{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:30:26Z","timestamp":1782930626471,"version":"3.54.5"},"reference-count":43,"publisher":"Royal Society of Chemistry (RSC)","issue":"31","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>The optimal extraction conditions (70% ethanol, 30 min, 45 \u00b0C, 1\u2009:\u200930 ratio) resulted in extracts with a well-balanced profile of bioactive compounds and biological activities.<\/jats:p>","DOI":"10.1039\/d6ra03013k","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:25:18Z","timestamp":1779805518000},"page":"28573-28582","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimization of ultrasound-assisted extraction and biological activities of\n                    <i>Crataegus monogyna<\/i>\n                    Jacq. flowering branches using experimental design and artificial neural networks"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-1719","authenticated-orcid":false,"given":"Sengul","family":"Uysal","sequence":"first","affiliation":[{"name":"Erciyes University, Halil Bayraktar Health Services Vocational College, Kayseri, Turkey"},{"name":"Erciyes University, Drug Application and Research Center, Kayseri, 38280, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Cvetanovi\u0107 Kljaki\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Technology Novi Sad, University of Novi Sad, Novi Sad, 21000, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Lon\u010dar","sequence":"additional","affiliation":[{"name":"Faculty of Technology Novi Sad, University of Novi Sad, Novi Sad, 21000, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Selcuk University, Department of Biology, Science Faculty, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Cakilcioglu","sequence":"additional","affiliation":[{"name":"Munzur University, Pertek Sakine Gen\u00e7 Vocational School, Pertek, Tunceli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA03013K\/cit1\/1","doi-asserted-by":"crossref","first-page":"1511049","DOI":"10.3389\/fnut.2025.1511049","volume":"12","author":"Sknepnek","year":"2025","journal-title":"Front. Nutr."},{"key":"D6RA03013K\/cit2\/1","first-page":"1","volume-title":"Plant Specialized Metabolites: Phytochemistry, Ecology and Biotechnology","author":"\u0160ovljanski","year":"2023","unstructured":"O.\u0160ovljanski ,  A. C.Kljaki\u0107  and  A.Tomi\u0107 , in  Plant Specialized Metabolites: Phytochemistry, Ecology and Biotechnology ,  Springer ,  2023 ,  pp. 1\u201343"},{"key":"D6RA03013K\/cit3\/1","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.3390\/molecules26237266","volume":"26","author":"Martinelli","year":"2021","journal-title":"Molecules"},{"key":"D6RA03013K\/cit4\/1","first-page":"289","volume-title":"Nonvitamin and Nonmineral Nutritional Supplements","author":"Attard","year":"2019","unstructured":"E.Attard  and  H.Attard , in  Nonvitamin and Nonmineral Nutritional Supplements ,  Elsevier ,  2019 ,  pp. 289\u2013293"},{"key":"D6RA03013K\/cit5\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.phytochem.2012.04.006","volume":"79","author":"Edwards","year":"2012","journal-title":"Phytochemistry"},{"key":"D6RA03013K\/cit6\/1","doi-asserted-by":"crossref","first-page":"7708","DOI":"10.3390\/nu7095361","volume":"7","author":"Nabavi","year":"2015","journal-title":"Nutrients"},{"key":"D6RA03013K\/cit7\/1","doi-asserted-by":"crossref","first-page":"101753","DOI":"10.1016\/j.jsps.2023.101753","volume":"31","author":"Radi","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"D6RA03013K\/cit8\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0975-3575(10)80008-2","volume":"2","author":"Arrieta","year":"2010","journal-title":"Pharmacogn. J."},{"key":"D6RA03013K\/cit9\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11010-006-9218-3","volume":"292","author":"Jayalakshmi","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"D6RA03013K\/cit10\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/J157v03n02_03","volume":"3","author":"Jouad","year":"2003","journal-title":"J. Herb. Pharmacother."},{"key":"D6RA03013K\/cit11\/1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/2212798410666180730095456","volume":"10","author":"Mecheri","year":"2019","journal-title":"Recent Pat. Food, Nutr. Agric."},{"key":"D6RA03013K\/cit12\/1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ijbiomac.2018.05.101","volume":"116","author":"Pawlaczyk-Graja","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D6RA03013K\/cit13\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/ajhp\/59.5.417","volume":"59","author":"Rigelsky","year":"2002","journal-title":"Am. J. Health-Syst. Pharm."},{"key":"D6RA03013K\/cit14\/1","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.29228\/jrp.514","volume":"27","author":"Baykan","year":"2023","journal-title":"J. Res. Pharm."},{"key":"D6RA03013K\/cit15\/1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jep.2013.07.016","volume":"149","author":"Bulut","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"D6RA03013K\/cit16\/1","first-page":"102","volume":"31","author":"Mumcu","year":"2018","journal-title":"Acta Biol. Turc."},{"key":"D6RA03013K\/cit17\/1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.indcrop.2014.09.044","volume":"65","author":"Cvetanovic","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"D6RA03013K\/cit18\/1","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1007\/s13197-022-05359-7","volume":"60","author":"Thilakarathna","year":"2023","journal-title":"J. Food Sci. Technol."},{"key":"D6RA03013K\/cit19\/1","doi-asserted-by":"crossref","first-page":"105325","DOI":"10.1016\/j.ultsonch.2020.105325","volume":"70","author":"Kumar","year":"2021","journal-title":"Ultrason. Sonochem."},{"key":"D6RA03013K\/cit20\/1","doi-asserted-by":"crossref","first-page":"106646","DOI":"10.1016\/j.ultsonch.2023.106646","volume":"101","author":"Shen","year":"2023","journal-title":"Ultrason. Sonochem."},{"key":"D6RA03013K\/cit21\/1","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.3390\/molecules26154536","volume":"26","author":"Mart\u00edn-Garc\u00eda","year":"2021","journal-title":"Molecules"},{"key":"D6RA03013K\/cit22\/1","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1080\/07391102.2023.2242960","volume":"42","author":"Mehmood","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D6RA03013K\/cit23\/1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.supflu.2013.05.007","volume":"81","author":"Shortle","year":"2013","journal-title":"J. Supercrit. Fluids"},{"key":"D6RA03013K\/cit24\/1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fphar.2017.00290","volume":"8","author":"Uysal","year":"2017","journal-title":"Front. Pharmacol"},{"key":"D6RA03013K\/cit25\/1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3390\/foods13050791","volume":"13","author":"Petkovic","year":"2024","journal-title":"Foods"},{"key":"D6RA03013K\/cit26\/1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.18517\/ijods.2.2.92-103.2021","volume":"2","author":"Ogundunmade","year":"2021","journal-title":"Int. J. Data Sci."},{"key":"D6RA03013K\/cit27\/1","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1109\/TNNLS.2019.2935033","volume":"31","author":"Chu","year":"2020","journal-title":"IEEE Trans. Neural Networks Learn. Syst."},{"key":"D6RA03013K\/cit28\/1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/antiox15010050","volume":"15","author":"Terzic","year":"2026","journal-title":"Antioxidants"},{"key":"D6RA03013K\/cit29\/1","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.3390\/molecules28186520","volume":"28","author":"\u00dclger","year":"2023","journal-title":"Molecules"},{"key":"D6RA03013K\/cit30\/1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13065-017-0324-y","volume":"11","author":"Azahar","year":"2017","journal-title":"Chem. Cent. J."},{"key":"D6RA03013K\/cit31\/1","first-page":"159","volume":"12","author":"Savikin","year":"2017","journal-title":"Nat. Prod. Commun."},{"key":"D6RA03013K\/cit32\/1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3390\/molecules25040787","volume":"25","author":"Zulkifli","year":"2020","journal-title":"Molecules"},{"key":"D6RA03013K\/cit33\/1","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3390\/life13122237","volume":"13","author":"Parzhanova","year":"2023","journal-title":"Life"},{"key":"D6RA03013K\/cit34\/1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3390\/ph17060786","volume":"17","author":"Amrati","year":"2024","journal-title":"Pharmaceuticals"},{"key":"D6RA03013K\/cit35\/1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/0028825X.2024.2392705","volume":"63","author":"Ghaffar","year":"2025","journal-title":"N. Z. J. Bot."},{"key":"D6RA03013K\/cit36\/1","doi-asserted-by":"crossref","first-page":"105658","DOI":"10.1016\/j.ultsonch.2021.105658","volume":"76","author":"Herrera-Pool","year":"2021","journal-title":"Ultrason. Sonochem."},{"key":"D6RA03013K\/cit37\/1","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/j.chroma.2011.02.059","volume":"1218","author":"Biesaga","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"D6RA03013K\/cit38\/1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3390\/pr8040434","volume":"8","author":"Chavez-Gonzalez","year":"2020","journal-title":"Processes"},{"key":"D6RA03013K\/cit39\/1","doi-asserted-by":"crossref","first-page":"11865","DOI":"10.3390\/app122211865","volume":"12","author":"Jurinjak Tu\u0161ek","year":"2022","journal-title":"Appl. Sci."},{"key":"D6RA03013K\/cit40\/1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/antiox14081003","volume":"14","author":"Nabiyeva","year":"2025","journal-title":"Antioxidants"},{"key":"D6RA03013K\/cit41\/1","doi-asserted-by":"crossref","first-page":"9325","DOI":"10.1007\/s11696-024-03745-3","volume":"78","author":"Saidene","year":"2024","journal-title":"Chem. Pap."},{"key":"D6RA03013K\/cit42\/1","first-page":"416722","volume":"2022","author":"Madhiarasan","year":"2022","journal-title":"J. Electr. Comput. Eng."},{"key":"D6RA03013K\/cit43\/1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.17221\/26\/2022-HORTSCI","volume":"50","author":"Malesevic","year":"2023","journal-title":"Hortic. Sci."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D6RA03013K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:02:23Z","timestamp":1782856943000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D6RA03013K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":43,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2026,5,26]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra03013k","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}