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Chem."},{"key":"D6NP00051G\/cit96\/1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1021\/acschembio.3c00782","volume":"19","author":"Phan","year":"2024","journal-title":"ACS Chem. Biol."},{"key":"D6NP00051G\/cit97\/1","doi-asserted-by":"crossref","first-page":"14328","DOI":"10.1021\/jacs.4c03994","volume":"146","author":"Woodard","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit98\/1","doi-asserted-by":"crossref","first-page":"11580","DOI":"10.1021\/jacs.2c00521","volume":"144","author":"Sugiyama","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit99\/1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1021\/acschembio.4c00693","volume":"20","author":"Khan","year":"2025","journal-title":"ACS Chem. Biol."},{"key":"D6NP00051G\/cit100\/1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.12.16.628070","volume-title":"bioRxiv","author":"Modaresi","year":"2024","unstructured":"S. M.Modaresi ,  R.Sugiyama ,  N. D. 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Commun."},{"key":"D6NP00051G\/cit112\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41586-021-03455-w","volume":"593","author":"Kaur","year":"2021","journal-title":"Nature"},{"key":"D6NP00051G\/cit113\/1","doi-asserted-by":"crossref","first-page":"154337","DOI":"10.1016\/j.tetlet.2023.154337","volume":"116","author":"Li","year":"2023","journal-title":"Tetrahedron Lett."},{"key":"D6NP00051G\/cit114\/1","doi-asserted-by":"crossref","first-page":"11882","DOI":"10.1039\/D1SC02725E","volume":"12","author":"Gro\u00df","year":"2021","journal-title":"Chem. Sci."},{"key":"D6NP00051G\/cit115\/1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ymben.2021.04.007","volume":"66","author":"Wuisan","year":"2021","journal-title":"Metab. Eng."},{"key":"D6NP00051G\/cit116\/1","doi-asserted-by":"crossref","first-page":"e01535","DOI":"10.1128\/spectrum.01535-21","volume":"9","author":"B\u00f6hringer","year":"2021","journal-title":"Microbiol. 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Microbiol."},{"key":"D6NP00051G\/cit122\/1","doi-asserted-by":"crossref","first-page":"31715","DOI":"10.1021\/jacs.4c10425","volume":"146","author":"Nguyen","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit123\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.31635\/ccschem.024.202404983","volume":"7","author":"Han","year":"2024","journal-title":"CCS Chem."},{"key":"D6NP00051G\/cit124\/1","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1128\/jb.174.4.1426-1427.1992","volume":"174","author":"Goosen","year":"1992","journal-title":"J. Bacteriol."},{"key":"D6NP00051G\/cit125\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2091-9-8","volume":"9","author":"Puehringer","year":"2008","journal-title":"BMC Biochem."},{"key":"D6NP00051G\/cit126\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cbpa.2020.05.001","volume":"59","author":"Zhu","year":"2020","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D6NP00051G\/cit127\/1","doi-asserted-by":"crossref","first-page":"8877","DOI":"10.1074\/jbc.C115.699918","volume":"291","author":"Barr","year":"2016","journal-title":"J. Biol. Chem."},{"key":"D6NP00051G\/cit128\/1","doi-asserted-by":"crossref","first-page":"15025","DOI":"10.1074\/jbc.RA119.009684","volume":"294","author":"Martins","year":"2019","journal-title":"J. Biol. Chem."},{"key":"D6NP00051G\/cit129\/1","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1021\/jacs.8b13453","volume":"141","author":"Koehn","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit130\/1","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.1021\/ja0493852","volume":"126","author":"Magnusson","year":"2004","journal-title":"J. Am. Chem. 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Sci."},{"key":"D6NP00051G\/cit136\/1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1039\/D5NP00012B","volume":"42","author":"Ellerhorst","year":"2025","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00051G\/cit137\/1","doi-asserted-by":"crossref","first-page":"101881","DOI":"10.1016\/j.jbc.2022.101881","volume":"298","author":"Kostenko","year":"2022","journal-title":"J. Biol. Chem."},{"key":"D6NP00051G\/cit138\/1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1021\/acschembio.3c00583","volume":"19","author":"Lien","year":"2024","journal-title":"ACS Chem. Biol."},{"key":"D6NP00051G\/cit139\/1","doi-asserted-by":"crossref","first-page":"8712","DOI":"10.1021\/acs.jmedchem.6b00472","volume":"59","author":"Talele","year":"2016","journal-title":"J. Med. Chem."},{"key":"D6NP00051G\/cit140\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.7164\/antibiotics.46.135","volume":"46","author":"Ezaki","year":"1993","journal-title":"J. Antibiot."},{"key":"D6NP00051G\/cit141\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1021\/cb500897w","volume":"10","author":"Appel","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"D6NP00051G\/cit142\/1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41589-022-01090-8","volume":"18","author":"Bushin","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"D6NP00051G\/cit143\/1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1021\/cb900133x","volume":"4","author":"Yu","year":"2009","journal-title":"ACS Chem. Biol."},{"key":"D6NP00051G\/cit144\/1","doi-asserted-by":"crossref","first-page":"15847","DOI":"10.1021\/jacs.5c03922","volume":"147","author":"Xiong","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit145\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nchembio.512","volume":"7","author":"Zhang","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"D6NP00051G\/cit146\/1","doi-asserted-by":"crossref","first-page":"11840","DOI":"10.1002\/anie.201407320","volume":"53","author":"Nicolet","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00051G\/cit147\/1","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.aad8995","volume":"351","author":"Sicoli","year":"2016","journal-title":"Science"},{"key":"D6NP00051G\/cit148\/1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1021\/jacs.7b09000","volume":"140","author":"Bhandari","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit149\/1","doi-asserted-by":"crossref","first-page":"17438","DOI":"10.1021\/jacs.7b08492","volume":"139","author":"LaMattina","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit150\/1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1021\/acs.orglett.9b00293","volume":"21","author":"Qiu","year":"2019","journal-title":"Org. Lett."},{"key":"D6NP00051G\/cit151\/1","doi-asserted-by":"crossref","first-page":"22892","DOI":"10.1021\/jacs.6c03999","volume":"148","author":"Wang","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit152\/1","doi-asserted-by":"crossref","first-page":"16260","DOI":"10.1016\/S0021-9258(18)37587-2","volume":"263","author":"Buchman","year":"1988","journal-title":"J. Biol. Chem."},{"key":"D6NP00051G\/cit153\/1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1128\/jb.171.3.1597-1601.1989","volume":"171","author":"Kaletta","year":"1989","journal-title":"J. Bacteriol."},{"key":"D6NP00051G\/cit154\/1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1432-1033.1991.tb16138.x","volume":"199","author":"Kaletta","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"D6NP00051G\/cit155\/1","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.7164\/antibiotics.43.1421","volume":"43","author":"Hayashi","year":"1990","journal-title":"J. Antibiot."},{"key":"D6NP00051G\/cit156\/1","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1021\/jacs.9b01519","volume":"141","author":"Hudson","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit157\/1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1021\/jacs.8b11060","volume":"141","author":"Caruso","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit158\/1","doi-asserted-by":"crossref","first-page":"e202308733","DOI":"10.1002\/anie.202308733","volume":"62","author":"Cheng","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00051G\/cit159\/1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1021\/acschembio.9b00457","volume":"14","author":"Precord","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"D6NP00051G\/cit160\/1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1021\/acscentsci.2c00501","volume":"8","author":"Eastman","year":"2022","journal-title":"ACS Cent. Sci."},{"key":"D6NP00051G\/cit161\/1","doi-asserted-by":"crossref","first-page":"11734","DOI":"10.1021\/jacs.7b01283","volume":"139","author":"Grove","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit162\/1","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1021\/acs.biochem.6b00145","volume":"55","author":"Bruender","year":"2016","journal-title":"Biochemistry"},{"key":"D6NP00051G\/cit163\/1","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1093\/bbb\/zbab117","volume":"85","author":"Nakai","year":"2021","journal-title":"Biosci., Biotechnol., Biochem."},{"key":"D6NP00051G\/cit164\/1","doi-asserted-by":"crossref","first-page":"10450","DOI":"10.1021\/ja504692v","volume":"136","author":"Mukherjee","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit165\/1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1021\/acschembio.5b00007","volume":"10","author":"Yang","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"D6NP00051G\/cit166\/1","doi-asserted-by":"crossref","DOI":"10.1002\/9780470452882","volume-title":"Quinone Methides","author":"Rokita","year":"2009","unstructured":"S. E.Rokita ,  Quinone Methides ,  John Wiley & Sons ,  2009"},{"key":"D6NP00051G\/cit167\/1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1039\/D4OB01395F","volume":"23","author":"Delawsk\u00e1","journal-title":"Org. Biomol. Chem."},{"key":"D6NP00051G\/cit168\/1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/oxfordjournals.jbchem.a135315","volume":"98","author":"Babasaki","year":"1985","journal-title":"J. Biochem."},{"key":"D6NP00051G\/cit169\/1","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1021\/ja029654t","volume":"125","author":"Kawulka","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00051G\/cit170\/1","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1021\/bi0359527","volume":"43","author":"Kawulka","year":"2004","journal-title":"Biochemistry"},{"key":"D6NP00051G\/cit171\/1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1126\/science.1086462","volume":"301","author":"Gonz\u00e1lez-Pastor","year":"2003","journal-title":"Science"},{"key":"D6NP00051G\/cit172\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1574-6968.2009.01749.x","volume":"299","author":"Lee","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"D6NP00051G\/cit173\/1","doi-asserted-by":"crossref","first-page":"9352","DOI":"10.1073\/pnas.0913554107","volume":"107","author":"Rea","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6NP00051G\/cit174\/1","doi-asserted-by":"crossref","first-page":"18793","DOI":"10.1002\/anie.201908490","volume":"58","author":"Mo","year":"2019","journal-title":"Angew. Chem., Int. 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