{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:41:22Z","timestamp":1789076482244,"version":"build-2803163510"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"28","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":133,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>This study focused on design and synthesis of novel pyrazole-pyrrolinone and pyridazinone derivatives and evaluation of their antimicrobial, antibiofilm, and mechanistic properties to identify promising lead compounds.<\/jats:p>","DOI":"10.1039\/d6ra02508k","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:03:26Z","timestamp":1778763806000},"page":"25529-25547","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design, synthesis, bioevaluation, and\n                    <i>in silico<\/i>\n                    insights of pyrazole-pyrrolinone and pyridazinone hybrids as potential antimicrobial agents"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2743-6544","authenticated-orcid":false,"given":"Sayed K.","family":"Ramadan","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selwan","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy, Capital University, Ain Helwan, Helwan, 11795, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science in Yanbu, Taibah University, Yanbu Governorate, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarfah","family":"Al-Warhi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P. O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuha S.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Taibah University, Madinah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-6170","authenticated-orcid":false,"given":"Eman A. E.","family":"El-Helw","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA02508K\/cit1\/1","doi-asserted-by":"crossref","first-page":"117565","DOI":"10.1016\/j.ejmech.2025.117565","volume":"290","author":"El-Helw","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA02508K\/cit2\/1","doi-asserted-by":"crossref","first-page":"108090","DOI":"10.1016\/j.bioorg.2024.108090","volume":"154","author":"Ramadan","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"38","key":"D6RA02508K\/cit3\/1","doi-asserted-by":"crossref","first-page":"27935","DOI":"10.1039\/D4RA04728A","volume":"14","author":"Morsy","year":"2024","journal-title":"RSC Adv."},{"issue":"8","key":"D6RA02508K\/cit4\/1","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1080\/10406638.2022.2128831","volume":"43","author":"Ramadan","year":"2023","journal-title":"Polycyclic Aromat. Compd."},{"issue":"6","key":"D6RA02508K\/cit5\/1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3184\/174751918X15295796734379","volume":"42","author":"Ramadan","year":"2018","journal-title":"J. Chem. Res."},{"issue":"5","key":"D6RA02508K\/cit6\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/00397911.2016.1271896","volume":"47","author":"El-Ziaty","year":"2017","journal-title":"Synth. Commun."},{"issue":"4","key":"D6RA02508K\/cit7\/1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/jhet.4233","volume":"58","author":"El-Helw","year":"2021","journal-title":"J. Heterocycl. Chem."},{"issue":"9","key":"D6RA02508K\/cit8\/1","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1007\/s13738-023-02814-w","volume":"20","author":"Youssef","year":"2023","journal-title":"J. Iran. Chem. Soc."},{"issue":"16","key":"D6RA02508K\/cit9\/1","doi-asserted-by":"crossref","first-page":"8854","DOI":"10.3390\/ijms23168854","volume":"23","author":"Ivan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"D6RA02508K\/cit10\/1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.bmcl.2004.12.002","volume":"15","author":"Pohlmann","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"D6RA02508K\/cit11\/1","first-page":"19","volume":"2","author":"Abdelbaset","year":"2019","journal-title":"J. Adv. Biomed. Pharm. Sci."},{"issue":"4","key":"D6RA02508K\/cit12\/1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0960-894X(01)00802-2","volume":"12","author":"Zarantonello","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"D6RA02508K\/cit13\/1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1161\/01.RES.68.3.689","volume":"68","author":"B\u00f6hm","year":"1991","journal-title":"Circ. Res."},{"key":"D6RA02508K\/cit14\/1","first-page":"1","volume":"35","author":"G\u00f6k\u00e7e","year":"2010","journal-title":"Fabad J. Pharm. Sci."},{"issue":"2","key":"D6RA02508K\/cit15\/1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2298\/JSC0902103H","volume":"74","author":"Husain","year":"2009","journal-title":"J. Serb. Chem. Soc."},{"issue":"3","key":"D6RA02508K\/cit16\/1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jscs.2014.05.007","volume":"19","author":"Ahmad","year":"2015","journal-title":"J. Saudi Chem. Soc."},{"issue":"1","key":"D6RA02508K\/cit17\/1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3109\/14756360902940860","volume":"25","author":"Husain","year":"2010","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"14","key":"D6RA02508K\/cit18\/1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1080\/00397911.2016.1193755","volume":"46","author":"Abou-Elmagd","year":"2016","journal-title":"Synth. Commun."},{"key":"D6RA02508K\/cit19\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bioorg.2016.03.007","volume":"66","author":"Abbas","year":"2016","journal-title":"Bioorg. Chem."},{"issue":"17","key":"D6RA02508K\/cit20\/1","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1080\/07391102.2021.1900918","volume":"40","author":"Singh","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"1","key":"D6RA02508K\/cit21\/1","doi-asserted-by":"crossref","first-page":"2189126","DOI":"10.1080\/14756366.2023.2189126","volume":"38","author":"Ramzan","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"7","key":"D6RA02508K\/cit22\/1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1080\/00397911.2020.1731549","volume":"50","author":"El-Helw","year":"2020","journal-title":"Synth. Commun."},{"key":"D6RA02508K\/cit23\/1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bioorg.2018.06.003","volume":"80","author":"Abdelbaset","year":"2018","journal-title":"Bioorg. Chem."},{"key":"D6RA02508K\/cit24\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3389\/fchem.2020.00465","volume":"8","author":"Kumar","year":"2020","journal-title":"Front. Chem."},{"issue":"20","key":"D6RA02508K\/cit25\/1","doi-asserted-by":"crossref","first-page":"9146","DOI":"10.1021\/acs.jmedchem.8b00605","volume":"61","author":"Ortiz Zacar\u00edas","year":"2018","journal-title":"J. Med. Chem."},{"issue":"41","key":"D6RA02508K\/cit26\/1","doi-asserted-by":"crossref","first-page":"12135","DOI":"10.1021\/ja0205434","volume":"124","author":"Lee","year":"2002","journal-title":"J. Am. Chem. Soc."},{"issue":"7","key":"D6RA02508K\/cit27\/1","doi-asserted-by":"crossref","first-page":"o1783","DOI":"10.1107\/S1600536811023713","volume":"67","author":"Fun","year":"2011","journal-title":"Acta Crystallogr., Sect. E:Struct. Rep. Online"},{"issue":"4","key":"D6RA02508K\/cit28\/1","doi-asserted-by":"crossref","first-page":"01934","DOI":"10.1128\/JCM.01934-17","volume":"56","author":"Humphries","year":"2018","journal-title":"J. Clin. Microbiol."},{"issue":"2","key":"D6RA02508K\/cit29\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3329\/bjp.v12i2.30892","volume":"12","author":"Bahuguna","year":"2017","journal-title":"Bangladesh J. Pharmacol."},{"key":"D6RA02508K\/cit30\/1","doi-asserted-by":"crossref","first-page":"178184","DOI":"10.1016\/j.scitotenv.2024.178184","volume":"959","author":"Lavrikova","year":"2025","journal-title":"Sci. Total Environ."},{"issue":"2","key":"D6RA02508K\/cit31\/1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00284-022-03151-6","volume":"80","author":"Hamed","year":"2023","journal-title":"Curr. Microbiol."},{"issue":"6","key":"D6RA02508K\/cit32\/1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bjp.2014.10.014","volume":"24","author":"Miron","year":"2014","journal-title":"Rev. Bras. Farmacogn."},{"issue":"5","key":"D6RA02508K\/cit33\/1","doi-asserted-by":"crossref","first-page":"02608","DOI":"10.1128\/mBio.02608-21","volume":"12","author":"Whittle","year":"2021","journal-title":"mBio"},{"issue":"14","key":"D6RA02508K\/cit34\/1","first-page":"3366","volume":"29","author":"Arzine","year":"2024","journal-title":"Pharmaceuticals"},{"issue":"5","key":"D6RA02508K\/cit35\/1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4155\/fmc-2023-0304","volume":"16","author":"El-Helw","year":"2024","journal-title":"Future Med. Chem."},{"issue":"5","key":"D6RA02508K\/cit36\/1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/17415993.2021.1909591","volume":"42","author":"Ramadan","year":"2021","journal-title":"J. Sulfur Chem."},{"key":"D6RA02508K\/cit37\/1","doi-asserted-by":"crossref","first-page":"141789","DOI":"10.1016\/j.molstruc.2025.141789","volume":"1333","author":"Abdelrahman","year":"2025","journal-title":"J. Mol. Struct."},{"key":"D6RA02508K\/cit38\/1","doi-asserted-by":"crossref","first-page":"109036","DOI":"10.1016\/j.bioorg.2025.109036","volume":"165","author":"Ramadan","year":"2025","journal-title":"Bioorg. Chem."},{"key":"D6RA02508K\/cit39\/1","doi-asserted-by":"crossref","first-page":"141415","DOI":"10.1016\/j.molstruc.2025.141415","volume":"1329","author":"Khodair","year":"2025","journal-title":"J. Mol. Struct."},{"key":"D6RA02508K\/cit40\/1","doi-asserted-by":"crossref","first-page":"17869","DOI":"10.1038\/s41598-023-44615-4","volume":"13","author":"El-Sewedy","year":"2023","journal-title":"Sci. Rep."},{"issue":"9","key":"D6RA02508K\/cit41\/1","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1021\/acsomega.4c11076","volume":"10","author":"El-Hema","year":"2025","journal-title":"ACS Omega"},{"issue":"6","key":"D6RA02508K\/cit42\/1","first-page":"8","volume":"16","author":"El-Gendy","year":"2020","journal-title":"Am. J. Sci."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D6RA02508K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:45:03Z","timestamp":1783449903000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/16\/28\/25529-25547\/1238887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":42,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2026,5,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra02508k","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}