{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:30:35Z","timestamp":1786563035834,"version":"build-2736575974"},"reference-count":33,"publisher":"Royal Society of Chemistry (RSC)","issue":"37","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":193,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>A series of compounds by hybridizing the natural product Genistein and the non-nucleoside METTL3 inhibitor STM2457 were designed and screened by molecular docking, and H1 was synthesized and evaluated to be a potential METTL3 inhibitor.<\/jats:p>","DOI":"10.1039\/d6ra02851a","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:04:26Z","timestamp":1783929866000},"page":"39847-39857","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of novel METTL3 inhibitors: design, synthesis, and\n                    <i>in silico<\/i>\n                    and\n                    <i>in vitro<\/i>\n                    evaluations"],"prefix":"10.1039","volume":"16","author":[{"given":"Yun","family":"Zhang","sequence":"first","affiliation":[{"name":"Affiliated Yongkang First People's Hospital and School of Pharmacy, Hangzhou Medical College, Hangzhou 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Yongkang First People's Hospital and School of Pharmacy, Hangzhou Medical College, Hangzhou 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"He","sequence":"additional","affiliation":[{"name":"Affiliated Yongkang First People's Hospital and School of Pharmacy, Hangzhou Medical College, Hangzhou 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinlan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health, Hangzhou Medical College, Hangzhou 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongdi","family":"Han","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Hangzhou Medical College, Hangzhou 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianling","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation, Hangzhou Medical College, Hangzhou 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Qian","sequence":"additional","affiliation":[{"name":"Affiliated Yongkang First People's Hospital and School of Pharmacy, Hangzhou Medical College, Hangzhou 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Affiliated Yongkang First People's Hospital and School of Pharmacy, Hangzhou Medical College, Hangzhou 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Yongkang First People's Hospital and School of Pharmacy, Hangzhou Medical College, Hangzhou 310013, China"},{"name":"Yongkang First People's Hospital, Yongkang 321306, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-3665","authenticated-orcid":false,"given":"Zunyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Yongkang First People's Hospital and School of Pharmacy, Hangzhou Medical College, Hangzhou 310013, China"},{"name":"Yongkang First People's Hospital, Yongkang 321306, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"7683","key":"D6RA02851A\/cit1\/1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nature24678","volume":"552","author":"Barbieri","year":"2017","journal-title":"Nature"},{"issue":"11","key":"D6RA02851A\/cit2\/1","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1038\/s41375-022-01696-w","volume":"36","author":"Li","year":"2022","journal-title":"Leukemia"},{"key":"D6RA02851A\/cit3\/1","doi-asserted-by":"publisher","first-page":"873903","DOI":"10.3389\/fonc.2022.873903","volume":"12","author":"Wu","year":"2022","journal-title":"Front. Oncol."},{"issue":"4","key":"D6RA02851A\/cit4\/1","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.1021\/acs.analchem.8b05500","volume":"91","author":"Wiedmer","year":"2019","journal-title":"Anal. Chem."},{"issue":"7860","key":"D6RA02851A\/cit5\/1","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41586-021-03536-w","volume":"593","author":"Yankova","year":"2021","journal-title":"Nature"},{"issue":"1","key":"D6RA02851A\/cit6\/1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13046-023-02638-9","volume":"42","author":"Sun","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"D6RA02851A\/cit7\/1","doi-asserted-by":"publisher","first-page":"216122","DOI":"10.1016\/j.canlet.2023.216122","volume":"559","author":"Wang","year":"2023","journal-title":"Cancer Lett."},{"issue":"4","key":"D6RA02851A\/cit8\/1","doi-asserted-by":"publisher","first-page":"111530","DOI":"10.1016\/j.celrep.2022.111530","volume":"41","author":"Zhang","year":"2022","journal-title":"Cell Rep."},{"issue":"6","key":"D6RA02851A\/cit9\/1","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41594-021-00606-5","volume":"28","author":"Li","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"11","key":"D6RA02851A\/cit10\/1","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1021\/acsmedchemlett.5c00465","volume":"16","author":"Zhang","year":"2025","journal-title":"ACS Med. Chem. Lett."},{"key":"D6RA02851A\/cit11\/1","doi-asserted-by":"publisher","first-page":"108980","DOI":"10.1016\/j.bioorg.2025.108980","volume":"165","author":"Miao","year":"2025","journal-title":"Bioorg. Chem."},{"key":"D6RA02851A\/cit12\/1","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1039\/D5MD00867K","volume":"17","author":"Zhang","year":"2026","journal-title":"RSC Med. Chem."},{"key":"D6RA02851A\/cit13\/1","unstructured":"STORM Therapeutics LTD. STC-15 as a Part of Combination Therapy with Toripalimab in Selected Advanced Cancers .  https:\/\/clinicaltrials.gov\/study\/NCT06975293"},{"issue":"1","key":"D6RA02851A\/cit14\/1","doi-asserted-by":"publisher","first-page":"33087","DOI":"10.1038\/s41598-025-16614-0","volume":"15","author":"Morshed","year":"2025","journal-title":"Sci. Rep."},{"issue":"23","key":"D6RA02851A\/cit15\/1","doi-asserted-by":"publisher","first-page":"8367","DOI":"10.3390\/molecules27238367","volume":"27","author":"Naeem","year":"2022","journal-title":"Molecules"},{"key":"D6RA02851A\/cit16\/1","doi-asserted-by":"publisher","first-page":"878135","DOI":"10.3389\/fphar.2022.878135","volume":"13","author":"Du","year":"2022","journal-title":"Front. Pharmacol"},{"issue":"4","key":"D6RA02851A\/cit17\/1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1080\/17460441.2024.2322990","volume":"19","author":"de Sena","year":"2024","journal-title":"Expert Opin. Drug Discovery"},{"issue":"33","key":"D6RA02851A\/cit18\/1","doi-asserted-by":"publisher","first-page":"7314","DOI":"10.2174\/0109298673309489240816063313","volume":"32","author":"Cheng","year":"2025","journal-title":"Curr. Med. Chem."},{"issue":"6","key":"D6RA02851A\/cit19\/1","doi-asserted-by":"publisher","first-page":"102733","DOI":"10.1016\/j.jiph.2025.102733","volume":"18","author":"Xu","year":"2025","journal-title":"J. Infect. Public Health"},{"key":"D6RA02851A\/cit20\/1","doi-asserted-by":"publisher","first-page":"114351","DOI":"10.1016\/j.biopha.2023.114351","volume":"160","author":"Goel","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"D6RA02851A\/cit21\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10637-026-01596-1","volume":"44","author":"Liu","year":"2026","journal-title":"Invest. New Drugs"},{"issue":"11","key":"D6RA02851A\/cit22\/1","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1080\/14740338.2024.2396387","volume":"24","author":"Li","year":"2025","journal-title":"Expert Opin. Drug Saf."},{"issue":"6","key":"D6RA02851A\/cit23\/1","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.cgh.2024.01.022","volume":"22","author":"Peng","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"D6RA02851A\/cit24\/1","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"W1","key":"D6RA02851A\/cit25\/1","doi-asserted-by":"publisher","first-page":"W422","DOI":"10.1093\/nar\/gkae236","volume":"52","author":"Fu","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"D6RA02851A\/cit26\/1","doi-asserted-by":"publisher","first-page":"111241","DOI":"10.1016\/j.cbi.2024.111241","volume":"403","author":"Wang","year":"2024","journal-title":"Chem.-Biol. Interact."},{"issue":"18","key":"D6RA02851A\/cit27\/1","doi-asserted-by":"publisher","first-page":"8780","DOI":"10.3390\/ijms26188780","volume":"26","author":"Chen","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA02851A\/cit28\/1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.drudis.2019.10.014","volume":"25","author":"Jia","year":"2020","journal-title":"Drug Discov. Today"},{"issue":"15","key":"D6RA02851A\/cit29\/1","doi-asserted-by":"publisher","first-page":"5638","DOI":"10.1080\/07391102.2020.1792346","volume":"39","author":"Idris","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"8","key":"D6RA02851A\/cit30\/1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/ph13080161","volume":"13","author":"Varano","year":"2020","journal-title":"Pharmaceuticals"},{"issue":"12","key":"D6RA02851A\/cit31\/1","doi-asserted-by":"publisher","first-page":"5047","DOI":"10.1007\/s00204-025-04170-5","volume":"99","author":"Fija\u0142kowska","year":"2025","journal-title":"Arch. Toxicol."},{"issue":"3","key":"D6RA02851A\/cit32\/1","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1021\/acs.jmedchem.2c01601","volume":"66","author":"Fiorentino","year":"2023","journal-title":"J. Med. Chem."},{"issue":"19","key":"D6RA02851A\/cit33\/1","doi-asserted-by":"publisher","first-page":"e2424796122","DOI":"10.1073\/pnas.2424796122","volume":"122","author":"Zhao","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"updated-by":[{"DOI":"10.1039\/d6ra90088g","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000}}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA02851A\/0\/D6RA02851A.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:59:19Z","timestamp":1786561159000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA02851A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":33,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2026,8,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra02851a","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}