{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:02:05Z","timestamp":1789581725820,"version":"build-2803163510"},"reference-count":39,"publisher":"Royal Society of Chemistry (RSC)","issue":"41","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":230,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["25ZD1IZX027"],"award-info":[{"award-number":["25ZD1IZX027"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024YFFK0123"],"award-info":[{"award-number":["2024YFFK0123"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\u00b5ORScreen integrates leakage-aware benchmarking and a LightGBM\u2013TabPFN\u2013RF consensus to prioritize \u00b5-opioid receptor antagonist-like compounds, with SHAP interpretation and an openly accessible deployment workflow.<\/jats:p>","DOI":"10.1039\/d6ra03044k","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:21:07Z","timestamp":1787149267000},"page":"49012-49023","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u00b5ORScreen: a lightweight consensus modeling framework for \u00b5-opioid receptor ligand prediction and virtual screening"],"prefix":"10.1039","volume":"16","author":[{"given":"Keyu","family":"Chen","sequence":"first","affiliation":[{"name":"Sichuan Police College, Luzhou 646000, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Huang","sequence":"additional","affiliation":[{"name":"Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3147-3786","authenticated-orcid":false,"given":"Jiangcheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Hangzhou Polytechnic University, Hangzhou 310014, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengwen","family":"Bai","sequence":"additional","affiliation":[{"name":"National Anti-Drug Laboratory Sichuan Regional Center, Chengdu 610299, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-3478","authenticated-orcid":false,"given":"Tao","family":"Bi","sequence":"additional","affiliation":[{"name":"Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengjin","family":"Liu","sequence":"additional","affiliation":[{"name":"Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Sun","sequence":"additional","affiliation":[{"name":"Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Dai","sequence":"additional","affiliation":[{"name":"Sichuan Police College, Luzhou 646000, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"3","key":"D6RA03044K\/cit1\/1","doi-asserted-by":"publisher","first-page":"e195","DOI":"10.1016\/S2468-2667(22)00043-3","volume":"7","author":"The Lancet Public Health","year":"2022","journal-title":"The Lancet Public Health"},{"issue":"1","key":"D6RA03044K\/cit2\/1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41398-020-0847-1","volume":"10","author":"Blanco","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"D6RA03044K\/cit3\/1","volume-title":"StatPearls","author":"Herman","year":"2024","unstructured":"T.Herman ,  M.Cascella  and  M. R.Muzio ,  Mu Receptors ,  StatPearls ,  2024"},{"issue":"13","key":"D6RA03044K\/cit4\/1","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1038\/s41386-018-0225-3","volume":"43","author":"Valentino","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"D6RA03044K\/cit5\/1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13321-024-00855-8","volume":"16","author":"Moshawih","year":"2024","journal-title":"J. Cheminformatics"},{"issue":"1","key":"D6RA03044K\/cit6\/1","doi-asserted-by":"publisher","first-page":"28321","DOI":"10.1038\/s41598-024-79799-w","volume":"14","author":"Noor","year":"2024","journal-title":"Sci. Rep."},{"issue":"15","key":"D6RA03044K\/cit7\/1","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1021\/acschemneuro.4c00212","volume":"15","author":"Oh","year":"2024","journal-title":"ACS Chem. Neurosci."},{"issue":"2","key":"D6RA03044K\/cit8\/1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10822-025-00686-1","volume":"39","author":"Ugurlu","year":"2025","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"6","key":"D6RA03044K\/cit9\/1","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1021\/acs.jcim.1c00439","volume":"61","author":"Sakamuru","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"6","key":"D6RA03044K\/cit10\/1","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1021\/ci034160g","volume":"43","author":"Svetnik","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"D6RA03044K\/cit11\/1","volume-title":"An Introduction to Support Vector Machines and Other Kernel-Based Learning Methods","author":"Cristianini","year":"2010","unstructured":"N.Cristianini  and  J.Shawe-Taylor ,  An Introduction to Support Vector Machines and Other Kernel-Based Learning Methods ,  2010"},{"key":"D6RA03044K\/cit12\/1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1145\/2939672.2939785","volume-title":"Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining","author":"Chen","year":"2016","unstructured":"T.Chen  and  C.Guestrin ,  XGBoost: A Scalable Tree Boosting System , in  Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining ,  ACM: San Francisco California USA ,  2016 ,  pp. 785\u2013794 ,  10.1145\/2939672.2939785"},{"key":"D6RA03044K\/cit13\/1","volume-title":"In Proceedings of the 31st Annual Conference on Neural Information Processing Systems","author":"Ke","year":"2017","unstructured":"G. L.Ke ,  Q.Meng ,  T.Finley ,  T. F.Wang ,  W.Chen ,  W. D.Ma ,  Q. W.Ye  and  T. Y.Liu ,  LightGBM: A Highly Efficient Gradient Boosting Decision Tree , in  In Proceedings of the 31st Annual Conference on Neural Information Processing Systems ,  Long Beach ,  CA, USA ,  2017"},{"issue":"1","key":"D6RA03044K\/cit14\/1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1021\/acs.jcim.3c01250","volume":"64","author":"Heid","year":"2024","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"D6RA03044K\/cit15\/1","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1021\/acs.jcim.5c02332","volume":"66","author":"Graff","year":"2026","journal-title":"J. Chem. Inf. Model."},{"issue":"8045","key":"D6RA03044K\/cit16\/1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41586-024-08328-6","volume":"637","author":"Hollmann","year":"2025","journal-title":"Nature"},{"issue":"1","key":"D6RA03044K\/cit17\/1","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1038\/s41467-025-58606-8","volume":"16","author":"Joeres","year":"2025","journal-title":"Nat. Commun."},{"issue":"23","key":"D6RA03044K\/cit18\/1","doi-asserted-by":"publisher","first-page":"5938","DOI":"10.1021\/acs.jcim.2c01073","volume":"62","author":"van Tilborg","year":"2022","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"D6RA03044K\/cit20\/1","doi-asserted-by":"publisher","first-page":"7568","DOI":"10.1038\/s41467-023-43214-1","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"D6RA03044K\/cit21\/1","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1021\/acsengineeringau.5c00027","volume":"5","author":"Liao","year":"2025","journal-title":"ACS Eng. Au"},{"key":"D6RA03044K\/cit22\/1","volume-title":"Advances in Neural Information Processing Systems","volume":"30","author":"Vaswani","year":"2017","unstructured":"A.Vaswani ,  N.Shazeer ,  N.Parmar ,  J.Uszkoreit ,  L.Jones ,  A. N.Gomez ,  \u0141.Kaiser  and  I.Polosukhin ,  Attention Is All You Need , in  Advances in Neural Information Processing Systems , ed.  I. Guyon ,  U. V. Luxburg ,  S. Bengio ,  H. Wallach ,  R. Fergus ,  S. Vishwanathan  and  R. Garnett ,  Curran Associates, Inc. ,  2017 , vol.  30"},{"issue":"7","key":"D6RA03044K\/cit23\/1","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1021\/acs.jcim.5c02823","volume":"66","author":"Chen","year":"2026","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"D6RA03044K\/cit24\/1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1021\/acs.jcim.5c02094","volume":"66","author":"Chupakhin","year":"2026","journal-title":"J. Chem. Inf. Model."},{"issue":"D1","key":"D6RA03044K\/cit25\/1","doi-asserted-by":"publisher","first-page":"D440","DOI":"10.1093\/nar\/gkx1109","volume":"46","author":"P\u00e1ndy-Szekeres","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"D6RA03044K\/cit26\/1","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1021\/acs.jcim.4c00095","volume":"64","author":"Jin","year":"2024","journal-title":"J. Chem. Inf. Model."},{"issue":"12","key":"D6RA03044K\/cit27\/1","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/s42256-022-00580-7","volume":"4","author":"Ross","year":"2022","journal-title":"Nat. Mach. Intell."},{"issue":"1","key":"D6RA03044K\/cit28\/1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13321-024-00812-5","volume":"16","author":"Loeffler","year":"2024","journal-title":"J. Cheminf."},{"issue":"17","key":"D6RA03044K\/cit29\/1","doi-asserted-by":"publisher","first-page":"e13556","DOI":"10.1002\/advs.202513556","volume":"13","author":"Wang","year":"2026","journal-title":"Adv. Sci."},{"issue":"10","key":"D6RA03044K\/cit30\/1","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1039\/D5DD00311C","volume":"4","author":"Zhan","year":"2025","journal-title":"Digit. Discov."},{"key":"D6RA03044K\/cit31\/1","first-page":"4593","volume-title":"Proceedings of the 29th International Conference on Computational Linguistics","author":"Mosca","year":"2022","unstructured":"E.Mosca ,  F.Szigeti ,  S.Tragianni ,  D.Gallagher  and  G.Groh ,  SHAP-Based Explanation Methods: A Review for NLP Interpretability , in  Proceedings of the 29th International Conference on Computational Linguistics ,  2022 ,  pp. 4593\u20134603"},{"key":"D6RA03044K\/cit32\/1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s42256-019-0318-9","volume":"2","author":"Lundberg","year":"2020","journal-title":"Nature Machine Intelligence"},{"issue":"3","key":"D6RA03044K\/cit33\/1","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0022-3565(24)39155-4","volume":"294","author":"Broadbear","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"D6RA03044K\/cit34\/1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0014-2999(86)90333-X","volume":"129","author":"Ling","year":"1986","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"D6RA03044K\/cit35\/1","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1021\/acsmedchemlett.9b00406","volume":"10","author":"Long","year":"2019","journal-title":"ACS Med. Chem. Lett."},{"issue":"3","key":"D6RA03044K\/cit36\/1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0014-2999(88)90018-0","volume":"150","author":"Gulya","year":"1988","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"D6RA03044K\/cit37\/1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00213-007-0898-5","volume":"195","author":"Steinmiller","year":"2008","journal-title":"Psychopharmacol."},{"issue":"2","key":"D6RA03044K\/cit38\/1","doi-asserted-by":"publisher","first-page":"R463","DOI":"10.1152\/ajpregu.00390.2007","volume":"295","author":"Sahr","year":"2008","journal-title":"Am. J. Physiol.: Regul., Integr. Comp. Physiol."},{"issue":"3","key":"D6RA03044K\/cit39\/1","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1124\/jpet.104.082966","volume":"313","author":"Raehal","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"D6RA03044K\/cit40\/1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/gutjnl-2018-316001","volume":"68","author":"Luthra","year":"2019","journal-title":"Gut"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA03044K\/0\/D6RA03044K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:07:54Z","timestamp":1789578474000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA03044K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":39,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra03044k","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}