{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:47:29Z","timestamp":1791884849204,"version":"4.3.4"},"reference-count":65,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":285,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    Feruloyl amino acid and dipeptide derivatives showed superior antioxidant activity compared to standard references. They also displayed high radical-scavenging rates and strong Cu(\n                    <jats:sc>ii<\/jats:sc>\n                    ) chelation, highlighting their therapeutic potential.\n                  <\/jats:p>","DOI":"10.1039\/d6ra03650c","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:09:31Z","timestamp":1791882571000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant and free radical scavenging potential of feruloyl amino acids and dipeptide derivatives: an experimental and theoretical investigation"],"prefix":"10.1039","author":[{"given":"Imene","family":"Amine Khodja","sequence":"first","affiliation":[{"name":"Laboratory of Synthesis of Molecules with Biological Interest, University of Fr\u00e8res Mentouri Constantine 1, Constantine 25017, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-1026","authenticated-orcid":false,"given":"Maciej","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Pharmaceutical Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw 50-556, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4119-7447","authenticated-orcid":false,"given":"Abdelaaty","family":"Hamed","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souhir","family":"Abid","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majdi","family":"Abid","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman A.","family":"Alsalamah","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-2129","authenticated-orcid":false,"given":"Massuo J.","family":"Kato","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, University of S\u00e3o Paulo, Av.Prof.Lineu Prestes, 748, S\u00e3o Paulo, 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7727-8583","authenticated-orcid":false,"given":"Houssem","family":"Boulebd","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis of Molecules with Biological Interest, University of Fr\u00e8res Mentouri Constantine 1, Constantine 25017, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA03650C\/cit1\/1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0009-8981(02)00344-3","volume":"327","author":"Kim","year":"2003","journal-title":"Clin. Chim. Acta"},{"key":"D6RA03650C\/cit2\/1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.mrfmmm.2005.03.023","volume":"579","author":"Soobrattee","year":"2005","journal-title":"Mutat. Res., Fundam. Mol. Mech. Mutagen."},{"key":"D6RA03650C\/cit3\/1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1021\/jf9908345","volume":"48","author":"Wang","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"D6RA03650C\/cit4\/1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1080\/10942912.2018.1439958","volume":"21","author":"Adeyemi","year":"2018","journal-title":"Int. J. Food Prop."},{"key":"D6RA03650C\/cit5\/1","doi-asserted-by":"publisher","first-page":"4132","DOI":"10.3390\/molecules24224132","volume":"24","author":"Louren\u00e7o","year":"2019","journal-title":"Molecules"},{"key":"D6RA03650C\/cit6\/1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/(SICI)1097-0010(19990301)79:3<362::AID-JSFA256>3.0.CO;2-D","volume":"79","author":"Clifford","year":"1999","journal-title":"J. Sci. Food Agric."},{"key":"D6RA03650C\/cit7\/1","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.3390\/molecules26102959","volume":"26","author":"Arfaoui","year":"2021","journal-title":"Molecules"},{"key":"D6RA03650C\/cit8\/1","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3390\/molecules28041845","volume":"28","author":"Sun","year":"2023","journal-title":"Molecules"},{"key":"D6RA03650C\/cit9\/1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/10715760100300741","volume":"35","author":"Rechner","year":"2001","journal-title":"Free Radical Res."},{"key":"D6RA03650C\/cit10\/1","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/1541-4337.12266","volume":"16","author":"de Oliveira Silva","year":"2017","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"D6RA03650C\/cit11\/1","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.3389\/fnut.2021.777576","volume":"8","author":"Antonopoulou","year":"2022","journal-title":"Front. Nutr."},{"key":"D6RA03650C\/cit12\/1","doi-asserted-by":"publisher","first-page":"8927","DOI":"10.1021\/jf101514j","volume":"58","author":"Dobberstein","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"D6RA03650C\/cit13\/1","doi-asserted-by":"publisher","first-page":"146994","DOI":"10.1016\/j.foodchem.2025.146994","volume":"497","author":"Sun","year":"2025","journal-title":"Food Chem."},{"key":"D6RA03650C\/cit14\/1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/appliedchem5040037","volume":"5","author":"Shikama","year":"2025","journal-title":"Appl. Chem."},{"key":"D6RA03650C\/cit15\/1","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1021\/acschemneuro.3c00679","volume":"15","author":"Singh","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"D6RA03650C\/cit16\/1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.comptc.2013.02.018","volume":"1012","author":"Urbaniak","year":"2013","journal-title":"Comput. Theor. Chem."},{"key":"D6RA03650C\/cit17\/1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3390\/molecules22040527","volume":"22","author":"Karama\u0107","year":"2017","journal-title":"Molecules"},{"key":"D6RA03650C\/cit18\/1","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.3390\/antiox12091669","volume":"12","author":"Boulebd","year":"2023","journal-title":"Antioxidants"},{"key":"D6RA03650C\/cit19\/1","doi-asserted-by":"publisher","first-page":"112905","DOI":"10.1016\/j.comptc.2020.112905","volume":"1185","author":"Truong","year":"2020","journal-title":"Comput. Theor. Chem."},{"key":"D6RA03650C\/cit20\/1","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3390\/antiox10081303","volume":"10","author":"Ami\u0107","year":"2021","journal-title":"Antioxidants"},{"key":"D6RA03650C\/cit21\/1","doi-asserted-by":"publisher","first-page":"5615","DOI":"10.3390\/ijms26125615","volume":"26","author":"Kowalska-Baron","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA03650C\/cit22\/1","doi-asserted-by":"publisher","first-page":"6015","DOI":"10.3390\/molecules26196015","volume":"26","author":"Bargagna","year":"2021","journal-title":"Molecules"},{"key":"D6RA03650C\/cit23\/1","doi-asserted-by":"publisher","first-page":"12288","DOI":"10.1038\/s41598-020-68732-6","volume":"10","author":"Das","year":"2020","journal-title":"Sci. Rep."},{"key":"D6RA03650C\/cit24\/1","doi-asserted-by":"publisher","first-page":"103678","DOI":"10.1016\/j.bioorg.2020.103678","volume":"97","author":"Hamed","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D6RA03650C\/cit25\/1","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"Re","year":"1999","journal-title":"Free Radical Biol. Med."},{"key":"D6RA03650C\/cit26\/1","doi-asserted-by":"publisher","first-page":"4288","DOI":"10.1039\/C3AY40367J","volume":"5","author":"Pyrzynska","year":"2013","journal-title":"Anal. Methods"},{"key":"D6RA03650C\/cit28\/1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00214-007-0310-x","volume":"120","author":"Zhao","year":"2008","journal-title":"Theor. Chem. Acc."},{"key":"D6RA03650C\/cit29\/1","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1002\/jcc.23715","volume":"35","author":"Galano","year":"2014","journal-title":"J. Comput. Chem."},{"key":"D6RA03650C\/cit30\/1","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1021\/jp7109127","volume":"112","author":"Zhao","year":"2008","journal-title":"J. Phys. Chem. A"},{"key":"D6RA03650C\/cit31\/1","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1002\/jcc.23715","volume":"35","author":"Galano","year":"2014","journal-title":"J. Comput. Chem."},{"key":"D6RA03650C\/cit32\/1","doi-asserted-by":"publisher","first-page":"6378","DOI":"10.1021\/jp810292n","volume":"113","author":"Marenich","year":"2009","journal-title":"J. Phys. Chem. B"},{"key":"D6RA03650C\/cit33\/1","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/jcc.22885","volume":"33","author":"Lu","year":"2012","journal-title":"J. Comput. Chem."},{"key":"D6RA03650C\/cit34\/1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graphics"},{"key":"D6RA03650C\/cit35\/1","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1021\/acs.jcim.6b00310","volume":"56","author":"Galano","year":"2016","journal-title":"J. Chem. Inf. Model."},{"key":"D6RA03650C\/cit36\/1","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1002\/jcc.23409","volume":"34","author":"Galano","year":"2013","journal-title":"J. Comput. Chem."},{"key":"D6RA03650C\/cit37\/1","doi-asserted-by":"publisher","first-page":"e25665","DOI":"10.1002\/qua.25665","volume":"119","author":"Galano","year":"2019","journal-title":"Int. J. Quantum Chem."},{"key":"D6RA03650C\/cit38\/1","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1021\/ja00478a009","volume":"100","author":"Pollak","year":"1978","journal-title":"J. Am. Chem. Soc."},{"key":"D6RA03650C\/cit39\/1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s00214-007-0328-0","volume":"118","author":"Fern\u00e1ndez-Ramos","year":"2007","journal-title":"Theor. Chem. Acc."},{"key":"D6RA03650C\/cit40\/1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/jcc.23470","volume":"35","author":"Canneaux","year":"2014","journal-title":"J. Comput. Chem."},{"key":"D6RA03650C\/cit41\/1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0095-8522(49)90023-9","volume":"4","author":"Collins","year":"1949","journal-title":"J. Colloid Interface Sci."},{"key":"D6RA03650C\/cit42\/1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev.pc.15.100164.001103","volume":"15","author":"Marcus","year":"1964","journal-title":"Annu. Rev. Phys. Chem."},{"key":"D6RA03650C\/cit43\/1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1103\/RevModPhys.65.599","volume":"65","author":"Marcus","year":"1993","journal-title":"Rev. Mod. Phys."},{"key":"D6RA03650C\/cit44\/1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0095-8522(49)90023-9","volume":"4","author":"Collins","year":"1949","journal-title":"J. Colloid Sci."},{"key":"D6RA03650C\/cit45\/1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1515\/zpch-1918-9209","volume":"92U","author":"Smoluchowski","year":"1918","journal-title":"Z. Phys. Chem."},{"key":"D6RA03650C\/cit46\/1","volume-title":"Investigations on the Theory of the Brownian Movement","author":"Einstein","year":"1956","unstructured":"A.Einstein Investigations on the Theory of the Brownian Movement ,  Dover Publications ,  1956"},{"key":"D6RA03650C\/cit47\/1","doi-asserted-by":"publisher","first-page":"161103","DOI":"10.1063\/1.2126975","volume":"123","author":"Zhao","year":"2005","journal-title":"J. Chem. Phys."},{"key":"D6RA03650C\/cit48\/1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/molecules26010089","volume":"26","author":"Lambruschini","year":"2021","journal-title":"Molecules"},{"key":"D6RA03650C\/cit49\/1","doi-asserted-by":"publisher","first-page":"100023","DOI":"10.1016\/j.pscia.2023.100023","volume":"2","author":"Halpani","year":"2024","journal-title":"Pharm. Sci. Adv."},{"key":"D6RA03650C\/cit50\/1","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.3389\/fphar.2023.1133655","volume":"14","author":"Mao","year":"2023","journal-title":"Front. Pharmacol"},{"key":"D6RA03650C\/cit51\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-3-030-87222-9_5","volume-title":"Lipid Oxidation in Food and Biological Systems: A Physical Chemistry Perspective","author":"Guo","year":"2022","unstructured":"Y.Guo , and  R.Amorati The Underrecognized Role of the Hydroperoxyl (HOO\u02d9) Radical in Chain Propagation of Lipids and its Implication in Antioxidant Activity ,  Lipid Oxidation in Food and Biological Systems: A Physical Chemistry Perspective , Ed.,  C. Bravo-Diaz ,  Springer International Publishing ,  Cham ,  2022 ,  pp. 115\u2013132"},{"key":"D6RA03650C\/cit52\/1","doi-asserted-by":"publisher","first-page":"8168","DOI":"10.1021\/acs.joc.4c00851","volume":"89","author":"Boulebd","year":"2024","journal-title":"J. Org. Chem."},{"key":"D6RA03650C\/cit53\/1","doi-asserted-by":"publisher","first-page":"16047","DOI":"10.1039\/D4NJ03030C","volume":"48","author":"Foti","year":"2024","journal-title":"New J. Chem."},{"key":"D6RA03650C\/cit54\/1","doi-asserted-by":"publisher","first-page":"138044","DOI":"10.1016\/j.ijbiomac.2024.138044","volume":"284","author":"Boulebd","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D6RA03650C\/cit55\/1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/kin.21540","volume":"54","author":"Boulebd","year":"2022","journal-title":"Int. J. Chem. Kinet."},{"key":"D6RA03650C\/cit56\/1","doi-asserted-by":"publisher","first-page":"11142","DOI":"10.1021\/ja012732c","volume":"124","author":"Mayer","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D6RA03650C\/cit57\/1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s11144-017-1286-8","volume":"123","author":"Milenkovi\u0107","year":"2018","journal-title":"React. Kinet., Mech. Catal."},{"key":"D6RA03650C\/cit58\/1","doi-asserted-by":"publisher","first-page":"5745","DOI":"10.1021\/acs.joc.3c00193","volume":"88","author":"Boulebd","year":"2023","journal-title":"J. Org. Chem."},{"key":"D6RA03650C\/cit59\/1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1039\/D1NJ04771J","volume":"46","author":"Boulebd","year":"2022","journal-title":"New J. Chem."},{"key":"D6RA03650C\/cit60\/1","doi-asserted-by":"publisher","first-page":"113608","DOI":"10.1016\/j.phytochem.2023.113608","volume":"208","author":"Boulebd","year":"2023","journal-title":"Phytochemistry"},{"key":"D6RA03650C\/cit61\/1","doi-asserted-by":"publisher","first-page":"e4421","DOI":"10.1002\/poc.4421","volume":"35","author":"Boulebd","year":"2022","journal-title":"J. Phys. Org. Chem."},{"key":"D6RA03650C\/cit62\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-5793(98)01665-2","volume":"443","author":"Hippeli","year":"1999","journal-title":"FEBS Lett."},{"key":"D6RA03650C\/cit63\/1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11243-012-9583-6","volume":"37","author":"Jomova","year":"2012","journal-title":"Transition Met. Chem."},{"key":"D6RA03650C\/cit64\/1","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1016\/j.apsusc.2010.09.005","volume":"257","author":"Akhavan","year":"2010","journal-title":"Appl. Surf. Sci."},{"key":"D6RA03650C\/cit65\/1","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1021\/acs.joc.4c02837","volume":"90","author":"Boulebd","year":"2025","journal-title":"J. Org. Chem."},{"key":"D6RA03650C\/cit66\/1","doi-asserted-by":"publisher","first-page":"22546","DOI":"10.1039\/D5RA02914G","volume":"15","author":"Boulebd","year":"2025","journal-title":"RSC Adv."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA03650C\/0\/D6RA03650C.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:09:33Z","timestamp":1791882573000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA03650C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":65,"URL":"https:\/\/doi.org\/10.1039\/d6ra03650c","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}