{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:51:59Z","timestamp":1791370319196,"version":"4.3.1"},"reference-count":29,"publisher":"Royal Society of Chemistry (RSC)","issue":"38","license":[{"start":{"date-parts":[[2027,9,8]],"date-time":"2027-09-08T00:00:00Z","timestamp":1820361600000},"content-version":"am","delay-in-days":615,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-53-56029"],"award-info":[{"award-number":["20-53-56029"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["40408144"],"award-info":[{"award-number":["40408144"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>Conjugation of pyrazolyl-piperidinones with 8-aminoindolizidine enhances anticancer activity.<\/jats:p>","DOI":"10.1039\/d6ob01064d","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:23:16Z","timestamp":1788884596000},"page":"7940-7956","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scalable synthesis of both diastereomers of\n                    <i>rac<\/i>\n                    -8-aminoindolizidines and their pyrazolyl-piperidinone hybrids with promising anticancer activity"],"prefix":"10.1039","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-5772","authenticated-orcid":false,"given":"Dmitry A.","family":"Merzliakov","sequence":"first","affiliation":[{"name":"A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky Prospect 29, 119991 Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0368-2177","authenticated-orcid":false,"given":"Anastasia A.","family":"Danshina","sequence":"additional","affiliation":[{"name":"A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov st. 28, 119991 Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Mandegani","sequence":"additional","affiliation":[{"name":"Professor Rashidi Laboratory of Organometallic Chemistry, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71467-13565, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaber Tajodini","family":"Rabor","sequence":"additional","affiliation":[{"name":"Professor Rashidi Laboratory of Organometallic Chemistry, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71467-13565, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3976-7869","authenticated-orcid":false,"given":"S. Masoud","family":"Nabavizadeh","sequence":"additional","affiliation":[{"name":"Professor Rashidi Laboratory of Organometallic Chemistry, Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71467-13565, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2702-5366","authenticated-orcid":false,"given":"Nikolai Yu.","family":"Kuznetsov","sequence":"additional","affiliation":[{"name":"A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky Prospect 29, 119991 Moscow, Russian Federation"},{"name":"A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov st. 28, 119991 Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6OB01064D\/cit1\/1","doi-asserted-by":"crossref","first-page":"20130690","DOI":"10.1098\/rspa.2013.0690","volume":"470","author":"Nicolaou","year":"2014","journal-title":"Proc. R. Soc. A"},{"key":"D6OB01064D\/cit2\/1","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1073\/pnas.1103205108","volume":"108","author":"Schreiber","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6OB01064D\/cit3\/1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"D6OB01064D\/cit4\/1","doi-asserted-by":"crossref","first-page":"10257","DOI":"10.1021\/jm501100b","volume":"57","author":"Vitaku","year":"2014","journal-title":"J. Med. Chem."},{"key":"D6OB01064D\/cit5\/1","first-page":"89","volume-title":"The Alkaloids","volume":"26","author":"Strunz","year":"1985","unstructured":"G. M.Strunz  and  J. A.Findlay , in  The Alkaloids , ed.  A. Brossi ,  Academic Press ,  Orlando ,  1985 , vol.  26 , pp.  89\u2013183"},{"key":"D6OB01064D\/cit6\/1","first-page":"1","volume-title":"Alkaloids: Chemical and Biological Perspectives","volume":"3","author":"Fodor","year":"1985","unstructured":"G. B.Fodor  and  B.Colasanti , in  Alkaloids: Chemical and Biological Perspectives , ed.  S. W. Pelletier ,  Wiley ,  New York ,  1985 , vol.  3 , pp.  1\u201390"},{"key":"D6OB01064D\/cit7\/1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/med.21747","volume":"41","author":"Zhang","year":"2021","journal-title":"Med. Res. Rev."},{"key":"D6OB01064D\/cit8\/1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1039\/b310689f","volume":"21","author":"Michael","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"D6OB01064D\/cit12\/1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0960-894X(00)80636-8","volume":"2","author":"Hadley","year":"1992","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6OB01064D\/cit13\/1","doi-asserted-by":"crossref","first-page":"8376","DOI":"10.1021\/jo8014598","volume":"73","author":"Albano","year":"2008","journal-title":"J. Org. Chem."},{"key":"D6OB01064D\/cit14\/1","doi-asserted-by":"crossref","first-page":"7056","DOI":"10.1016\/j.tet.2009.06.043","volume":"65","author":"Stecko","year":"2009","journal-title":"Tetrahedron"},{"key":"D6OB01064D\/cit15\/1","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/cmdc.201600161","volume":"11","author":"Bolognesi","year":"2016","journal-title":"ChemMedChem"},{"key":"D6OB01064D\/cit16\/1","doi-asserted-by":"crossref","first-page":"106055","DOI":"10.1016\/j.phrs.2021.106055","volume":"176","author":"Kabir","year":"2022","journal-title":"Pharmacol. Res."},{"key":"D6OB01064D\/cit17\/1","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1021\/acs.chemrev.8b00271","volume":"119","author":"Kenny","year":"2019","journal-title":"Chem. Rev."},{"key":"D6OB01064D\/cit18\/1","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1039\/D0OB00287A","volume":"18","author":"Tikhov","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"D6OB01064D\/cit19\/1","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1039\/D3OB00022B","volume":"21","author":"Bulygina","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"D6OB01064D\/cit20\/1","doi-asserted-by":"crossref","first-page":"120251","DOI":"10.1016\/j.ica.2021.120251","volume":"518","author":"Guerriero","year":"2021","journal-title":"Inorg. Chim. Acta"},{"key":"D6OB01064D\/cit21\/1","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1021\/acs.orglett.8b01317","volume":"20","author":"Kuznetsov","year":"2018","journal-title":"Org. Lett."},{"key":"D6OB01064D\/cit22\/1","doi-asserted-by":"crossref","first-page":"7115","DOI":"10.1039\/C8OB02152J","volume":"16","author":"Kuznetsov","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"D6OB01064D\/cit23\/1","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/cssc.201700415","volume":"10","author":"Guo","year":"2017","journal-title":"ChemSusChem"},{"key":"D6OB01064D\/cit24\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/1381-1169(95)00039-9","volume":"99","author":"Schuchardt","year":"1995","journal-title":"J. Mol. Catal. A: Chem."},{"key":"D6OB01064D\/cit25\/1","unstructured":"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/lung-cancer"},{"key":"D6OB01064D\/cit26\/1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.21037\/tlcr-24-979","volume":"14","author":"Tang","year":"2025","journal-title":"Transl. Lung Cancer Res."},{"key":"D6OB01064D\/cit27\/1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/ejoc.201101114","author":"Kuznetsov","year":"2012","journal-title":"Eur. J. Org. Chem."},{"key":"D6OB01064D\/cit28\/1","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/j.tet.2005.01.048","volume":"61","author":"Molander","year":"2005","journal-title":"Tetrahedron"},{"key":"D6OB01064D\/cit29\/1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Crystallogr."},{"key":"D6OB01064D\/cit30\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053273314026370","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr., Sect. A: Found. Adv."},{"key":"D6OB01064D\/cit31\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1107\/S2053273314022207","volume":"71","author":"Bourhis","year":"2015","journal-title":"Acta Crystallogr., Sect. A: Found. Adv."},{"key":"D6OB01064D\/cit32\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2320525: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2hwpnr","DOI":"10.5517\/ccdc.csd.cc2hwpnr"}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/OB\/article-pdf\/doi\/10.1039\/D6OB01064D\/0\/D6OB01064D.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:12:04Z","timestamp":1791367924000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/OB\/article-lookup\/doi\/10.1039\/D6OB01064D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":29,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ob01064d","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}