{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:31:00Z","timestamp":1786444260399,"version":"build-2736575974"},"reference-count":67,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":222,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["17X(3)\/Adhoc\/3\/2022-ITR"],"award-info":[{"award-number":["17X(3)\/Adhoc\/3\/2022-ITR"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Spherical silk fibroin-stabilised artemisinin nanoparticles were evaluated for anti-melanoma efficacy and demonstrated enhanced stability, improved aqueous dispersibility, high drug-loading efficiency, and sustained drug-release profile.<\/jats:p>","DOI":"10.1039\/d6ra04405k","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:43:25Z","timestamp":1786441405000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted nanotherapeutic strategy for melanoma using silk-fibroin based artemisinin nanoparticles"],"prefix":"10.1039","author":[{"given":"Deepinder","family":"Sharda","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, 147004, Punjab, India"},{"name":"Thapar Institute of Engineering and Technology-Virginia Tech (USA), Center of Excellence in Emerging Materials, Thapar Institute of Engineering and Technology, Patiala, Punjab-147004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5499-777X","authenticated-orcid":false,"given":"Amanpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Thapar Institute of Engineering and Technology-Virginia Tech (USA), Center of Excellence in Emerging Materials, Thapar Institute of Engineering and Technology, Patiala, Punjab-147004, India"},{"name":"Department of Electronics and Communication Engineering, Thapar Institute of Engineering and Technology, Patiala, 147004, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Pattanayak","sequence":"additional","affiliation":[{"name":"Department of Electronics and Communication Engineering, Thapar Institute of Engineering and Technology, Patiala, 147004, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1080-4558","authenticated-orcid":false,"given":"Diptiman","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, 147004, Punjab, India"},{"name":"Thapar Institute of Engineering and Technology-Virginia Tech (USA), Center of Excellence in Emerging Materials, Thapar Institute of Engineering and Technology, Patiala, Punjab-147004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA04405K\/cit1\/1","doi-asserted-by":"crossref","first-page":"17875","DOI":"10.1038\/s41598-023-43725-3","volume":"13","author":"Attri","year":"2023","journal-title":"Sci. Rep."},{"issue":"15","key":"D6RA04405K\/cit2\/1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1039\/D2SU00137C","volume":"1","author":"Attri","year":"2023","journal-title":"RSC Sustainability"},{"key":"D6RA04405K\/cit3\/1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12943-022-01708-4","volume":"22","author":"Zeng","year":"2023","journal-title":"Mol. Cancer"},{"key":"D6RA04405K\/cit4\/1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/CM9.0000000000003416","volume":"138","author":"Wang","year":"2025","journal-title":"Chin. Med. J."},{"key":"D6RA04405K\/cit5\/1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.otc.2020.11.001","volume":"54","author":"O'Leary","year":"2021","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"D6RA04405K\/cit6\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","volume":"73","author":"Siegel","year":"2023","journal-title":"Ca-Cancer J. Clin."},{"key":"D6RA04405K\/cit7\/1","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.7314\/APJCP.2016.17.S2.19","volume":"17","author":"Gupta","year":"2016","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"D6RA04405K\/cit8\/1","doi-asserted-by":"crossref","first-page":"33831","DOI":"10.1038\/s41598-025-03221-2","volume":"15","author":"Sharda","year":"2025","journal-title":"Sci. Rep."},{"key":"D6RA04405K\/cit9\/1","doi-asserted-by":"crossref","first-page":"100063","DOI":"10.1016\/j.amolm.2025.100063","author":"amin Hussen","year":"2025","journal-title":"Asp. Mol. Med."},{"key":"D6RA04405K\/cit10\/1","first-page":"1","volume-title":"Plastic Surgery-Principles and Practice","author":"Sullivan","year":"2022","unstructured":"J. V.Sullivan  and  S.Myers , in  Plastic Surgery-Principles and Practice ,  Elsevier ,  2022 ,  pp. 1\u201314"},{"key":"D6RA04405K\/cit11\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12935-023-03012-7","volume":"23","author":"Khayyati Kohnehshahri","year":"2023","journal-title":"Cancer Cell Int."},{"key":"D6RA04405K\/cit12\/1","volume-title":"StatPearls","author":"Gruber","year":"2026","unstructured":"P.Gruber  and  P.M.Zito , in  StatPearls ,  StatPearls Publishing ,  Treasure Island (FL) ,  2026"},{"key":"D6RA04405K\/cit13\/1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/jamadermatol.2022.0160","volume":"158","author":"Arnold","year":"2022","journal-title":"JAMA Dermatol."},{"key":"D6RA04405K\/cit14\/1","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.3390\/cancers14133271","volume":"14","author":"Solimando","year":"2022","journal-title":"Cancers"},{"key":"D6RA04405K\/cit15\/1","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.5958\/0974-360X.2019.00435.9","volume":"12","author":"Sreelatha","year":"2019","journal-title":"Res. J. Pharm. Technol."},{"key":"D6RA04405K\/cit16\/1","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.3390\/ijerph18105479","volume":"18","author":"Dildar","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"D6RA04405K\/cit17\/1","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1586\/era.10.154","volume":"10","author":"Zhao","year":"2010","journal-title":"Expert Rev. Anticancer Ther."},{"key":"D6RA04405K\/cit18\/1","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.3390\/cancers15102855","volume":"15","author":"de Jong","year":"2023","journal-title":"Cancers"},{"key":"D6RA04405K\/cit19\/1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.hoc.2009.03.006","volume":"23","author":"Yang","year":"2009","journal-title":"Hematol.\/Oncol. Clin."},{"key":"D6RA04405K\/cit20\/1","doi-asserted-by":"crossref","first-page":"e23016","DOI":"10.1002\/ima.23016","volume":"34","author":"Kaur","year":"2024","journal-title":"Int. J. Imaging Syst. Technol."},{"key":"D6RA04405K\/cit21\/1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s40257-020-00517-z","volume":"21","author":"Heibel","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"key":"D6RA04405K\/cit22\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jare.2021.06.003","volume":"34","author":"Fatima","year":"2021","journal-title":"J. Adv. Res."},{"key":"D6RA04405K\/cit23\/1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/molecules29030728","volume":"29","author":"Kowalski","year":"2024","journal-title":"Molecules"},{"key":"D6RA04405K\/cit24\/1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/molecules21050559","volume":"21","author":"Yuan","year":"2016","journal-title":"Molecules"},{"key":"D6RA04405K\/cit25\/1","first-page":"328","volume":"3","author":"Hasima","year":"2012","journal-title":"Int. J. Biochem. Mol. Biol."},{"key":"D6RA04405K\/cit26\/1","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.3390\/molecules24173087","volume":"24","author":"Moac\u0103","year":"2019","journal-title":"Molecules"},{"key":"D6RA04405K\/cit27\/1","doi-asserted-by":"crossref","first-page":"29490","DOI":"10.1021\/acsami.9b07390","volume":"11","author":"Luo","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6RA04405K\/cit28\/1","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1016\/j.biomaterials.2014.04.028","volume":"35","author":"Chen","year":"2014","journal-title":"Biomaterials"},{"key":"D6RA04405K\/cit29\/1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3390\/pharmaceutics12080748","volume":"12","author":"Alven","year":"2020","journal-title":"Pharmaceutics"},{"key":"D6RA04405K\/cit30\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"D6RA04405K\/cit31\/1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41580-020-0241-0","volume":"21","author":"Nakatogawa","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D6RA04405K\/cit32\/1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.canlet.2013.09.035","volume":"343","author":"Hu","year":"2014","journal-title":"Cancer Lett."},{"key":"D6RA04405K\/cit33\/1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s10637-012-9873-z","volume":"31","author":"Lai","year":"2013","journal-title":"Invest. New Drugs"},{"key":"D6RA04405K\/cit34\/1","first-page":"247597","volume":"2012","author":"Crespo-Ortiz","year":"2012","journal-title":"BioMed Res. Int."},{"key":"D6RA04405K\/cit35\/1","doi-asserted-by":"crossref","first-page":"828856","DOI":"10.3389\/fphar.2021.828856","volume":"12","author":"Ma","year":"2021","journal-title":"Front. Pharmacol."},{"key":"D6RA04405K\/cit36\/1","first-page":"1","author":"Summer","year":"2024","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"D6RA04405K\/cit37\/1","first-page":"34","volume":"24","author":"Mohammed","year":"2025","journal-title":"EXCLI J."},{"key":"D6RA04405K\/cit38\/1","doi-asserted-by":"crossref","first-page":"34565","DOI":"10.1039\/D4RA05611F","volume":"14","author":"Attri","year":"2024","journal-title":"RSC Adv."},{"key":"D6RA04405K\/cit39\/1","first-page":"1","author":"Kirubakaran","year":"2025","journal-title":"Biomed. Mater. & Devices"},{"key":"D6RA04405K\/cit40\/1","doi-asserted-by":"crossref","first-page":"22594","DOI":"10.1021\/acsanm.3c04487","volume":"6","author":"Wang","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"D6RA04405K\/cit41\/1","doi-asserted-by":"crossref","first-page":"20321","DOI":"10.1039\/D3RA01473H","volume":"13","author":"Sharda","year":"2023","journal-title":"RSC Adv."},{"issue":"25","key":"D6RA04405K\/cit42\/1","first-page":"4926","volume":"7","author":"Jahanshahi","year":"2008","journal-title":"Afr. J. Biotechnol."},{"key":"D6RA04405K\/cit43\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s11671-023-03903-8","volume":"18","author":"Sharda","year":"2023","journal-title":"Discover Nano"},{"key":"D6RA04405K\/cit44\/1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2217\/nnm.10.51","volume":"5","author":"Mathur","year":"2010","journal-title":"Nanomedicine"},{"key":"D6RA04405K\/cit45\/1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.rpor.2014.11.010","volume":"20","author":"Jastrzebska","year":"2015","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"D6RA04405K\/cit46\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1039\/C3IB40184G","volume":"6","author":"Subia","year":"2014","journal-title":"Integr. Biol."},{"key":"D6RA04405K\/cit47\/1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jconrel.2015.03.020","volume":"206","author":"Mottaghitalab","year":"2015","journal-title":"J. Controlled Release"},{"key":"D6RA04405K\/cit48\/1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41401-018-0048-0","volume":"40","author":"Wang","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"D6RA04405K\/cit49\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.22270\/jddt.v13i2.5733","volume":"13","author":"Singh","year":"2023","journal-title":"J. Drug Delivery Ther."},{"key":"D6RA04405K\/cit50\/1","doi-asserted-by":"crossref","first-page":"556248","DOI":"10.3389\/fphar.2020.556248","volume":"11","author":"Shi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"D6RA04405K\/cit51\/1","first-page":"55","volume":"13","author":"Savitri","year":"2022","journal-title":"Life Sci."},{"key":"D6RA04405K\/cit52\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nano.2018.08.013","volume":"15","author":"Kaur","year":"2019","journal-title":"Nanomedicine"},{"issue":"5","key":"D6RA04405K\/cit53\/1","doi-asserted-by":"crossref","first-page":"e01648","DOI":"10.1016\/j.heliyon.2019.e01648","volume":"5","author":"Bolla","year":"2019","journal-title":"Heliyon"},{"issue":"12","key":"D6RA04405K\/cit54\/1","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1039\/D4MA00278D","volume":"5","author":"Sharda","year":"2024","journal-title":"Mater. Adv."},{"key":"D6RA04405K\/cit55\/1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.biochi.2013.02.010","volume":"95","author":"Choudhury","year":"2013","journal-title":"Biochimie"},{"key":"D6RA04405K\/cit56\/1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/1061186X.2020.1864740","volume":"29","author":"Kaur","year":"2021","journal-title":"J. Drug Targeting"},{"key":"D6RA04405K\/cit57\/1","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.3390\/ijms13045060","volume":"13","author":"Yu","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA04405K\/cit58\/1","doi-asserted-by":"crossref","first-page":"6722","DOI":"10.1021\/acsabm.0c00632","volume":"3","author":"Yadav","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"D6RA04405K\/cit59\/1","doi-asserted-by":"crossref","first-page":"24656","DOI":"10.1039\/D1RA03597E","volume":"11","author":"Sharda","year":"2021","journal-title":"RSC Adv."},{"key":"D6RA04405K\/cit60\/1","doi-asserted-by":"crossref","first-page":"117206","DOI":"10.1016\/j.saa.2019.117206","volume":"221","author":"Hou","year":"2019","journal-title":"Spectrochim. Acta, Part A"},{"key":"D6RA04405K\/cit61\/1","doi-asserted-by":"crossref","first-page":"18014","DOI":"10.1039\/D0CP03257C","volume":"22","author":"Bogaerts","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D6RA04405K\/cit62\/1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1479-5876-10-117","volume":"10","author":"Zhang","year":"2012","journal-title":"J. Transl. Med."},{"key":"D6RA04405K\/cit63\/1","first-page":"451","volume":"71","author":"Ansari","year":"2014","journal-title":"Acta Pol. Pharm."},{"key":"D6RA04405K\/cit64\/1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s10637-008-9188-2","volume":"27","author":"Buommino","year":"2009","journal-title":"Invest. New Drugs"},{"key":"D6RA04405K\/cit65\/1","doi-asserted-by":"crossref","first-page":"727275","DOI":"10.3389\/fphar.2021.727275","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"D6RA04405K\/cit66\/1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/jid.2012.341","volume":"133","author":"Ugurel","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"D6RA04405K\/cit67\/1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1200\/JCO.2014.56.6018","volume":"33","author":"Maio","year":"2015","journal-title":"J. Clin. Oncol."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA04405K\/0\/D6RA04405K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:43:33Z","timestamp":1786441413000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA04405K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":67,"URL":"https:\/\/doi.org\/10.1039\/d6ra04405k","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}