{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:26:19Z","timestamp":1789615579091,"version":"build-2803163510"},"reference-count":47,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","license":[{"start":{"date-parts":[[2027,4,17]],"date-time":"2027-04-17T00:00:00Z","timestamp":1807920000000},"content-version":"am","delay-in-days":471,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2703004"],"award-info":[{"award-number":["2022YFC2703004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477122"],"award-info":[{"award-number":["22477122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51925307"],"award-info":[{"award-number":["51925307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52273220"],"award-info":[{"award-number":["52273220"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2293760"],"award-info":[{"award-number":["T2293760"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2025CXGC010419"],"award-info":[{"award-number":["2025CXGC010419"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB1030000"],"award-info":[{"award-number":["XDB1030000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0960000"],"award-info":[{"award-number":["XDB0960000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["JQ24007"],"award-info":[{"award-number":["JQ24007"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Mater. Horiz."],"abstract":"<jats:p>\n                    We introduce ICE-grinding, overcoming chemistry constraints and contamination in soft nanoparticle synthesis. Cryogenic vitrification embrittles gels\n                    <jats:italic>via<\/jats:italic>\n                    glassy ice, directing nanoscale fracture while preserving polymer networks for nanomedicine.\n                  <\/jats:p>","DOI":"10.1039\/d6mh00347h","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:12:03Z","timestamp":1776438723000},"page":"5407-5416","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ice-assisted cryogenic embrittlement grinding for surfactant-free fabrication of soft nanomaterials"],"prefix":"10.1039","volume":"13","author":[{"given":"Yangjie","family":"Fu","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China"},{"name":"School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunan","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P. R. China"},{"name":"Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Peng","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwang","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-818X","authenticated-orcid":false,"given":"Dongsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong 999077, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-9922","authenticated-orcid":false,"given":"Jianjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China"},{"name":"School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0653-7760","authenticated-orcid":false,"given":"Yuanchen","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P. R. China"},{"name":"Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0153-7515","authenticated-orcid":false,"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China"},{"name":"School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6MH00347H\/cit1\/1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nmat3776","volume":"12","author":"Mura","year":"2013","journal-title":"Nat. Mater."},{"key":"D6MH00347H\/cit2\/1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41578-024-00695-w","volume":"9","author":"Gao","year":"2024","journal-title":"Nat. Rev. Mater."},{"key":"D6MH00347H\/cit3\/1","doi-asserted-by":"crossref","first-page":"2002020","DOI":"10.1002\/advs.202002020","volume":"8","author":"Hu","year":"2021","journal-title":"Adv. Sci."},{"key":"D6MH00347H\/cit4\/1","first-page":"1","volume":"11","author":"Xie","year":"2020","journal-title":"Nat. Commun."},{"key":"D6MH00347H\/cit5\/1","first-page":"327","volume":"12","author":"Xue","year":"2022","journal-title":"Bioact. Mater."},{"key":"D6MH00347H\/cit6\/1","first-page":"127","volume":"8","author":"Lin","year":"2025","journal-title":"Nat. Electron."},{"key":"D6MH00347H\/cit7\/1","first-page":"156","author":"Ying","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"D6MH00347H\/cit8\/1","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1039\/C7CS00399D","volume":"47","author":"Wang","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"D6MH00347H\/cit9\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41578-019-0148-6","volume":"5","author":"Daly","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"D6MH00347H\/cit10\/1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nbt.4181","volume":"36","author":"Tang","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"D6MH00347H\/cit11\/1","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/s44222-024-00214-0","volume":"2","author":"Wang","year":"2024","journal-title":"Nat. Rev. Bioeng."},{"key":"D6MH00347H\/cit12\/1","doi-asserted-by":"crossref","first-page":"2201794","DOI":"10.1002\/adhm.202201794","volume":"12","author":"Keller","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"D6MH00347H\/cit13\/1","doi-asserted-by":"crossref","first-page":"1804121","DOI":"10.1002\/adfm.201804121","volume":"28","author":"Zhu","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"D6MH00347H\/cit14\/1","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1158\/1078-0432.CCR-06-2496","volume":"13","author":"Mita","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"D6MH00347H\/cit15\/1","doi-asserted-by":"crossref","first-page":"11675","DOI":"10.1021\/acs.chemrev.2c00035","volume":"122","author":"Scotti","year":"2022","journal-title":"Chem. Rev."},{"key":"D6MH00347H\/cit16\/1","doi-asserted-by":"crossref","first-page":"e202420926","DOI":"10.1002\/anie.202420926","volume":"64","author":"Li","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MH00347H\/cit17\/1","doi-asserted-by":"crossref","first-page":"10096","DOI":"10.1021\/ja051977c","volume":"127","author":"Rolland","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"D6MH00347H\/cit18\/1","doi-asserted-by":"crossref","first-page":"e202403834","DOI":"10.1002\/anie.202403834","volume":"63","author":"Hu","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MH00347H\/cit19\/1","doi-asserted-by":"crossref","first-page":"1803087","DOI":"10.1002\/adma.201803087","volume":"30","author":"Sinclair","year":"2018","journal-title":"Adv. Mater."},{"key":"D6MH00347H\/cit20\/1","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1039\/D3SM01740K","volume":"20","author":"Divoux","year":"2024","journal-title":"Soft Matter"},{"key":"D6MH00347H\/cit21\/1","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1007\/s40843-022-2120-8","volume":"65","author":"Zhang","year":"2022","journal-title":"Sci. China Mater."},{"key":"D6MH00347H\/cit22\/1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/09506608.2020.1825175","volume":"66","author":"Katiyar","year":"2021","journal-title":"Int. Mater. Rev."},{"key":"D6MH00347H\/cit23\/1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/24540","volume":"396","author":"Mishima","year":"1998","journal-title":"Nature"},{"key":"D6MH00347H\/cit24\/1","doi-asserted-by":"crossref","first-page":"11504","DOI":"10.1021\/acs.nanolett.4c02870","volume":"24","author":"Park","year":"2024","journal-title":"Nano Lett."},{"key":"D6MH00347H\/cit25\/1","doi-asserted-by":"crossref","first-page":"11757","DOI":"10.1073\/pnas.1303001110","volume":"110","author":"Thurmer","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6MH00347H\/cit26\/1","doi-asserted-by":"crossref","first-page":"415655","DOI":"10.1016\/j.physb.2023.415655","volume":"676","author":"Fedorov","year":"2024","journal-title":"Phys. B"},{"key":"D6MH00347H\/cit27\/1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2320\/matertrans1989.30.895","volume":"30","author":"Narita","year":"1989","journal-title":"Mater. Trans."},{"key":"D6MH00347H\/cit28\/1","doi-asserted-by":"crossref","first-page":"2301421","DOI":"10.1002\/adfm.202301421","volume":"33","author":"Kuzina","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D6MH00347H\/cit29\/1","doi-asserted-by":"crossref","first-page":"113184","DOI":"10.1016\/j.eurpolymj.2024.113184","volume":"214","author":"Rekha Rout","year":"2024","journal-title":"Eur. Polym. J."},{"key":"D6MH00347H\/cit30\/1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/s41551-024-01230-6","volume":"8","author":"Wang","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"D6MH00347H\/cit31\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41565-021-00997-y","volume":"17","author":"Myerson","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"D6MH00347H\/cit32\/1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.biomaterials.2016.06.002","volume":"101","author":"He","year":"2016","journal-title":"Biomaterials"},{"key":"D6MH00347H\/cit33\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.10.032","volume":"192","author":"Wan","year":"2019","journal-title":"Biomaterials"},{"key":"D6MH00347H\/cit34\/1","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1039\/D0NA01051K","volume":"3","author":"Whiteley","year":"2021","journal-title":"Nanoscale Adv."},{"key":"D6MH00347H\/cit35\/1","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1039\/D2NR06401D","volume":"15","author":"Whiteley","year":"2023","journal-title":"Nanoscale"},{"key":"D6MH00347H\/cit36\/1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nmat2724","volume":"9","author":"Vasudevan","year":"2010","journal-title":"Nat. Mater."},{"key":"D6MH00347H\/cit37\/1","doi-asserted-by":"crossref","first-page":"1806693","DOI":"10.1002\/adfm.201806693","volume":"29","author":"Zhang","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"D6MH00347H\/cit38\/1","doi-asserted-by":"crossref","first-page":"10567","DOI":"10.1002\/anie.201903309","volume":"58","author":"Ferguson","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MH00347H\/cit39\/1","doi-asserted-by":"crossref","first-page":"2203492","DOI":"10.1002\/adfm.202203492","volume":"32","author":"Hao","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"D6MH00347H\/cit40\/1","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41467-023-37150-3","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"D6MH00347H\/cit41\/1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.addr.2012.02.002","volume":"64","author":"Chacko","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6MH00347H\/cit42\/1","doi-asserted-by":"crossref","first-page":"2107678","DOI":"10.1002\/adfm.202107678","volume":"31","author":"Lin","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"D6MH00347H\/cit43\/1","doi-asserted-by":"crossref","first-page":"2401094","DOI":"10.1002\/adma.202401094","volume":"36","author":"Sun","year":"2024","journal-title":"Adv. Mater."},{"key":"D6MH00347H\/cit44\/1","doi-asserted-by":"crossref","first-page":"e202304908","DOI":"10.1002\/anie.202304908","volume":"62","author":"Mathews","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MH00347H\/cit45\/1","doi-asserted-by":"crossref","first-page":"e202300031","DOI":"10.1002\/anie.202300031","volume":"62","author":"Dong","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6MH00347H\/cit46\/1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.dental.2011.01.006","volume":"27","author":"Moraes","year":"2011","journal-title":"Dent. Mater."},{"key":"D6MH00347H\/cit47\/1","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1038\/s41467-019-10640-z","volume":"10","author":"Chen","year":"2019","journal-title":"Nat. Commun."}],"updated-by":[{"DOI":"10.1039\/d6mh90056a","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000}}],"container-title":["Materials Horizons"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/MH\/D6MH00347H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:42:18Z","timestamp":1783014138000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/mh\/article\/13\/11\/5407-5416\/1235655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d6mh00347h","relation":{},"ISSN":["2051-6347","2051-6355"],"issn-type":[{"value":"2051-6347","type":"print"},{"value":"2051-6355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}