{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:44:04Z","timestamp":1792010644497,"version":"4.4.0"},"reference-count":48,"publisher":"Royal Society of Chemistry (RSC)","issue":"45","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":266,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Novel quinazolinone\u2013diarylpyrazole hybrids as dual EGFR and COX-2 inhibitors.<\/jats:p>","DOI":"10.1039\/d6ra07867b","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:38:56Z","timestamp":1790257136000},"page":"57241-57257","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quinazolinone\u2013diarylpyrazole hybrids as dual EGFR\/COX-2 inhibitors: antiproliferative, mechanistic, and\n                    <i>in silico<\/i>\n                    studies"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2000-2620","authenticated-orcid":false,"given":"Abdullah","family":"Alkhammash","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Al-Dawadmi Campus, Shaqra University, Shaqra 11961, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-701X","authenticated-orcid":false,"given":"Basima A. A.","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, University of Mosul, Mosul 41001, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-7129","authenticated-orcid":false,"given":"Khulood H.","family":"Oudah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mazaya University College, Nasiriyah, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1943-8419","authenticated-orcid":false,"given":"Mohamed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"College of Medicine, Dhofar University, Salalah 122, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-7170","authenticated-orcid":false,"given":"Kasim Sakran","family":"Abass","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Kirkuk, Kirkuk 36001, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7857-2020","authenticated-orcid":false,"given":"Sara Mahmoud","family":"Farhan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, New Minia 61768, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-9202","authenticated-orcid":false,"given":"Magdi E. A.","family":"Zaki","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-2837","authenticated-orcid":false,"given":"Sobhi M.","family":"Gomha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6RA07867B\/cit1\/1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discovery"},{"key":"D6RA07867B\/cit2\/1","doi-asserted-by":"publisher","first-page":"103904","DOI":"10.1016\/j.drudis.2024.103904","volume":"29","author":"Maddeboina","year":"2024","journal-title":"Drug Discov. Today"},{"key":"D6RA07867B\/cit3\/1","doi-asserted-by":"publisher","first-page":"106055","DOI":"10.1016\/j.phrs.2021.106055","volume":"176","author":"Kabir","year":"2022","journal-title":"Pharmacol. Res."},{"key":"D6RA07867B\/cit4\/1","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.3390\/cancers15082374","volume":"15","author":"Finetti","year":"2023","journal-title":"Cancers"},{"key":"D6RA07867B\/cit5\/1","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1124\/pharmrev.123.000906","volume":"75","author":"Zhang","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"D6RA07867B\/cit6\/1","doi-asserted-by":"publisher","first-page":"117677","DOI":"10.1016\/j.ejmech.2025.117677","volume":"292","author":"Gao","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA07867B\/cit7\/1","doi-asserted-by":"publisher","first-page":"e2400057","DOI":"10.1002\/ardp.202400057","volume":"357","author":"Ghoneim","year":"2024","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"D6RA07867B\/cit8\/1","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3390\/ph16040534","volume":"16","author":"Sandor","year":"2023","journal-title":"Pharmaceuticals"},{"key":"D6RA07867B\/cit9\/1","doi-asserted-by":"publisher","first-page":"109640","DOI":"10.1016\/j.compbiomed.2024.109640","volume":"186","author":"El-Mahdy","year":"2025","journal-title":"Comput. Biol. Med."},{"key":"D6RA07867B\/cit10\/1","doi-asserted-by":"publisher","first-page":"107951","DOI":"10.1016\/j.bioorg.2024.107951","volume":"153","author":"Hamdi","year":"2024","journal-title":"Bioorg. Chem."},{"key":"D6RA07867B\/cit11\/1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1039\/d1md00280e","volume":"13","author":"Ahmadi","year":"2022","journal-title":"RSC Med. Chem."},{"key":"D6RA07867B\/cit12\/1","doi-asserted-by":"publisher","first-page":"116259","DOI":"10.1016\/j.bcp.2024.116259","volume":"228","author":"Chun","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"D6RA07867B\/cit13\/1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3390\/biology9120434","volume":"9","author":"Finetti","year":"2020","journal-title":"Biology"},{"key":"D6RA07867B\/cit14\/1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/978-3-030-50224-9_6","volume-title":"Tumor Microenvironment : Molecular Players \u2013 Part B","author":"Zhang","year":"2020","unstructured":"Y.Zhang ,  S.Tighe  and  Y.-T.Zhu ,  COX-2 Signaling in the Tumor Microenvironment , in  Tumor Microenvironment : Molecular Players \u2013 Part B , ed.  A. Birbrair ,  Springer International Publishing ,  Cham ,  2020 ,  pp. 87\u2013104 ,  10.1007\/978-3-030-50224-9_6"},{"key":"D6RA07867B\/cit15\/1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1124\/pharmrev.123.000901","volume":"76","author":"Santiso","year":"2024","journal-title":"Pharmacol. Rev."},{"key":"D6RA07867B\/cit16\/1","doi-asserted-by":"publisher","first-page":"2974","DOI":"10.1039\/d5md00196j","volume":"16","author":"Kassab","year":"2025","journal-title":"RSC Med. Chem."},{"key":"D6RA07867B\/cit17\/1","doi-asserted-by":"publisher","first-page":"30647","DOI":"10.1039\/d4ra04686b","volume":"14","author":"Khalil","year":"2024","journal-title":"RSC Adv."},{"key":"D6RA07867B\/cit18\/1","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.2174\/1568026623666230714161726","volume":"23","author":"Kumar","year":"2023","journal-title":"Curr. Top. Med. Chem."},{"key":"D6RA07867B\/cit19\/1","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s11030-024-10906-9","volume":"29","author":"Ghoneim","year":"2025","journal-title":"Mol. Diversity"},{"key":"D6RA07867B\/cit20\/1","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1039\/d2md00206j","volume":"13","author":"Li","year":"2022","journal-title":"RSC Med. Chem."},{"key":"D6RA07867B\/cit21\/1","doi-asserted-by":"publisher","first-page":"109444","DOI":"10.1016\/j.bioorg.2025.109444","volume":"170","author":"Farag","year":"2026","journal-title":"Bioorg. Chem."},{"key":"D6RA07867B\/cit22\/1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/1756-9966-31-72","volume":"31","author":"Tveteraas","year":"2012","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"D6RA07867B\/cit23\/1","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.3390\/cancers3043894","volume":"3","author":"Wang","year":"2011","journal-title":"Cancers"},{"key":"D6RA07867B\/cit24\/1","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41598-017-00288-4","volume":"7","author":"Hu","year":"2017","journal-title":"Sci. Rep."},{"key":"D6RA07867B\/cit25\/1","doi-asserted-by":"publisher","first-page":"e0131363","DOI":"10.1371\/journal.pone.0131363","volume":"10","author":"Valverde","year":"2015","journal-title":"PLoS One"},{"key":"D6RA07867B\/cit26\/1","doi-asserted-by":"publisher","first-page":"25204","DOI":"10.1039\/d2ra04498f","volume":"12","author":"Ahmed","year":"2022","journal-title":"RSC Adv."},{"key":"D6RA07867B\/cit27\/1","doi-asserted-by":"publisher","first-page":"2199166","DOI":"10.1080\/14756366.2023.2199166","volume":"38","author":"Kothayer","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D6RA07867B\/cit28\/1","doi-asserted-by":"publisher","first-page":"117340","DOI":"10.1016\/j.ejmech.2025.117340","volume":"287","author":"Kahk","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D6RA07867B\/cit29\/1","doi-asserted-by":"publisher","first-page":"130416","DOI":"10.1016\/j.bmcl.2025.130416","volume":"130","author":"Soltan","year":"2026","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D6RA07867B\/cit30\/1","doi-asserted-by":"publisher","first-page":"109162","DOI":"10.1016\/j.bioorg.2025.109162","volume":"166","author":"Serag","year":"2025","journal-title":"Bioorg. Chem."},{"key":"D6RA07867B\/cit31\/1","doi-asserted-by":"publisher","first-page":"107223","DOI":"10.1016\/j.bioorg.2024.107223","volume":"145","author":"Gaber","year":"2024","journal-title":"Bioorg. Chem."},{"key":"D6RA07867B\/cit32\/1","doi-asserted-by":"publisher","first-page":"18576","DOI":"10.1039\/d4ra02944e","volume":"14","author":"Shaaban","year":"2024","journal-title":"RSC Adv."},{"key":"D6RA07867B\/cit33\/1","doi-asserted-by":"publisher","first-page":"6025","DOI":"10.1039\/d5nj00367a","volume":"49","author":"Al-Karmalawy","year":"2025","journal-title":"New J. Chem."},{"key":"D6RA07867B\/cit34\/1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13065-023-00924-3","volume":"17","author":"Hawash","year":"2023","journal-title":"BMC Chem."},{"key":"D6RA07867B\/cit35\/1","doi-asserted-by":"publisher","first-page":"134358","DOI":"10.1016\/j.molstruc.2022.134358","volume":"1273","author":"Ghorab","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D6RA07867B\/cit36\/1","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.jsps.2017.04.022","volume":"25","author":"Abuelizz","year":"2017","journal-title":"Saudi Pharm. J."},{"key":"D6RA07867B\/cit37\/1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/14728222.2023.2218613","volume":"27","author":"Halder","year":"2023","journal-title":"Expert Opin. Ther. Targets"},{"key":"D6RA07867B\/cit38\/1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12964-023-01082-8","volume":"21","author":"Li","year":"2023","journal-title":"Cell Commun. Signaling"},{"key":"D6RA07867B\/cit39\/1","doi-asserted-by":"publisher","first-page":"31990","DOI":"10.1039\/d4ra04762a","volume":"14","author":"Althikrallah","year":"2024","journal-title":"RSC Adv."},{"key":"D6RA07867B\/cit40\/1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1039\/d4nj04376f","volume":"49","author":"Shaaban","year":"2025","journal-title":"New J. Chem."},{"key":"D6RA07867B\/cit41\/1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/cdd.2017.186","volume":"25","author":"Kale","year":"2018","journal-title":"Cell Death Differ."},{"key":"D6RA07867B\/cit42\/1","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.3892\/ol.2018.7863","volume":"15","author":"Pan","year":"2018","journal-title":"Oncol. Lett."},{"key":"D6RA07867B\/cit43\/1","doi-asserted-by":"publisher","first-page":"118688","DOI":"10.1016\/j.bbamcr.2020.118688","volume":"1867","author":"Boice","year":"2020","journal-title":"Biochim. Biophys. Acta \u2013 Mol. Cell Res."},{"key":"D6RA07867B\/cit44\/1","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.3390\/molecules23051038","volume":"23","author":"Ram\u00edrez","year":"2018","journal-title":"Molecules"},{"key":"D6RA07867B\/cit45\/1","doi-asserted-by":"publisher","first-page":"107832","DOI":"10.1016\/j.carres.2019.107832","volume":"486","author":"Khodair","year":"2019","journal-title":"Carbohydr. Res."},{"key":"D6RA07867B\/cit46\/1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","volume-title":"Cancer Cell Culture: Methods and Protocols","author":"van Meerloo","year":"2011","unstructured":"J.van Meerloo ,  G. J. L.Kaspers  and  J.Cloos ,  Cell Sensitivity Assays: The MTT Assay , in  Cancer Cell Culture: Methods and Protocols , ed.  I. A. Cree ,  Humana Press ,  Totowa, NJ ,  2011 ,  pp. 237\u2013245 ,  10.1007\/978-1-61779-080-5_20"},{"key":"D6RA07867B\/cit47\/1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"D6RA07867B\/cit48\/1","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA07867B\/0\/D6RA07867B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:44:38Z","timestamp":1792007078000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA07867B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":48,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2026,10,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra07867b","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}