{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:54:32Z","timestamp":1790949272625,"version":"4.1.0"},"reference-count":148,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2027,10,2]],"date-time":"2027-10-02T00:00:00Z","timestamp":1822435200000},"content-version":"am","delay-in-days":639,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82321004"],"award-info":[{"award-number":["82321004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82525062"],"award-info":[{"award-number":["82525062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574275"],"award-info":[{"award-number":["82574275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20804"],"award-info":[{"award-number":["U24A20804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1515040015"],"award-info":[{"award-number":["2023B1515040015"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515030103"],"award-info":[{"award-number":["2024A1515030103"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202102070001"],"award-info":[{"award-number":["202102070001"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2026M793892"],"award-info":[{"award-number":["2026M793892"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nat. Prod. Rep."],"abstract":"<jats:p>This review highlights the evolution of the vinylogous Mannich reaction into a powerful strategy for constructing structurally diverse and stereochemically complex alkaloids.<\/jats:p>","DOI":"10.1039\/d6np00076b","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:06:11Z","timestamp":1790946371000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vinylogous Mannich reaction in total synthesis of alkaloids"],"prefix":"10.1039","author":[{"given":"Guan-Qiu","family":"Qin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, P. R. China"},{"name":"Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, P. R. China"},{"name":"Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-1001","authenticated-orcid":false,"given":"Wen-Cai","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, P. R. China"},{"name":"Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3019-6548","authenticated-orcid":false,"given":"Li-Jun","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, P. R. China"},{"name":"Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-1812","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, P. R. China"},{"name":"Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6NP00076B\/cit1\/1","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1039\/D5NP00025D","volume":"42","author":"Lee","year":"2025","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit2\/1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1039\/D5NP00046G","volume":"43","author":"Chen","year":"2026","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit3\/1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.phymed.2016.05.003","volume":"23","author":"Bribi","year":"2016","journal-title":"Phytomedicine"},{"key":"D6NP00076B\/cit4\/1","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1039\/D5NP00051C","volume":"43","author":"Liu","year":"2026","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit5\/1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1039\/D3NP00044C","volume":"41","author":"Jayawardena","year":"2024","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit6\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/736895","volume":"2015","author":"Bribi","year":"2015","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D6NP00076B\/cit7\/1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1039\/D0NP00036A","volume":"38","author":"Reu\u00df","year":"2021","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit8\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1039\/D3NP00029J","volume":"41","author":"Cheng","year":"2024","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit9\/1","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1039\/D4NP00023D","volume":"41","author":"Yang","year":"2024","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit10\/1","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1039\/D2NP00058J","volume":"39","author":"Olivier","year":"2022","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit11\/1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1039\/D1NP00060H","volume":"39","author":"Ma","year":"2022","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit12\/1","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1016\/0040-4039(96)01205-1","volume":"37","author":"Fortunak","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"D6NP00076B\/cit13\/1","doi-asserted-by":"crossref","first-page":"8999","DOI":"10.1016\/S0040-4020(98)00543-2","volume":"54","author":"Iwao","year":"1998","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit14\/1","doi-asserted-by":"crossref","first-page":"11393","DOI":"10.1016\/j.tet.2005.09.013","volume":"61","author":"Hayashi","year":"2005","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit15\/1","doi-asserted-by":"crossref","first-page":"6761","DOI":"10.1016\/j.tetlet.2006.07.083","volume":"47","author":"Hirose","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"D6NP00076B\/cit16\/1","doi-asserted-by":"crossref","first-page":"6420","DOI":"10.1002\/anie.201902155","volume":"58","author":"Tan","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00076B\/cit17\/1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1039\/C3NP70115H","volume":"31","author":"Kang","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit18\/1","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1021\/jm001049i","volume":"43","author":"Razet","year":"2000","journal-title":"J. Med. Chem."},{"key":"D6NP00076B\/cit19\/1","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1002\/adsc.201100572","volume":"353","author":"Sartori","year":"2011","journal-title":"Adv. Synth. Catal."},{"key":"D6NP00076B\/cit20\/1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1021\/ol4037117","volume":"16","author":"Rao","year":"2014","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit21\/1","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S0040-4020(00)01167-4","volume":"57","author":"Nadin","year":"2001","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit22\/1","first-page":"319","volume":"19","author":"Ishida","year":"1975","journal-title":"Chem. Lett."},{"key":"D6NP00076B\/cit23\/1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1246\/bcsj.50.1161","volume":"50","author":"Ishida","year":"1977","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"D6NP00076B\/cit24\/1","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1246\/bcsj.51.2077","volume":"51","author":"Ishida","year":"1978","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"D6NP00076B\/cit25\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1246\/cl.2007.8","volume":"36","author":"Nagao","year":"2007","journal-title":"Chem. Lett."},{"key":"D6NP00076B\/cit26\/1","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1021\/jo900977y","volume":"74","author":"Gu","year":"2009","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit27\/1","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/S0040-4020(01)00035-7","volume":"57","author":"Bur","year":"2001","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit28\/1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1021\/ar950230w","volume":"35","author":"Martin","year":"2002","journal-title":"Acc. Chem. Res."},{"key":"D6NP00076B\/cit29\/1","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1021\/cr100304n","volume":"111","author":"Casiraghi","year":"2011","journal-title":"Chem. Rev."},{"key":"D6NP00076B\/cit30\/1","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1055\/s-0035-1561650","volume":"48","author":"Rosell\u00f3","year":"2016","journal-title":"Synthesis"},{"key":"D6NP00076B\/cit31\/1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1039\/np9971400559","volume":"14","author":"Saxton","year":"1997","journal-title":"Nat. Prod. Rep."},{"key":"D6NP00076B\/cit32\/1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/molecules26020488","volume":"26","author":"Mohammed","year":"2021","journal-title":"Molecules"},{"key":"D6NP00076B\/cit33\/1","doi-asserted-by":"crossref","first-page":"8916","DOI":"10.1002\/chem.201901130","volume":"25","author":"Saya","year":"2019","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6NP00076B\/cit34\/1","first-page":"25","volume":"3","author":"Liu","year":"2022","journal-title":"Green Synth. Catal."},{"key":"D6NP00076B\/cit35\/1","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1021\/acs.accounts.5c00461","volume":"58","author":"Wang","year":"2025","journal-title":"Acc. Chem. Res."},{"key":"D6NP00076B\/cit36\/1","doi-asserted-by":"crossref","first-page":"2155639","DOI":"10.1080\/14756366.2022.2155639","volume":"38","author":"Wang","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6NP00076B\/cit37\/1","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.1021\/ja00016a036","volume":"113","author":"Martin","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit38\/1","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.3390\/molecules28052370","volume":"28","author":"Liao","year":"2023","journal-title":"Molecules"},{"key":"D6NP00076B\/cit39\/1","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1021\/jo00115a044","volume":"60","author":"Martin","year":"1995","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit40\/1","doi-asserted-by":"crossref","first-page":"9804","DOI":"10.1021\/ja962577f","volume":"118","author":"Martin","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit41\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF02178329","volume":"9","author":"Millson","year":"1953","journal-title":"Experientia"},{"key":"D6NP00076B\/cit42\/1","doi-asserted-by":"crossref","first-page":"9293","DOI":"10.1021\/ja00073a057","volume":"115","author":"Knight","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit43\/1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1021\/acs.orglett.9b04093","volume":"22","author":"Wood","year":"2020","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit44\/1","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1021\/ol5029223","volume":"16","author":"Yang","year":"2014","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit45\/1","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1016\/S0040-4020(01)83369-X","volume":"23","author":"Merlini","year":"1967","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit46\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-2999(84)90698-8","volume":"106","author":"Roquebert","year":"1984","journal-title":"Eur. J. Pharmacol."},{"key":"D6NP00076B\/cit47\/1","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.1021\/ja01054a025","volume":"91","author":"Van Tamelen","year":"1969","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit48\/1","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1021\/ja0296024","volume":"125","author":"Deiters","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit49\/1","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1021\/jo100516g","volume":"75","author":"Sirasani","year":"2010","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit50\/1","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.tetlet.2011.01.090","volume":"52","author":"Yang","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"D6NP00076B\/cit51\/1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1021\/cr60307a001","volume":"77","author":"Schmeltz","year":"1977","journal-title":"Chem. Rev."},{"key":"D6NP00076B\/cit52\/1","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1021\/ol302871u","volume":"14","author":"Abels","year":"2012","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit53\/1","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1002\/chem.201304086","volume":"20","author":"Abels","year":"2014","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6NP00076B\/cit54\/1","doi-asserted-by":"crossref","first-page":"12724","DOI":"10.1021\/acs.joc.0c01885","volume":"85","author":"Tripathy","year":"2020","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit55\/1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0040-4020(01)89998-1","volume":"43","author":"Tokuyama","year":"1987","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit56\/1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1039\/D2OB01723G","volume":"21","author":"Mazeh","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"D6NP00076B\/cit57\/1","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1021\/acs.joc.1c01346","volume":"86","author":"Veliu","year":"2021","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit58\/1","doi-asserted-by":"crossref","first-page":"18894","DOI":"10.1039\/C4RA14418J","volume":"5","author":"Yang","year":"2015","journal-title":"RSC Adv."},{"key":"D6NP00076B\/cit59\/1","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1016\/S0040-4020(01)85567-8","volume":"50","author":"Leclercq","year":"1994","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit60\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/10915810305090","volume":"22","author":"Yi","year":"2003","journal-title":"Int. J. Toxicol."},{"key":"D6NP00076B\/cit61\/1","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1016\/0040-4020(81)85024-7","volume":"37","author":"Slosse","year":"1981","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit62\/1","doi-asserted-by":"crossref","first-page":"12327","DOI":"10.1002\/anie.201707249","volume":"56","author":"Chen","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00076B\/cit63\/1","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1021\/jo9001883","volume":"74","author":"Wakayama","year":"2009","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit64\/1","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1021\/ol0495220","volume":"6","author":"McMahon","year":"2004","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit65\/1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/jo0616512","volume":"72","author":"Tanuwidjaja","year":"2007","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit66\/1","doi-asserted-by":"crossref","first-page":"15652","DOI":"10.1021\/ja044753n","volume":"126","author":"Kochi","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit67\/1","doi-asserted-by":"crossref","first-page":"11276","DOI":"10.1021\/ja0363462","volume":"125","author":"Kochi","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit68\/1","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.tet.2018.11.046","volume":"75","author":"Chen","year":"2019","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit69\/1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41467-022-28535-x","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"key":"D6NP00076B\/cit70\/1","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3987\/COM-08-S(D)65","volume":"79","author":"Morita","year":"2009","journal-title":"Heterocycles"},{"key":"D6NP00076B\/cit71\/1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1021\/np5009619","volume":"78","author":"Xu","year":"2015","journal-title":"J. Nat. Prod."},{"key":"D6NP00076B\/cit72\/1","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1016\/j.bmc.2012.04.013","volume":"20","author":"Arai","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"D6NP00076B\/cit73\/1","doi-asserted-by":"crossref","first-page":"e202218935","DOI":"10.1002\/anie.202218935","volume":"62","author":"Tian","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00076B\/cit74\/1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0031-9422(00)95118-5","volume":"32","author":"Kam","year":"1993","journal-title":"Phytochemistry"},{"key":"D6NP00076B\/cit75\/1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1021\/np0703747","volume":"70","author":"Subramaniam","year":"2007","journal-title":"J. Nat. Prod."},{"key":"D6NP00076B\/cit76\/1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0031-9422(95)00920-5","volume":"42","author":"Kam","year":"1996","journal-title":"Phytochemistry"},{"key":"D6NP00076B\/cit77\/1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1021\/np9703712","volume":"61","author":"Mok","year":"1998","journal-title":"J. Nat. Prod."},{"key":"D6NP00076B\/cit78\/1","doi-asserted-by":"crossref","first-page":"8803","DOI":"10.1021\/acs.orglett.4c03177","volume":"26","author":"Liu","year":"2024","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit79\/1","doi-asserted-by":"crossref","first-page":"113786","DOI":"10.1016\/j.phytochem.2023.113786","volume":"213","author":"Li","year":"2023","journal-title":"Phytochemistry"},{"key":"D6NP00076B\/cit80\/1","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1021\/acs.orglett.6c00802","volume":"28","author":"Wang","year":"2026","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit81\/1","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1039\/jr9610002085","volume":"164","author":"Spilsbury","year":"1961","journal-title":"J. Chem. Soc."},{"key":"D6NP00076B\/cit82\/1","first-page":"1333","volume":"39","author":"Ohmomo","year":"1975","journal-title":"Agric. Biol. Chem."},{"key":"D6NP00076B\/cit83\/1","doi-asserted-by":"crossref","first-page":"10450","DOI":"10.1021\/ja00075a107","volume":"115","author":"Martin","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit84\/1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/00021369.1969.10859341","volume":"33","author":"Abe","year":"1969","journal-title":"Agric. Biol. Chem."},{"key":"D6NP00076B\/cit85\/1","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1021\/ja010577w","volume":"123","author":"Liras","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit86\/1","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/hlca.19570400526","volume":"40","author":"Hoffmann","year":"1957","journal-title":"Helv. Chim. Acta"},{"key":"D6NP00076B\/cit87\/1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11101-019-09602-6","volume":"18","author":"Greger","year":"2019","journal-title":"Phytochem. Rev."},{"key":"D6NP00076B\/cit88\/1","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1021\/ja9542146","volume":"118","author":"Martin","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit89\/1","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1021\/ja990077r","volume":"121","author":"Martin","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit90\/1","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1021\/ol010106e","volume":"3","author":"Kende","year":"2001","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit91\/1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0040-4020(01)01138-3","volume":"58","author":"Kende","year":"2002","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit92\/1","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1021\/ol202140y","volume":"13","author":"Tuo","year":"2011","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit93\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1021\/jo3014484","volume":"78","author":"Liu","year":"2013","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit94\/1","doi-asserted-by":"crossref","first-page":"18386","DOI":"10.1021\/jacs.7b10944","volume":"139","author":"Yoritate","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit95\/1","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1002\/anie.201612367","volume":"56","author":"Fuentes de Arriba","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00076B\/cit96\/1","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1021\/jacs.6b02324","volume":"138","author":"Katahara","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit97\/1","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1021\/acs.orglett.5b00664","volume":"17","author":"Nakajima","year":"2015","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit98\/1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/chem.201405256","volume":"21","author":"Gregory","year":"2015","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6NP00076B\/cit99\/1","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1039\/b821317h","volume":"45","author":"Motoyama","year":"2009","journal-title":"Chem. Commun."},{"key":"D6NP00076B\/cit100\/1","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1021\/ja00522a064","volume":"102","author":"Daly","year":"1980","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit101\/1","doi-asserted-by":"crossref","first-page":"8905","DOI":"10.1016\/S0040-4020(99)00452-4","volume":"55","author":"Martin","year":"1999","journal-title":"Tetrahedron"},{"key":"D6NP00076B\/cit102\/1","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1021\/ja00007a044","volume":"113","author":"Fox","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit103\/1","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1021\/ol2020384","volume":"13","author":"Ruan","year":"2011","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit104\/1","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1002\/ejoc.201201618","volume":"2013","author":"Guo","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"D6NP00076B\/cit105\/1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1039\/C5QO00098J","volume":"2","author":"Ye","year":"2015","journal-title":"Org. Chem. Front."},{"key":"D6NP00076B\/cit106\/1","doi-asserted-by":"crossref","first-page":"5796","DOI":"10.1002\/anie.201400048","volume":"53","author":"Wu","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00076B\/cit107\/1","doi-asserted-by":"crossref","first-page":"107045","DOI":"10.1039\/C5RA22191A","volume":"5","author":"Zhang","year":"2015","journal-title":"RSC Adv."},{"key":"D6NP00076B\/cit108\/1","doi-asserted-by":"crossref","first-page":"6274","DOI":"10.1021\/acs.orglett.5b03320","volume":"17","author":"Zhang","year":"2015","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit109\/1","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1021\/acs.orglett.8b03432","volume":"20","author":"Wu","year":"2018","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit110\/1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1021\/acs.jnatprod.9b00142","volume":"82","author":"Park","year":"2019","journal-title":"J. Nat. Prod."},{"key":"D6NP00076B\/cit111\/1","doi-asserted-by":"crossref","first-page":"19609","DOI":"10.1002\/anie.202103878","volume":"60","author":"He","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00076B\/cit112\/1","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1038\/s41467-026-72871-1","volume":"17","author":"Lee","year":"2026","journal-title":"Nat. Commun."},{"key":"D6NP00076B\/cit113\/1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/10286020.2014.930443","volume":"16","author":"Zhou","year":"2014","journal-title":"J. Asian Nat. Prod. Res."},{"key":"D6NP00076B\/cit114\/1","first-page":"1","volume-title":"The Alkaloids: Chemistry and Biology","volume":"74","author":"Chirkin","year":"2015","unstructured":"E.Chirkin ,  W.Atkatlian  and  F.-H.Por\u00e9e , in  The Alkaloids: Chemistry and Biology , ed.  H.-J. Kn\u00f6lker ,  Elsevier ,  2015 ,  vol. 74 ,  pp. 1\u2013120"},{"key":"D6NP00076B\/cit115\/1","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1055\/s-0036-1590864","volume":"28","author":"Jeon","year":"2017","journal-title":"Synlett"},{"key":"D6NP00076B\/cit116\/1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/ajoc.201700142","volume":"6","author":"Wehlauch","year":"2017","journal-title":"Asian J. Org. Chem."},{"key":"D6NP00076B\/cit117\/1","doi-asserted-by":"crossref","first-page":"114190","DOI":"10.1016\/j.biopha.2022.114190","volume":"158","author":"Hou","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"D6NP00076B\/cit118\/1","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1179\/016164104225014148","volume":"26","author":"Lin","year":"2004","journal-title":"Neurol. Res."},{"key":"D6NP00076B\/cit119\/1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1134\/S1819712411030056","volume":"5","author":"Neganova","year":"2011","journal-title":"Neurochem. J."},{"key":"D6NP00076B\/cit120\/1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10600-015-1240-9","volume":"51","author":"Al-Rehaily","year":"2015","journal-title":"Chem. Nat. Compd."},{"key":"D6NP00076B\/cit121\/1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejmech.2016.06.021","volume":"122","author":"Hou","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"D6NP00076B\/cit122\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8302636","volume":"2017","author":"Leonoudakis","year":"2017","journal-title":"Mediators Inflammation"},{"key":"D6NP00076B\/cit123\/1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1021\/ol0070482","volume":"3","author":"Liras","year":"2001","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit124\/1","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1021\/ol0522079","volume":"7","author":"Alib\u00e9s","year":"2005","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit125\/1","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1021\/jo901059n","volume":"74","author":"Gonz\u00e1lez-G\u00e1lvez","year":"2009","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit126\/1","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.3762\/bjoc.21.206","volume":"21","author":"M\u00f6gel","year":"2025","journal-title":"Beilstein J. Org. Chem."},{"key":"D6NP00076B\/cit127\/1","doi-asserted-by":"crossref","first-page":"25086","DOI":"10.1021\/jacs.3c10362","volume":"145","author":"Shao","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit128\/1","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1002\/anie.200603496","volume":"45","author":"Carswell","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00076B\/cit129\/1","doi-asserted-by":"crossref","first-page":"17961","DOI":"10.1021\/ja807243t","volume":"130","author":"Mandai","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit130\/1","doi-asserted-by":"crossref","first-page":"7657","DOI":"10.1021\/jo801470u","volume":"73","author":"Bardaj\u00ed","year":"2008","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit131\/1","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1039\/c3cc38783f","volume":"49","author":"Miyatake-Ondozabal","year":"2013","journal-title":"Chem. Commun."},{"key":"D6NP00076B\/cit132\/1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1021\/acs.orglett.6b03716","volume":"19","author":"Wehlauch","year":"2017","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit133\/1","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1038\/s41467-022-32902-z","volume":"13","author":"Park","year":"2022","journal-title":"Nat. Commun."},{"key":"D6NP00076B\/cit134\/1","doi-asserted-by":"crossref","first-page":"e202423900","DOI":"10.1002\/anie.202423900","volume":"64","author":"Qin","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6NP00076B\/cit135\/1","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1039\/D5QO01704A","volume":"13","author":"Waddell","year":"2026","journal-title":"Org. Chem. Front."},{"key":"D6NP00076B\/cit136\/1","doi-asserted-by":"crossref","first-page":"11574","DOI":"10.1002\/chem.201903122","volume":"25","author":"Antien","year":"2019","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6NP00076B\/cit137\/1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1038\/s41467-026-68816-3","volume":"17","author":"Choung","year":"2026","journal-title":"Nat. Commun."},{"key":"D6NP00076B\/cit138\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2026.08.028","author":"Dong","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"D6NP00076B\/cit139\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1021\/np50020a001","volume":"45","author":"Blask\u00f3","year":"1982","journal-title":"J. Nat. Prod."},{"key":"D6NP00076B\/cit140\/1","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/j.tetlet.2010.01.104","volume":"51","author":"Soriano","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"D6NP00076B\/cit141\/1","doi-asserted-by":"crossref","first-page":"15725","DOI":"10.1021\/acscatal.3c03917","volume":"13","author":"Liu","year":"2023","journal-title":"ACS Catal."},{"key":"D6NP00076B\/cit142\/1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1039\/C6QO00022C","volume":"3","author":"Ye","year":"2016","journal-title":"Org. Chem. Front."},{"key":"D6NP00076B\/cit143\/1","doi-asserted-by":"crossref","first-page":"9430","DOI":"10.1021\/jo051499o","volume":"70","author":"Mugishima","year":"2005","journal-title":"J. Org. Chem."},{"key":"D6NP00076B\/cit144\/1","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1021\/ol048900y","volume":"6","author":"Tsuda","year":"2004","journal-title":"Org. Lett."},{"key":"D6NP00076B\/cit145\/1","doi-asserted-by":"crossref","first-page":"10886","DOI":"10.1021\/ja405547f","volume":"135","author":"Bian","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit146\/1","doi-asserted-by":"crossref","first-page":"14184","DOI":"10.1021\/ja5074646","volume":"136","author":"Bian","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D6NP00076B\/cit147\/1","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1021\/np900112d","volume":"72","author":"Zhang","year":"2009","journal-title":"J. Nat. Prod."},{"key":"D6NP00076B\/cit148\/1","doi-asserted-by":"crossref","first-page":"11713","DOI":"10.1021\/jacs.9b05641","volume":"141","author":"Guo","year":"2019","journal-title":"J. Am. Chem. Soc."}],"container-title":["Natural Product Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/NP\/article-pdf\/doi\/10.1039\/D6NP00076B\/0\/D6NP00076B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:06:26Z","timestamp":1790946386000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/NP\/article-lookup\/doi\/10.1039\/D6NP00076B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":148,"URL":"https:\/\/doi.org\/10.1039\/d6np00076b","relation":{},"ISSN":["0265-0568","1460-4752"],"issn-type":[{"value":"0265-0568","type":"print"},{"value":"1460-4752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}