{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:30:50Z","timestamp":1786563050813,"version":"build-2736575974"},"reference-count":39,"publisher":"Royal Society of Chemistry (RSC)","issue":"37","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":193,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007787","name":"National Research Centre","doi-asserted-by":"publisher","award":["13010137"],"award-info":[{"award-number":["13010137"]}],"id":[{"id":"10.13039\/100007787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Telomerase is an enzyme that rebuilds chromosomal ends called telomeres, allowing cells to keep dividing.<\/jats:p>","DOI":"10.1039\/d6ra03196j","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:07:46Z","timestamp":1783940866000},"page":"39987-39998","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, synthesis, anticancer activity and molecular modeling of new pyrazoline derivatives as telomerase inhibitors"],"prefix":"10.1039","volume":"16","author":[{"given":"Mai M.","family":"Elghonemy","sequence":"first","affiliation":[{"name":"Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-3613","authenticated-orcid":false,"given":"Eman Y.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-3888","authenticated-orcid":false,"given":"Mohamed K.","family":"El-Ashrey","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, 11562, Cairo, Egypt"},{"name":"Medicinal Chemistry Department, Faculty of Pharmacy, King Salman International University, South Sinai, Ras Sudr, 46612, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar E. A.","family":"Elasasy","sequence":"additional","affiliation":[{"name":"Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3970-2371","authenticated-orcid":false,"given":"Hanem M.","family":"Awad","sequence":"additional","affiliation":[{"name":"Tanning Materials and Leather Technology Department, National Research Centre, Dokki, Cairo, 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-3784","authenticated-orcid":false,"given":"Rasha Z.","family":"Batran","sequence":"additional","affiliation":[{"name":"Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehad A.","family":"Abdel Latif","sequence":"additional","affiliation":[{"name":"Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"3","key":"D6RA03196J\/cit1\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"Bray","year":"2024","journal-title":"Ca-Cancer J. Clin."},{"issue":"20","key":"D6RA03196J\/cit2\/1","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1056\/NEJMp1508811","volume":"373","author":"Vogelstein","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"D6RA03196J\/cit3\/1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1128\/MMBR.66.3.407-425.2002","volume":"66","author":"Cong","year":"2002","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"2","key":"D6RA03196J\/cit4\/1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0092-8674(85)90170-9","volume":"43","author":"Greider","year":"1985","journal-title":"cell"},{"issue":"1","key":"D6RA03196J\/cit5\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/carcin\/bgp268","volume":"31","author":"Artandi","year":"2010","journal-title":"Carcinogenesis"},{"issue":"6087","key":"D6RA03196J\/cit6\/1","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1126\/science.1222394","volume":"336","author":"Shay","year":"2012","journal-title":"Science"},{"issue":"1","key":"D6RA03196J\/cit7\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5958\/2319-4324.2017.00005.0","volume":"6","author":"Meena","year":"2017","journal-title":"J. Adv. Med."},{"issue":"1\u20132","key":"D6RA03196J\/cit8\/1","first-page":"90","volume":"730","author":"Buseman","year":"2012","journal-title":"Mutat. Res., Fundam. Mol. Mech. Mutagen."},{"issue":"5","key":"D6RA03196J\/cit9\/1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41576-019-0099-1","volume":"20","author":"Shay","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"3","key":"D6RA03196J\/cit10\/1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrc2275","volume":"8","author":"Harley","year":"2008","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"D6RA03196J\/cit11\/1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1158\/1078-0432.397.11.1","volume":"11","author":"Camp","year":"2005","journal-title":"Clin. Cancer Res."},{"issue":"36","key":"D6RA03196J\/cit12\/1","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1038\/s41388-020-01405-w","volume":"39","author":"Guterres","year":"2020","journal-title":"Oncogene"},{"issue":"9","key":"D6RA03196J\/cit13\/1","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/nar\/gki609","volume":"33","author":"Huppert","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"D6RA03196J\/cit14\/1","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1038\/s41467-020-19115-y","volume":"11","author":"Sanford","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"D6RA03196J\/cit15\/1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/annonc\/mdu550","volume":"26","author":"Chiappori","year":"2015","journal-title":"Ann. Oncol."},{"issue":"18","key":"D6RA03196J\/cit16\/1","doi-asserted-by":"crossref","first-page":"15566","DOI":"10.1074\/jbc.M201266200","volume":"277","author":"Pascolo","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"4","key":"D6RA03196J\/cit17\/1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.bmcl.2012.12.010","volume":"23","author":"Luo","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6RA03196J\/cit18\/1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejmech.2016.02.009","volume":"112","author":"Wang","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"15","key":"D6RA03196J\/cit19\/1","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.3390\/ijms21155507","volume":"21","author":"Matiadis","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"74","key":"D6RA03196J\/cit20\/1","doi-asserted-by":"crossref","first-page":"46999","DOI":"10.1039\/C7RA08939B","volume":"7","author":"Varghese","year":"2017","journal-title":"RSC Adv."},{"key":"D6RA03196J\/cit21\/1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jconrel.2018.12.014","volume":"294","author":"Zhuang","year":"2019","journal-title":"J. Controlled Release"},{"issue":"1","key":"D6RA03196J\/cit22\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s44371-026-00550-7","volume":"3","author":"Thorat","year":"2026","journal-title":"Discov. Chem."},{"key":"D6RA03196J\/cit23\/1","doi-asserted-by":"crossref","first-page":"137510","DOI":"10.1016\/j.molstruc.2024.137510","volume":"1303","author":"Kassem","year":"2024","journal-title":"J. Mol. Struct."},{"issue":"3","key":"D6RA03196J\/cit24\/1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.25004\/IJPSDR.2009.010302","volume":"1","author":"Siddiqui","year":"2009","journal-title":"Int. J. Pharm. Sci. Drug Res."},{"key":"D6RA03196J\/cit25\/1","doi-asserted-by":"crossref","first-page":"133479","DOI":"10.1016\/j.molstruc.2022.133479","volume":"1266","author":"Singh","year":"2022","journal-title":"J. Mol. Struct."},{"issue":"13","key":"D6RA03196J\/cit26\/1","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.3390\/molecules27133994","volume":"27","author":"Arshad","year":"2022","journal-title":"Molecules"},{"issue":"35","key":"D6RA03196J\/cit27\/1","doi-asserted-by":"crossref","first-page":"11501","DOI":"10.1021\/bi982829k","volume":"38","author":"Hayakawa","year":"1999","journal-title":"Biochemistry"},{"issue":"12","key":"D6RA03196J\/cit28\/1","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1021\/acs.jcim.5b00336","volume":"55","author":"Shirgahi Talari","year":"2015","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"D6RA03196J\/cit29\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/ph15010082","volume":"15","author":"Culletta","year":"2022","journal-title":"Pharmaceuticals"},{"key":"D6RA03196J\/cit30\/1","doi-asserted-by":"crossref","first-page":"104077","DOI":"10.1016\/j.bioorg.2020.104077","volume":"102","author":"Liu","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"1","key":"D6RA03196J\/cit31\/1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13578-023-01181-6","volume":"13","author":"Yan","year":"2023","journal-title":"Cell Biosci."},{"issue":"31","key":"D6RA03196J\/cit32\/1","doi-asserted-by":"crossref","first-page":"22434","DOI":"10.1039\/D4RA01801J","volume":"14","author":"Batran","year":"2024","journal-title":"RSC Adv."},{"key":"D6RA03196J\/cit33\/1","doi-asserted-by":"crossref","first-page":"136358","DOI":"10.1016\/j.molstruc.2023.136358","volume":"1294","author":"Kassem","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"24","key":"D6RA03196J\/cit34\/1","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.3390\/molecules25245944","volume":"25","author":"Abuelizz","year":"2020","journal-title":"Molecules"},{"issue":"17","key":"D6RA03196J\/cit35\/1","first-page":"129","volume":"8","author":"Younis","year":"2016","journal-title":"Der Pharm. Chem."},{"issue":"42","key":"D6RA03196J\/cit36\/1","doi-asserted-by":"crossref","first-page":"29070","DOI":"10.1039\/D3RA03483F","volume":"13","author":"Batran","year":"2023","journal-title":"RSC Adv."},{"issue":"39","key":"D6RA03196J\/cit37\/1","doi-asserted-by":"crossref","first-page":"32821","DOI":"10.1039\/D5RA04395F","volume":"15","author":"Ahmed","year":"2025","journal-title":"RSC Adv."},{"key":"D6RA03196J\/cit38\/1","doi-asserted-by":"crossref","first-page":"137790","DOI":"10.1016\/j.molstruc.2024.137790","volume":"1305","author":"Batran","year":"2024","journal-title":"J. Mol. Struct."},{"issue":"8","key":"D6RA03196J\/cit39\/1","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA03196J\/0\/D6RA03196J.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:00:32Z","timestamp":1786561232000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA03196J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":39,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2026,8,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra03196j","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}