{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:14:18Z","timestamp":1790162058900,"version":"4.1.0"},"reference-count":136,"publisher":"Royal Society of Chemistry (RSC)","issue":"42","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":246,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Illustrative mechanistic elaboration of the NDM-1 protein and its plausible biophysical mitigation strategies (image partly generated by the Nano Banana 2 tool).<\/jats:p>","DOI":"10.1039\/d6ra04475a","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:54:04Z","timestamp":1788533644000},"page":"49922-49953","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combating New Delhi metallo-beta-lactamase-1 (NDM-1): an integrated review of inhibitor development and next-generation therapeutic platforms"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6472-9603","authenticated-orcid":false,"given":"Akankhya","family":"Mohanty","sequence":"first","affiliation":[{"name":"Centre for Biotechnology, Siksha \u2018O\u2019 Anusandhan (Deemed to be University), Kalinga Nagar, Ghatikia, Bhubaneswar-751003, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-4168","authenticated-orcid":false,"given":"Rajesh Kumar","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology, Siksha \u2018O\u2019 Anusandhan (Deemed to be University), Kalinga Nagar, Ghatikia, Bhubaneswar-751003, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-1185","authenticated-orcid":false,"given":"A. Swaroop","family":"Sanket","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology, Siksha \u2018O\u2019 Anusandhan (Deemed to be University), Kalinga Nagar, Ghatikia, Bhubaneswar-751003, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9362-3257","authenticated-orcid":false,"given":"Ellojita","family":"Rout","sequence":"additional","affiliation":[{"name":"Directorate of Research, Malla Reddy Vishwavidyapeeth (Deemed to be University), Hyderabad, 500055, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA04475A\/cit1\/1","doi-asserted-by":"crossref","first-page":"105923","DOI":"10.1016\/j.micpath.2022.105923","volume":"174","author":"Akram","year":"2023","journal-title":"Microb. Pathog."},{"key":"D6RA04475A\/cit2\/1","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1016\/j.jmb.2019.04.002","volume":"431","author":"Tooke","year":"2019","journal-title":"J. Mol. Biol."},{"key":"D6RA04475A\/cit3\/1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3389\/fmicb.2017.01580","volume":"8","author":"Chandar","year":"2017","journal-title":"Front. Microbiol."},{"key":"D6RA04475A\/cit4\/1","doi-asserted-by":"crossref","first-page":"18580","DOI":"10.1038\/s41598-020-75247-7","volume":"10","author":"Kohler","year":"2020","journal-title":"Sci. Rep."},{"key":"D6RA04475A\/cit5\/1","doi-asserted-by":"crossref","first-page":"13192","DOI":"10.1038\/s41598-020-69944-6","volume":"10","author":"Do Nascimento","year":"2020","journal-title":"Sci. Rep."},{"key":"D6RA04475A\/cit6\/1","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1128\/AAC.00230-12","volume":"56","author":"Arpin","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"D6RA04475A\/cit7\/1","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1128\/AAC.48.7.2347-2349.2004","volume":"48","author":"Garau","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA04475A\/cit8\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/acsinfecdis.8b00247","volume":"5","author":"Linciano","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"D6RA04475A\/cit9\/1","doi-asserted-by":"crossref","first-page":"113747","DOI":"10.1016\/j.ejmech.2021.113747","volume":"225","author":"Nagulapalli Venkata","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA04475A\/cit10\/1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1128\/CMR.00116-14","volume":"28","author":"Mathers","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"D6RA04475A\/cit11\/1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3390\/antibiotics14060567","volume":"14","author":"Chatzidimitriou","year":"2025","journal-title":"Antibiotics"},{"key":"D6RA04475A\/cit12\/1","doi-asserted-by":"crossref","first-page":"100918","DOI":"10.1016\/j.jbc.2021.100918","volume":"297","author":"Sychantha","year":"2021","journal-title":"J. Biol. Chem."},{"key":"D6RA04475A\/cit13\/1","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1021\/jm501844d","volume":"58","author":"Klingler","year":"2015","journal-title":"J. Med. Chem."},{"key":"D6RA04475A\/cit14\/1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4155\/fmc-2017-0143","volume":"10","author":"Khan","year":"2018","journal-title":"Future Med. Chem."},{"key":"D6RA04475A\/cit15\/1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3390\/ijms23010197","volume":"23","author":"Li","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA04475A\/cit16\/1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4236\/abc.2012.24040","volume":"02","author":"Saini","year":"2012","journal-title":"Adv. Biol. Chem."},{"key":"D6RA04475A\/cit17\/1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s13238-011-1055-9","volume":"2","author":"Guo","year":"2011","journal-title":"Protein Cell"},{"key":"D6RA04475A\/cit18\/1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/1389203724666230816154117","volume":"24","author":"Farooq","year":"2023","journal-title":"Curr. Protein Pept. Sci."},{"key":"D6RA04475A\/cit19\/1","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.3390\/antibiotics13121158","volume":"13","author":"Al-Marzooq","year":"2024","journal-title":"Antibiotics"},{"key":"D6RA04475A\/cit20\/1","doi-asserted-by":"crossref","first-page":"12606","DOI":"10.1074\/jbc.RA118.003835","volume":"293","author":"Cheng","year":"2018","journal-title":"J. Biol. Chem."},{"key":"D6RA04475A\/cit21\/1","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.3390\/microorganisms10112243","volume":"10","author":"Tavares","year":"2022","journal-title":"Microorganisms"},{"key":"D6RA04475A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/s41467-022-28819-2","volume":"13","author":"Acman","year":"2022","journal-title":"Nat. Commun."},{"key":"D6RA04475A\/cit23\/1","doi-asserted-by":"crossref","first-page":"1281838","DOI":"10.3389\/fmicb.2023.1281838","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Microbiol."},{"key":"D6RA04475A\/cit24\/1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/jac\/dku403","volume":"70","author":"Makena","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"D6RA04475A\/cit25\/1","doi-asserted-by":"crossref","first-page":"7957","DOI":"10.1021\/acs.chemrev.1c00138","volume":"121","author":"Bahr","year":"2021","journal-title":"Chem. Rev."},{"key":"D6RA04475A\/cit26\/1","doi-asserted-by":"crossref","first-page":"107574","DOI":"10.1016\/j.micpath.2025.107574","volume":"204","author":"Karthik","year":"2025","journal-title":"Microb. Pathog."},{"key":"D6RA04475A\/cit27\/1","doi-asserted-by":"crossref","first-page":"9207","DOI":"10.1038\/s41598-017-09588-1","volume":"7","author":"Khan","year":"2017","journal-title":"Sci. Rep."},{"key":"D6RA04475A\/cit28\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/CMR.00037-09","volume":"23","author":"Drawz","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"D6RA04475A\/cit29\/1","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.1021\/ja410376s","volume":"136","author":"Yang","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D6RA04475A\/cit30\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/0976-9668.107260","volume":"4","author":"Hassan","year":"2013","journal-title":"J. Nat. Sci., Biol. Med."},{"key":"D6RA04475A\/cit31\/1","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.3390\/molecules26185489","volume":"26","author":"Piccirilli","year":"2021","journal-title":"Molecules"},{"key":"D6RA04475A\/cit32\/1","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1096\/fj.11-184036","volume":"25","author":"Zhang","year":"2011","journal-title":"FASEB J."},{"key":"D6RA04475A\/cit33\/1","doi-asserted-by":"crossref","first-page":"112163","DOI":"10.1016\/j.jinorgbio.2023.112163","volume":"242","author":"Bognanni","year":"2023","journal-title":"J. Inorg. Biochem."},{"key":"D6RA04475A\/cit34\/1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/pro.697","volume":"20","author":"King","year":"2011","journal-title":"Protein Sci."},{"key":"D6RA04475A\/cit35\/1","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1038\/s41467-017-02339-w","volume":"8","author":"Feng","year":"2017","journal-title":"Nat. Commun."},{"key":"D6RA04475A\/cit36\/1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41467-017-00601-9","volume":"8","author":"Lisa","year":"2017","journal-title":"Nat. Commun."},{"key":"D6RA04475A\/cit37\/1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nchembio.2083","volume":"12","author":"Gonz\u00e1lez","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"D6RA04475A\/cit38\/1","doi-asserted-by":"crossref","first-page":"e0183621","DOI":"10.1128\/mBio.01836-21","volume":"12","author":"Mart\u00ednez","year":"2021","journal-title":"mBio"},{"key":"D6RA04475A\/cit39\/1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1128\/AAC.05620-11","volume":"56","author":"Poirel","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA04475A\/cit40\/1","doi-asserted-by":"crossref","first-page":"7245","DOI":"10.1128\/AAC.01755-16","volume":"60","author":"Bontron","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA04475A\/cit41\/1","doi-asserted-by":"crossref","first-page":"979558","DOI":"10.3389\/fmicb.2022.979558","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Microbiol."},{"issue":"4","key":"D6RA04475A\/cit42\/1","doi-asserted-by":"crossref","first-page":"e01449","DOI":"10.1128\/spectrum.01449-22","volume":"10","author":"Ariyoshi","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"D6RA04475A\/cit43\/1","first-page":"523","volume":"30","author":"Doi","year":"2016","journal-title":"Infect. Dis. Clin."},{"key":"D6RA04475A\/cit44\/1","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1128\/AAC.01686-07","volume":"52","author":"Liu","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA04475A\/cit45\/1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3390\/biom10050720","volume":"10","author":"Ramirez","year":"2020","journal-title":"Biomolecules"},{"key":"D6RA04475A\/cit46\/1","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3390\/antibiotics12111590","volume":"12","author":"Gauba","year":"2023","journal-title":"Antibiotics"},{"key":"D6RA04475A\/cit47\/1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1089\/mdr.2017.0165","volume":"24","author":"Hamzaoui","year":"2018","journal-title":"Microb. Drug Resist."},{"key":"D6RA04475A\/cit48\/1","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1038\/s41467-019-11756-y","volume":"10","author":"Wong","year":"2019","journal-title":"Nat. Commun."},{"key":"D6RA04475A\/cit49\/1","doi-asserted-by":"crossref","first-page":"e1010334","DOI":"10.1371\/journal.ppat.1010334","volume":"18","author":"David","year":"2022","journal-title":"PLoS Pathog."},{"key":"D6RA04475A\/cit50\/1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/antibiotics10091117","volume":"10","author":"Davin-Regli","year":"2021","journal-title":"Antibiotics"},{"key":"D6RA04475A\/cit51\/1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3390\/antibiotics12020328","volume":"12","author":"Michaelis","year":"2023","journal-title":"Antibiotics"},{"key":"D6RA04475A\/cit52\/1","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.3389\/fmicb.2019.01933","volume":"10","author":"Sun","year":"2019","journal-title":"Front. Microbiol."},{"key":"D6RA04475A\/cit53\/1","first-page":"1","volume":"2022","author":"Tao","year":"2022","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"D6RA04475A\/cit54\/1","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1039\/D4MD00031E","volume":"15","author":"Meng","year":"2024","journal-title":"RSC Med. Chem."},{"key":"D6RA04475A\/cit55\/1","doi-asserted-by":"crossref","first-page":"15802","DOI":"10.1021\/acs.jmedchem.0c01535","volume":"63","author":"Davies","year":"2020","journal-title":"J. Med. Chem."},{"key":"D6RA04475A\/cit56\/1","doi-asserted-by":"crossref","first-page":"10556","DOI":"10.1021\/acs.jmedchem.5c00553","volume":"68","author":"De Falco","year":"2025","journal-title":"J. Med. Chem."},{"key":"D6RA04475A\/cit57\/1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1128\/AAC.01335-15","volume":"60","author":"Brem","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA04475A\/cit58\/1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/jacsau.2c00651","volume":"3","author":"Cheng","year":"2023","journal-title":"JACS Au"},{"key":"D6RA04475A\/cit59\/1","doi-asserted-by":"crossref","first-page":"11362","DOI":"10.1021\/ja303579d","volume":"134","author":"King","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D6RA04475A\/cit60\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fphar.2012.00093","volume":"3","author":"Eberlin","year":"2012","journal-title":"Front. Pharmacol."},{"key":"D6RA04475A\/cit61\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpba.2016.05.008","volume":"128","author":"Chiguru","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D6RA04475A\/cit62\/1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1021\/acsinfecdis.7b00094","volume":"3","author":"Tehrani","year":"2017","journal-title":"ACS Infect. Dis."},{"key":"D6RA04475A\/cit63\/1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2019.05.035","volume":"140","author":"Ulrich","year":"2019","journal-title":"Free Radical Biol. Med."},{"key":"D6RA04475A\/cit64\/1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cotox.2018.03.005","volume":"7","author":"Baba","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"D6RA04475A\/cit65\/1","doi-asserted-by":"crossref","first-page":"116055","DOI":"10.1016\/j.ejmech.2023.116055","volume":"265","author":"Wu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA04475A\/cit66\/1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/acsinfecdis.5b00033","volume":"1","author":"Falconer","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"D6RA04475A\/cit67\/1","doi-asserted-by":"crossref","first-page":"113667","DOI":"10.1016\/j.ejmech.2021.113667","volume":"223","author":"Wang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA04475A\/cit68\/1","doi-asserted-by":"crossref","first-page":"12406","DOI":"10.1038\/ncomms12406","volume":"7","author":"Brem","year":"2016","journal-title":"Nat. Commun."},{"key":"D6RA04475A\/cit69\/1","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1021\/acs.jmedchem.9b01518","volume":"63","author":"Liu","year":"2020","journal-title":"J. Med. Chem."},{"key":"D6RA04475A\/cit70\/1","doi-asserted-by":"crossref","first-page":"7491","DOI":"10.1021\/acs.jmedchem.9b01976","volume":"63","author":"Hecker","year":"2020","journal-title":"J. Med. Chem."},{"key":"D6RA04475A\/cit71\/1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1473-3099(23)00069-5","volume":"23","author":"Le Terrier","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"D6RA04475A\/cit72\/1","doi-asserted-by":"crossref","first-page":"7700","DOI":"10.1080\/07391102.2022.2123402","volume":"41","author":"S","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D6RA04475A\/cit73\/1","first-page":"1","author":"Tran","year":"2025","journal-title":"Indian J. Dermatol. Venereol."},{"key":"D6RA04475A\/cit74\/1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1517\/13543784.9.3.607","volume":"9","author":"Parnham","year":"2000","journal-title":"Expert Opin. Invest. Drugs"},{"key":"D6RA04475A\/cit75\/1","doi-asserted-by":"crossref","first-page":"9543","DOI":"10.1039\/C5CC02594J","volume":"51","author":"Chiou","year":"2015","journal-title":"Chem. Commun."},{"key":"D6RA04475A\/cit76\/1","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.4103\/1673-5374.251334","volume":"14","author":"Slusarczyk","year":"2019","journal-title":"Neural Regener. Res."},{"key":"D6RA04475A\/cit77\/1","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3390\/antibiotics11121752","volume":"11","author":"Lajarin-Reinares","year":"2022","journal-title":"Antibiotics"},{"key":"D6RA04475A\/cit78\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2020.04.019","volume":"32","author":"Bernier","year":"2020","journal-title":"Cell Metab."},{"key":"D6RA04475A\/cit79\/1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature25016","volume":"552","author":"Skrott","year":"2017","journal-title":"Nature"},{"key":"D6RA04475A\/cit80\/1","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1039\/C9CC09074F","volume":"56","author":"Chen","year":"2020","journal-title":"Chem. Commun."},{"key":"D6RA04475A\/cit81\/1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ijantimicag.2019.03.024","volume":"53","author":"Thakare","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"8","key":"D6RA04475A\/cit82\/1","doi-asserted-by":"crossref","first-page":"e00609","DOI":"10.1128\/AAC.00609-19","volume":"63","author":"Krajaejun","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA04475A\/cit83\/1","doi-asserted-by":"crossref","first-page":"1619416","DOI":"10.3389\/fmicb.2025.1619416","volume":"16","author":"Luo","year":"2025","journal-title":"Front. Microbiol."},{"key":"D6RA04475A\/cit84\/1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/antibiotics12030524","volume":"12","author":"Lanz","year":"2023","journal-title":"Antibiotics"},{"key":"D6RA04475A\/cit85\/1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3390\/pharmaceutics15030985","volume":"15","author":"Tolbatov","year":"2023","journal-title":"Pharmaceutics"},{"key":"D6RA04475A\/cit86\/1","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.3390\/molecules26247600","volume":"26","author":"Tolbatov","year":"2021","journal-title":"Molecules"},{"key":"D6RA04475A\/cit87\/1","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1038\/s41467-020-18939-y","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"key":"D6RA04475A\/cit88\/1","doi-asserted-by":"crossref","first-page":"108272","DOI":"10.1016\/j.intimp.2021.108272","volume":"101","author":"Yamashita","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"D6RA04475A\/cit89\/1","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1021\/acs.inorgchem.9b03072","volume":"59","author":"Pickering","year":"2020","journal-title":"Inorg. Chem."},{"key":"D6RA04475A\/cit90\/1","doi-asserted-by":"crossref","first-page":"9593","DOI":"10.1021\/acsomega.9b00529","volume":"4","author":"Abhishek","year":"2019","journal-title":"ACS Omega"},{"key":"D6RA04475A\/cit91\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.comptc.2014.09.005","volume":"1048","author":"Dos Santos","year":"2014","journal-title":"Comput. Theor. Chem."},{"key":"D6RA04475A\/cit92\/1","first-page":"1","volume":"2019","author":"Zhang","year":"2019","journal-title":"BioMed Res. Int."},{"key":"D6RA04475A\/cit93\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41420-018-0029-6","volume":"4","author":"Liu","year":"2018","journal-title":"Cell Death Discovery"},{"key":"D6RA04475A\/cit94\/1","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/jac\/dky226","volume":"73","author":"Liu","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"D6RA04475A\/cit95\/1","doi-asserted-by":"crossref","first-page":"632767","DOI":"10.3389\/fphar.2021.632767","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Pharmacol."},{"key":"D6RA04475A\/cit96\/1","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1104\/pp.17.01183","volume":"175","author":"Loussouarn","year":"2017","journal-title":"Plant Physiol."},{"key":"D6RA04475A\/cit97\/1","doi-asserted-by":"crossref","first-page":"581001","DOI":"10.3389\/fphar.2020.581001","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"D6RA04475A\/cit98\/1","doi-asserted-by":"crossref","first-page":"24169","DOI":"10.1038\/s41598-025-08532-y","volume":"15","author":"Ren","year":"2025","journal-title":"Sci. Rep."},{"key":"D6RA04475A\/cit99\/1","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3390\/ph16040570","volume":"16","author":"Bajek-Bil","year":"2023","journal-title":"Pharmaceuticals"},{"key":"D6RA04475A\/cit100\/1","doi-asserted-by":"crossref","first-page":"102953","DOI":"10.1016\/j.bioorg.2019.102953","volume":"88","author":"Shi","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D6RA04475A\/cit101\/1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3390\/biology14060637","volume":"14","author":"Qiu","year":"2025","journal-title":"Biology"},{"key":"D6RA04475A\/cit102\/1","doi-asserted-by":"crossref","first-page":"1168052","DOI":"10.3389\/fmicb.2023.1168052","volume":"14","author":"Li","year":"2023","journal-title":"Front. Microbiol."},{"key":"D6RA04475A\/cit103\/1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13445","volume":"510","author":"King","year":"2014","journal-title":"Nature"},{"key":"D6RA04475A\/cit104\/1","doi-asserted-by":"crossref","first-page":"e01849","DOI":"10.1128\/AAC.01849-17","volume":"62","author":"Bahr","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"issue":"18","key":"D6RA04475A\/cit105\/1","doi-asserted-by":"crossref","first-page":"e00698","DOI":"10.1128\/AEM.00698-18","volume":"84","author":"Somboro","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"D6RA04475A\/cit106\/1","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1039\/D5MD00035A","volume":"16","author":"Reddy","year":"2025","journal-title":"RSC Med. Chem."},{"key":"D6RA04475A\/cit107\/1","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1039\/C7RA12778B","volume":"8","author":"Wang","year":"2018","journal-title":"RSC Adv."},{"key":"D6RA04475A\/cit108\/1","doi-asserted-by":"crossref","first-page":"062","DOI":"10.1055\/s-0042-1751317","volume":"15","author":"Rudresh","year":"2023","journal-title":"J. Lab. Physicians"},{"key":"D6RA04475A\/cit109\/1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00044-024-03330-z","volume":"34","author":"Shkuratova","year":"2025","journal-title":"Med. Chem. Res."},{"key":"D6RA04475A\/cit110\/1","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1021\/acs.jmedchem.7b00407","volume":"60","author":"Chen","year":"2017","journal-title":"J. Med. Chem."},{"key":"D6RA04475A\/cit111\/1","doi-asserted-by":"crossref","first-page":"1599113","DOI":"10.3389\/fcimb.2025.1599113","volume":"15","author":"Khalifa","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D6RA04475A\/cit112\/1","doi-asserted-by":"crossref","first-page":"15254","DOI":"10.1038\/s41598-022-19698-0","volume":"12","author":"Haji","year":"2022","journal-title":"Sci. Rep."},{"key":"D6RA04475A\/cit113\/1","doi-asserted-by":"crossref","first-page":"20685","DOI":"10.1038\/s41598-022-24531-9","volume":"12","author":"Muddassir","year":"2022","journal-title":"Sci. Rep."},{"key":"D6RA04475A\/cit114\/1","doi-asserted-by":"crossref","first-page":"21199","DOI":"10.1039\/D5RA01697E","volume":"15","author":"Piccirilli","year":"2025","journal-title":"RSC Adv."},{"issue":"1","key":"D6RA04475A\/cit115\/1","doi-asserted-by":"crossref","first-page":"5518999","DOI":"10.1155\/2021\/5518999","volume":"2021","author":"Rhazouani","year":"2021","journal-title":"BioMed Res. Int."},{"issue":"9","key":"D6RA04475A\/cit116\/1","doi-asserted-by":"crossref","first-page":"e00843","DOI":"10.1128\/AAC.00843-20","volume":"64","author":"Hao","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA04475A\/cit117\/1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/nbt.3011","volume":"32","author":"Citorik","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"11","key":"D6RA04475A\/cit118\/1","doi-asserted-by":"crossref","first-page":"e01454","DOI":"10.1128\/AAC.01454-19","volume":"63","author":"Rodrigues","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA04475A\/cit119\/1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3389\/fmicb.2020.00578","volume":"11","author":"Tagliaferri","year":"2020","journal-title":"Front. Microbiol."},{"key":"D6RA04475A\/cit120\/1","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1039\/D4NA00037D","volume":"6","author":"Hassan","year":"2024","journal-title":"Nanoscale Adv."},{"key":"D6RA04475A\/cit121\/1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1080\/10717544.2021.1879316","volume":"28","author":"Wei","year":"2021","journal-title":"Drug Delivery"},{"key":"D6RA04475A\/cit122\/1","doi-asserted-by":"crossref","first-page":"7782","DOI":"10.1021\/acsami.8b21698","volume":"11","author":"Sava Gallis","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6RA04475A\/cit123\/1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1039\/C8TX00087E","volume":"7","author":"Bhardwaj","year":"2018","journal-title":"Toxicol. Res."},{"key":"D6RA04475A\/cit124\/1","doi-asserted-by":"crossref","first-page":"10611","DOI":"10.3390\/app131910611","volume":"13","author":"Anim","year":"2023","journal-title":"Appl. Sci."},{"key":"D6RA04475A\/cit125\/1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3390\/ijms20040819","volume":"20","author":"Rehman","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA04475A\/cit126\/1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3389\/fchem.2018.00564","volume":"6","author":"Shi","year":"2018","journal-title":"Front. Chem."},{"key":"D6RA04475A\/cit127\/1","doi-asserted-by":"crossref","first-page":"115437","DOI":"10.1016\/j.bmc.2020.115437","volume":"28","author":"Guo","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"D6RA04475A\/cit128\/1","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1093\/bioinformatics\/btx350","volume":"33","author":"Jim\u00e9nez","year":"2017","journal-title":"Bioinformatics"},{"key":"D6RA04475A\/cit129\/1","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.1038\/s41598-022-10418-2","volume":"12","author":"Knutson","year":"2022","journal-title":"Sci. Rep."},{"key":"D6RA04475A\/cit130\/1","doi-asserted-by":"crossref","first-page":"e13163","DOI":"10.7717\/peerj.13163","volume":"10","author":"Tran","year":"2022","journal-title":"PeerJ"},{"key":"D6RA04475A\/cit131\/1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1021\/acscentsci.0c00229","volume":"6","author":"Gentile","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"D6RA04475A\/cit132\/1","doi-asserted-by":"crossref","first-page":"103439","DOI":"10.1016\/j.drudis.2022.103439","volume":"28","author":"Danel","year":"2023","journal-title":"Drug Discovery Today"},{"key":"D6RA04475A\/cit133\/1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3390\/ph17091183","volume":"17","author":"Alkhatabi","year":"2024","journal-title":"Pharmaceuticals"},{"key":"D6RA04475A\/cit134\/1","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.3390\/molecules26206185","volume":"26","author":"Wieder","year":"2021","journal-title":"Molecules"},{"key":"D6RA04475A\/cit135\/1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/s41587-019-0224-x","volume":"37","author":"Zhavoronkov","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"D6RA04475A\/cit136\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13321-024-00812-5","volume":"16","author":"Loeffler","year":"2024","journal-title":"J. Cheminf."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA04475A\/0\/D6RA04475A.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:47:35Z","timestamp":1790160455000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA04475A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":136,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2026,9,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra04475a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6RA04475A\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA04475A\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA04475A\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA04475A\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA04475A\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA04475A\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA04475A\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA04475A\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}