{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:11:52Z","timestamp":1782936712363,"version":"3.54.5"},"reference-count":30,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","license":[{"start":{"date-parts":[[2027,3,19]],"date-time":"2027-03-19T00:00:00Z","timestamp":1805414400000},"content-version":"am","delay-in-days":442,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>Direct palladium-catalysed arylation of unprotected barbituric and Meldrum's acids is achieved via high-throughput experimentation (HTE). This approach identifies favorable conditions not easily attainable through one-factor-at-a-time screenings.<\/jats:p>","DOI":"10.1039\/d6ob00287k","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:34:32Z","timestamp":1773927272000},"page":"2904-2909","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HTE-enabled discovery of palladium-catalysed (hetero)arylation of barbituric and meldrum's acid"],"prefix":"10.1039","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4000-1006","authenticated-orcid":false,"given":"Kacper J.","family":"Patej","sequence":"first","affiliation":[{"name":"Roche Pharma Research and Early Development, pCMC Drug Substance, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Bigolin","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, pCMC Drug Substance, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Jost","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, pCMC Drug Substance, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Haertel","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, pCMC Drug Substance, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3842-2295","authenticated-orcid":false,"given":"Marius D. R.","family":"Lutz","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, pCMC Drug Substance, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6682-1213","authenticated-orcid":false,"given":"Georg","family":"Wuitschik","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, pCMC Drug Substance, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6OB00287K\/cit1\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/epi.12027","volume":"53","author":"Brodie","year":"2012","journal-title":"Epilepsia"},{"key":"D6OB00287K\/cit2\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/epi.12026","volume":"53","author":"Yasiry","year":"2012","journal-title":"Epilepsia"},{"key":"D6OB00287K\/cit3\/1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1515\/BC.2001.159","volume":"382","author":"Grams","year":"2001","journal-title":"Biol. Chem."},{"key":"D6OB00287K\/cit4\/1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0960-894X(01)00104-4","volume":"11","author":"Foley","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6OB00287K\/cit5\/1","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1016\/j.bmcl.2005.04.039","volume":"15","author":"Duan","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6OB00287K\/cit6\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0065-2725(08)60921-6","volume":"38","author":"Bojarski","year":"1985","journal-title":"Adv. Heterocycl. Chem."},{"key":"D6OB00287K\/cit7\/1","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1021\/ja808014h","volume":"131","author":"Ruble","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"D6OB00287K\/cit8\/1","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.3390\/molecules25122856","volume":"25","author":"Liao","year":"2020","journal-title":"Molecules"},{"key":"D6OB00287K\/cit9\/1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11030-009-9136-x","volume":"13","author":"Lipson","year":"2009","journal-title":"Mol. Divers."},{"key":"D6OB00287K\/cit10\/1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1039\/b716020h","volume":"37","author":"Ivanov","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"D6OB00287K\/cit11\/1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/qsar.200540212","volume":"25","author":"Gerencs\u00e9r","year":"2006","journal-title":"QSAR Comb. Sci."},{"key":"D6OB00287K\/cit12\/1","doi-asserted-by":"crossref","first-page":"e20230215","DOI":"10.1002\/slct.202302152","volume":"8","author":"Ziarani","year":"2023","journal-title":"ChemistrySelect"},{"key":"D6OB00287K\/cit13\/1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1021\/ar900229z","volume":"43","author":"Dumas","year":"2010","journal-title":"Acc. Chem. Res."},{"key":"D6OB00287K\/cit14\/1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0040-4039(00)77752-5","volume":"21","author":"Pinhey","year":"1980","journal-title":"Tetrahedron Lett."},{"key":"D6OB00287K\/cit15\/1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1055\/s-1988-27542","author":"Hiratake","year":"1988","journal-title":"Synthesis"},{"key":"D6OB00287K\/cit16\/1","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1002\/chem.201800641","volume":"24","author":"de Oliveira","year":"2018","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6OB00287K\/cit17\/1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/jlac.19043350303","volume":"335","author":"Fischer","year":"1904","journal-title":"Justus Liebigs Ann. Chem."},{"key":"D6OB00287K\/cit18\/1","doi-asserted-by":"crossref","first-page":"7760","DOI":"10.1021\/acs.joc.6b01426","volume":"81","author":"Best","year":"2016","journal-title":"J. Org. Chem."},{"key":"D6OB00287K\/cit19\/1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1039\/D3CC05356C","volume":"60","author":"Pandey","year":"2023","journal-title":"Chem. Commun."},{"key":"D6OB00287K\/cit20\/1","doi-asserted-by":"crossref","first-page":"13891","DOI":"10.1021\/acs.joc.2c01597","volume":"87","author":"Johnson","year":"2022","journal-title":"J. Org. Chem."},{"key":"D6OB00287K\/cit21\/1","doi-asserted-by":"crossref","first-page":"10466","DOI":"10.1021\/jo502075p","volume":"79","author":"Senaweera","year":"2014","journal-title":"J. Org. Chem."},{"key":"D6OB00287K\/cit22\/1","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1002\/anie.201502324","volume":"54","author":"Best","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6OB00287K\/cit23\/1","doi-asserted-by":"crossref","first-page":"14252","DOI":"10.1021\/acsomega.2c00889","volume":"7","author":"Yun","year":"2022","journal-title":"ACS Omega"},{"key":"D6OB00287K\/cit24\/1","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1039\/D5QO00259A","volume":"12","author":"He","year":"2025","journal-title":"Org. Chem. Front."},{"key":"D6OB00287K\/cit25\/1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1021\/acs.oprd.9b00140","volume":"23","author":"Mennen","year":"2019","journal-title":"Org. Process Res. Dev."},{"key":"D6OB00287K\/cit26\/1","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1021\/acs.oprd.4c00160","volume":"28","author":"Wuitschik","year":"2024","journal-title":"Org. Process Res. Dev."},{"key":"D6OB00287K\/cit27\/1","doi-asserted-by":"crossref","first-page":"11511","DOI":"10.1021\/acs.joc.0c01768","volume":"85","author":"Orlandi","year":"2020","journal-title":"J. Org. Chem."},{"key":"D6OB00287K\/cit28\/1","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.1021\/acs.orglett.2c03246","volume":"24","author":"Kozlowski","year":"2022","journal-title":"Org. Lett."},{"key":"D6OB00287K\/cit29\/1","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1021\/cr9000836","volume":"110","author":"Bellina","year":"2010","journal-title":"Chem. Rev."},{"key":"D6OB00287K\/cit30\/1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/anie.200903424","volume":"49","author":"Johansson","year":"2010","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/OB\/D6OB00287K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:22:10Z","timestamp":1782930130000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/24\/14\/2904-2909\/1229616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":30,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,4,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ob00287k","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6OB00287K\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00287K\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00287K\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00287K\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00287K\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}