{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T13:21:36Z","timestamp":1788096096388,"version":"build-2803163510"},"reference-count":26,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP1\/68\/46"],"award-info":[{"award-number":["RGP1\/68\/46"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    <jats:italic>Euphorbia tirucalli<\/jats:italic>\n                    latex metabolites showed modest antibacterial activity against resistant\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    ; network pharmacology and molecular modeling supported putative target interactions.\n                  <\/jats:p>","DOI":"10.1039\/d6ra00720a","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:06:13Z","timestamp":1774962373000},"page":"14959-14974","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phytochemical profiling of\n                    <i>Euphorbia tirucalli<\/i>\n                    Linn. latex and evaluation of its\n                    <i>in vitro<\/i>\n                    antibacterial activity against resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    : an integrative network pharmacology and molecular dynamics simulation study"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-034X","authenticated-orcid":false,"given":"Fathy A.","family":"Behery","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt"},{"name":"Department of Pharmacy, College of Pharmacy, Nursing and Medical Sciences, Riyadh Elm University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer H.","family":"Elmaidomy","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab Mahmoud","family":"Abd El-Baky","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, Egypt"},{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Mawhoup","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-8614","authenticated-orcid":false,"given":"Ruqaiah I.","family":"Bedaiwi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6993-3325","authenticated-orcid":false,"given":"Hesham A.","family":"Abou-Zied","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4043-2687","authenticated-orcid":false,"given":"Mostafa E.","family":"Rateb","sequence":"additional","affiliation":[{"name":"Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Birkat Al Mauz, Nizwa, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-6922","authenticated-orcid":false,"given":"Usama Ramadan","family":"Abdelmohsen","sequence":"additional","affiliation":[{"name":"Deraya Center for Scientific Research, Deraya University, New Minia, Egypt"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA00720A\/cit1\/1","doi-asserted-by":"crossref","first-page":"1008881","DOI":"10.3389\/fpls.2022.1008881","volume":"13","author":"Benjamaa","year":"2022","journal-title":"Front. Plant Sci."},{"key":"D6RA00720A\/cit2\/1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.apjtb.2017.06.002","volume":"7","author":"Mali","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"D6RA00720A\/cit3\/1","doi-asserted-by":"crossref","first-page":"750662","DOI":"10.3389\/fmicb.2021.750662","volume":"12","author":"Chang","year":"2021","journal-title":"Front. Microbiol."},{"key":"D6RA00720A\/cit4\/1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12941-018-0302-9","volume":"18","author":"Liu","year":"2019","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"D6RA00720A\/cit5\/1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/femsre\/fux013","volume":"41","author":"Navon-Venezia","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"D6RA00720A\/cit6\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jor.23656","volume":"36","author":"Li","year":"2018","journal-title":"J. Orthop. Res."},{"key":"D6RA00720A\/cit7\/1","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1093\/infdis\/jiw282","volume":"215","author":"Logan","year":"2017","journal-title":"J. Infect. Dis."},{"key":"D6RA00720A\/cit8\/1","volume-title":"Thin-layer Chromatography; a Laboratory Handbook","author":"Ganshirt","year":"1965","unstructured":"H.Ganshirt , ,  M.Brenner ,  H.Bolliger  and  E.Stahl et al. ,  Thin-layer Chromatography; a Laboratory Handbook ,  Springer-Verlag ,  1965"},{"key":"D6RA00720A\/cit9\/1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3390\/antiox11050881","volume":"11","author":"Al-Warhi","year":"2022","journal-title":"Antioxidants"},{"key":"D6RA00720A\/cit10\/1","doi-asserted-by":"crossref","first-page":"11769","DOI":"10.1039\/D2RA01340A","volume":"12","author":"Elmaidomy","year":"2022","journal-title":"RSC Adv."},{"key":"D6RA00720A\/cit11\/1","doi-asserted-by":"crossref","first-page":"5617","DOI":"10.3390\/molecules27175617","volume":"27","author":"Elmaidomy","year":"2022","journal-title":"Molecules"},{"key":"D6RA00720A\/cit12\/1","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.3390\/plants12122382","volume":"12","author":"Bakhsh","year":"2023","journal-title":"Plants"},{"key":"D6RA00720A\/cit13\/1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3390\/metabo13060732","volume":"13","author":"Mohamed","year":"2023","journal-title":"Metabolites"},{"key":"D6RA00720A\/cit14\/1","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1039\/D2FO03212K","volume":"14","author":"Elmaidomy","year":"2023","journal-title":"Food Funct."},{"key":"D6RA00720A\/cit15\/1","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.3390\/antiox10121860","volume":"10","author":"Alnusaire","year":"2021","journal-title":"Antioxidants"},{"key":"D6RA00720A\/cit16\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43088-023-00453-x","volume":"13","author":"Bakhsh","year":"2024","journal-title":"Beni-Suef Univ. J. Basic Appl. Sci. Journal of Basic and Applied Sciences"},{"key":"D6RA00720A\/cit17\/1","doi-asserted-by":"crossref","first-page":"e0338733","DOI":"10.1371\/journal.pone.0338733","volume":"20","author":"Samir","year":"2025","journal-title":"PLoS One"},{"key":"D6RA00720A\/cit18\/1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","author":"CLSI","year":"2024","unstructured":"CLSI ,  Performance Standards for Antimicrobial Susceptibility Testing ,  Clinical and Laboratory Standards Institute ,  Wayne, PA ,  2024"},{"key":"D6RA00720A\/cit19\/1","doi-asserted-by":"crossref","first-page":"D433","DOI":"10.1093\/nar\/gki005","volume":"33","author":"Von Mering","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"D6RA00720A\/cit20\/1","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"D6RA00720A\/cit21\/1","doi-asserted-by":"crossref","first-page":"32595","DOI":"10.1038\/s41598-025-03891-y","volume":"15","author":"Behery","year":"2025","journal-title":"Sci. Rep."},{"key":"D6RA00720A\/cit22\/1","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1002\/jcc.24890","volume":"38","author":"Beu","year":"2017","journal-title":"J. Comput. Chem."},{"key":"D6RA00720A\/cit23\/1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.31254\/phyto.2016.5302","volume":"5","author":"Nyigo","year":"2016","journal-title":"J. Phytopharmacol."},{"key":"D6RA00720A\/cit24\/1","doi-asserted-by":"crossref","first-page":"e0140242","DOI":"10.1371\/journal.pone.0140242","volume":"10","author":"L\u00f3pez-Mart\u00ednez","year":"2015","journal-title":"PLoS One"},{"key":"D6RA00720A\/cit25\/1","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.3390\/polym11101566","volume":"11","author":"Pivec","year":"2019","journal-title":"Polymers"},{"key":"D6RA00720A\/cit26\/1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.sajb.2025.06.007","volume":"184","author":"Abdelaleem","year":"2025","journal-title":"S. Afr. J. Bot."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D6RA00720A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:46:10Z","timestamp":1783449970000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/16\/14959-14974\/1232220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":26,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,3,13]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra00720a","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}