{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:52:16Z","timestamp":1791971536476,"version":"4.3.4"},"reference-count":66,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":284,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100010579","name":"Deutsch-Franz\u00f6sische Hochschule","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003768","name":"Universit\u00e9 de Strasbourg","doi-asserted-by":"publisher","award":["ANR-10-IDEX-0002"],"award-info":[{"award-number":["ANR-10-IDEX-0002"]}],"id":[{"id":"10.13039\/501100003768","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>Lithographically defined gold bowtie nanoantennas enable dual infrared and Raman detection of a membrane protein, providing strong signal improvement, high sensitivity, and selectivity, while preserving its native secondary structure.<\/jats:p>","DOI":"10.1039\/d6nr00784h","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:43:20Z","timestamp":1791805400000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasmonic gold bowtie nanoantennas for dual infrared and Raman detection of a cytochrome\n                    <i>bd<\/i>\n                    -type oxidase"],"prefix":"10.1039","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7892-6754","authenticated-orcid":false,"given":"Ariadna","family":"Murillo Bello","sequence":"first","affiliation":[{"name":"Bioelectrochemistry and Spectroscopy Laboratory \u2013 University of Strasbourg, UMR 7140, CNRS, Strasbourg 67081, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicham","family":"Majjad","sequence":"additional","affiliation":[{"name":"Institute of Physics and Chemistry of Materials of Strasbourg (IPCMS) \u2013 University of Strasbourg, UMR 7504, CNRS, Strasbourg 67200, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Javahiraly","sequence":"additional","affiliation":[{"name":"Bioelectrochemistry and Spectroscopy Laboratory \u2013 University of Strasbourg, UMR 7140, CNRS, Strasbourg 67081, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ali","family":"Khaled","sequence":"additional","affiliation":[{"name":"Institute of Physics and Chemistry of Materials of Strasbourg (IPCMS) \u2013 University of Strasbourg, UMR 7504, CNRS, Strasbourg 67200, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Intitute of Biochemistry \u2013 University of Freiburg, Freiburg 79104, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6294-5163","authenticated-orcid":false,"given":"Petra","family":"Hellwig","sequence":"additional","affiliation":[{"name":"Bioelectrochemistry and Spectroscopy Laboratory \u2013 University of Strasbourg, UMR 7140, CNRS, Strasbourg 67081, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6NR00784H\/cit1\/1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nature01937","volume":"424","author":"Barnes","year":"2003","journal-title":"Nature"},{"key":"D6NR00784H\/cit2\/1","doi-asserted-by":"crossref","first-page":"108386","DOI":"10.1016\/j.rinp.2025.108386","volume":"76","author":"Farooq","year":"2025","journal-title":"Results Phys."},{"key":"D6NR00784H\/cit3\/1","doi-asserted-by":"crossref","first-page":"14656","DOI":"10.1364\/OE.20.014656","volume":"20","author":"Pavaskar","year":"2012","journal-title":"Opt. Express"},{"key":"D6NR00784H\/cit4\/1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nmat2162","volume":"7","author":"Anker","year":"2008","journal-title":"Nat. Mater."},{"key":"D6NR00784H\/cit5\/1","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/j.bbamem.2013.04.026","volume":"1828","author":"Ataka","year":"2013","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"D6NR00784H\/cit6\/1","doi-asserted-by":"crossref","first-page":"e00226","DOI":"10.1016\/j.teac.2024.e00226","volume":"41","author":"Wang","year":"2024","journal-title":"Trends Environ. Anal. Chem."},{"key":"D6NR00784H\/cit7\/1","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.1038\/s41467-018-07869-5","volume":"9","author":"Mao","year":"2018","journal-title":"Nat. Commun."},{"key":"D6NR00784H\/cit8\/1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1103\/PhysRevLett.45.201","volume":"45","author":"Hartstein","year":"1980","journal-title":"Phys. Rev. Lett."},{"key":"D6NR00784H\/cit9\/1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1021\/la971110v","volume":"14","author":"Ataka","year":"1998","journal-title":"Langmuir"},{"key":"D6NR00784H\/cit10\/1","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1021\/nn4004764","volume":"7","author":"D'Andrea","year":"2013","journal-title":"ACS Nano"},{"key":"D6NR00784H\/cit11\/1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1039\/C6AN02596J","volume":"142","author":"Bibikova","year":"2017","journal-title":"Analyst"},{"key":"D6NR00784H\/cit12\/1","doi-asserted-by":"crossref","first-page":"2211154","DOI":"10.1002\/adfm.202211154","volume":"33","author":"Oksenberg","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D6NR00784H\/cit13\/1","first-page":"111","volume":"72","author":"Ataka","year":"2003","journal-title":"Prog. Surf. Sci."},{"key":"D6NR00784H\/cit14\/1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1366\/0003702934067478","volume":"47","author":"Osawa","year":"1993","journal-title":"Appl. Spectrosc."},{"key":"D6NR00784H\/cit15\/1","doi-asserted-by":"crossref","first-page":"157403","DOI":"10.1103\/PhysRevLett.101.157403","volume":"101","author":"Neubrech","year":"2008","journal-title":"Phys. Rev. Lett."},{"key":"D6NR00784H\/cit16\/1","doi-asserted-by":"crossref","first-page":"13857","DOI":"10.1021\/jp0516846","volume":"109","author":"Murphy","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"D6NR00784H\/cit17\/1","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1021\/acssensors.1c00238","volume":"6","author":"Santos Sei\u00e7a","year":"2021","journal-title":"ACS Sens."},{"key":"D6NR00784H\/cit18\/1","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1021\/acs.chemrev.6b00743","volume":"117","author":"Neubrech","year":"2017","journal-title":"Chem. Rev."},{"key":"D6NR00784H\/cit19\/1","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1038\/s41467-023-40511-7","volume":"14","author":"Paggi","year":"2023","journal-title":"Nat. Commun."},{"key":"D6NR00784H\/cit20\/1","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1021\/nl071008a","volume":"7","author":"Jain","year":"2007","journal-title":"Nano Lett."},{"key":"D6NR00784H\/cit21\/1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1126\/science.aab2051","volume":"349","author":"Rodrigo","year":"2015","journal-title":"Science"},{"key":"D6NR00784H\/cit22\/1","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1021\/nl101693a","volume":"10","author":"Schnell","year":"2010","journal-title":"Nano Lett."},{"key":"D6NR00784H\/cit23\/1","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1021\/acs.nanolett.1c04175","volume":"22","author":"Boyce","year":"2022","journal-title":"Nano Lett."},{"key":"D6NR00784H\/cit24\/1","doi-asserted-by":"crossref","first-page":"2300411","DOI":"10.1002\/adfm.202300411","volume":"33","author":"Berger","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D6NR00784H\/cit25\/1","doi-asserted-by":"crossref","first-page":"eadg9644","DOI":"10.1126\/sciadv.adg9644","volume":"9","author":"Kavungal","year":"2023","journal-title":"Sci. Adv."},{"key":"D6NR00784H\/cit26\/1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1017\/S0033583502003815","volume":"35","author":"Barth","year":"2002","journal-title":"Q. Rev. Biophys."},{"key":"D6NR00784H\/cit27\/1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/cphc.200900119","volume":"10","author":"Schl\u00fccker","year":"2009","journal-title":"ChemPhysChem"},{"key":"D6NR00784H\/cit28\/1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1039\/c0nr00122h","volume":"2","author":"Kennedy","year":"2010","journal-title":"Nanoscale"},{"key":"D6NR00784H\/cit29\/1","doi-asserted-by":"crossref","first-page":"16580","DOI":"10.1038\/s41598-021-96217-7","volume":"11","author":"Aguayo-Ortiz","year":"2021","journal-title":"Sci. Rep."},{"key":"D6NR00784H\/cit30\/1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.sbi.2008.07.001","volume":"18","author":"Carpenter","year":"2008","journal-title":"Curr. Opin. Struct. Biol."},{"key":"D6NR00784H\/cit31\/1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1515\/hsz-2012-0344","volume":"394","author":"Melin","year":"2013","journal-title":"Biol. Chem."},{"key":"D6NR00784H\/cit32\/1","doi-asserted-by":"crossref","first-page":"9068","DOI":"10.1021\/acsnano.7b03717","volume":"11","author":"Wasserberg","year":"2017","journal-title":"ACS Nano"},{"key":"D6NR00784H\/cit33\/1","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1021\/la063719e","volume":"23","author":"Kang","year":"2007","journal-title":"Langmuir"},{"key":"D6NR00784H\/cit34\/1","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.bbabio.2011.06.016","volume":"1807","author":"Borisov","year":"2011","journal-title":"Biochim. Biophys. Acta, Bioenerg."},{"key":"D6NR00784H\/cit35\/1","doi-asserted-by":"crossref","first-page":"141065","DOI":"10.1016\/j.bbapap.2025.141065","volume":"1873","author":"Bartkowiak","year":"2025","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"D6NR00784H\/cit36\/1","doi-asserted-by":"crossref","first-page":"2590244","DOI":"10.1080\/21505594.2025.2590244","volume":"16","author":"Xiao","year":"2025","journal-title":"Virulence"},{"key":"D6NR00784H\/cit37\/1","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.febslet.2014.03.036","volume":"588","author":"Hoeser","year":"2014","journal-title":"FEBS Lett."},{"key":"D6NR00784H\/cit38\/1","volume-title":"Electroless Gold Plating Bath Using Ascorbic Acid as Reducing Agent \u2013 Recent Improvements 7","author":"Kato","year":"2003","unstructured":"M.Kato ,  Y.Yazawa  and  Y.Okinaka , in  Electroless Gold Plating Bath Using Ascorbic Acid as Reducing Agent \u2013 Recent Improvements 7 ,  2003"},{"key":"D6NR00784H\/cit39\/1","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1021\/acssensors.0c00824","volume":"5","author":"Omeis","year":"2020","journal-title":"ACS Sens."},{"key":"D6NR00784H\/cit40\/1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1109\/TAP.1966.1138693","volume":"14","author":"Yee","year":"1966","journal-title":"IEEE Trans. Antennas Propag."},{"key":"D6NR00784H\/cit41\/1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1021\/acs.jpcc.5b10800","volume":"120","author":"Ross","year":"2016","journal-title":"J. Phys. Chem. C"},{"key":"D6NR00784H\/cit42\/1","doi-asserted-by":"crossref","first-page":"23203","DOI":"10.1038\/srep23203","volume":"6","author":"Kaniber","year":"2016","journal-title":"Sci. Rep."},{"key":"D6NR00784H\/cit43\/1","first-page":"6603019","volume":"11","author":"Dong","year":"2019","journal-title":"IEEE Photonics J."},{"key":"D6NR00784H\/cit44\/1","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1021\/nn500903v","volume":"8","author":"Huck","year":"2014","journal-title":"ACS Nano"},{"key":"D6NR00784H\/cit45\/1","doi-asserted-by":"crossref","first-page":"9780","DOI":"10.1021\/acsnano.7b02743","volume":"11","author":"Le","year":"2017","journal-title":"ACS Nano"},{"key":"D6NR00784H\/cit46\/1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3390\/bios15070401","volume":"15","author":"Garc\u00eda Garc\u00eda","year":"2025","journal-title":"Biosensors"},{"key":"D6NR00784H\/cit47\/1","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1039\/C5NR07476B","volume":"8","author":"Chien","year":"2016","journal-title":"Nanoscale"},{"key":"D6NR00784H\/cit48\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11468-025-02916-6","volume":"20","author":"Jamil","year":"2025","journal-title":"Plasmonics"},{"key":"D6NR00784H\/cit49\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3390\/photonics8040109","volume":"8","author":"Kostyukov","year":"2021","journal-title":"Photonics"},{"key":"D6NR00784H\/cit50\/1","doi-asserted-by":"crossref","first-page":"16199","DOI":"10.1021\/ja045951h","volume":"126","author":"Ataka","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"D6NR00784H\/cit51\/1","doi-asserted-by":"crossref","first-page":"12868","DOI":"10.1021\/la503439g","volume":"30","author":"Lim","year":"2014","journal-title":"Langmuir"},{"key":"D6NR00784H\/cit52\/1","doi-asserted-by":"crossref","first-page":"2201025","DOI":"10.1002\/adom.202201025","volume":"10","author":"Najem","year":"2022","journal-title":"Adv. Opt. Mater."},{"key":"D6NR00784H\/cit53\/1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bpc.2006.07.008","volume":"125","author":"Rozenberg","year":"2007","journal-title":"Biophys. Chem."},{"key":"D6NR00784H\/cit54\/1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0304-386X(03)00137-3","volume":"72","author":"Palacios-Beas","year":"2004","journal-title":"Hydrometallurgy"},{"key":"D6NR00784H\/cit55\/1","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1073\/pnas.1621431114","volume":"114","author":"Grytsyk","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"S8","key":"D6NR00784H\/cit56\/1","first-page":"6","volume":"36","author":"Mayerh\u00f6fer","year":"2021","journal-title":"Spectrosc. Suppl."},{"key":"D6NR00784H\/cit57\/1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1432-1033.1990.tb19354.x","volume":"193","author":"Goormaghtigh","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"D6NR00784H\/cit58\/1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.bbabio.2007.06.004","volume":"1767","author":"Barth","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"D6NR00784H\/cit59\/1","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1089\/ars.2020.8039","volume":"34","author":"Borisov","year":"2021","journal-title":"Antioxid. Redox Signaling"},{"key":"D6NR00784H\/cit60\/1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1021\/bi00053a001","volume":"32","author":"Surewicz","year":"1993","journal-title":"Biochemistry"},{"key":"D6NR00784H\/cit61\/1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00249-021-01502-y","volume":"50","author":"De Meutter","year":"2021","journal-title":"Eur. Biophys. J."},{"key":"D6NR00784H\/cit62\/1","doi-asserted-by":"crossref","first-page":"50049","DOI":"10.1021\/acsomega.4c00591","volume":"9","author":"Chandra","year":"2024","journal-title":"ACS Omega"},{"key":"D6NR00784H\/cit63\/1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0065-3233(08)60064-9","volume":"37","author":"Spiro","year":"1985","journal-title":"Adv. Protein Chem."},{"key":"D6NR00784H\/cit64\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.vibspec.2005.02.016","volume":"38","author":"Wood","year":"2005","journal-title":"Vib. Spectrosc."},{"key":"D6NR00784H\/cit65\/1","doi-asserted-by":"crossref","first-page":"12144","DOI":"10.1021\/bi00038a007","volume":"34","author":"Sun","year":"1995","journal-title":"Biochemistry"},{"key":"D6NR00784H\/cit66\/1","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1021\/acs.jpcb.3c00514","volume":"127","author":"Zhang","year":"2023","journal-title":"J. Phys. Chem. B"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/NR\/article-pdf\/doi\/10.1039\/D6NR00784H\/0\/D6NR00784H.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:23:52Z","timestamp":1791969832000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/NR\/article-lookup\/doi\/10.1039\/D6NR00784H"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":66,"URL":"https:\/\/doi.org\/10.1039\/d6nr00784h","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6NR00784H\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6NR00784H\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6NR00784H\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6NR00784H\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6NR00784H\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6NR00784H\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6NR00784H\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6NR00784H\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}