{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:32:54Z","timestamp":1782970374759,"version":"3.54.5"},"reference-count":71,"publisher":"Royal Society of Chemistry (RSC)","issue":"28","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":133,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Novel phenyl triazole-pyridylpiperazine derivatives were synthesized &amp; tested against cancer cells. Compounds 15 &amp; 18 showed potent anticancer activity comparable to doxorubicin, with favorable ADME profiles &amp; stable EGFR binding.<\/jats:p>","DOI":"10.1039\/d6ra01413e","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:35:41Z","timestamp":1778762141000},"page":"25330-25347","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Click chemistry of phenyl 1,2,3-triazole\u20132-pyridylpiperazine hybrids: synthesis, targeted anticancer activity, molecular modeling and computational studies"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-3857","authenticated-orcid":false,"given":"Tamer","family":"El Malah","sequence":"first","affiliation":[{"name":"Photochemistry Department, Chemical Industries Research Institute, National Research Centre, 33 El Buhouth Street, P.O. Box 12622, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"El-Rashedy","sequence":"additional","affiliation":[{"name":"Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, 12622 Cairo, Egypt"},{"name":"Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Monofia 32897, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA01413E\/cit1\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/1878-0261.70196","volume":"20","author":"Mantzari","year":"2026","journal-title":"Mol. Oncol."},{"key":"D6RA01413E\/cit2\/1","doi-asserted-by":"crossref","first-page":"e71573","DOI":"10.1002\/cam4.71573","volume":"15","author":"Jinadasa","year":"2026","journal-title":"Cancer Med."},{"key":"D6RA01413E\/cit3\/1","first-page":"e70043","volume":"76","author":"Siegel","year":"2026","journal-title":"Ca"},{"key":"D6RA01413E\/cit4\/1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1473-3099(24)00567-X","volume":"25","author":"Sengupta","year":"2025","journal-title":"Lancet Infect. Dis."},{"key":"D6RA01413E\/cit5\/1","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1097\/CM9.0000000000003140","volume":"137","author":"Cao","year":"2024","journal-title":"Chin. Med. J."},{"key":"D6RA01413E\/cit6\/1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1201\/9781003563723-10","volume-title":"Advanced Nanohybrids for Biomedical Applications","author":"Surya","year":"2026","unstructured":"P. D.Surya ,  S.Sirohi ,  P.Vashist  and  A. K.Nelapati , in  Advanced Nanohybrids for Biomedical Applications ,  CRC Press ,  2026 ,  pp. 177\u2013194"},{"key":"D6RA01413E\/cit7\/1","doi-asserted-by":"crossref","first-page":"e2025JD044068","DOI":"10.1029\/2025JD044068","volume":"131","author":"Zhou","year":"2026","journal-title":"J. Geophys. Res.:Atmos."},{"key":"D6RA01413E\/cit8\/1","first-page":"1","volume-title":"Nitrogen Heterocycles in Cancer Therapy","author":"Pathak","year":"2026","unstructured":"A.Pathak ,  S. K.Sahu ,  N.Upmanyu  and  A.Vaidya , in  Nitrogen Heterocycles in Cancer Therapy ,  Elsevier ,  2026 ,  pp. 1\u201317"},{"key":"D6RA01413E\/cit9\/1","doi-asserted-by":"crossref","first-page":"e202500729","DOI":"10.1002\/cbic.202500729","volume":"27","author":"Huang","year":"2026","journal-title":"ChemBioChem"},{"issue":"6","key":"D6RA01413E\/cit10\/1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2174\/0115680266419594251103103459","volume":"26","author":"Neha","year":"2026","journal-title":"Curr. Top. Med. Chem."},{"key":"D6RA01413E\/cit11\/1","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1039\/D5RA07369C","volume":"16","author":"Banerjee","year":"2026","journal-title":"RSC Adv."},{"key":"D6RA01413E\/cit12\/1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/targets4010004","volume":"4","author":"Dr\u0103goi","year":"2026","journal-title":"Targets"},{"key":"D6RA01413E\/cit13\/1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/B978-0-443-33106-0.00002-4","volume-title":"Nitrogen Heterocycles in Cancer Therapy","author":"Hosseininezhad","year":"2026","unstructured":"S.Hosseininezhad  and  A.Ramazani , in  Nitrogen Heterocycles in Cancer Therapy ,  Elsevier ,  2026 ,  pp. 73\u201392"},{"key":"D6RA01413E\/cit14\/1","doi-asserted-by":"crossref","first-page":"e202500057","DOI":"10.1002\/tcr.202500057","author":"Geedkar","year":"2026","journal-title":"Chem. Rec."},{"key":"D6RA01413E\/cit15\/1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1134\/S1068162025010121","volume":"51","author":"Kapletiya","year":"2025","journal-title":"Russ. J. Bioorg. Chem."},{"key":"D6RA01413E\/cit16\/1","first-page":"1","volume-title":"Azoles-Synthesis, Properties, Applications and Perspectives","author":"Ali","year":"2020","unstructured":"A. A.Ali ,  Azoles-Synthesis, Properties, Applications and Perspectives ,  2020 ,  pp. 1\u201313"},{"key":"D6RA01413E\/cit17\/1","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1080\/10406638.2025.2554206","volume":"45","author":"Khalaf Alshamari","year":"2025","journal-title":"Polycyclic Aromat. Compd."},{"key":"D6RA01413E\/cit18\/1","first-page":"1","author":"Khalaf Alshamari","year":"2025","journal-title":"Polycyclic Aromat. Compd."},{"key":"D6RA01413E\/cit19\/1","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1002\/chem.201200414","volume":"18","author":"El Malah","year":"2012","journal-title":"Chem.\u2013Eur. J."},{"key":"D6RA01413E\/cit20\/1","doi-asserted-by":"crossref","first-page":"e02238","DOI":"10.1002\/chem.202502238","author":"Bahjou","year":"2026","journal-title":"Chem.\u2013Eur. J."},{"key":"D6RA01413E\/cit21\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-981-97-4596-8_7","volume-title":"Click Chemistry","author":"Tiwari","year":"2024","unstructured":"V. K.Tiwari ,  M. K.Jaiswal ,  S.Rajkhowa  and  S. K.Singh , in  Click Chemistry ,  Springer ,  2024 ,  pp. 205\u2013238"},{"key":"D6RA01413E\/cit22\/1","doi-asserted-by":"crossref","first-page":"10822","DOI":"10.1039\/D1NJ00773D","volume":"45","author":"El Malah","year":"2021","journal-title":"New J. Chem."},{"key":"D6RA01413E\/cit23\/1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3390\/molecules25040790","volume":"25","author":"El Malah","year":"2020","journal-title":"Molecules"},{"key":"D6RA01413E\/cit24\/1","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1039\/D5RA09528J","volume":"16","author":"El Malah","year":"2026","journal-title":"RSC Adv."},{"key":"D6RA01413E\/cit25\/1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3389\/fcimb.2017.00304","volume":"7","author":"Khalil","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D6RA01413E\/cit26\/1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1039\/D4MD00555D","volume":"16","author":"Gao","year":"2025","journal-title":"RSC Med. Chem."},{"key":"D6RA01413E\/cit27\/1","first-page":"1","author":"Babagond","year":"2025","journal-title":"Polycyclic Aromat. Compd."},{"key":"D6RA01413E\/cit28\/1","doi-asserted-by":"crossref","first-page":"15861","DOI":"10.1021\/acsomega.3c08148","volume":"9","author":"Eissa","year":"2024","journal-title":"ACS Omega"},{"key":"D6RA01413E\/cit29\/1","doi-asserted-by":"crossref","first-page":"e0328305","DOI":"10.1371\/journal.pone.0328305","volume":"20","author":"Eissa","year":"2025","journal-title":"PLoS One"},{"key":"D6RA01413E\/cit30\/1","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1039\/C4NJ01625D","volume":"39","author":"Singh","year":"2015","journal-title":"New J. Chem."},{"key":"D6RA01413E\/cit31\/1","first-page":"1","author":"Khalaf Alshamari","year":"2025","journal-title":"Polycyclic Aromat. Compd."},{"key":"D6RA01413E\/cit32\/1","first-page":"1","author":"El Malah","year":"2025","journal-title":"Polycyclic Aromat. Compd."},{"key":"D6RA01413E\/cit33\/1","doi-asserted-by":"crossref","first-page":"140245","DOI":"10.1016\/j.molstruc.2024.140245","volume":"1321","author":"El Malah","year":"2025","journal-title":"J. Mol. Struct."},{"key":"D6RA01413E\/cit34\/1","doi-asserted-by":"crossref","first-page":"125088","DOI":"10.1016\/j.molliq.2024.125088","volume":"406","author":"El Malah","year":"2024","journal-title":"J. Mol. Liq."},{"key":"D6RA01413E\/cit35\/1","doi-asserted-by":"crossref","first-page":"137573","DOI":"10.1016\/j.molstruc.2024.137573","volume":"1303","author":"El Malah","year":"2024","journal-title":"J. Mol. Struct."},{"key":"D6RA01413E\/cit36\/1","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1039\/D3NJ05003C","volume":"48","author":"El Malah","year":"2024","journal-title":"New J. Chem."},{"key":"D6RA01413E\/cit37\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0022-2836(84)90231-6","volume":"178","author":"Richmond","year":"1984","journal-title":"J. Mol. Biol."},{"key":"D6RA01413E\/cit38\/1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12013-018-0852-7","volume":"76","author":"Machaba","year":"2018","journal-title":"Cell Biochem. Biophys."},{"key":"D6RA01413E\/cit39\/1","doi-asserted-by":"crossref","first-page":"e1501240","DOI":"10.1126\/sciadv.1501240","volume":"2","author":"Chen","year":"2016","journal-title":"Sci. Adv."},{"key":"D6RA01413E\/cit40\/1","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1021\/acs.jcim.7b00564","volume":"57","author":"Cournia","year":"2017","journal-title":"J. Chem. Inf. Model."},{"key":"D6RA01413E\/cit41\/1","doi-asserted-by":"crossref","first-page":"11763","DOI":"10.1039\/D6RA00668J","volume":"16","author":"El Malah","year":"2026","journal-title":"RSC Adv."},{"key":"D6RA01413E\/cit42\/1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejmech.2012.03.044","volume":"53","author":"Alafeefy","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA01413E\/cit43\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6RA01413E\/cit44\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.saa.2013.10.042","volume":"120","author":"Saravanan","year":"2014","journal-title":"Spectrochim. Acta, Part A"},{"key":"D6RA01413E\/cit45\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s44442-025-00004-2","volume":"29","author":"Alshamari","year":"2025","journal-title":"J. Saudi Chem. Soc."},{"key":"D6RA01413E\/cit46\/1","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1039\/D5RA07315D","volume":"16","author":"Al-Amin","year":"2026","journal-title":"RSC Adv."},{"key":"D6RA01413E\/cit47\/1","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1134\/S1070363224100190","volume":"94","author":"Shamroukh","year":"2024","journal-title":"Russ. J. Gen. Chem."},{"key":"D6RA01413E\/cit48\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"D6RA01413E\/cit49\/1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","volume":"89","author":"Denizot","year":"1986","journal-title":"J. Immunol. Methods"},{"key":"D6RA01413E\/cit50\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/BJ20121513","volume":"448","author":"Park","year":"2012","journal-title":"Biochem. J."},{"key":"D6RA01413E\/cit51\/1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"D6RA01413E\/cit52\/1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/prot.20660","volume":"61","author":"Li","year":"2005","journal-title":"Proteins: Struct., Funct., Bioinf."},{"key":"D6RA01413E\/cit53\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1021\/cen-09233-scitech1","volume":"92","author":"Halford","year":"2014","journal-title":"Chem. Eng. News"},{"key":"D6RA01413E\/cit54\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-2946-4-17","volume":"4","author":"Hanwell","year":"2012","journal-title":"J. Cheminf."},{"issue":"2","key":"D6RA01413E\/cit55\/1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"D6RA01413E\/cit56\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1758-2946-1-15","volume":"1","author":"Bikadi","year":"2009","journal-title":"J. Cheminf."},{"key":"D6RA01413E\/cit57\/1","volume-title":"Undefined using autodock with auto\u2011docktools: a tutorial","author":"Huey","year":"2006","unstructured":"R.Huey ,  Undefined using autodock with auto\u2011docktools: a tutorial ,  Researchgate.net ,  2006"},{"key":"D6RA01413E\/cit58\/1","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","volume":"19","author":"Morris","year":"1998","journal-title":"Comput. Chem."},{"key":"D6RA01413E\/cit59\/1","first-page":"37","author":"Hospital","year":"2015","journal-title":"Adv. Appl. Bioinf. Chem."},{"key":"D6RA01413E\/cit60\/1","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1021\/acs.jcim.8b00462","volume":"58","author":"Lee","year":"2018","journal-title":"J. Chem. Inf. Model."},{"key":"D6RA01413E\/cit61\/1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmgm.2005.12.005","volume":"25","author":"Wang","year":"2006","journal-title":"J. Mol. Graphics Modell."},{"key":"D6RA01413E\/cit62\/1","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","volume":"81","author":"Berendsen","year":"1984","journal-title":"J. Chem. Phys."},{"key":"D6RA01413E\/cit63\/1","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theory Comput."},{"key":"D6RA01413E\/cit64\/1","doi-asserted-by":"crossref","first-page":"20570","DOI":"10.1074\/jbc.M114.565457","volume":"289","author":"Adijanto","year":"2014","journal-title":"J. Biol. Chem."},{"key":"D6RA01413E\/cit65\/1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/ar000033j","volume":"33","author":"Kollman","year":"2000","journal-title":"Acc. Chem. Res."},{"key":"D6RA01413E\/cit66\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ci100275a","volume":"51","author":"Hou","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"D6RA01413E\/cit67\/1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1021\/ci300425v","volume":"53","author":"Greenidge","year":"2013","journal-title":"J. Chem. Inf. Model."},{"key":"D6RA01413E\/cit68\/1","first-page":"193","volume-title":"Protein Dynamics: Methods and Protocols","author":"David","year":"2013","unstructured":"C. C.David  and  D. J.Jacobs , in  Protein Dynamics: Methods and Protocols ,  Springer ,  2013 ,  pp. 193\u2013226"},{"key":"D6RA01413E\/cit69\/1","doi-asserted-by":"crossref","first-page":"e112419","DOI":"10.1371\/journal.pone.0112419","volume":"9","author":"Kasahara","year":"2014","journal-title":"PLoS One"},{"key":"D6RA01413E\/cit70\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/prot.340110305","volume":"11","author":"Ichiye","year":"1991","journal-title":"Proteins: Struct., Funct., Bioinf."},{"key":"D6RA01413E\/cit71\/1","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D6RA01413E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:18:49Z","timestamp":1782965929000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/28\/25330-25347\/1231088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":71,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2026,5,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra01413e","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}