{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:52:06Z","timestamp":1791370326793,"version":"4.3.1"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"38","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":256,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100018694","name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["101073003"],"award-info":[{"award-number":["101073003"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>\n                    Nickel electrocatalysis couples activated carboxylic acids with secondary alkylamine-derived pyridinium salts to form C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2013C(sp\n                    <jats:sup>3<\/jats:sup>\n                    ) bonds. Controlled radical generation enables broad scope, stable operation and telescoped synthesis.\n                  <\/jats:p>","DOI":"10.1039\/d6ob01144f","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:23:32Z","timestamp":1789381412000},"page":"8000-8008","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nickel electrocatalytic C(sp\n                    <sup>3<\/sup>\n                    )\u2013C(sp\n                    <sup>3<\/sup>\n                    ) cross-coupling from activated carboxylic acids and amines"],"prefix":"10.1039","volume":"24","author":[{"given":"Bingqing","family":"Tang","sequence":"first","affiliation":[{"name":"Discovery Chemistry, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-7975","authenticated-orcid":false,"given":"Jennifer","family":"Morvan","sequence":"additional","affiliation":[{"name":"Discovery Chemistry, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1027-348X","authenticated-orcid":false,"given":"Filippo","family":"Begal","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Chemical Technology ICT, Joseph-von-Fraunhofer-Str. 7, 76327 Pfinztal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen P. L.","family":"Kuijpers","sequence":"additional","affiliation":[{"name":"API SM Technology, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-2369","authenticated-orcid":false,"given":"Robin","family":"Kunkel","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Chemical Technology ICT, Joseph-von-Fraunhofer-Str. 7, 76327 Pfinztal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-196X","authenticated-orcid":false,"given":"Jesus","family":"Alcazar","sequence":"additional","affiliation":[{"name":"Discovery Chemistry, Johnson & Johnson, C\/Jarama 75, Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-0823","authenticated-orcid":false,"given":"Peter J. J. A.","family":"Buijnsters","sequence":"additional","affiliation":[{"name":"Discovery Chemistry, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Renders","sequence":"additional","affiliation":[{"name":"Discovery Chemistry, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9262-2197","authenticated-orcid":false,"given":"Alexander X.","family":"Jones","sequence":"additional","affiliation":[{"name":"Discovery Chemistry, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"21","key":"D6OB01144F\/cit1\/1","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1021\/jm901241e","volume":"52","author":"Lovering","year":"2009","journal-title":"J. Med. Chem."},{"issue":"3","key":"D6OB01144F\/cit2\/1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1039\/c2md20347b","volume":"4","author":"Lovering","year":"2013","journal-title":"MedChemComm"},{"issue":"24","key":"D6OB01144F\/cit3\/1","doi-asserted-by":"crossref","first-page":"10257","DOI":"10.1021\/jm501100b","volume":"57","author":"Vitaku","year":"2014","journal-title":"J. Med. Chem."},{"issue":"49","key":"D6OB01144F\/cit4\/1","doi-asserted-by":"crossref","first-page":"e202315108","DOI":"10.1002\/anie.202315108","volume":"62","author":"Hu","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"issue":"14","key":"D6OB01144F\/cit5\/1","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1021\/jm4017625","volume":"57","author":"Taylor","year":"2014","journal-title":"J. Med. Chem."},{"issue":"34","key":"D6OB01144F\/cit6\/1","doi-asserted-by":"crossref","first-page":"12226","DOI":"10.1021\/acs.joc.5c01742","volume":"90","author":"Phillips","year":"2025","journal-title":"J. Org. Chem."},{"issue":"6728","key":"D6OB01144F\/cit7\/1","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1126\/science.adr9368","volume":"386","author":"He","year":"2024","journal-title":"Science"},{"issue":"23","key":"D6OB01144F\/cit8\/1","doi-asserted-by":"crossref","first-page":"13397","DOI":"10.1021\/acs.chemrev.4c00524","volume":"124","author":"Ehehalt","year":"2024","journal-title":"Chem. Rev."},{"issue":"6","key":"D6OB01144F\/cit9\/1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1021\/acsmedchemlett.3c00118","volume":"14","author":"Liu","year":"2023","journal-title":"ACS Med. Chem. Lett."},{"key":"D6OB01144F\/cit10\/1","doi-asserted-by":"crossref","first-page":"117583","DOI":"10.1016\/j.ejmech.2025.117583","volume":"291","author":"Morvan","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"D6OB01144F\/cit11\/1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1021\/acsmedchemlett.0c00093","volume":"11","author":"Dombrowski","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"D6OB01144F\/cit12\/1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1021\/acsorginorgau.5c00056","volume":"5","author":"Kathiravan","year":"2025","journal-title":"ACS Org. Inorg. Au"},{"issue":"6","key":"D6OB01144F\/cit13\/1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1021\/acs.organomet.2c00032","volume":"41","author":"Kranthikumar","year":"2022","journal-title":"Organometallics"},{"issue":"14","key":"D6OB01144F\/cit14\/1","doi-asserted-by":"crossref","first-page":"7736","DOI":"10.1021\/jacs.3c01488","volume":"145","author":"Lyon","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"6689","key":"D6OB01144F\/cit15\/1","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.adl5890","volume":"383","author":"Chen","year":"2024","journal-title":"Science"},{"issue":"7913","key":"D6OB01144F\/cit16\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41586-022-04691-4","volume":"606","author":"Zhang","year":"2022","journal-title":"Nature"},{"issue":"7905","key":"D6OB01144F\/cit17\/1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41586-022-04540-4","volume":"604","author":"Zhang","year":"2022","journal-title":"Nature"},{"key":"D6OB01144F\/cit18\/1","unstructured":"Substructure search of Enamine Building Block Catalog (  https:\/\/enamine.net\/building-blocks\/building-blocks-catalog ) as performed on 01.06.2026"},{"issue":"52","key":"D6OB01144F\/cit19\/1","doi-asserted-by":"crossref","first-page":"27293","DOI":"10.1002\/anie.202112454","volume":"60","author":"Zhang","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6OB01144F\/cit20\/1","doi-asserted-by":"crossref","first-page":"19461","DOI":"10.1021\/jacs.6c05065","volume":"148","author":"Zhao","year":"2026","journal-title":"J. Am. Chem. Soc."},{"issue":"12","key":"D6OB01144F\/cit21\/1","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1039\/D5DD00309A","volume":"4","author":"Shim","year":"2025","journal-title":"Digital Discovery"},{"key":"D6OB01144F\/cit22\/1","doi-asserted-by":"crossref","first-page":"19453","DOI":"10.1021\/jacs.6c04676","volume":"148","author":"Zhao","year":"2026","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"D6OB01144F\/cit23\/1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.jmedchem.4c02047","volume":"68","author":"McGrath","year":"2025","journal-title":"J. Med. Chem."},{"issue":"7801","key":"D6OB01144F\/cit24\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-020-2142-y","volume":"580","author":"Mahjour","year":"2020","journal-title":"Nature"},{"issue":"8034","key":"D6OB01144F\/cit25\/1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41586-024-07987-9","volume":"634","author":"Al Zubaydi","year":"2024","journal-title":"Nature"},{"issue":"6","key":"D6OB01144F\/cit26\/1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/anie.198404201","volume":"23","author":"Katritzky","year":"1984","journal-title":"Angew. Chem., Int. Ed. Engl."},{"issue":"6","key":"D6OB01144F\/cit27\/1","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1021\/jacs.9b00111","volume":"141","author":"Plunkett","year":"2019","journal-title":"J. Am. Chem. Soc."},{"issue":"23","key":"D6OB01144F\/cit28\/1","doi-asserted-by":"crossref","first-page":"9738","DOI":"10.1021\/acs.orglett.9b03899","volume":"21","author":"Baker","year":"2019","journal-title":"Org. Lett."},{"issue":"18","key":"D6OB01144F\/cit29\/1","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1021\/acs.orglett.1c02458","volume":"23","author":"Bercher","year":"2021","journal-title":"Org. Lett."},{"issue":"20","key":"D6OB01144F\/cit30\/1","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1039\/D5OB00467E","volume":"23","author":"Jat","year":"2025","journal-title":"Org. Biomol. Chem."},{"key":"D6OB01144F\/cit31\/1","doi-asserted-by":"crossref","first-page":"e202402621","DOI":"10.1002\/chem.202402621","volume":"30","author":"Liu","year":"2024","journal-title":"Chem. \u2013 Eur. J."},{"issue":"6582","key":"D6OB01144F\/cit32\/1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1126\/science.abn1395","volume":"375","author":"Harwood","year":"2022","journal-title":"Science"},{"issue":"11","key":"D6OB01144F\/cit33\/1","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1021\/jo500507s","volume":"79","author":"Everson","year":"2014","journal-title":"J. Org. Chem."},{"key":"D6OB01144F\/cit34\/1","doi-asserted-by":"crossref","first-page":"e15979","DOI":"10.1002\/anie.202515979","volume":"65","author":"Fan","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6OB01144F\/cit35\/1","doi-asserted-by":"crossref","first-page":"16121","DOI":"10.1021\/acs.joc.3c00859","volume":"89","author":"Wesenberg","year":"2024","journal-title":"J. Org. Chem."},{"issue":"31","key":"D6OB01144F\/cit36\/1","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1021\/jacs.3c07313","volume":"145","author":"Ibrahim","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"47","key":"D6OB01144F\/cit37\/1","doi-asserted-by":"crossref","first-page":"eads5410","DOI":"10.1126\/sciadv.ads5410","volume":"10","author":"Tao","year":"2024","journal-title":"Sci. Adv."},{"issue":"10","key":"D6OB01144F\/cit38\/1","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1021\/jacs.2c11451","volume":"145","author":"Twitty","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"12","key":"D6OB01144F\/cit39\/1","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1021\/acs.analchem.5c00099","volume":"97","author":"Pence","year":"2025","journal-title":"Anal. Chem."},{"issue":"1","key":"D6OB01144F\/cit40\/1","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1038\/s41467-024-47210-x","volume":"15","author":"Sheng","year":"2024","journal-title":"Nat. Commun."},{"issue":"24","key":"D6OB01144F\/cit41\/1","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1039\/D2CC00124A","volume":"58","author":"Naito","year":"2022","journal-title":"Chem. Commun."},{"key":"D6OB01144F\/cit42\/1","doi-asserted-by":"crossref","first-page":"102952","DOI":"10.1016\/j.chempr.2026.102952","volume":"7","author":"Rial-Rodr\u00edguez","year":"2026","journal-title":"Chem."},{"key":"D6OB01144F\/cit43\/1","doi-asserted-by":"publisher","author":"Kaplaneris","unstructured":"N. S. E.Kaplaneris ,  Z.He ,  N.Stini ,  M.Vanzella ,  M.Fillols ,  et al. , Machine Learning-Guided Discovery of Robust Conditions for Photochemical Nickel-Catalyzed Cysteine Arylation,  ChemRxiv , 2025, preprint,  10.26434\/chemrxiv-2025-zwqnt","DOI":"10.26434\/chemrxiv-2025-zwqnt"},{"issue":"16","key":"D6OB01144F\/cit44\/1","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.1039\/D3SC06885D","volume":"15","author":"Ware","year":"2024","journal-title":"Chem. Sci."},{"issue":"2","key":"D6OB01144F\/cit45\/1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1039\/C9SC04288A","volume":"11","author":"Jiang","year":"2020","journal-title":"Chem. Sci."},{"key":"D6OB01144F\/cit46\/1","unstructured":"NiBr 2 (dpp) was used instead of NiCl 2 (dpp) for the CV experiment due to greater solubility in ACN\/THF"},{"issue":"14","key":"D6OB01144F\/cit47\/1","doi-asserted-by":"crossref","first-page":"8456","DOI":"10.1021\/acscatal.1c01860","volume":"11","author":"Tcyrulnikov","year":"2021","journal-title":"ACS Catal."},{"issue":"1","key":"D6OB01144F\/cit48\/1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/anie.201903726","volume":"59","author":"Leifert","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"issue":"6","key":"D6OB01144F\/cit49\/1","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1021\/acs.accounts.5b00057","volume":"48","author":"Weix","year":"2015","journal-title":"Acc. Chem. Res."},{"issue":"3","key":"D6OB01144F\/cit50\/1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1021\/acs.orglett.8b04090","volume":"21","author":"Koyanagi","year":"2019","journal-title":"Org. Lett."},{"issue":"14","key":"D6OB01144F\/cit51\/1","doi-asserted-by":"crossref","first-page":"8456","DOI":"10.1021\/acscatal.1c01860","volume":"11","author":"Tcyrulnikov","year":"2021","journal-title":"ACS Catal."},{"issue":"33","key":"D6OB01144F\/cit52\/1","doi-asserted-by":"crossref","first-page":"e202205673","DOI":"10.1002\/anie.202205673","volume":"61","author":"Salgueiro","year":"2022","journal-title":"Angew. Chem., Int. Ed."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/OB\/article-pdf\/doi\/10.1039\/D6OB01144F\/0\/D6OB01144F.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:12:57Z","timestamp":1791367977000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/OB\/article-lookup\/doi\/10.1039\/D6OB01144F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":52,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ob01144f","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}