{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:13:42Z","timestamp":1788952422963,"version":"build-2803163510"},"reference-count":32,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":229,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL161456"],"award-info":[{"award-number":["R01HL161456"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL165294"],"award-info":[{"award-number":["R01HL165294"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007890","name":"University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM122741"],"award-info":[{"award-number":["T32GM122741"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-2439854"],"award-info":[{"award-number":["DGE-2439854"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD034328"],"award-info":[{"award-number":["S10OD034328"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016086"],"award-info":[{"award-number":["P30CA016086"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Pharm."],"abstract":"<jats:p>Heart damage caused by anthracycline chemotherapy is a major concern for cancer patients and their doctors. This toxicity may be reduced by NanoDMX, a liposomal formulation of the drug DMX5804.<\/jats:p>","DOI":"10.1039\/d6pm00059b","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:43:06Z","timestamp":1787053386000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phosphatidylserine-based liposomes encapsulating DMX-5804 protect against doxorubicin-induced cardiotoxicity"],"prefix":"10.1039","author":[{"given":"Jessica","family":"Tetterton-Kellner","sequence":"first","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 4205 Marsico Hall, 125 Mason Farm Rd, Chapel Hill, NC 27514, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audreanna","family":"Miserendino","sequence":"additional","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 4205 Marsico Hall, 125 Mason Farm Rd, Chapel Hill, NC 27514, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Tariq","sequence":"additional","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 4205 Marsico Hall, 125 Mason Farm Rd, Chapel Hill, NC 27514, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Jensen","sequence":"additional","affiliation":[{"name":"McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA"},{"name":"Department of Medicine, Division of Cardiology, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8578-7396","authenticated-orcid":false,"given":"Juliane","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 4205 Marsico Hall, 125 Mason Farm Rd, Chapel Hill, NC 27514, USA"},{"name":"McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6PM00059B\/cit1\/1","doi-asserted-by":"crossref","first-page":"115361","DOI":"10.1016\/j.addr.2024.115361","volume":"211","author":"Tetterton-Kellner","year":"2024","journal-title":"Adv. Drug Delivery Rev."},{"issue":"2","key":"D6PM00059B\/cit2\/1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/annonc\/mdw604","volume":"28","author":"Zaorsky","year":"2017","journal-title":"Ann. Oncol."},{"key":"D6PM00059B\/cit3\/1","volume-title":"StatPearls","author":"Eneh","year":"2024","unstructured":"C.Eneh  and  M. R.Lekkala ,  Dexrazoxane , in  StatPearls ,  StatPearls Publishing ,  Treasure Island (FL) ,  2024"},{"key":"D6PM00059B\/cit4\/1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1186\/1471-2407-14-842","volume":"14","author":"Deng","year":"2014","journal-title":"BMC Cancer"},{"issue":"2","key":"D6PM00059B\/cit5\/1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI72931","volume":"124","author":"Ichikawa","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"12","key":"D6PM00059B\/cit6\/1","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1111\/jcmm.15305","volume":"24","author":"Osataphan","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"S1","key":"D6PM00059B\/cit7\/1","doi-asserted-by":"crossref","first-page":"R4542","DOI":"10.1096\/fasebj.2022.36.S1.R4542","volume":"36","author":"Imaralu","year":"2022","journal-title":"FASEB J."},{"issue":"758","key":"D6PM00059B\/cit8\/1","doi-asserted-by":"crossref","first-page":"eabn8017","DOI":"10.1126\/scisignal.abn8017","volume":"15","author":"Abe","year":"2022","journal-title":"Sci. Signal."},{"issue":"1","key":"D6PM00059B\/cit9\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41514-024-00135-7","volume":"10","author":"Linders","year":"2024","journal-title":"npj Aging"},{"key":"D6PM00059B\/cit10\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fcvm.2020.00035","volume":"7","author":"Murabito","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"D6PM00059B\/cit11\/1","first-page":"9583268","volume":"2016","author":"Xia","year":"2016","journal-title":"BioMed Res. Int."},{"issue":"4","key":"D6PM00059B\/cit12\/1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.stem.2019.01.013","volume":"24","author":"Fiedler","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"1","key":"D6PM00059B\/cit13\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00395-021-00875-7","volume":"116","author":"Te Lintel Hekkert","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"D6PM00059B\/cit14\/1","first-page":"e929824","volume":"27","author":"Wu","year":"2021","journal-title":"Med. Sci. Monit."},{"issue":"4","key":"D6PM00059B\/cit15\/1","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3892\/etm.2021.10548","volume":"22","author":"Wen","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"D6PM00059B\/cit16\/1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/CIRCHEARTFAILURE.114.001180","volume":"8","author":"Moulin","year":"2015","journal-title":"Circ. Heart Fail."},{"issue":"7","key":"D6PM00059B\/cit17\/1","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1021\/acs.molpharmaceut.8b00237","volume":"15","author":"Deci","year":"2018","journal-title":"Mol. Pharm."},{"issue":"159","key":"D6PM00059B\/cit18\/1","first-page":"e61158","author":"Liu","year":"2020","journal-title":"J. Vis. Exp."},{"issue":"1","key":"D6PM00059B\/cit19\/1","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1038\/s41598-019-38986-w","volume":"9","author":"Bulten","year":"2019","journal-title":"Sci. Rep."},{"key":"D6PM00059B\/cit20\/1","doi-asserted-by":"crossref","first-page":"102201","DOI":"10.1016\/j.nano.2020.102201","volume":"27","author":"Wang","year":"2020","journal-title":"Nanomedicine"},{"key":"D6PM00059B\/cit21\/1","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.2147\/IJN.S178650","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"D6PM00059B\/cit22\/1","doi-asserted-by":"crossref","first-page":"e2201094","DOI":"10.1002\/adhm.202201094","volume":"12","author":"Jasiewicz","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"5","key":"D6PM00059B\/cit23\/1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1161\/CIRCRESAHA.115.307604","volume":"118","author":"Fu","year":"2016","journal-title":"Circ. Res."},{"issue":"7","key":"D6PM00059B\/cit24\/1","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.3390\/cimb45070385","volume":"45","author":"Adams","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"issue":"46","key":"D6PM00059B\/cit25\/1","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1523\/JNEUROSCI.0905-17.2017","volume":"37","author":"Larhammar","year":"2017","journal-title":"J. Neurosci."},{"issue":"11","key":"D6PM00059B\/cit26\/1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1124\/dmd.114.059097","volume":"42","author":"Johnston","year":"2014","journal-title":"Drug Metab. Dispos."},{"issue":"11","key":"D6PM00059B\/cit27\/1","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.stemcr.2023.09.002","volume":"18","author":"Loos","year":"2023","journal-title":"Stem Cell Rep."},{"issue":"9","key":"D6PM00059B\/cit28\/1","doi-asserted-by":"crossref","first-page":"e73294","DOI":"10.1371\/journal.pone.0073294","volume":"8","author":"Windak","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"D6PM00059B\/cit29\/1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s13287-023-03544-9","volume":"14","author":"Su","year":"2023","journal-title":"Stem Cell Res. Ther."},{"issue":"9","key":"D6PM00059B\/cit30\/1","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.3390\/ijms22094401","volume":"22","author":"Schumacher","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"D6PM00059B\/cit31\/1","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1073\/pnas.1015623108","volume":"108","author":"Harel-Adar","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"D6PM00059B\/cit32\/1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1186\/s12951-024-02755-3","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Nanobiotechnol."}],"container-title":["RSC Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/PM\/article-pdf\/doi\/10.1039\/D6PM00059B\/0\/D6PM00059B.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/PM\/article-pdf\/doi\/10.1039\/D6PM00059B\/0\/D6PM00059B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:33:15Z","timestamp":1788949995000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/PM\/article-lookup\/doi\/10.1039\/D6PM00059B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":32,"URL":"https:\/\/doi.org\/10.1039\/d6pm00059b","relation":{},"ISSN":["2976-8713"],"issn-type":[{"value":"2976-8713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}