":"10.1021\/jf505425d","volume":"63","author":"Simsek","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"D6MD00685J\/cit13\/1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3164\/jcbn.13-59","volume":"54","author":"Cheng","year":"2014","journal-title":"J. Clin. Biochem. Nutr."},{"key":"D6MD00685J\/cit14\/1","doi-asserted-by":"publisher","first-page":"130981","DOI":"10.1016\/j.foodchem.2021.130981","volume":"370","author":"Lim","year":"2022","journal-title":"Food Chem."},{"key":"D6MD00685J\/cit15\/1","doi-asserted-by":"publisher","first-page":"3415","DOI":"10.3390\/foods12183415","volume":"12","author":"Guo","year":"2023","journal-title":"Foods"},{"key":"D6MD00685J\/cit16\/1","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1039\/c7fo00220c","volume":"8","author":"Rasouli","year":"2017","journal-title":"Food Funct."},{"key":"D6MD00685J\/cit17\/1","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1002\/fsn3.3983","volume":"12","author":"Aryal","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"D6MD00685J\/cit18\/1","doi-asserted-by":"publisher","first-page":"5760","DOI":"10.3390\/molecules29235760","volume":"29","author":"Intharuksa","year":"2024","journal-title":"Molecules"},{"key":"D6MD00685J\/cit19\/1","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.3390\/foods13244131","volume":"13","author":"Ciupei","year":"2024","journal-title":"Foods"},{"key":"D6MD00685J\/cit20\/1","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1080\/14756366.2017.1368503","volume":"32","author":"Proen\u00e7a","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6MD00685J\/cit21\/1","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1039\/d1fo02995a","volume":"13","author":"Proen\u00e7a","year":"2022","journal-title":"Food Funct."},{"key":"D6MD00685J\/cit22\/1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.11648\/j.sjc.20221002.12","volume":"10","author":"Mulugeta","year":"2022","journal-title":"Sci. J. Chem."},{"key":"D6MD00685J\/cit23\/1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11101-014-9387-8","volume":"15","author":"Rozmer","year":"2016","journal-title":"Phytochem. Rev."},{"key":"D6MD00685J\/cit24\/1","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.3390\/foods13172809","volume":"13","author":"Jia","year":"2024","journal-title":"Foods"},{"key":"D6MD00685J\/cit25\/1","doi-asserted-by":"publisher","first-page":"3332","DOI":"10.1039\/c9fo02806d","volume":"11","author":"Tang","year":"2020","journal-title":"Food Funct."},{"key":"D6MD00685J\/cit26\/1","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1080\/10408398.2020.1862755","volume":"62","author":"Proen\u00e7a","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D6MD00685J\/cit27\/1","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1080\/14756366.2018.1558221","volume":"34","author":"Proen\u00e7a","year":"2019","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6MD00685J\/cit28\/1","doi-asserted-by":"publisher","first-page":"10521","DOI":"10.1021\/acs.jafc.9b04943","volume":"67","author":"Jia","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"D6MD00685J\/cit29\/1","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1007\/s10068-015-0249-y","volume":"24","author":"Kang","year":"2015","journal-title":"Food Sci. Biotechnol."},{"key":"D6MD00685J\/cit30\/1","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1007\/s00018-016-2247-5","volume":"73","author":"Okuyama","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"D6MD00685J\/cit31\/1","doi-asserted-by":"publisher","first-page":"635633","DOI":"10.3389\/fphys.2021.635633","volume":"12","author":"da Costa-Latg\u00e9","year":"2021","journal-title":"Front. Physiol"},{"key":"D6MD00685J\/cit32\/1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1152\/physiolgenomics.00152.2002","volume":"13","author":"Fleet","year":"2003","journal-title":"Physiol. Genomics"},{"key":"D6MD00685J\/cit33\/1","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.3390\/foods10081939","volume":"10","author":"Barber","year":"2021","journal-title":"Foods"},{"key":"D6MD00685J\/cit34\/1","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.3390\/ijms24043595","volume":"24","author":"Haddad","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6MD00685J\/cit35\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10565-005-0085-6","volume":"21","author":"Sambuy","year":"2005","journal-title":"Cell Biol. Toxicol."},{"key":"D6MD00685J\/cit36\/1","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1021\/jf500431z","volume":"62","author":"Wong","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"D6MD00685J\/cit37\/1","doi-asserted-by":"publisher","first-page":"5510","DOI":"10.1039\/c9fo01298b","volume":"10","author":"Rocha","year":"2019","journal-title":"Food Funct."},{"key":"D6MD00685J\/cit38\/1","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1038\/s41598-020-59623-x","volume":"10","author":"Geicu","year":"2020","journal-title":"Sci. Rep."},{"key":"D6MD00685J\/cit39\/1","doi-asserted-by":"publisher","first-page":"107508","DOI":"10.1016\/j.vascn.2024.107508","volume":"127","author":"Ikeda","year":"2024","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"D6MD00685J\/cit40\/1","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s11306-025-02342-z","volume":"21","author":"Amaro","year":"2025","journal-title":"Metabolomics"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/MD\/article-pdf\/doi\/10.1039\/D6MD00685J\/0\/D6MD00685J.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:47:28Z","timestamp":1792673248000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/MD\/article-lookup\/doi\/10.1039\/D6MD00685J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d6md00685j","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}