{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:53:22Z","timestamp":1791280402694,"version":"4.1.0"},"reference-count":26,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":278,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Herein, we report the synthesis and evaluation of 18 novel naphthalimide-based derivatives for their activity against hAChE, esBuChE, MAO-A, MAO-B, A\u03b2, and PHF6 aggregation.<\/jats:p>","DOI":"10.1039\/d6ra07131g","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:16:04Z","timestamp":1791278164000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, synthesis, and biological evaluation of naphthalimide derivatives as dual monoamine oxidase-B and amyloid-\u03b2 aggregation inhibitors for Alzheimer's disease"],"prefix":"10.1039","author":[{"given":"Rukshar","family":"Praveen","sequence":"first","affiliation":[{"name":"Drug Design and Synthesis Lab., Department of Chemistry, Jamia Millia Islamia, New Delhi-110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gadaleta","sequence":"additional","affiliation":[{"name":"Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella La","family":"Spada","sequence":"additional","affiliation":[{"name":"Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Valeria","family":"Miniero","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, LUM University Giuseppe Degennaro, Torre Rossi, 70010 Casamassima, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aquib","family":"Reza","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Jamia Hamdard, New Delhi, 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohasib Yusub","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Drug Design and Synthesis Lab., Department of Chemistry, Jamia Millia Islamia, New Delhi-110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Drug Design and Synthesis Lab., Department of Chemistry, Jamia Millia Islamia, New Delhi-110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-304X","authenticated-orcid":false,"given":"Marco","family":"Catto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-2056","authenticated-orcid":false,"given":"Nasimul","family":"Hoda","sequence":"additional","affiliation":[{"name":"Drug Design and Synthesis Lab., Department of Chemistry, Jamia Millia Islamia, New Delhi-110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA07131G\/cit1\/1","first-page":"3708","volume-title":"Alzheimer\u2019s Dementia","volume":"20","year":"2024","unstructured":"Alzheimer\u2019s disease facts and figures ,  Alzheimer\u2019s Dementia ,  2024 ,  20 ,  37083821"},{"key":"D6RA07131G\/cit2\/1","first-page":"e70235","volume-title":"Alzheimer\u2019s Dementia","volume":"21","year":"2025","unstructured":"Alzheimer\u2019s disease facts and figures ,  Alzheimer\u2019s Dementia ,  2025 ,  21 ,  e70235"},{"key":"D6RA07131G\/cit3\/1","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1021\/acschemneuro.0c00403","volume":"11","author":"Gupta","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"D6RA07131G\/cit4\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrn2967","volume":"12","author":"Ittner","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"D6RA07131G\/cit5\/1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol."},{"key":"D6RA07131G\/cit6\/1","doi-asserted-by":"crossref","first-page":"112787","DOI":"10.1016\/j.ejmech.2020.112787","volume":"206","author":"Manzoor","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA07131G\/cit7\/1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2353\/ajpath.2008.080175","volume":"173","author":"Paulson","year":"2008","journal-title":"Am. J. Pathol."},{"key":"D6RA07131G\/cit8\/1","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1093\/brain\/awu213","volume":"137","author":"Collin","year":"2014","journal-title":"Brain"},{"key":"D6RA07131G\/cit9\/1","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"D6RA07131G\/cit10\/1","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.addr.2008.06.002","volume":"60","author":"Bortolato","year":"2008","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6RA07131G\/cit11\/1","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.bmc.2014.01.046","volume":"22","author":"Mertens","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"D6RA07131G\/cit12\/1","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1021\/acsabm.3c00583","volume":"6","author":"Mondal","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"D6RA07131G\/cit13\/1","doi-asserted-by":"crossref","first-page":"7594","DOI":"10.1021\/acs.analchem.3c00099","volume":"95","author":"Sidhu","year":"2023","journal-title":"Anal. Chem."},{"key":"D6RA07131G\/cit14\/1","doi-asserted-by":"crossref","first-page":"11573","DOI":"10.1021\/acs.analchem.2c01850","volume":"94","author":"Sun","year":"2022","journal-title":"Anal. Chem."},{"key":"D6RA07131G\/cit15\/1","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1021\/acschemneuro.1c00235","volume":"12","author":"Pasieka","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"D6RA07131G\/cit16\/1","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1080\/14756366.2018.1491564","volume":"33","author":"Piemontese","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6RA07131G\/cit17\/1","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1021\/jm3017317","volume":"56","author":"Bulic","year":"2013","journal-title":"J. Med. Chem."},{"key":"D6RA07131G\/cit18\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6RA07131G\/cit19\/1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.chembiol.2014.08.013","volume":"21","author":"Doak","year":"2014","journal-title":"Chem. Biol."},{"key":"D6RA07131G\/cit20\/1","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.3390\/molecules24234298","volume":"24","author":"Bolognino","year":"2019","journal-title":"Molecules"},{"key":"D6RA07131G\/cit21\/1","doi-asserted-by":"crossref","first-page":"116266","DOI":"10.1016\/j.ejmech.2024.116266","volume":"269","author":"Al-Saad","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA07131G\/cit22\/1","doi-asserted-by":"crossref","first-page":"116353","DOI":"10.1016\/j.ejmech.2024.116353","volume":"270","author":"Samarelli","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA07131G\/cit23\/1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"D6RA07131G\/cit24\/1","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1007\/s11030-025-11447-5","volume":"30","author":"Ansari","year":"2026","journal-title":"Mol. Diversity"},{"key":"D6RA07131G\/cit25\/1","doi-asserted-by":"crossref","first-page":"9662","DOI":"10.1038\/s41598-022-13622-2","volume":"12","author":"Gupta","year":"2022","journal-title":"Sci. Rep."},{"key":"D6RA07131G\/cit26\/1","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-025-01402-0","author":"Saima","year":"2026","journal-title":"Folia Microbiol."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA07131G\/0\/D6RA07131G.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:16:08Z","timestamp":1791278168000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA07131G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":26,"URL":"https:\/\/doi.org\/10.1039\/d6ra07131g","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}