{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:23:04Z","timestamp":1785406984139,"version":"3.56.0"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"24","license":[{"start":{"date-parts":[[2027,5,28]],"date-time":"2027-05-28T00:00:00Z","timestamp":1811462400000},"content-version":"am","delay-in-days":512,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2024TQ08A572"],"award-info":[{"award-number":["2024TQ08A572"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515030037"],"award-info":[{"award-number":["2024A1515030037"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["252300420796"],"award-info":[{"award-number":["252300420796"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["242300420201"],"award-info":[{"award-number":["242300420201"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>\n                    Cu(\n                    <jats:sc>i<\/jats:sc>\n                    )-catalysed trifluoromethylation of vinyl azides with BrCF\n                    <jats:sub>2<\/jats:sub>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    K\/H\n                    <jats:sub>2<\/jats:sub>\n                    O produces \u03b1-trifluoromethyl ketones without external fluoride. Copper\u2013difluorocarbene pathway enables broad scope, advancing metal difluorocarbene synthetic chemistry.\n                  <\/jats:p>","DOI":"10.1039\/d6ob00710d","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:43:08Z","timestamp":1779954188000},"page":"5007-5012","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Copper-catalyzed trifluoromethylation of vinyl azides with BrCF\n                    <sub>2<\/sub>\n                    CO\n                    <sub>2<\/sub>\n                    K: synthesis of \u03b1-trifluoromethyl ketones without external fluoride sources"],"prefix":"10.1039","volume":"24","author":[{"given":"Qinhong","family":"Wen","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Jia","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China"},{"name":"School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichen","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Pingdingshan University, Pingdingshan 467000, P. R. China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Pingdingshan University, Pingdingshan 467000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghui","family":"Kang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-244X","authenticated-orcid":false,"given":"Jiuling","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Pingdingshan University, Pingdingshan 467000, P. R. China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6OB00710D\/cit1\/1","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1002\/adsc.201801121","volume":"361","author":"Lemos","year":"2019","journal-title":"Adv. Synth. Catal."},{"key":"D6OB00710D\/cit2\/1","doi-asserted-by":"crossref","first-page":"9197","DOI":"10.1039\/D0CS00604A","volume":"49","author":"Ma","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"D6OB00710D\/cit3\/1","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1039\/D4QO02309A","volume":"12","author":"Tang","year":"2025","journal-title":"Org. Chem. Front."},{"key":"D6OB00710D\/cit4\/1","doi-asserted-by":"crossref","first-page":"8461","DOI":"10.3390\/molecules27238461","volume":"27","author":"Dong","year":"2022","journal-title":"Molecules"},{"key":"D6OB00710D\/cit5\/1","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1021\/cr941140s","volume":"96","author":"Burton","year":"1996","journal-title":"Chem. Rev."},{"key":"D6OB00710D\/cit6\/1","first-page":"412","volume":"6","author":"Yu","year":"2025","journal-title":"Green Synth. Catal."},{"key":"D6OB00710D\/cit7\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gresc.2025.03.013","author":"Dong","year":"2025","journal-title":"Green Synth. Catal."},{"key":"D6OB00710D\/cit8\/1","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1002\/anie.201508698","volume":"55","author":"Xu","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6OB00710D\/cit9\/1","doi-asserted-by":"crossref","first-page":"e202200642","DOI":"10.1002\/chem.202200642","volume":"28","author":"Zhang","year":"2022","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6OB00710D\/cit10\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/acs.orglett.7b03826","volume":"20","author":"Liu","year":"2018","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit11\/1","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.1021\/acs.orglett.9b02689","volume":"21","author":"Ma","year":"2019","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit12\/1","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/anie.201611697","volume":"56","author":"Nie","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6OB00710D\/cit13\/1","doi-asserted-by":"crossref","first-page":"e202417858","DOI":"10.1002\/anie.202417858","volume":"64","author":"Tong","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6OB00710D\/cit14\/1","doi-asserted-by":"crossref","first-page":"16902","DOI":"10.1021\/jacs.4c04949","volume":"146","author":"Zeng","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D6OB00710D\/cit15\/1","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1039\/D2QO00468B","volume":"9","author":"Sheng","year":"2022","journal-title":"Org. Chem. Front."},{"key":"D6OB00710D\/cit16\/1","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1039\/D4QO00392F","volume":"11","author":"Xia","year":"2024","journal-title":"Org. Chem. Front."},{"key":"D6OB00710D\/cit17\/1","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.1021\/acs.orglett.0c02688","volume":"22","author":"Liang","year":"2020","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit18\/1","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1038\/s41467-025-59903-y","volume":"16","author":"Zeng","year":"2025","journal-title":"Nat. Commun."},{"key":"D6OB00710D\/cit19\/1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s41557-023-01236-8","volume":"15","author":"Zeng","year":"2023","journal-title":"Nat. Chem."},{"key":"D6OB00710D\/cit20\/1","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1039\/C0CC04548A","volume":"47","author":"Wang","year":"2011","journal-title":"Chem. Commun."},{"key":"D6OB00710D\/cit21\/1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/ol702851t","volume":"10","author":"Fujioka","year":"2008","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit22\/1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1039\/D3QO01422C","volume":"11","author":"Pan","year":"2024","journal-title":"Org. Chem. Front."},{"key":"D6OB00710D\/cit23\/1","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1038\/s41467-021-25313-z","volume":"12","author":"Su","year":"2021","journal-title":"Nat. Commun."},{"key":"D6OB00710D\/cit24\/1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.31635\/ccschem.021.202100979","volume":"4","author":"Zhang","year":"2022","journal-title":"CCS Chem."},{"key":"D6OB00710D\/cit25\/1","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1038\/s41467-024-49054-x","volume":"15","author":"Su","year":"2024","journal-title":"Nat. Commun."},{"key":"D6OB00710D\/cit26\/1","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1021\/acs.orglett.1c00467","volume":"23","author":"Liu","year":"2021","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit27\/1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1021\/jacs.3c13044","volume":"146","author":"Sheng","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D6OB00710D\/cit28\/1","doi-asserted-by":"crossref","first-page":"e202400009","DOI":"10.1002\/ejoc.202400009","author":"Mou","year":"2024","journal-title":"Eur. J. Org. Chem."},{"key":"D6OB00710D\/cit29\/1","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1021\/acscentsci.0c00779","volume":"6","author":"Su","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"D6OB00710D\/cit30\/1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1039\/D1QO01899J","volume":"9","author":"Wang","year":"2022","journal-title":"Org. Chem. Front."},{"key":"D6OB00710D\/cit31\/1","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1021\/acs.orglett.1c01484","volume":"23","author":"Wang","year":"2021","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit32\/1","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1007\/s11426-023-1599-4","volume":"66","author":"Zhou","year":"2023","journal-title":"Sci. China: Chem."},{"key":"D6OB00710D\/cit33\/1","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1039\/D3QO00157A","volume":"10","author":"Li","year":"2023","journal-title":"Org. Chem. Front."},{"key":"D6OB00710D\/cit34\/1","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1039\/D0QO00775G","volume":"7","author":"Yu","year":"2020","journal-title":"Org. Chem. Front."},{"key":"D6OB00710D\/cit35\/1","doi-asserted-by":"crossref","first-page":"7861","DOI":"10.1021\/acs.orglett.2c03399","volume":"24","author":"Yu","year":"2022","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit36\/1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.cclet.2021.08.089","volume":"33","author":"Wang","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"D6OB00710D\/cit37\/1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nchem.1756","volume":"5","author":"Huiban","year":"2013","journal-title":"Nat. Chem."},{"key":"D6OB00710D\/cit38\/1","doi-asserted-by":"crossref","first-page":"8449","DOI":"10.1021\/acs.joc.5b01343","volume":"80","author":"Ambler","year":"2015","journal-title":"J. Org. Chem."},{"key":"D6OB00710D\/cit39\/1","doi-asserted-by":"crossref","first-page":"75465","DOI":"10.1039\/C6RA15547B","volume":"6","author":"Lin","year":"2016","journal-title":"RSC Adv."},{"key":"D6OB00710D\/cit40\/1","doi-asserted-by":"crossref","first-page":"107960","DOI":"10.1016\/j.cclet.2022.107960","volume":"34","author":"Yuan","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"D6OB00710D\/cit41\/1","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1039\/D3QO00609C","volume":"10","author":"Wu","year":"2023","journal-title":"Org. Chem. Front."},{"key":"D6OB00710D\/cit42\/1","doi-asserted-by":"crossref","first-page":"6643","DOI":"10.1038\/s41467-025-61947-z","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"D6OB00710D\/cit43\/1","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1021\/cr4002879","volume":"114","author":"Wang","year":"2013","journal-title":"Chem. Rev."},{"key":"D6OB00710D\/cit44\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0968-0896(02)00457-1","volume":"11","author":"Blazejewski","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"D6OB00710D\/cit45\/1","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.3390\/molecules25174031","volume":"25","author":"Citarella","year":"2020","journal-title":"Molecules"},{"key":"D6OB00710D\/cit46\/1","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1039\/C8CC01568F","volume":"54","author":"Xu","year":"2018","journal-title":"Chem. Commun."},{"key":"D6OB00710D\/cit47\/1","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1021\/acs.orglett.9b00518","volume":"21","author":"Wang","year":"2019","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit48\/1","doi-asserted-by":"crossref","first-page":"8589","DOI":"10.1021\/acs.orglett.4c03266","volume":"26","author":"Wu","year":"2024","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit49\/1","doi-asserted-by":"crossref","first-page":"e202301135","DOI":"10.1002\/ejoc.202301135","author":"Gao","year":"2024","journal-title":"Eur. J. Org. Chem."},{"key":"D6OB00710D\/cit50\/1","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1021\/acs.orglett.6c00813","volume":"28","author":"Tong","year":"2026","journal-title":"Org. Lett."},{"key":"D6OB00710D\/cit51\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.6023\/cjoc202411018","volume":"45","author":"Cao","year":"2025","journal-title":"Chin. J. Org. Chem."},{"key":"D6OB00710D\/cit52\/1","doi-asserted-by":"crossref","first-page":"10290","DOI":"10.1039\/D5OB01535A","volume":"23","author":"Ma","year":"2025","journal-title":"Org. Biomol. Chem."},{"key":"D6OB00710D\/cit53\/1","doi-asserted-by":"crossref","first-page":"eaea4120","DOI":"10.1126\/sciadv.aea4120","volume":"11","author":"Cao","year":"2025","journal-title":"Sci. Adv."},{"key":"D6OB00710D\/cit54\/1","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1021\/acs.joc.2c01624","volume":"87","author":"Li","year":"2022","journal-title":"J. Org. Chem."},{"key":"D6OB00710D\/cit55\/1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41557-024-01730-7","volume":"17","author":"Tan","year":"2025","journal-title":"Nat. Chem."},{"key":"D6OB00710D\/cit56\/1","doi-asserted-by":"crossref","first-page":"e202505033","DOI":"10.1002\/anie.202505033","volume":"64","author":"Zhou","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6OB00710D\/cit57\/1","doi-asserted-by":"crossref","first-page":"8960","DOI":"10.1039\/C8CC04298E","volume":"54","author":"Ma","year":"2018","journal-title":"Chem. Commun."},{"key":"D6OB00710D\/cit58\/1","doi-asserted-by":"crossref","first-page":"10913","DOI":"10.1021\/acs.joc.0c01518","volume":"85","author":"Zheng","year":"2020","journal-title":"J. Org. Chem."},{"key":"D6OB00710D\/cit59\/1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1021\/ol503548s","volume":"17","author":"Zheng","year":"2015","journal-title":"Org. Lett."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/OB\/D6OB00710D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:13:11Z","timestamp":1782231191000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D6OB00710D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":59,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2026,6,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ob00710d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6OB00710D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00710D\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00710D\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00710D\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00710D\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00710D\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00710D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00710D\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}