{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:01:59Z","timestamp":1791392519460,"version":"4.3.3"},"reference-count":66,"publisher":"Royal Society of Chemistry (RSC)","issue":"44","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF0714402"],"award-info":[{"award-number":["2023YFF0714402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009101","name":"Education Department of Henan Province","doi-asserted-by":"publisher","award":["24A310021"],"award-info":[{"award-number":["24A310021"]}],"id":[{"id":"10.13039\/501100009101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>The 2HPoP lip@SF formulation exhibits favorable physicochemical characteristics and enables synergistic chemo-photodynamic therapy against liver cancer.<\/jats:p>","DOI":"10.1039\/d6ra05195b","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:49:32Z","timestamp":1790077772000},"page":"56285-56296","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sorafenib-loaded porphyrin-phospholipid liposomes for enhanced chemophototherapy in hepatocellular carcinoma"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2072-4434","authenticated-orcid":false,"given":"Meiling","family":"Tian","sequence":"first","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5085-516X","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9497-2810","authenticated-orcid":false,"given":"Ming","family":"Gao","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7072-2733","authenticated-orcid":false,"given":"Chaoyuan","family":"Xia","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjie","family":"Han","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningjing","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1495-8890","authenticated-orcid":false,"given":"Siyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3737-7153","authenticated-orcid":false,"given":"Baihui","family":"Xie","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Biological Sample Bank, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-1816","authenticated-orcid":false,"given":"Fazhan","family":"Wang","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9100-1831","authenticated-orcid":false,"given":"Shengnan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Qin","sequence":"additional","affiliation":[{"name":"Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA05195B\/cit1\/1","doi-asserted-by":"crossref","first-page":"12975","DOI":"10.2147\/IJN.S498099","volume":"19","author":"Zhou","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"D6RA05195B\/cit2\/1","doi-asserted-by":"crossref","first-page":"2313696","DOI":"10.1080\/15476278.2024.2313696","volume":"20","author":"Lehrich","year":"2024","journal-title":"Organogenesis"},{"key":"D6RA05195B\/cit3\/1","first-page":"2025","author":"Chen","year":"2025","journal-title":"Cochrane Database Syst. Rev."},{"key":"D6RA05195B\/cit4\/1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0140-6736(25)00403-9","volume":"405","author":"Yau","year":"2025","journal-title":"Lancet"},{"key":"D6RA05195B\/cit5\/1","doi-asserted-by":"crossref","first-page":"101181","DOI":"10.1016\/j.drup.2024.101181","volume":"78","author":"Shi","year":"2025","journal-title":"Drug Resist. Updat."},{"key":"D6RA05195B\/cit6\/1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s11671-022-03729-w","volume":"17","author":"Wang","year":"2022","journal-title":"Nanoscale Res. Lett."},{"key":"D6RA05195B\/cit7\/1","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.1039\/C8TB01641K","volume":"6","author":"He","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"D6RA05195B\/cit8\/1","doi-asserted-by":"crossref","first-page":"188391","DOI":"10.1016\/j.bbcan.2020.188391","volume":"1874","author":"Zhao","year":"2020","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"D6RA05195B\/cit9\/1","doi-asserted-by":"crossref","first-page":"189310","DOI":"10.1016\/j.bbcan.2025.189310","volume":"1880","author":"Zhang","year":"2025","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"D6RA05195B\/cit10\/1","doi-asserted-by":"crossref","first-page":"29804","DOI":"10.1021\/acsnano.4c09500","volume":"18","author":"Tang","year":"2024","journal-title":"ACS Nano"},{"key":"D6RA05195B\/cit11\/1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41392-020-0187-x","volume":"5","author":"Tang","year":"2020","journal-title":"Signal Transduction Targeted Ther."},{"key":"D6RA05195B\/cit12\/1","doi-asserted-by":"crossref","first-page":"4972523","DOI":"10.1155\/2024\/4972523","volume":"2024","author":"de Melo Silva","year":"2024","journal-title":"Int. J. Cell Biol."},{"key":"D6RA05195B\/cit13\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12943-020-01281-8","volume":"19","author":"Xu","year":"2020","journal-title":"Mol. Cancer"},{"key":"D6RA05195B\/cit14\/1","doi-asserted-by":"crossref","first-page":"104765","DOI":"10.1016\/j.critrevonc.2025.104765","volume":"212","author":"Yousef","year":"2025","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"D6RA05195B\/cit15\/1","first-page":"16","author":"Krupa","year":"2024","journal-title":"Cancers"},{"key":"D6RA05195B\/cit16\/1","doi-asserted-by":"crossref","first-page":"102153","DOI":"10.1016\/j.jsps.2024.102153","volume":"32","author":"Yao","year":"2024","journal-title":"Saudi Pharm. J."},{"key":"D6RA05195B\/cit17\/1","doi-asserted-by":"crossref","first-page":"e2100536","DOI":"10.1002\/adhm.202100536","volume":"10","author":"Wang","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"D6RA05195B\/cit18\/1","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.7150\/thno.51193","volume":"11","author":"She","year":"2021","journal-title":"Theranostics"},{"key":"D6RA05195B\/cit19\/1","doi-asserted-by":"crossref","first-page":"e70005","DOI":"10.1002\/jbio.70005","volume":"18","author":"Nkune","year":"2025","journal-title":"J. Biophotonics"},{"key":"D6RA05195B\/cit20\/1","doi-asserted-by":"crossref","first-page":"20230163","DOI":"10.1002\/EXP.20230163","volume":"4","author":"Liang","year":"2024","journal-title":"Exploration"},{"key":"D6RA05195B\/cit21\/1","doi-asserted-by":"crossref","first-page":"e202408874","DOI":"10.1002\/anie.202408874","volume":"63","author":"Wang","year":"2024","journal-title":"Angew. Chem."},{"issue":"15","key":"D6RA05195B\/cit22\/1","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.3390\/ijms25158258","volume":"25","author":"Aebisher","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA05195B\/cit23\/1","doi-asserted-by":"crossref","first-page":"e268892","DOI":"10.1590\/1519-6984.268892","volume":"84","author":"Younus","year":"2023","journal-title":"Braz. J. Biol."},{"issue":"9","key":"D6RA05195B\/cit24\/1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3390\/pharmaceutics13091332","volume":"13","author":"Correia","year":"2021","journal-title":"Pharmaceutics"},{"key":"D6RA05195B\/cit25\/1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jconrel.2023.12.056","volume":"366","author":"Xu","year":"2024","journal-title":"J. Controlled Release"},{"key":"D6RA05195B\/cit26\/1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.32725\/jab.2022.013","volume":"20","author":"Gustalik","year":"2022","journal-title":"J. Appl. Biomed."},{"issue":"20","key":"D6RA05195B\/cit27\/1","doi-asserted-by":"crossref","first-page":"11325","DOI":"10.3390\/ijms252011325","volume":"25","author":"Aebisher","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA05195B\/cit28\/1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1039\/D4NA00834K","volume":"7","author":"Varvar\u00e0","year":"2025","journal-title":"Nanoscale Adv."},{"key":"D6RA05195B\/cit29\/1","doi-asserted-by":"crossref","first-page":"1600106","DOI":"10.1002\/advs.201600106","volume":"4","author":"Luo","year":"2017","journal-title":"Adv. Sci."},{"key":"D6RA05195B\/cit30\/1","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1021\/acs.molpharmaceut.4c00203","volume":"21","author":"Ning","year":"2024","journal-title":"Mol. Pharmaceutics"},{"key":"D6RA05195B\/cit31\/1","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.2147\/IJN.S530041","volume":"20","author":"Du","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"D6RA05195B\/cit32\/1","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1021\/acs.jmedchem.5c00120","volume":"68","author":"Zhu","year":"2025","journal-title":"J. Med. Chem."},{"key":"D6RA05195B\/cit33\/1","doi-asserted-by":"crossref","first-page":"67203","DOI":"10.1021\/acsami.4c12936","volume":"16","author":"Yang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6RA05195B\/cit34\/1","doi-asserted-by":"crossref","first-page":"e202400616","DOI":"10.1002\/asia.202400616","volume":"19","author":"Pal","year":"2024","journal-title":"Chem. \u2013 Asian J."},{"key":"D6RA05195B\/cit35\/1","doi-asserted-by":"crossref","first-page":"33890","DOI":"10.1021\/acsami.3c05926","volume":"15","author":"Hu","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6RA05195B\/cit36\/1","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1039\/D4TB00364K","volume":"12","author":"Lin","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"D6RA05195B\/cit37\/1","doi-asserted-by":"crossref","first-page":"100083","DOI":"10.1016\/j.ntm.2025.100083","volume":"4","author":"Ewii","year":"2025","journal-title":"Nano TransMed"},{"key":"D6RA05195B\/cit38\/1","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1039\/D5PM00137D","volume":"2","author":"Goshisht","year":"2025","journal-title":"RSC Pharm."},{"key":"D6RA05195B\/cit39\/1","doi-asserted-by":"crossref","first-page":"2003679","DOI":"10.1002\/advs.202003679","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"key":"D6RA05195B\/cit40\/1","doi-asserted-by":"crossref","first-page":"1219785","DOI":"10.3389\/fimmu.2023.1219785","volume":"14","author":"Jia","year":"2023","journal-title":"Front. Immunol."},{"key":"D6RA05195B\/cit41\/1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jconrel.2024.11.032","volume":"377","author":"Li","year":"2025","journal-title":"J. Controlled Release"},{"key":"D6RA05195B\/cit42\/1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s10103-025-04472-1","volume":"40","author":"Pereira","year":"2025","journal-title":"Lasers Med. Sci."},{"key":"D6RA05195B\/cit43\/1","doi-asserted-by":"crossref","first-page":"20230115","DOI":"10.1002\/EXP.20230115","volume":"5","author":"Guo","year":"2025","journal-title":"Exploration"},{"issue":"12","key":"D6RA05195B\/cit44\/1","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.3390\/ijms26125571","volume":"26","author":"Ahmmed","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"D6RA05195B\/cit45\/1","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.3390\/ijms26031212","volume":"26","author":"Rohrbach","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA05195B\/cit46\/1","doi-asserted-by":"crossref","first-page":"119341","DOI":"10.1016\/j.biomaterials.2019.119341","volume":"218","author":"Ghosh","year":"2019","journal-title":"Biomaterials"},{"key":"D6RA05195B\/cit47\/1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.biomaterials.2015.10.027","volume":"75","author":"Luo","year":"2016","journal-title":"Biomaterials"},{"key":"D6RA05195B\/cit48\/1","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.7150\/thno.15701","volume":"6","author":"Carter","year":"2016","journal-title":"Theranostics"},{"key":"D6RA05195B\/cit49\/1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1158\/1535-7163.MCT-18-0549","volume":"18","author":"Carter","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"D6RA05195B\/cit50\/1","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/php.13677","volume":"99","author":"Ghosh","year":"2023","journal-title":"Photochem. Photobiol."},{"key":"D6RA05195B\/cit51\/1","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.3390\/pharmaceutics13122183","volume":"13","author":"Ghosh","year":"2021","journal-title":"Pharmaceutics"},{"key":"D6RA05195B\/cit52\/1","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1007\/s12274-022-4090-3","volume":"15","author":"Sun","year":"2022","journal-title":"Nano Res."},{"key":"D6RA05195B\/cit53\/1","doi-asserted-by":"crossref","first-page":"114665","DOI":"10.1016\/j.ejpb.2025.114665","volume":"209","author":"Sevarika","year":"2025","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D6RA05195B\/cit54\/1","doi-asserted-by":"crossref","first-page":"13685","DOI":"10.1021\/acsnano.4c14625","volume":"19","author":"Zhao","year":"2025","journal-title":"ACS Nano"},{"key":"D6RA05195B\/cit55\/1","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1021\/acsanm.4c06867","volume":"8","author":"Yang","year":"2025","journal-title":"ACS Appl. Nano Mater."},{"issue":"9","key":"D6RA05195B\/cit56\/1","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3390\/pharmaceutics14091760","volume":"14","author":"Wu","year":"2022","journal-title":"Pharmaceutics"},{"key":"D6RA05195B\/cit57\/1","doi-asserted-by":"crossref","first-page":"2412543","DOI":"10.1002\/advs.202412543","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"D6RA05195B\/cit58\/1","doi-asserted-by":"crossref","first-page":"9643","DOI":"10.7150\/thno.118976","volume":"15","author":"Gao","year":"2025","journal-title":"Theranostics"},{"key":"D6RA05195B\/cit59\/1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nmat2986","volume":"10","author":"Lovell","year":"2011","journal-title":"Nat. Mater."},{"key":"D6RA05195B\/cit60\/1","doi-asserted-by":"crossref","first-page":"1605048","DOI":"10.3389\/fimmu.2025.1605048","volume":"16","author":"Qi","year":"2025","journal-title":"Front. Immunol."},{"key":"D6RA05195B\/cit61\/1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/s12951-023-02260-z","volume":"21","author":"Lei","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"D6RA05195B\/cit62\/1","doi-asserted-by":"crossref","first-page":"1760783","DOI":"10.3389\/fnano.2026.1760783","volume":"8","author":"Yang","year":"2026","journal-title":"Front. Nanotechnol."},{"key":"D6RA05195B\/cit63\/1","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.2147\/IJN.S489777","volume":"20","author":"Liu","year":"2025","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"D6RA05195B\/cit64\/1","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.3390\/ijms25063392","volume":"25","author":"De Leo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA05195B\/cit65\/1","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s43630-023-00382-9","volume":"22","author":"de Melo Gomes","year":"2023","journal-title":"Photochem. Photobiol. Sci."},{"key":"D6RA05195B\/cit66\/1","doi-asserted-by":"crossref","first-page":"100054","DOI":"10.1016\/j.ntm.2024.100054","volume":"3","author":"Shehata","year":"2024","journal-title":"Nano TransMed"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA05195B\/0\/D6RA05195B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:48:04Z","timestamp":1791391684000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA05195B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":66,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra05195b","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}