{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:14:09Z","timestamp":1790810049806,"version":"4.1.0"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2027,2,4]],"date-time":"2027-02-04T00:00:00Z","timestamp":1801699200000},"content-version":"am","delay-in-days":399,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B18035"],"award-info":[{"award-number":["B18035"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2025ZNSFSC0130"],"award-info":[{"award-number":["2025ZNSFSC0130"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>Twenty-one fluorinated derivatives of Bergenin were synthesized, among which the C4-position modified analogs exhibited potently enhanced anti-inflammatory or antitussive activity relative to the parent compound.<\/jats:p>","DOI":"10.1039\/d6ob00031b","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T01:21:21Z","timestamp":1770168081000},"page":"1852-1856","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis and biological evaluation of fluorinated bergenin derivatives"],"prefix":"10.1039","volume":"24","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8004-821X","authenticated-orcid":false,"given":"Lin","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6OB00031B\/cit1\/1","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1038\/s41467-024-47502-2","volume":"15","author":"Yan","year":"2024","journal-title":"Nat. Commun."},{"key":"D6OB00031B\/cit2\/1","doi-asserted-by":"crossref","first-page":"114307","DOI":"10.1016\/j.ejpb.2024.114307","volume":"200","author":"Nnamani","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D6OB00031B\/cit3a\/1","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3390\/molecules23102668","volume":"23","author":"Qi","year":"2018","journal-title":"Molecules"},{"key":"D6OB00031B\/cit3b\/1","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/j.ejmech.2011.03.025","volume":"46","author":"Nazir","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"D6OB00031B\/cit4\/1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1021\/np960074h","volume":"59","author":"Piacente","year":"1996","journal-title":"J. Nat. Prod."},{"key":"D6OB00031B\/cit5\/1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.fitote.2011.12.008","volume":"83","author":"Kumar","year":"2012","journal-title":"Fitoterapia"},{"key":"D6OB00031B\/cit6\/1","doi-asserted-by":"crossref","first-page":"110207","DOI":"10.1016\/j.cbi.2022.110207","volume":"368","author":"Salama","year":"2022","journal-title":"Chem.-Biol. Interact."},{"key":"D6OB00031B\/cit7\/1","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1039\/D2MD00116K","volume":"13","author":"Venkateswara Rao","year":"2022","journal-title":"RSC Med. Chem."},{"key":"D6OB00031B\/cit8\/1","doi-asserted-by":"crossref","first-page":"122680","DOI":"10.1016\/j.jchromb.2021.122680","volume":"1173","author":"Zhang","year":"2021","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"D6OB00031B\/cit9\/1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1476-5381.2010.01198.x","volume":"163","author":"Dicpinigaitis","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"D6OB00031B\/cit10a\/1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jep.2017.02.013","volume":"200","author":"Yang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"D6OB00031B\/cit10b\/1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jep.2019.02.006","volume":"235","author":"Jing","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"D6OB00031B\/cit10c\/1","doi-asserted-by":"crossref","first-page":"101921","DOI":"10.1016\/j.pupt.2020.101921","volume":"62","author":"Chen","year":"2020","journal-title":"Pulm. Pharmacol. Ther."},{"key":"D6OB00031B\/cit11a\/1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.molliq.2016.05.015","volume":"220","author":"Shakeel","year":"2016","journal-title":"J. Mol. Liq."},{"key":"D6OB00031B\/cit11b\/1","doi-asserted-by":"crossref","first-page":"120537","DOI":"10.1016\/j.ijpharm.2021.120537","volume":"601","author":"Liu","year":"2021","journal-title":"Int. J. Pharm."},{"key":"D6OB00031B\/cit11c\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/aps.2009.171","volume":"31","author":"Qin","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"D6OB00031B\/cit11d\/1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1208\/s12249-018-0984-5","volume":"19","author":"Gao","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"D6OB00031B\/cit12a\/1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s12272-012-0903-3","volume":"35","author":"Kashima","year":"2012","journal-title":"Arch. Pharmacal Res."},{"key":"D6OB00031B\/cit12b\/1","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1016\/j.bmcl.2011.04.131","volume":"21","author":"Vijaya Kumar","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6OB00031B\/cit12c\/1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1747-0285.2011.01194.x","volume":"78","author":"Jung","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"D6OB00031B\/cit12d\/1","doi-asserted-by":"crossref","first-page":"135048","DOI":"10.1016\/j.molstruc.2023.135048","volume":"1280","author":"Venkateswara Rao","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D6OB00031B\/cit12e\/1","first-page":"929","volume":"12","author":"Yan","year":"2014","journal-title":"Chin. J. Nat. Med."},{"key":"D6OB00031B\/cit12f\/1","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.1016\/j.bmc.2017.08.011","volume":"25","author":"Singh","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"D6OB00031B\/cit13a\/1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3184\/174751915X14419910149674","volume":"39","author":"Yang","year":"2015","journal-title":"J. Chem. Res."},{"key":"D6OB00031B\/cit13b\/1","doi-asserted-by":"crossref","first-page":"7085","DOI":"10.1021\/jm500901e","volume":"57","author":"Jain","year":"2014","journal-title":"J. Med. Chem."},{"key":"D6OB00031B\/cit13c\/1","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1016\/j.bmcl.2012.02.096","volume":"22","author":"Shah","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6OB00031B\/cit13d\/1","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1007\/s00044-014-1050-9","volume":"23","author":"Liu","year":"2014","journal-title":"Med. Chem. Res."},{"key":"D6OB00031B\/cit13e\/1","doi-asserted-by":"crossref","first-page":"103161","DOI":"10.1016\/j.bioorg.2019.103161","volume":"91","author":"Pavan Kumar","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D6OB00031B\/cit14a\/1","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1021\/acs.jmedchem.5b00258","volume":"58","author":"Gillis","year":"2015","journal-title":"J. Med. Chem."},{"key":"D6OB00031B\/cit14b\/1","first-page":"333","volume":"6","author":"Shen","year":"2025","journal-title":"Green Synth. Catal."},{"key":"D6OB00031B\/cit14c\/1","first-page":"14","volume":"5","author":"He","year":"2024","journal-title":"Green Synth. Catal."},{"key":"D6OB00031B\/cit14d\/1","first-page":"91","volume":"6","author":"Luo","year":"2025","journal-title":"Green Synth. Catal."},{"key":"D6OB00031B\/cit14e\/1","doi-asserted-by":"crossref","first-page":"18707","DOI":"10.1021\/acs.joc.4c02299","volume":"89","author":"Zhang","year":"2024","journal-title":"J. Org. Chem."},{"key":"D6OB00031B\/cit14f\/1","doi-asserted-by":"crossref","first-page":"109648","DOI":"10.1016\/j.cclet.2024.109648","volume":"35","author":"Luo","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"D6OB00031B\/cit15\/1","doi-asserted-by":"crossref","first-page":"109780","DOI":"10.1016\/j.cclet.2024.109780","volume":"35","author":"Wang","year":"2024","journal-title":"Chin. Chem. Lett."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/OB\/D6OB00031B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:57:12Z","timestamp":1782885432000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/24\/9\/1852-1856\/920517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,3,4]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ob00031b","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6OB00031B\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00031B\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00031B\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00031B\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00031B\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00031B\/v2\/review1","asserted-by":"object"}]},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}