{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:39:19Z","timestamp":1792489159868,"version":"4.5.0"},"reference-count":48,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":292,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    A series of two sets of 1,2,3-triazolyl indole-piperazine hybrids (R1\u2013R17) were synthesized and tested against M.tb H37Rv, with R11 exhibiting significant potency with an MIC of 1.56 \u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , equipotent to the first-line drug isoniazid.\n                  <\/jats:p>","DOI":"10.1039\/d6ra05893k","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:46:45Z","timestamp":1792486005000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["1,2,3-Triazolyl indole-piperazine hybrids as potential anti-tubercular agents: design, synthesis,\n                    <i>in vitro<\/i>\n                    , and\n                    <i>in silico<\/i>\n                    evaluation"],"prefix":"10.1039","author":[{"given":"Rajkumar","family":"Reddyrajula","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Technology & School of Sciences, Woxsen University, Hyderabad-502345, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umadevi","family":"Etikyala","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500 076, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Muzaffar-Ur-Rehman","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani-333031, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7493-9738","authenticated-orcid":false,"given":"Sampat","family":"Parayya Vibhutimath","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Institute of Technology Karnataka, Surathkal-575025, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-878X","authenticated-orcid":false,"given":"Udayakumar","family":"Dalimba","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Institute of Technology Karnataka, Surathkal-575025, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2678-7481","authenticated-orcid":false,"given":"Shreeganesh Subraya","family":"Hegde","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Institute of Technology Karnataka, Surathkal-575025, Mangalore, Karnataka, India"},{"name":"Department of Chemistry, School of Engineering, Dayananda Sagar University, Harohalli, Bengaluru-562112, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2319-8297","authenticated-orcid":false,"given":"Chandra Sekhar","family":"Kondapalli Venkata Gowri","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad 500078, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9056-8385","authenticated-orcid":false,"given":"Vijjulatha","family":"Manga","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500 076, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA05893K\/cit1\/1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/31159","volume":"393","author":"Cole","year":"1998","journal-title":"Nature"},{"key":"D6RA05893K\/cit2\/1","volume-title":"Global tuberculosis report 2025","author":"World Health Organization","year":"2025","unstructured":"World Health Organization ,  Global tuberculosis report 2025 ,  World Health Organization ,  2025 ,  https:\/\/www.who.int\/teams\/global-programme-on-tuberculosis-and-lung-health\/tb-reports\/global-tuberculosis-report-2025\/ , (accessed 15 October 2026)."},{"key":"D6RA05893K\/cit3\/1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.tips.2008.08.001","volume":"29","author":"Balganesh","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"D6RA05893K\/cit4\/1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/S0140-6736(13)62675-6","volume":"383","author":"Pietersen","year":"2014","journal-title":"Lancet"},{"key":"D6RA05893K\/cit5\/1","volume-title":"Drug-resistant Mycobacterium tuberculosis","volume":"13","author":"Boshoff","year":"2023","unstructured":"H. I.Boshoff ,  D. F.Warner  and  B.Gold , in  Drug-resistant Mycobacterium tuberculosis ,  Frontiers Media SA ,  2023 , vol.  13"},{"key":"D6RA05893K\/cit6\/1","first-page":"52","volume":"18","author":"Alavi-Naini","year":"2013","journal-title":"J. Res. Med. Sci."},{"key":"D6RA05893K\/cit7\/1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1186\/s12879-025-11566-2","volume":"25","author":"Tan","year":"2025","journal-title":"BMC Infect. Dis."},{"key":"D6RA05893K\/cit8\/1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tips.2021.11.016","volume":"43","author":"Mehta","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"D6RA05893K\/cit9\/1","doi-asserted-by":"crossref","first-page":"8879019","DOI":"10.1155\/jotm\/8879019","volume":"2026","author":"Ibrahim","year":"2026","journal-title":"J. Trop. Med."},{"key":"D6RA05893K\/cit10\/1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1039\/D3MD00677H","volume":"15","author":"Zeng","year":"2024","journal-title":"RSC Med. Chem."},{"key":"D6RA05893K\/cit11\/1","doi-asserted-by":"crossref","first-page":"103021","DOI":"10.1016\/j.bioorg.2019.103021","volume":"89","author":"Kumari","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D6RA05893K\/cit12\/1","doi-asserted-by":"crossref","first-page":"138569","DOI":"10.1016\/j.molstruc.2024.138569","volume":"1312","author":"Etikyala","year":"2024","journal-title":"J. Mol. Struct."},{"key":"D6RA05893K\/cit13\/1","doi-asserted-by":"crossref","first-page":"108668","DOI":"10.1016\/j.bioorg.2025.108668","volume":"163","author":"Khan","year":"2025","journal-title":"Bioorg. Chem."},{"key":"D6RA05893K\/cit14\/1","doi-asserted-by":"crossref","first-page":"28782","DOI":"10.1021\/acsomega.6c01431","volume":"11","author":"Punkvang","year":"2026","journal-title":"ACS Omega"},{"key":"D6RA05893K\/cit15\/1","doi-asserted-by":"crossref","first-page":"214ra168","DOI":"10.1126\/scitranslmed.3007355","volume":"5","author":"Rao","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"D6RA05893K\/cit16\/1","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1128\/AAC.03229-14","volume":"58","author":"Li","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA05893K\/cit17\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijmyco.2015.02.002","volume":"4","author":"Chandran","year":"2015","journal-title":"Int. J. Mycobact."},{"key":"D6RA05893K\/cit18\/1","doi-asserted-by":"crossref","first-page":"e14537","DOI":"10.1111\/cbdd.14537","volume":"103","author":"Faizan","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"key":"D6RA05893K\/cit19\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejmech.2011.12.035","volume":"49","author":"Forge","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA05893K\/cit20\/1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ejmech.2014.11.034","volume":"90","author":"Rotta","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA05893K\/cit21\/1","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3390\/biom15091305","volume":"15","author":"\u00d6zcan","year":"2025","journal-title":"Biomolecules"},{"key":"D6RA05893K\/cit22\/1","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.5599\/admet.3322","volume":"14","author":"Thakkar","year":"2026","journal-title":"ADMET and DMPK"},{"key":"D6RA05893K\/cit23\/1","doi-asserted-by":"crossref","first-page":"e202405930","DOI":"10.1002\/slct.202405930","volume":"10","author":"Lingaswamy","year":"2025","journal-title":"ChemistrySelect"},{"key":"D6RA05893K\/cit24\/1","doi-asserted-by":"crossref","first-page":"134013","DOI":"10.1016\/j.molstruc.2022.134013","volume":"1271","author":"Jagadeesan","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D6RA05893K\/cit25\/1","first-page":"515","volume":"36","author":"Akko\u00e7","year":"2012","journal-title":"Turk. J. Chem."},{"key":"D6RA05893K\/cit26\/1","doi-asserted-by":"crossref","first-page":"129148","DOI":"10.1016\/j.bmcl.2023.129148","volume":"81","author":"Liang","year":"2023","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6RA05893K\/cit27\/1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1248\/cpb.c22-00635","volume":"71","author":"Xing","year":"2023","journal-title":"Chem. Pharm. Bull."},{"key":"D6RA05893K\/cit28\/1","doi-asserted-by":"crossref","first-page":"114597","DOI":"10.1016\/j.ejmech.2022.114597","volume":"241","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA05893K\/cit29\/1","doi-asserted-by":"crossref","first-page":"e03727","DOI":"10.1002\/slct.202503727","volume":"10","author":"Thopate","year":"2025","journal-title":"ChemistrySelect"},{"key":"D6RA05893K\/cit30\/1","doi-asserted-by":"crossref","first-page":"127654","DOI":"10.1016\/j.bmcl.2020.127654","volume":"30","author":"Huang","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6RA05893K\/cit31\/1","doi-asserted-by":"crossref","first-page":"129829","DOI":"10.1016\/j.molstruc.2020.129829","volume":"1229","author":"Verma","year":"2021","journal-title":"J. Mol. Struct."},{"key":"D6RA05893K\/cit32\/1","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/j.bmcl.2016.03.059","volume":"26","author":"Naidu","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6RA05893K\/cit33\/1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ejmech.2015.10.024","volume":"105","author":"Penta","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA05893K\/cit34\/1","doi-asserted-by":"crossref","first-page":"117562","DOI":"10.1016\/j.bmc.2023.117562","volume":"98","author":"Reddyrajula","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"D6RA05893K\/cit35\/1","doi-asserted-by":"crossref","first-page":"2307989","DOI":"10.1080\/17518253.2024.2307989","volume":"17","author":"Vaishnani","year":"2024","journal-title":"Green Chem. Lett. Rev."},{"key":"D6RA05893K\/cit36\/1","doi-asserted-by":"crossref","first-page":"141242","DOI":"10.1016\/j.molstruc.2024.141242","volume":"1327","author":"Narkedimilli","year":"2025","journal-title":"J. Mol. Struct."},{"key":"D6RA05893K\/cit37\/1","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.3390\/molecules30102119","volume":"30","author":"Magwaza","year":"2025","journal-title":"Molecules"},{"key":"D6RA05893K\/cit38\/1","doi-asserted-by":"crossref","first-page":"140696","DOI":"10.1016\/j.molstruc.2024.140696","volume":"1323","author":"Reddyrajula","year":"2025","journal-title":"J. Mol. Struct."},{"key":"D6RA05893K\/cit39\/1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3998\/ark.5550190.0008.f18","volume":"15","author":"Lourenco","year":"2007","journal-title":"Arkivoc"},{"key":"D6RA05893K\/cit40\/1","doi-asserted-by":"crossref","first-page":"e3851","DOI":"10.1002\/aoc.3851","volume":"31","author":"Hegde","year":"2017","journal-title":"Appl. Organomet. Chem."},{"key":"D6RA05893K\/cit41\/1","doi-asserted-by":"crossref","DOI":"10.1201\/9781420014495","volume-title":"Antimicrobial Susceptibility Testing Protocols","author":"Schwalbe","year":"2007","unstructured":"R.Schwalbe ,  L.Steele-Moore  and  A. C.Goodwin , in  Antimicrobial Susceptibility Testing Protocols ,  CRC Press ,  2007"},{"key":"D6RA05893K\/cit42\/1","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","volume":"47","author":"Halgren","year":"2004","journal-title":"J. Med. Chem."},{"key":"D6RA05893K\/cit43\/1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","volume":"10","author":"Genheden","year":"2015","journal-title":"Expert Opin. Drug Discovery"},{"key":"D6RA05893K\/cit44\/1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nsb0902-646","volume":"9","author":"Karplus","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"D6RA05893K\/cit45\/1","doi-asserted-by":"crossref","first-page":"se202200491","DOI":"10.1002\/cphc.202200491","volume":"24","author":"Palma","year":"2023","journal-title":"ChemPhysChem"},{"key":"D6RA05893K\/cit46\/1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jmgm.2009.01.006","volume":"27","author":"Papaleo","year":"2009","journal-title":"J. Mol. Graphics Modell."},{"key":"D6RA05893K\/cit47\/1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s11030-024-10887-9","volume":"29","author":"Etikyala","year":"2025","journal-title":"Mol. Diversity"},{"key":"D6RA05893K\/cit48\/1","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1080\/10406638.2023.2266091","volume":"44","author":"Shinde","year":"2024","journal-title":"Polycyclic Aromat. Compd."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA05893K\/0\/D6RA05893K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:46:50Z","timestamp":1792486010000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA05893K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":48,"URL":"https:\/\/doi.org\/10.1039\/d6ra05893k","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}