{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:56:12Z","timestamp":1791446172179,"version":"4.3.3"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":280,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["116282"],"award-info":[{"award-number":["116282"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004695","name":"Inyuvesi Yakwazulu-Natali","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>A series of thiazole-2-imines (1a\u20131f) with unsubstituted aryl groups or aryl groups bearing methyl, methoxy, fluoro, or nitro substituents was designed using selected structural features of thiamine as inspiration.<\/jats:p>","DOI":"10.1039\/d6ra07024h","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:32:55Z","timestamp":1791444775000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, characterization, X-ray diffraction,\n                    <i>in silico<\/i>\n                    studies and\n                    <i>in vitro<\/i>\n                    biological evaluation of acylthiourea-derived thiazole-2-imines"],"prefix":"10.1039","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0541-2429","authenticated-orcid":false,"given":"Edmore F.","family":"Kangara","sequence":"first","affiliation":[{"name":"Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag X3, Johannesburg, 2050, South Africa"},{"name":"Discipline of Chemistry, School of Agriculture and Engineering, University of KwaZulu-Natal, Private Bag X54001, Westville, Durban, 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-4540","authenticated-orcid":false,"given":"Thishana","family":"Singh","sequence":"additional","affiliation":[{"name":"Discipline of Chemistry, School of Agriculture and Engineering, University of KwaZulu-Natal, Private Bag X54001, Westville, Durban, 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phindile","family":"Khoza","sequence":"additional","affiliation":[{"name":"Discipline of Chemistry, School of Agriculture and Engineering, University of KwaZulu-Natal, Private Bag X54001, Westville, Durban, 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darian","family":"Naidu","sequence":"additional","affiliation":[{"name":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nompumelelo P.","family":"Mkwananzi","sequence":"additional","affiliation":[{"name":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibusiso","family":"Senzani","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Medical Science, College of Health Sciences, University of KwaZulu-Natal, Medical School Campus, Durban, 4001, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatoba E.","family":"Oyeneyin","sequence":"additional","affiliation":[{"name":"Department of Chemical and Physical Sciences, Walter Sisulu University (WSU), Private Bag X01, Mthatha, Eastern Cape, 4099, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-5335","authenticated-orcid":false,"given":"Manuel A.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag X3, Johannesburg, 2050, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-8584","authenticated-orcid":false,"given":"Werner","family":"Van Zyl","sequence":"additional","affiliation":[{"name":"Discipline of Chemistry, School of Agriculture and Engineering, University of KwaZulu-Natal, Private Bag X54001, Westville, Durban, 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1844-3614","authenticated-orcid":false,"given":"Matshawandile","family":"Tukulula","sequence":"additional","affiliation":[{"name":"Discipline of Chemistry, School of Agriculture and Engineering, University of KwaZulu-Natal, Private Bag X54001, Westville, Durban, 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA07024H\/cit1\/1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1177\/1533210110392941","volume":"16","author":"Fattal-Valevski","year":"2011","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D6RA07024H\/cit2\/1","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.3390\/molecules23061464","volume":"23","author":"Liu","year":"2018","journal-title":"Molecules"},{"key":"D6RA07024H\/cit3\/1","doi-asserted-by":"publisher","first-page":"e077586","DOI":"10.1136\/bmjopen-2023-077586","volume":"14","author":"Vine","year":"2024","journal-title":"BMJ Open"},{"key":"D6RA07024H\/cit4\/1","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3390\/agriculture15030284","volume":"15","author":"Lee","year":"2025","journal-title":"Agriculture"},{"key":"D6RA07024H\/cit5\/1","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3390\/polym14040771","volume":"14","author":"Al Hagbani","year":"2022","journal-title":"Polymers"},{"key":"D6RA07024H\/cit6\/1","doi-asserted-by":"publisher","first-page":"114217","DOI":"10.1016\/j.ejmech.2022.114217","volume":"233","author":"Popovi\u0107-Djordjevi\u0107","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA07024H\/cit7\/1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.jfluchem.2009.11.005","volume":"131","author":"Saeed","year":"2010","journal-title":"J. Fluorine Chem."},{"key":"D6RA07024H\/cit8\/1","first-page":"106","volume":"4","author":"Saeed","year":"2012","journal-title":"Der Pharma Chemica"},{"key":"D6RA07024H\/cit9\/1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1021\/ml300322n","volume":"4","author":"Zheng","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"D6RA07024H\/cit10\/1","doi-asserted-by":"publisher","first-page":"100656","DOI":"10.1016\/j.rechem.2022.100656","volume":"4","author":"Shafique","year":"2022","journal-title":"Results Chem."},{"key":"D6RA07024H\/cit11\/1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/joim.12264","volume":"277","author":"Parida","year":"2015","journal-title":"J. Intern. Med."},{"key":"D6RA07024H\/cit12\/1","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1371\/journal.pmed.0050188","volume":"5","author":"Escombe","year":"2008","journal-title":"PLoS Med."},{"issue":"9","key":"D6RA07024H\/cit13\/1","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1039\/d6np00036c","volume":"43","author":"Gordzevich","year":"2026","journal-title":"Nat. Prod. Rep."},{"key":"D6RA07024H\/cit14\/1","doi-asserted-by":"publisher","first-page":"903258","DOI":"10.3389\/fmicb.2022.903258","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Microbiol."},{"key":"D6RA07024H\/cit15\/1","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.chembiol.2022.07.001","volume":"29","author":"Kim","year":"2022","journal-title":"Cell Chem. Biol."},{"key":"D6RA07024H\/cit16\/1","doi-asserted-by":"publisher","first-page":"10081","DOI":"10.1074\/jbc.ra120.013295","volume":"295","author":"Kim","year":"2020","journal-title":"J. Biol. Chem."},{"key":"D6RA07024H\/cit17\/1","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1055\/s-2004-829127","volume":"11","author":"Katritzky","year":"2004","journal-title":"Synthesis"},{"key":"D6RA07024H\/cit18\/1","doi-asserted-by":"publisher","first-page":"138818","DOI":"10.1016\/j.molstruc.2024.138818","volume":"1314","author":"Makhakhayi","year":"2024","journal-title":"J. Mol. Struct."},{"key":"D6RA07024H\/cit19\/1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.5772\/intechopen.93037","volume-title":"Azoles \u2013 Synth. Prop. Appl. Perspect.","author":"Ibrahim","year":"2021","unstructured":"S. A.Ibrahim  and  H. F.Rizk ,  Synthesis and Biological Evaluation of Thiazole Derivatives , in  Azoles \u2013 Synth. Prop. Appl. Perspect. ,  IntechOpen ,  2021 ,  pp. 2\u20133 ,  10.5772\/intechopen.93037"},{"key":"D6RA07024H\/cit20\/1","doi-asserted-by":"publisher","first-page":"e02608","DOI":"10.1016\/j.sciaf.2025.e02608","volume":"27","author":"Oyeneyin","year":"2025","journal-title":"Sci. Afr."},{"key":"D6RA07024H\/cit21\/1","doi-asserted-by":"publisher","first-page":"100080","DOI":"10.1016\/j.chphi.2022.100080","volume":"4","author":"Puthanveedu","year":"2022","journal-title":"Chem. Phys. Impact"},{"key":"D6RA07024H\/cit22\/1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/1747519820932091","volume":"45","author":"Miar","year":"2021","journal-title":"J. Chem. Res."},{"key":"D6RA07024H\/cit23\/1","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.3390\/ijms13022160","volume":"13","author":"Islam","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"D6RA07024H\/cit24\/1","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1021\/ar300109n","volume":"46","author":"Wheeler","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"D6RA07024H\/cit25\/1","doi-asserted-by":"publisher","first-page":"e2331620","DOI":"10.1080\/00268976.2024.2331620","volume":"122","author":"Sharma","year":"2024","journal-title":"Mol. Phys."},{"key":"D6RA07024H\/cit26\/1","doi-asserted-by":"publisher","first-page":"14430","DOI":"10.1021\/acsomega.1c01314","volume":"6","author":"Chhabra","year":"2021","journal-title":"ACS Omega"},{"key":"D6RA07024H\/cit27\/1","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1021\/ci700359j","volume":"48","author":"von Korff","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"D6RA07024H\/cit28\/1","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1021\/ci500588j","volume":"55","author":"Sander","year":"2015","journal-title":"J. Chem. Inf. Model."},{"key":"D6RA07024H\/cit29\/1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"D6RA07024H\/cit30\/1","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"D6RA07024H\/cit31\/1","volume-title":"Bruker, APEX3, SAINT-Plus, XPREP, SAINT","year":"2016","unstructured":"Bruker, APEX3, SAINT-Plus, XPREP, SAINT ,  Bruker AXS Inc. ,  Madison, Wisconsin, USA ,  2016"},{"key":"D6RA07024H\/cit32\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S1600576714022985","volume":"48","author":"Krause","year":"2015","journal-title":"J. Appl. Crystallogr."},{"key":"D6RA07024H\/cit33\/1","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1107\/S0021889812029111","volume":"45","author":"Farrugia","year":"2012","journal-title":"J. Appl. Crystallogr."},{"key":"D6RA07024H\/cit34\/1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1107\/S2053229614024218","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr., Sect. C:Struct. Chem."},{"key":"D6RA07024H\/cit35\/1","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1107\/S0021889808042726","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Crystallogr."},{"key":"D6RA07024H\/cit36\/1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1107\/S090744490804362X","volume":"65","author":"Spek","year":"2009","journal-title":"Acta Crystallogr., Sect. D:Biol. Crystallogr."},{"key":"D6RA07024H\/cit37\/1","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1107\/S0021889807067908","volume":"41","author":"Macrae","year":"2008","journal-title":"J. Appl. Crystallogr."},{"key":"D6RA07024H\/cit38\/1","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1063\/1.438955","volume":"72","author":"Krishnan","year":"1980","journal-title":"J. Chem. Phys."},{"key":"D6RA07024H\/cit39\/1","doi-asserted-by":"publisher","first-page":"5639","DOI":"10.1063\/1.438980","volume":"72","author":"McLean","year":"1980","journal-title":"J. Chem. Phys."},{"key":"D6RA07024H\/cit40\/1","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/jcc.540040303","volume":"4","author":"Clark","year":"1983","journal-title":"J. Comp. Chem."},{"key":"D6RA07024H\/cit41\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/en13082032","volume":"13","author":"Mohammadpourasl","year":"2020","journal-title":"Energies"},{"key":"D6RA07024H\/cit42\/1","doi-asserted-by":"publisher","first-page":"118373","DOI":"10.1016\/j.molliq.2021.118373","volume":"348","author":"Aslam","year":"2022","journal-title":"J. Mol. Liq."},{"key":"D6RA07024H\/cit43\/1","doi-asserted-by":"publisher","first-page":"139335","DOI":"10.1016\/j.molstruc.2024.139335","volume":"1318","author":"Hussain","year":"2024","journal-title":"J. Mol. Struct."},{"key":"D6RA07024H\/cit44\/1","doi-asserted-by":"publisher","first-page":"138660","DOI":"10.1016\/j.molstruc.2024.138660","volume":"1312","author":"Ibrahim","year":"2024","journal-title":"J. Mol. Struct."},{"key":"D6RA07024H\/cit45\/1","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1080\/00268976.2013.793841","volume":"111","author":"Eriksen","year":"2013","journal-title":"Mol. Phys."},{"key":"D6RA07024H\/cit46\/1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1021\/ct700187z","volume":"4","author":"Jacquemin","year":"2008","journal-title":"J. Chem. Theory Comput."},{"key":"D6RA07024H\/cit47\/1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.comptc.2018.01.002","volume":"1125","author":"Fahim","year":"2018","journal-title":"Comput. Theor. Chem."},{"key":"D6RA07024H\/cit48\/1","volume-title":"Discovery Studio Visualizer","author":"BIOVIA Dassault Syst\u00e8mes","year":"2021","unstructured":"BIOVIA Dassault Syst\u00e8mes ,  Discovery Studio Visualizer ,  2021"},{"key":"D6RA07024H\/cit49\/1","doi-asserted-by":"publisher","first-page":"e03100","DOI":"10.1016\/j.sciaf.2025.e03100","author":"Mashaba","year":"2025","journal-title":"Sci. Afr."},{"key":"D6RA07024H\/cit50\/1","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.3390\/molecules30102119","volume":"30","author":"Magwaza","year":"2025","journal-title":"Molecules"},{"key":"D6RA07024H\/cit51\/1","doi-asserted-by":"publisher","first-page":"118301","DOI":"10.1016\/j.ejmech.2025.118301","author":"Ragedi","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA07024H\/cit52\/1","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1128\/AAC.46.6.1896-1905.2002","volume":"46","author":"Wei","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6RA07024H\/cit53a\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2549158: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2rklxv","DOI":"10.5517\/ccdc.csd.cc2rklxv"},{"key":"D6RA07024H\/cit53b\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2549159: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2rklyw","DOI":"10.5517\/ccdc.csd.cc2rklyw"},{"key":"D6RA07024H\/cit53c\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2549160: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2rklzx","DOI":"10.5517\/ccdc.csd.cc2rklzx"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA07024H\/0\/D6RA07024H.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:32:57Z","timestamp":1791444777000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA07024H"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":55,"URL":"https:\/\/doi.org\/10.1039\/d6ra07024h","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}