{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:01:46Z","timestamp":1788487306537,"version":"build-2803163510"},"reference-count":81,"publisher":"Royal Society of Chemistry (RSC)","issue":"32","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":151,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Due to their multitargeting potential, coumarin-based hybrid molecules represent a new and valuable drug development strategy for the treatment of Alzheimer's disease (AD).<\/jats:p>","DOI":"10.1039\/d6ra03862j","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:52:21Z","timestamp":1780325541000},"page":"29631-29660","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bridging the gap in Alzheimer's therapy: strategic design and SAR evolution of coumarin-based hybrids as potent MTDLs"],"prefix":"10.1039","volume":"16","author":[{"given":"Omar K.","family":"El-Mokaddem","sequence":"first","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt"},{"name":"Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4445-5280","authenticated-orcid":false,"given":"Ghada F.","family":"Elmasry","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa R.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3884-8755","authenticated-orcid":false,"given":"Lina M. A.","family":"Abdel Ghany","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA03862J\/cit1\/1","doi-asserted-by":"publisher","first-page":"108024","DOI":"10.1016\/j.bioorg.2024.108024","volume":"154","author":"Abd El-Mageed","year":"2025","journal-title":"Bioorg. Chem."},{"key":"D6RA03862J\/cit2\/1","doi-asserted-by":"publisher","first-page":"895483","DOI":"10.3389\/fchem.2022.895483","volume":"10","author":"Babaei","year":"2022","journal-title":"Front. Chem."},{"key":"D6RA03862J\/cit3\/1","doi-asserted-by":"publisher","first-page":"802","DOI":"10.2174\/1567205018666211208140551","volume":"18","author":"Bhatia","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"D6RA03862J\/cit4\/1","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.3390\/PH18111685","volume":"18","author":"Almaghrabi","year":"2025","journal-title":"Pharmaceuticals"},{"key":"D6RA03862J\/cit5\/1","doi-asserted-by":"publisher","first-page":"111585","DOI":"10.1016\/J.EJMECH.2019.111585","volume":"181","author":"Li","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA03862J\/cit6\/1","doi-asserted-by":"publisher","DOI":"10.2174\/0118715273315191241002115155","volume":"24","author":"Shome","year":"2024","journal-title":"CNS Neurol. Disord.:Drug Targets"},{"key":"D6RA03862J\/cit7\/1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2270781","volume":"38","author":"Zou","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6RA03862J\/cit8\/1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1080\/14756366.2019.1571270","volume":"34","author":"de Souza","year":"2019","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6RA03862J\/cit9\/1","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1111\/CBDD.13316","volume":"92","author":"Hiremathad","year":"2018","journal-title":"Chem. Biol. Drug Des."},{"key":"D6RA03862J\/cit10\/1","doi-asserted-by":"publisher","first-page":"130618","DOI":"10.1016\/J.MOLSTRUC.2021.130618","volume":"1241","author":"Husain","year":"2021","journal-title":"J. Mol. Struct."},{"key":"D6RA03862J\/cit11\/1","doi-asserted-by":"publisher","first-page":"118949","DOI":"10.1016\/J.EJMECH.2026.118949","volume":"315","author":"El-Mokaddem","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA03862J\/cit12\/1","doi-asserted-by":"publisher","first-page":"11161","DOI":"10.1021\/acsomega.2c07993","volume":"8","author":"Sharma","year":"2023","journal-title":"ACS Omega"},{"key":"D6RA03862J\/cit13\/1","doi-asserted-by":"publisher","first-page":"129927","DOI":"10.1016\/j.bmcl.2024.129927","volume":"112","author":"Khandelwal","year":"2024","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6RA03862J\/cit14\/1","doi-asserted-by":"publisher","first-page":"100289","DOI":"10.1016\/j.ejmcr.2025.100289","volume":"15","author":"Dar","year":"2025","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"D6RA03862J\/cit15\/1","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.3390\/molecules31040595","volume":"31","author":"Wang","year":"2026","journal-title":"Molecules"},{"key":"D6RA03862J\/cit16\/1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.bioorg.2018.10.056","volume":"83","author":"Najafi","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D6RA03862J\/cit17\/1","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1039\/d4md00782d","volume":"16","author":"Singh","year":"2025","journal-title":"RSC Med. Chem."},{"key":"D6RA03862J\/cit18\/1","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.3390\/molecules30102121","volume":"30","author":"Dimkovski","year":"2025","journal-title":"Molecules"},{"key":"D6RA03862J\/cit19\/1","doi-asserted-by":"publisher","first-page":"127477","DOI":"10.1016\/j.bmcl.2020.127477","volume":"30","author":"Singh","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6RA03862J\/cit20\/1","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1039\/d4md00270a","volume":"15","author":"Visansirikul","year":"2024","journal-title":"RSC Med. Chem."},{"key":"D6RA03862J\/cit21\/1","doi-asserted-by":"publisher","first-page":"810233","DOI":"10.3389\/fchem.2021.810233","volume":"9","author":"Pourabdi","year":"2022","journal-title":"Front. Chem."},{"key":"D6RA03862J\/cit22\/1","doi-asserted-by":"publisher","first-page":"337318","DOI":"10.3389\/fchem.2018.00061","volume":"6","author":"Ibrar","year":"2018","journal-title":"Front. Chem."},{"key":"D6RA03862J\/cit23\/1","doi-asserted-by":"publisher","first-page":"e202401524","DOI":"10.1002\/cbdv.202401524","volume":"22","author":"Patowary","year":"2025","journal-title":"Chem. Biodiversity"},{"key":"D6RA03862J\/cit24\/1","doi-asserted-by":"publisher","first-page":"101977","DOI":"10.1016\/j.jksus.2022.101977","volume":"34","author":"George","year":"2022","journal-title":"J. King Saud Univ., Sci."},{"key":"D6RA03862J\/cit25\/1","doi-asserted-by":"publisher","first-page":"118499","DOI":"10.1016\/j.bmc.2025.118499","volume":"133","author":"Li","year":"2026","journal-title":"Bioorg. Med. Chem."},{"key":"D6RA03862J\/cit26\/1","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/slct.201803222","volume":"4","author":"Duarte","year":"2019","journal-title":"ChemistrySelect"},{"key":"D6RA03862J\/cit27\/1","doi-asserted-by":"publisher","first-page":"41752","DOI":"10.1038\/s41598-025-28665-4","volume":"15","author":"Zareen","year":"2025","journal-title":"Sci. Rep."},{"key":"D6RA03862J\/cit28\/1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16070971","volume":"16","author":"Hasan","year":"2023","journal-title":"Pharmaceuticals"},{"key":"D6RA03862J\/cit29\/1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ejmech.2016.05.014","volume":"121","author":"Ghanei-Nasab","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA03862J\/cit30\/1","doi-asserted-by":"publisher","first-page":"129784","DOI":"10.1016\/j.molstruc.2020.129784","volume":"1229","author":"Song","year":"2021","journal-title":"J. Mol. Struct."},{"key":"D6RA03862J\/cit31\/1","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.3390\/ijms252312803","volume":"25","author":"\u017bo\u0142ek","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA03862J\/cit32\/1","doi-asserted-by":"publisher","first-page":"114689","DOI":"10.1016\/j.ejmech.2022.114689","volume":"242","author":"Liu","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA03862J\/cit33\/1","doi-asserted-by":"publisher","first-page":"104564","DOI":"10.1016\/j.bioorg.2020.104564","volume":"108","author":"Guo","year":"2021","journal-title":"Bioorg. Chem."},{"key":"D6RA03862J\/cit34\/1","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.ejmech.2019.07.031","volume":"180","author":"Zhang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA03862J\/cit35\/1","doi-asserted-by":"publisher","first-page":"142439","DOI":"10.1016\/j.molstruc.2025.142439","volume":"1339","author":"Zhang","year":"2025","journal-title":"J. Mol. Struct."},{"key":"D6RA03862J\/cit36\/1","doi-asserted-by":"publisher","first-page":"e202303428","DOI":"10.1002\/slct.202303428","volume":"9","author":"Zhang","year":"2024","journal-title":"ChemistrySelect"},{"key":"D6RA03862J\/cit37\/1","doi-asserted-by":"publisher","first-page":"109630","DOI":"10.1016\/j.bioorg.2026.109630","volume":"173","author":"Emam","year":"2026","journal-title":"Bioorg. Chem."},{"key":"D6RA03862J\/cit38\/1","doi-asserted-by":"publisher","first-page":"3058861","DOI":"10.1155\/2021\/3058861","volume":"2021","author":"Chiu","year":"2021","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D6RA03862J\/cit39\/1","doi-asserted-by":"publisher","first-page":"110655","DOI":"10.1016\/J.CBI.2023.110655","volume":"383","author":"\u00c7elik Onar","year":"2023","journal-title":"Chem.-Biol. Interact."},{"key":"D6RA03862J\/cit40\/1","doi-asserted-by":"publisher","first-page":"11450","DOI":"10.1080\/07391102.2022.2162583","volume":"41","author":"Hasan","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D6RA03862J\/cit41\/1","doi-asserted-by":"publisher","first-page":"105572","DOI":"10.1016\/J.BIOORG.2021.105572","volume":"119","author":"Hasan","year":"2022","journal-title":"Bioorg. Chem."},{"key":"D6RA03862J\/cit42\/1","doi-asserted-by":"publisher","first-page":"126900","DOI":"10.1016\/j.bmcl.2019.126900","volume":"30","author":"Yun","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6RA03862J\/cit43\/1","doi-asserted-by":"publisher","first-page":"118302","DOI":"10.1016\/j.bmc.2025.118302","volume":"129","author":"Hamu\u013eakov\u00e1","year":"2025","journal-title":"Bioorg. Med. Chem."},{"key":"D6RA03862J\/cit44\/1","doi-asserted-by":"publisher","first-page":"131591","DOI":"10.1016\/j.molstruc.2021.131591","volume":"1249","author":"Benazzouz-Touami","year":"2022","journal-title":"J. Mol. Struct."},{"key":"D6RA03862J\/cit45\/1","doi-asserted-by":"publisher","first-page":"133747","DOI":"10.1016\/J.MOLSTRUC.2022.133747","volume":"1268","author":"Yang","year":"2022","journal-title":"J. Mol. Struct."},{"key":"D6RA03862J\/cit46\/1","doi-asserted-by":"publisher","first-page":"18496","DOI":"10.1039\/d3ra02344c","volume":"13","author":"Kamel","year":"2023","journal-title":"RSC Adv."},{"key":"D6RA03862J\/cit47\/1","doi-asserted-by":"publisher","first-page":"134535","DOI":"10.1016\/j.molstruc.2022.134535","volume":"1274","author":"\u00d6zdemir","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D6RA03862J\/cit48\/1","doi-asserted-by":"publisher","first-page":"111685","DOI":"10.1016\/j.cbi.2025.111685","volume":"420","author":"Santos Evangelista","year":"2025","journal-title":"Chem.-Biol. Interact."},{"key":"D6RA03862J\/cit49\/1","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.3390\/molecules30081830","volume":"30","author":"Rullo","year":"2025","journal-title":"Molecules"},{"key":"D6RA03862J\/cit50\/1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/S11030-018-9878-4","volume":"23","author":"Singh","year":"2019","journal-title":"Mol. Divers."},{"key":"D6RA03862J\/cit51\/1","doi-asserted-by":"publisher","first-page":"P473","DOI":"10.1016\/J.JALZ.2015.06.521","volume":"11","author":"Van Eldik","year":"2015","journal-title":"Alzheimer's Dementia"},{"key":"D6RA03862J\/cit52\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/IJMS21134618","volume":"21","author":"Annunziata","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA03862J\/cit53\/1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS22083830","volume":"22","author":"Hud\u00e1\u010dov\u00e1","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA03862J\/cit54\/1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS20041000","volume":"20","author":"Son","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA03862J\/cit55\/1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/J.NEUROPHARM.2019.05.025","volume":"155","author":"Zueva","year":"2019","journal-title":"Neuropharmacology"},{"key":"D6RA03862J\/cit56\/1","doi-asserted-by":"publisher","first-page":"e26039","DOI":"10.1371\/JOURNAL.PONE.0026039","volume":"6","author":"Berg","year":"2011","journal-title":"PLoS One"},{"key":"D6RA03862J\/cit57\/1","doi-asserted-by":"publisher","DOI":"10.3390\/PH18091398","volume":"18","author":"Nadur","year":"2025","journal-title":"Pharmaceuticals"},{"key":"D6RA03862J\/cit58\/1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30040891","volume":"30","author":"Rullo","year":"2025","journal-title":"Molecules"},{"key":"D6RA03862J\/cit59\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crstbi.2024.100124","volume":"7","author":"Saha","year":"2024","journal-title":"Curr. Res. Struct. Biol."},{"key":"D6RA03862J\/cit60\/1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/J.PHARMTHERA.2014.02.010","volume":"143","author":"Finberg","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"D6RA03862J\/cit61\/1","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1002\/MED.21561","volume":"39","author":"Tripathi","year":"2019","journal-title":"Med. Res. Rev."},{"key":"D6RA03862J\/cit62\/1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.33084\/jmd.v1i1.2357","volume":"1","author":"Mateev","year":"2021","journal-title":"Journal of Molecular Docking"},{"key":"D6RA03862J\/cit63\/1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS25126803","volume":"25","author":"Eddahmi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA03862J\/cit64\/1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24119583","volume":"24","author":"Pacureanu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA03862J\/cit65\/1","doi-asserted-by":"publisher","first-page":"4860","DOI":"10.1111\/j.1742-4658.2011.08386.x","volume":"278","author":"Milczek","year":"2011","journal-title":"FEBS J."},{"key":"D6RA03862J\/cit66\/1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092430","volume":"26","author":"Moya-Alvarado","year":"2021","journal-title":"Molecules"},{"key":"D6RA03862J\/cit67\/1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS241411820","volume":"24","author":"Vasi\u0107","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA03862J\/cit68\/1","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1080\/14756366.2019.1574297","volume":"34","author":"Yang","year":"2019","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6RA03862J\/cit69\/1","doi-asserted-by":"publisher","first-page":"26208","DOI":"10.1021\/acsomega.5c00134","volume":"10","author":"Chatzipieris","year":"2025","journal-title":"ACS Omega"},{"key":"D6RA03862J\/cit70\/1","doi-asserted-by":"publisher","first-page":"107968","DOI":"10.1016\/J.DYEPIG.2019.107968","volume":"173","author":"Cai","year":"2020","journal-title":"Dyes Pigments"},{"key":"D6RA03862J\/cit71\/1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES29051026","volume":"29","author":"Rohman","year":"2024","journal-title":"Molecules"},{"key":"D6RA03862J\/cit72\/1","first-page":"1217","volume":"17","author":"Fereidoonnezhad","year":"2018","journal-title":"Iran. J. Pharm. Res."},{"key":"D6RA03862J\/cit73\/1","doi-asserted-by":"publisher","first-page":"6564585","DOI":"10.1155\/2021\/6564585","volume":"2021","author":"Alahmari","year":"2021","journal-title":"Neural Plast."},{"key":"D6RA03862J\/cit74\/1","doi-asserted-by":"publisher","first-page":"11719","DOI":"10.3390\/MOLECULES200711719","volume":"20","author":"Yang","year":"2015","journal-title":"Molecules"},{"key":"D6RA03862J\/cit75\/1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/J.BIOORG.2018.11.034","volume":"84","author":"\u017bo\u0142ek","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D6RA03862J\/cit76\/1","doi-asserted-by":"publisher","first-page":"e0317261","DOI":"10.1371\/JOURNAL.PONE.0317261","volume":"20","author":"Guerguer","year":"2025","journal-title":"PLoS One"},{"key":"D6RA03862J\/cit77\/1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24065216","volume":"24","author":"Nunes","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA03862J\/cit78\/1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/S43556-025-00307-1","volume":"6","author":"Chen","year":"2025","journal-title":"Mol. Biomed."},{"key":"D6RA03862J\/cit79\/1","doi-asserted-by":"publisher","first-page":"114778","DOI":"10.1016\/J.PHYSBEH.2024.114778","volume":"290","author":"Manfredi","year":"2025","journal-title":"Physiol. Behav."},{"key":"D6RA03862J\/cit80\/1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.ABA0466","volume":"6","author":"Chen","year":"2020","journal-title":"Sci. Adv."},{"key":"D6RA03862J\/cit81\/1","doi-asserted-by":"publisher","first-page":"1362773","DOI":"10.3389\/FCIMB.2024.1362773\/BIBTEX","volume":"14","author":"Jung","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/RA\/D6RA03862J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:07:26Z","timestamp":1782889646000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D6RA03862J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":81,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra03862j","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6RA03862J\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA03862J\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA03862J\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA03862J\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA03862J\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA03862J\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}