{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:51:35Z","timestamp":1788191495463,"version":"build-2803163510"},"reference-count":40,"publisher":"Royal Society of Chemistry (RSC)","issue":"23","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":112,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","award":["GXGCYJZX2025003"],"award-info":[{"award-number":["GXGCYJZX2025003"]}],"id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52461043"],"award-info":[{"award-number":["52461043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012253","name":"Guangxi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    A porous biomimetic coating was fabricated on TA2 titanium alloy\n                    <jats:italic>via<\/jats:italic>\n                    MAO, whose porous structure promoted BMSC adhesion and spreading, activated mechanotransduction pathways, and enhanced implant-bone interfacial bonding.\n                  <\/jats:p>","DOI":"10.1039\/d6ra01182a","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:16:05Z","timestamp":1776939365000},"page":"21381-21396","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research on the regulation of osteogenic differentiation and mechanotransduction by porous bionic coatings on titanium alloy implant surfaces"],"prefix":"10.1039","volume":"16","author":[{"given":"Zhuan","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Spine and Osteopathic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"Chen","sequence":"additional","affiliation":[{"name":"Pediatric Dentistry Department, College & Hospital of Stomatology, Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinli","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Spine and Osteopathic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6359-5706","authenticated-orcid":false,"given":"Ronghe","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanzhi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"},{"name":"University Engineering Research Center of Advanced Technologies in Medical and Biological Intelligent Manufacturing, Guangxi Medical University, Nanning 530021, Guangxi, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"12","key":"D6RA01182A\/cit1\/1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"D6RA01182A\/cit2\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/natrevmats.2017.91","volume":"3","author":"Dalby","year":"2018","journal-title":"Nat. Rev. Mater."},{"issue":"3","key":"D6RA01182A\/cit3\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1083\/jcb.201108062","volume":"197","author":"Kim","year":"2012","journal-title":"J. Cell Biol."},{"issue":"10","key":"D6RA01182A\/cit4\/1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmat4051","volume":"13","author":"Wen","year":"2014","journal-title":"Nat. Mater."},{"issue":"2","key":"D6RA01182A\/cit5\/1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.7150\/thno.105840","volume":"15","author":"Wang","year":"2025","journal-title":"Theranostics"},{"key":"D6RA01182A\/cit6\/1","doi-asserted-by":"crossref","first-page":"e2302702","DOI":"10.1002\/advs.202302702","volume":"10","author":"Zhou","year":"2023","journal-title":"Adv. Sci."},{"key":"D6RA01182A\/cit7\/1","first-page":"8","volume":"4","author":"Li","year":"2025","journal-title":"Bio-Des. Manuf."},{"key":"D6RA01182A\/cit8\/1","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1039\/C9BM01968E","volume":"8","author":"Zhang","year":"2020","journal-title":"Biomater. Sci."},{"key":"D6RA01182A\/cit9\/1","first-page":"12","volume":"22","author":"Jin","year":"2023","journal-title":"Biomed. Eng."},{"key":"D6RA01182A\/cit10\/1","doi-asserted-by":"crossref","first-page":"6874","DOI":"10.1016\/j.jmrt.2025.04.322","volume":"36","author":"Chen","year":"2025","journal-title":"J. Mater. Res. Technol."},{"issue":"1","key":"D6RA01182A\/cit11\/1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41467-019-14146-6","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"D6RA01182A\/cit12\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41413-018-0007-x","volume":"6","author":"Morrell","year":"2018","journal-title":"Bone Res."},{"key":"D6RA01182A\/cit13\/1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3390\/bioengineering9110660","volume":"9","author":"Erben","year":"2022","journal-title":"Bioengineering"},{"key":"D6RA01182A\/cit14\/1","doi-asserted-by":"crossref","first-page":"17964","DOI":"10.1021\/acsami.6b05893","volume":"8","author":"Xiu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6RA01182A\/cit15\/1","first-page":"239112808","author":"Li","year":"2024","journal-title":"Mater. Des."},{"key":"D6RA01182A\/cit16\/1","doi-asserted-by":"crossref","first-page":"111674","DOI":"10.1016\/j.corsci.2023.111674","volume":"226","author":"Kun","year":"2024","journal-title":"Corros. Sci."},{"issue":"9","key":"D6RA01182A\/cit17\/1","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.bbadis.2015.05.010","volume":"1852","author":"Spyropoulou","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"D6RA01182A\/cit18\/1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13018-019-1163-4","volume":"14","author":"Zhang","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"D6RA01182A\/cit19\/1","first-page":"33","volume":"32","author":"Zhang","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"9","key":"D6RA01182A\/cit20\/1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.26599\/JAC.2023.9220787","volume":"12","author":"Shan","year":"2023","journal-title":"J.\nAdv. Ceram."},{"key":"D6RA01182A\/cit21\/1","doi-asserted-by":"crossref","first-page":"28684","DOI":"10.1021\/acsomega.0c03824","volume":"5","author":"Wang","year":"2020","journal-title":"ACS Omega"},{"key":"D6RA01182A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/jor.24711","volume":"38","author":"Zhang","year":"2020","journal-title":"J. Orthop. Res."},{"issue":"1","key":"D6RA01182A\/cit23\/1","doi-asserted-by":"crossref","first-page":"e13056","DOI":"10.1111\/acel.13056","volume":"19","author":"Hagan","year":"2020","journal-title":"Aging Cell"},{"issue":"45","key":"D6RA01182A\/cit24\/1","doi-asserted-by":"crossref","first-page":"38780","DOI":"10.1021\/acsami.8b14745","volume":"10","author":"Lee","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"37","key":"D6RA01182A\/cit25\/1","doi-asserted-by":"crossref","first-page":"31433","DOI":"10.1021\/acsami.7b08237","volume":"9","author":"Zhou","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"D6RA01182A\/cit26\/1","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.ceb.2009.08.001","volume":"21","author":"Mammoto","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"D6RA01182A\/cit27\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrm2592","volume":"10","author":"Wozniak","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D6RA01182A\/cit28\/1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3389\/fcell.2020.00735","volume":"8","author":"Heng","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"D6RA01182A\/cit29\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.msec.2015.11.012","volume":"60","author":"Yang","year":"2016","journal-title":"Mater. Sci. Eng., C"},{"issue":"5","key":"D6RA01182A\/cit30\/1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/jbm.a.35648","volume":"104","author":"Zhang","year":"2016","journal-title":"J. Biomed. Mater. Res., Part A"},{"issue":"1","key":"D6RA01182A\/cit31\/1","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1038\/s41598-017-03815-5","volume":"7","author":"Hwang","year":"2017","journal-title":"Sci. Rep."},{"issue":"48","key":"D6RA01182A\/cit32\/1","doi-asserted-by":"crossref","first-page":"41794","DOI":"10.1021\/acsami.7b16314","volume":"9","author":"Qian","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"10","key":"D6RA01182A\/cit33\/1","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1021\/acs.biomac.7b00773","volume":"18","author":"Arslan","year":"2017","journal-title":"Biomacromolecules"},{"key":"D6RA01182A\/cit34\/1","doi-asserted-by":"crossref","first-page":"28708","DOI":"10.1038\/srep28708","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"D6RA01182A\/cit35\/1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.actbio.2019.07.007","volume":"96","author":"Li","year":"2019","journal-title":"Acta Biomater."},{"issue":"1","key":"D6RA01182A\/cit36\/1","first-page":"122","volume":"31","author":"Yin","year":"2025","journal-title":"Mod. Med."},{"issue":"1","key":"D6RA01182A\/cit37\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4012\/dmj.2025-145","volume":"45","author":"Chen","year":"2026","journal-title":"Dent. Mater. J."},{"issue":"18","key":"D6RA01182A\/cit38\/1","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1080\/09205063.2025.2509425","volume":"36","author":"Mv","year":"2025","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"D6RA01182A\/cit39\/1","first-page":"145","volume":"15","author":"Luo","year":"2021","journal-title":"Bioact. Mater."},{"key":"D6RA01182A\/cit40\/1","first-page":"18","volume":"42","author":"Zhang","year":"2024","journal-title":"Bioact. Mater."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D6RA01182A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:10:53Z","timestamp":1782850253000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/23\/21381-21396\/1239548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":40,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2026,4,20]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra01182a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6RA01182A\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA01182A\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA01182A\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA01182A\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA01182A\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA01182A\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA01182A\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA01182A\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA01182A\/v2\/review1","asserted-by":"object"}]},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}