{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:54:27Z","timestamp":1792598067182,"version":"4.5.0"},"reference-count":25,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":293,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012465","name":"Dalian Medical University","doi-asserted-by":"publisher","award":["JCHZ2023011"],"award-info":[{"award-number":["JCHZ2023011"]}],"id":[{"id":"10.13039\/501100012465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012465","name":"Dalian Medical University","doi-asserted-by":"publisher","award":["DYYH2024004"],"award-info":[{"award-number":["DYYH2024004"]}],"id":[{"id":"10.13039\/501100012465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012131","name":"Department of Science and Technology of Liaoning Province","doi-asserted-by":"publisher","award":["2024-MSLH-115"],"award-info":[{"award-number":["2024-MSLH-115"]}],"id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Fibroblast activation protein \u03b1 (FAP) is a promising therapeutic target. We designed fluorescent probe DDAF with high FAP selectivity and sensitivity. DDAF can facilitate the screening of FAP inhibitors and visualizes FAP in tumor cells and tissues.<\/jats:p>","DOI":"10.1039\/d6ra05595h","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:17:43Z","timestamp":1792595863000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An activatable fluorescent probe for fibroblast activation protein \u03b1 and its bioimaging applications"],"prefix":"10.1039","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2377-0190","authenticated-orcid":false,"given":"Lei","family":"Feng","sequence":"first","affiliation":[{"name":"Second Affiliated Hospital, Dalian Medical University, Dalian, 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengjing","family":"Chen","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Dalian Medical University, Dalian, 116023, China"},{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhao","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Northwestern Polytechnical University, Xi'an 710072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Dang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjuan","family":"Xing","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Dalian Medical University, Dalian, 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Shu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8035-6802","authenticated-orcid":false,"given":"Jing","family":"Ning","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-537X","authenticated-orcid":false,"given":"Xiaochi","family":"Ma","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Dalian Medical University, Dalian, 116023, China"},{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA05595H\/cit1\/1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4161\/cbt.13.3.18696","volume":"13","author":"Liu","year":"2012","journal-title":"Cancer Biol. Ther."},{"key":"D6RA05595H\/cit2\/1","doi-asserted-by":"crossref","first-page":"129636","DOI":"10.1016\/j.bbagen.2020.129636","volume":"1864","author":"Dunaevsky","year":"2020","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"D6RA05595H\/cit3\/1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1006\/prep.2001.1572","volume":"24","author":"Sun","year":"2002","journal-title":"Protein Expression Purif."},{"key":"D6RA05595H\/cit4\/1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1080\/14728222.2017.1370455","volume":"21","author":"Juillerat-Jeanneret","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"D6RA05595H\/cit5\/1","doi-asserted-by":"crossref","first-page":"36505","DOI":"10.1074\/jbc.274.51.36505","volume":"274","author":"Park","year":"1999","journal-title":"J. Biol. Chem."},{"key":"D6RA05595H\/cit6\/1","doi-asserted-by":"crossref","first-page":"29231","DOI":"10.1074\/jbc.M202770200","volume":"277","author":"Ghersi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"D6RA05595H\/cit7\/1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/hep.510290631","volume":"29","author":"Levy","year":"1999","journal-title":"Hepatology"},{"key":"D6RA05595H\/cit8\/1","doi-asserted-by":"crossref","first-page":"R171","DOI":"10.1186\/ar2080","volume":"8","author":"Bauer","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"D6RA05595H\/cit9\/1","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.2741\/2918","volume":"13","author":"Wang","year":"2008","journal-title":"Front. Biosci."},{"key":"D6RA05595H\/cit10\/1","doi-asserted-by":"crossref","first-page":"e0178987","DOI":"10.1371\/journal.pone.0178987","volume":"12","author":"Uitte de Willige","year":"2017","journal-title":"PLoS One"},{"key":"D6RA05595H\/cit11\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.yexmp.2013.06.007","volume":"95","author":"Yang","year":"2013","journal-title":"Exp. Mol. Pathol."},{"key":"D6RA05595H\/cit12\/1","first-page":"7002","volume":"8","author":"Ji","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"D6RA05595H\/cit13\/1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3892\/ijo.2011.906","volume":"38","author":"Saigusa","year":"2011","journal-title":"Int. J. Oncol."},{"key":"D6RA05595H\/cit14\/1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/07357900600894732","volume":"24","author":"Nemunaitis","year":"2006","journal-title":"Cancer Invest."},{"key":"D6RA05595H\/cit15\/1","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1517\/13543784.16.9.1459","volume":"16","author":"Cunningham","year":"2007","journal-title":"Expert Opin. Invest. Drugs"},{"key":"D6RA05595H\/cit16\/1","doi-asserted-by":"crossref","first-page":"213026","DOI":"10.1016\/j.ccr.2019.213026","volume":"399","author":"Feng","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"D6RA05595H\/cit17\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/HM9.0000000000000105","volume":"4","author":"Chen","year":"2024","journal-title":"Acupunct. Herb. Med."},{"key":"D6RA05595H\/cit18\/1","doi-asserted-by":"crossref","first-page":"213740","DOI":"10.1016\/j.ccr.2020.213740","volume":"437","author":"Feng","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"D6RA05595H\/cit19\/1","doi-asserted-by":"crossref","first-page":"e202113191","DOI":"10.1002\/anie.202113191","volume":"61","author":"Ning","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6RA05595H\/cit20\/1","doi-asserted-by":"crossref","first-page":"108504","DOI":"10.1016\/j.cclet.2023.108504","volume":"35","author":"Yan","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"D6RA05595H\/cit21\/1","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1021\/bc300278r","volume":"23","author":"Li","year":"2012","journal-title":"Bioconjugate Chem."},{"key":"D6RA05595H\/cit22\/1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/anie.201710727","volume":"57","author":"Miao","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6RA05595H\/cit23\/1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1039\/C7TB03303F","volume":"6","author":"Xing","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"D6RA05595H\/cit24\/1","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1021\/acssensors.2c00126","volume":"7","author":"Liu","year":"2022","journal-title":"ACS Sens."},{"key":"D6RA05595H\/cit25\/1","doi-asserted-by":"crossref","first-page":"127872","DOI":"10.1016\/j.snb.2020.127872","volume":"310","author":"Tian","year":"2020","journal-title":"Sens. Actuators, B"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA05595H\/0\/D6RA05595H.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:17:47Z","timestamp":1792595867000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA05595H"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":25,"URL":"https:\/\/doi.org\/10.1039\/d6ra05595h","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}