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Polym."},{"issue":"11","key":"D6RA03927H\/cit104\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/adhm.201800160","volume":"7","author":"Xin","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"D6RA03927H\/cit105\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.actbio.2019.02.054","volume":"94","author":"Truong","year":"2019","journal-title":"Acta Biomater."},{"issue":"9","key":"D6RA03927H\/cit106\/1","first-page":"1059","volume":"11","author":"Gilbert","year":"2012","journal-title":"J. Drugs Dermatol."},{"key":"D6RA03927H\/cit107\/1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biomaterials.2021.121320","volume":"280","author":"Tang","year":"2022","journal-title":"Biomaterials"},{"key":"D6RA03927H\/cit108\/1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jconrel.2025.02.030","volume":"380","author":"Xu","year":"2025","journal-title":"J. Controlled Release"},{"issue":"30","key":"D6RA03927H\/cit109\/1","first-page":"18","volume":"11","author":"Yang","year":"2025","journal-title":"Sci. Adv."},{"key":"D6RA03927H\/cit110\/1","first-page":"8","volume":"265","author":"Wang","year":"2026","journal-title":"Colloids Surf., B"},{"issue":"13","key":"D6RA03927H\/cit111\/1","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.7150\/thno.111583","volume":"15","author":"Lu","year":"2025","journal-title":"Theranostics"},{"issue":"6","key":"D6RA03927H\/cit112\/1","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1021\/acs.nanolett.7b01123","volume":"17","author":"Rose","year":"2017","journal-title":"Nano Lett."},{"key":"D6RA03927H\/cit113\/1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.actbio.2019.11.009","volume":"101","author":"Xin","year":"2020","journal-title":"Acta Biomater."},{"issue":"12","key":"D6RA03927H\/cit114\/1","doi-asserted-by":"crossref","first-page":"6395","DOI":"10.1021\/acsbiomaterials.9b01205","volume":"5","author":"Isaac","year":"2019","journal-title":"ACS Biomater. Sci. 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