{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:05:37Z","timestamp":1785326737766,"version":"3.55.0"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"29","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":190,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>\n                    The fast deblocking, recyclable waste stream and improved atom economy of the 5\u2032-\n                    <jats:italic>O<\/jats:italic>\n                    -(2-methoxyisopropyl) protecting group can lower the overall PMI of solid-phase oligonucleotide synthesis.\n                  <\/jats:p>","DOI":"10.1039\/d6ob00858e","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:23:07Z","timestamp":1783689787000},"page":"6082-6091","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Toward a sustainable protection group approach for solid-phase oligonucleotide synthesis employing 5\u2032-\n                    <i>O<\/i>\n                    -(2-methoxyisopropyl) protection"],"prefix":"10.1039","volume":"24","author":[{"given":"Verneri","family":"Saari","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Turku, 20500 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Ora","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Turku, 20500 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gimenez Molina","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutica N.V., 30 Turnhoutseweg, B-2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Horvath","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutica N.V., 30 Turnhoutseweg, B-2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh S.","family":"Sanghvi","sequence":"additional","affiliation":[{"name":"Rasayan Inc., 2802 Crystal Ridge Road, Encinitas, CA 92024-6615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6218-2212","authenticated-orcid":false,"given":"Pasi","family":"Virta","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Turku, 20500 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6OB00858E\/cit1\/1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0040-4039(01)90461-7","volume":"22","author":"Beaucage","year":"1981","journal-title":"Tetrahedron Lett."},{"key":"D6OB00858E\/cit2\/1","volume-title":"Sustainability in TIDES chemistry: green approaches to oligonucleotides and oligopeptides synthesis","year":"2024","unstructured":"Sustainability in TIDES chemistry: green approaches to oligonucleotides and oligopeptides synthesis , ed.  A. Tolomelli ,  L. Ferrazzano  and  W. Cabri ,  Royal Society of Chemistry, Cambridge ,  2024"},{"key":"D6OB00858E\/cit3\/1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1021\/acs.joc.0c02291","volume":"86","author":"Andrews","year":"2021","journal-title":"J. Org. Chem."},{"key":"D6OB00858E\/cit4\/1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1351\/pac200173010175","volume":"73","author":"Sanghvi","year":"2001","journal-title":"Pure Appl. Chem."},{"key":"D6OB00858E\/cit5\/1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1039\/D2GC04547H","volume":"25","author":"Ferrazzano","year":"2023","journal-title":"Green Chem."},{"key":"D6OB00858E\/cit6\/1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1039\/c39780000639","author":"Chattopadhyaya","year":"1978","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"D6OB00858E\/cit7\/1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1039\/p19910001355","author":"Gaffney","year":"1991","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"D6OB00858E\/cit8\/1","doi-asserted-by":"crossref","first-page":"7911","DOI":"10.1016\/S0040-4039(99)01563-4","volume":"40","author":"Coleman","year":"1999","journal-title":"Tetrahedron Lett."},{"key":"D6OB00858E\/cit9\/1","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.1021\/jo026009w","volume":"67","author":"Coleman","year":"2002","journal-title":"J. Org. Chem."},{"key":"D6OB00858E\/cit10\/1","doi-asserted-by":"crossref","first-page":"154480","DOI":"10.1016\/j.tetlet.2023.154480","volume":"121","author":"Samudrala","year":"2023","journal-title":"Tetrahedron Lett."},{"key":"D6OB00858E\/cit11\/1","doi-asserted-by":"crossref","first-page":"11820","DOI":"10.1021\/ja980730v","volume":"120","author":"Scaringe","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"D6OB00858E\/cit12\/1","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1016\/S0040-4039(98)00440-7","volume":"39","author":"Hirao","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"D6OB00858E\/cit13\/1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1006\/meth.2000.1132","volume":"23","author":"Scaringe","year":"2001","journal-title":"Methods"},{"key":"D6OB00858E\/cit14\/1","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1016\/S0040-4039(97)01617-1","volume":"38","author":"Kamaike","year":"1997","journal-title":"Tetrahedron Lett."},{"key":"D6OB00858E\/cit15\/1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/07328318508077842","volume":"4","author":"Seliger","year":"1985","journal-title":"Nucleosides Nucleotides"},{"key":"D6OB00858E\/cit16\/1","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1093\/nar\/17.7.2379","volume":"17","author":"Lehman","year":"1989","journal-title":"Nucleic Acids Res."},{"key":"D6OB00858E\/cit17\/1","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1073\/pnas.91.11.5022","volume":"91","author":"Pease","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6OB00858E\/cit18\/1","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1021\/jo00110a011","volume":"60","author":"Pirrung","year":"1995","journal-title":"J. Org. Chem."},{"key":"D6OB00858E\/cit19\/1","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1016\/S0040-4020(97)00154-3","volume":"53","author":"Hasan","year":"1997","journal-title":"Tetrahedron"},{"key":"D6OB00858E\/cit20\/1","doi-asserted-by":"crossref","first-page":"8555","DOI":"10.1002\/anie.201502125","volume":"54","author":"Kretschy","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6OB00858E\/cit21\/1","first-page":"2.3.1","author":"Seliger","year":"2000","journal-title":"Curr. Protoc. Nucleic Acid Chem."},{"key":"D6OB00858E\/cit22\/1","doi-asserted-by":"crossref","first-page":"e999","DOI":"10.1002\/cpz1.999","volume":"4","author":"Seliger","year":"2024","journal-title":"Curr. Protoc."},{"key":"D6OB00858E\/cit23\/1","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.3762\/bjoc.10.237","volume":"10","author":"Molina","year":"2014","journal-title":"Beilstein J. Org. Chem."},{"key":"D6OB00858E\/cit24\/1","doi-asserted-by":"crossref","first-page":"12102","DOI":"10.3390\/molecules171012102","volume":"17","author":"Molina","year":"2012","journal-title":"Molecules"},{"key":"D6OB00858E\/cit25\/1","doi-asserted-by":"crossref","first-page":"13005","DOI":"10.1021\/acs.joc.4c01053","volume":"89","author":"Rosenqvist","year":"2024","journal-title":"J. Org. Chem."},{"key":"D6OB00858E\/cit26\/1","doi-asserted-by":"crossref","first-page":"10156","DOI":"10.1021\/acs.joc.3c01006","volume":"88","author":"Rosenqvist","year":"2023","journal-title":"J. Org. Chem."},{"key":"D6OB00858E\/cit27\/1","doi-asserted-by":"crossref","first-page":"e202300614","DOI":"10.1002\/ejoc.202300614","volume":"26","author":"Liang","year":"2023","journal-title":"Eur. J. Org. Chem."},{"key":"D6OB00858E\/cit28\/1","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1021\/acs.orglett.6c01438","volume":"28","author":"Marlyn","year":"2026","journal-title":"Org. Lett."},{"key":"D6OB00858E\/cit29\/1","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3762\/bjoc.15.70","volume":"15","author":"Liang","year":"2019","journal-title":"Beilstein J. Org. Chem."},{"key":"D6OB00858E\/cit30\/1","doi-asserted-by":"crossref","first-page":"8251","DOI":"10.1021\/acs.orglett.5c02400","volume":"27","author":"Saari","year":"2025","journal-title":"Org. Lett."},{"key":"D6OB00858E\/cit31\/1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/op9900378","volume":"4","author":"Eleuteri","year":"2000","journal-title":"Org. Process Res. Dev."},{"key":"D6OB00858E\/cit32\/1","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1016\/S0040-4020(99)00059-9","volume":"55","author":"W\u00f6rl","year":"1999","journal-title":"Tetrahedron"},{"key":"D6OB00858E\/cit33\/1","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.1002\/ejoc.201700686","volume":"2017","author":"Schwenger","year":"2017","journal-title":"Eur. J. Org. Chem."},{"key":"D6OB00858E\/cit35\/1","volume-title":"Improving Oligonucleotide Manufacture with Stirred-Bed Technology, [White paper]","author":"Samson","year":"2023","unstructured":"D.Samson  and  M.Marco ,  Improving Oligonucleotide Manufacture with Stirred-Bed Technology, [White paper] ,  BACHEM ,  2023"},{"key":"D6OB00858E\/cit36\/1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1021\/op980048l","volume":"2","author":"Guo","year":"1998","journal-title":"Org. Process Res. Dev."},{"key":"D6OB00858E\/cit37\/1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.aau3369","volume":"361","author":"Knouse","year":"2018","journal-title":"Science"},{"key":"D6OB00858E\/cit38\/1","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1126\/science.abi9727","volume":"373","author":"Huang","year":"2021","journal-title":"Science"},{"key":"D6OB00858E\/cit39\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1021\/acs.orglett.4c03980","volume":"27","author":"Nassir","year":"2025","journal-title":"Org. Lett."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/OB\/article-pdf\/doi\/10.1039\/D6OB00858E\/0\/D6OB00858E.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:19:42Z","timestamp":1785323982000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/OB\/article-lookup\/doi\/10.1039\/D6OB00858E"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":38,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2026,7,29]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ob00858e","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6OB00858E\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00858E\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00858E\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00858E\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6OB00858E\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}