{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:31:23Z","timestamp":1786563083289,"version":"build-2736575974"},"reference-count":64,"publisher":"Royal Society of Chemistry (RSC)","issue":"37","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":194,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005783","name":"University of Kashan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    Efficient synthesis of pyrido[2,3-\n                    <jats:italic>d<\/jats:italic>\n                    :5,6-\n                    <jats:italic>d<\/jats:italic>\n                    \u2032]dipyrimidines. Reusable catalyst. Green synthesis in aqueous-ethanolic media. &gt;90% atom economy.Strong molecular docking interactions with carbonic anhydrase (1H9N), indicating therapeutic potential.\n                  <\/jats:p>","DOI":"10.1039\/d6ra05387d","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:26:26Z","timestamp":1784053586000},"page":"40415-40430","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel acidic ionic liquid catalyst based on C8-modified caffeine for high-performance sustainable synthesis of pyridodipyrimidines and a study on their carbonic anhydrase inhibitory activity"],"prefix":"10.1039","volume":"16","author":[{"given":"Zahra Zare","family":"Josheghani","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Department of Organic Chemistry, University of Kashan, Kashan, Iran, P.O. Box 87317-51167"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-582X","authenticated-orcid":false,"given":"Azam Moazeni","family":"Bistgani","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Department of Organic Chemistry, University of Kashan, Kashan, Iran, P.O. Box 87317-51167"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6830-907X","authenticated-orcid":false,"given":"Leila","family":"Moradi","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Department of Organic Chemistry, University of Kashan, Kashan, Iran, P.O. Box 87317-51167"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA05387D\/cit1\/1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1039\/b918763b","volume":"39","author":"Anastas","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"D6RA05387D\/cit2\/1","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1039\/C1CS90064A","volume":"41","author":"Li","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"D6RA05387D\/cit3\/1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3390\/catal14090593","volume":"14","author":"Messire","year":"2024","journal-title":"Catalysts"},{"key":"D6RA05387D\/cit4\/1","doi-asserted-by":"publisher","first-page":"113113","DOI":"10.1016\/j.micromeso.2024.113113","volume":"372","author":"Bistgani","year":"2024","journal-title":"Microporous Mesoporous Mater."},{"key":"D6RA05387D\/cit5\/1","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1007\/s11164-024-05234-4","volume":"50","author":"Moradi","year":"2024","journal-title":"Res. Chem. Intermed."},{"key":"D6RA05387D\/cit6\/1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0160-9327(05)80086-9","volume":"18","author":"Ugi","year":"1994","journal-title":"Endeavour"},{"key":"D6RA05387D\/cit7\/1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.22036\/org.chem.2024.440339.1321","volume":"9","author":"Moazeni Bistgani","year":"2023","journal-title":"Org. Chem. Res."},{"key":"D6RA05387D\/cit8\/1","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1070\/RCR5010","volume":"89","author":"Nenajdenko","year":"2020","journal-title":"Russ. Chem. Rev."},{"key":"D6RA05387D\/cit9\/1","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.1002\/aoc.7617","volume":"38","author":"Dehnavian","year":"2024","journal-title":"Appl. Organomet. Chem."},{"key":"D6RA05387D\/cit10\/1","doi-asserted-by":"publisher","first-page":"136335","DOI":"10.1016\/j.molstruc.2023.136335","volume":"1294","author":"Toorbaf","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D6RA05387D\/cit11\/1","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1021\/cr100233r","volume":"112","author":"D\u00f6mling","year":"2012","journal-title":"Chem. Rev."},{"key":"D6RA05387D\/cit12\/1","doi-asserted-by":"publisher","first-page":"25194","DOI":"10.1039\/d2ra03887k","volume":"12","author":"Dehnavian","year":"2022","journal-title":"RSC Adv."},{"key":"D6RA05387D\/cit13\/1","doi-asserted-by":"publisher","first-page":"7250","DOI":"10.1002\/aoc.7250","volume":"37","author":"Safari","year":"2023","journal-title":"Appl. Organomet. Chem."},{"key":"D6RA05387D\/cit14\/1","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1039\/d3gc03693f","volume":"26","author":"Costa","year":"2024","journal-title":"Green Chem."},{"key":"D6RA05387D\/cit15\/1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2174\/2213346103666160530143059","volume":"3","author":"Melo","year":"2016","journal-title":"Curr. Green Chem."},{"key":"D6RA05387D\/cit16\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13738-024-03142-3","volume":"22","author":"Mallappa","year":"2025","journal-title":"J. Iran. Chem. Soc."},{"key":"D6RA05387D\/cit17\/1","doi-asserted-by":"publisher","first-page":"6611","DOI":"10.1039\/c6ob00936k","volume":"14","author":"Taylor","year":"2016","journal-title":"Org. Biomol. Chem."},{"key":"D6RA05387D\/cit18\/1","doi-asserted-by":"publisher","first-page":"128563","DOI":"10.1016\/j.molliq.2025.128563","volume":"437","author":"Bistgani","year":"2025","journal-title":"J. Mol. Liq."},{"key":"D6RA05387D\/cit19\/1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/1877946813666221021144829","volume":"13","author":"Baranwal","year":"2023","journal-title":"Curr. Phys. Chem."},{"key":"D6RA05387D\/cit20\/1","doi-asserted-by":"publisher","first-page":"122454","DOI":"10.1016\/j.apcatb.2023.122454","volume":"327","author":"Wang","year":"2023","journal-title":"Appl. Catal., B"},{"key":"D6RA05387D\/cit21\/1","doi-asserted-by":"publisher","first-page":"100606","DOI":"10.1016\/j.rechem.2022.100606","volume":"4","author":"Kabir","year":"2022","journal-title":"Results Chem."},{"key":"D6RA05387D\/cit22\/1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3390\/ph16020299","volume":"16","author":"Kumar","year":"2023","journal-title":"Pharmaceuticals"},{"key":"D6RA05387D\/cit23\/1","doi-asserted-by":"publisher","first-page":"8117","DOI":"10.3390\/ijms23158117","volume":"23","author":"Ebenezer","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA05387D\/cit24\/1","doi-asserted-by":"publisher","first-page":"20812","DOI":"10.1038\/s41598-022-24553-3","volume":"12","author":"Rasooll","year":"2022","journal-title":"Sci. Rep."},{"key":"D6RA05387D\/cit25\/1","doi-asserted-by":"publisher","first-page":"122398","DOI":"10.1016\/j.molliq.2023.122398","volume":"385","author":"Javahershenas","year":"2023","journal-title":"J. Mol. Liq."},{"key":"D6RA05387D\/cit26\/1","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1002\/asia.201000310","volume":"5","author":"Jiang","year":"2010","journal-title":"Chem.\u2013Asian J."},{"key":"D6RA05387D\/cit27\/1","doi-asserted-by":"publisher","first-page":"6771","DOI":"10.1002\/aoc.6771","volume":"36","author":"Sadeghi","year":"2022","journal-title":"Appl. Organomet. Chem."},{"key":"D6RA05387D\/cit28\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jorganchem.2019.04.023","volume":"893","author":"Saeidiroshan","year":"2019","journal-title":"J. Organomet. Chem."},{"key":"D6RA05387D\/cit29\/1","doi-asserted-by":"publisher","first-page":"6293","DOI":"10.1002\/aoc.6293","volume":"35","author":"Rostami","year":"2021","journal-title":"Appl. Organomet. Chem."},{"key":"D6RA05387D\/cit30\/1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.22036\/org.chem.2024.487724.1359","volume":"11","author":"Yaghoobi","year":"2025","journal-title":"Org. Chem. Res."},{"key":"D6RA05387D\/cit31\/1","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1007\/s12039-015-0964-1","volume":"127","author":"Mohsenimehr","year":"2015","journal-title":"J. Chem. Sci."},{"key":"D6RA05387D\/cit32\/1","doi-asserted-by":"publisher","first-page":"6633","DOI":"10.1021\/acs.chemrev.7b00246","volume":"117","author":"Lei","year":"2017","journal-title":"Chem. Rev."},{"key":"D6RA05387D\/cit33\/1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1039\/c1fd00112d","volume":"154","author":"Angell","year":"2012","journal-title":"Faraday Discuss."},{"key":"D6RA05387D\/cit34\/1","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1063\/1.2204959","volume":"35","author":"Zhang","year":"2006","journal-title":"J. Phys. Chem. Ref. Data"},{"key":"D6RA05387D\/cit35\/1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.molliq.2014.03.011","volume":"193","author":"Wang","year":"2014","journal-title":"J. Mol. Liq."},{"key":"D6RA05387D\/cit36\/1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1080\/00018738000101376","volume":"29","author":"Enderby","year":"1980","journal-title":"Adv. Phys."},{"key":"D6RA05387D\/cit37\/1","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1039\/d2gc04786a","volume":"25","author":"Xu","year":"2023","journal-title":"Green Chem."},{"key":"D6RA05387D\/cit38\/1","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1007\/s13738-020-01901-6","volume":"17","author":"Khazalpour","year":"2020","journal-title":"J. Iran. Chem. Soc."},{"key":"D6RA05387D\/cit39\/1","doi-asserted-by":"publisher","first-page":"106062","DOI":"10.1016\/j.bioorg.2022.106062","volume":"128","author":"Rad","year":"2022","journal-title":"Bioorg. Chem."},{"key":"D6RA05387D\/cit40\/1","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1039\/d2ra07683g","volume":"13","author":"Rad","year":"2023","journal-title":"RSC Adv."},{"key":"D6RA05387D\/cit41\/1","doi-asserted-by":"publisher","first-page":"28669","DOI":"10.1039\/d4ra06244b","volume":"14","author":"Rad","year":"2024","journal-title":"RSC Adv."},{"key":"D6RA05387D\/cit42\/1","doi-asserted-by":"publisher","first-page":"24656","DOI":"10.1039\/d3ra04817a","volume":"13","author":"Rad","year":"2023","journal-title":"RSC Adv."},{"key":"D6RA05387D\/cit43\/1","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.2174\/1381612826666200417154810","volume":"26","author":"Sharma","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"D6RA05387D\/cit44\/1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1039\/d0dt03569f","volume":"50","author":"Kant","year":"2021","journal-title":"Dalton Trans."},{"key":"D6RA05387D\/cit45\/1","doi-asserted-by":"publisher","first-page":"44247","DOI":"10.1039\/d0ra09198g","volume":"10","author":"Heravi","year":"2020","journal-title":"RSC Adv."},{"key":"D6RA05387D\/cit46\/1","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.13040\/IJPSR.0975-8232.6(10).4145-58","volume":"6","author":"Singh","year":"2015","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"D6RA05387D\/cit47\/1","doi-asserted-by":"publisher","first-page":"14537","DOI":"10.1111\/cbdd.14537","volume":"103","author":"Faizan","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"key":"D6RA05387D\/cit48\/1","doi-asserted-by":"publisher","first-page":"194","DOI":"10.20959\/wjpr202014-19021","volume":"9","author":"Perli","year":"2020","journal-title":"World J. Pharm. Res."},{"key":"D6RA05387D\/cit49\/1","doi-asserted-by":"publisher","first-page":"21956","DOI":"10.1039\/c9ra04098f","volume":"9","author":"Meng","year":"2019","journal-title":"RSC Adv."},{"key":"D6RA05387D\/cit50\/1","doi-asserted-by":"publisher","first-page":"8932","DOI":"10.1039\/d4ra00432a","volume":"14","author":"Chaudhary","year":"2024","journal-title":"RSC Adv."},{"key":"D6RA05387D\/cit51\/1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1134\/S1021443711020099","volume":"58","author":"Kupriyanova","year":"2011","journal-title":"J. Plant Physiol."},{"key":"D6RA05387D\/cit52\/1","doi-asserted-by":"publisher","first-page":"3841","DOI":"10.3390\/ijms20153841","volume":"20","author":"Occhipinti","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA05387D\/cit53\/1","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1042\/bcj20160115","volume":"473","author":"Supuran","year":"2016","journal-title":"Biochem. J."},{"key":"D6RA05387D\/cit54\/1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s40135-025-00332-x","volume":"13","author":"Hallaj","year":"2025","journal-title":"Curr. Ophthalmol. Rep."},{"key":"D6RA05387D\/cit55\/1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6RA05387D\/cit56\/1","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6RA05387D\/cit57\/1","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.2174\/138161212799504876","volume":"18","author":"Perez-Sayans","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"D6RA05387D\/cit58\/1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s12039-022-02116-3","volume":"134","author":"Chavan","year":"2022","journal-title":"J. Chem. Sci."},{"key":"D6RA05387D\/cit59\/1","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1007\/s13738-015-0604-1","volume":"12","author":"Rostamizadeh","year":"2015","journal-title":"J. Iran. Chem. Soc."},{"key":"D6RA05387D\/cit60\/1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ultsonch.2009.07.002","volume":"17","author":"Mosslemin","year":"2010","journal-title":"Ultrason. Sonochem."},{"key":"D6RA05387D\/cit61\/1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1080\/00304948.2010.490177","volume":"42","author":"Hajipour","year":"2010","journal-title":"Org. Prep. Proced. Int."},{"key":"D6RA05387D\/cit62\/1","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.4067\/S0717-97072015000200024","volume":"60","author":"Ziarani","year":"2015","journal-title":"J. Chil. Chem. Soc."},{"key":"D6RA05387D\/cit63\/1","doi-asserted-by":"publisher","first-page":"4854","DOI":"10.1039\/D3OB00626C","volume":"21","author":"Singh","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"D6RA05387D\/cit64\/1","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/jhet.3018","volume":"55","author":"Patil","year":"2018","journal-title":"J. Heterocycl. Chem."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA05387D\/0\/D6RA05387D.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:02:35Z","timestamp":1786561355000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA05387D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":64,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2026,8,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra05387d","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}