{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:41:04Z","timestamp":1792597264662,"version":"4.5.0"},"reference-count":48,"publisher":"Royal Society of Chemistry (RSC)","issue":"46","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    Inflammation is a protective response that can be exploited for diagnosis. [\n                    <jats:sup>99m<\/jats:sup>\n                    Tc]Tc-lornoxicam binds COX enzymes on inflammatory cells, and its \u03b3-emission enables imaging of COX-associated pathological disorders.\n                  <\/jats:p>","DOI":"10.1039\/d6ra08252a","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:34:28Z","timestamp":1791354868000},"page":"60553-60567","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and characterization of [\n                    <sup>99m<\/sup>\n                    Tc]Tc-lornoxicam as a potential COX-assisted radiopharmaceutical for inflammation imaging"],"prefix":"10.1039","volume":"16","author":[{"given":"Atifa","family":"Batool","sequence":"first","affiliation":[{"name":"Department of Chemistry, Government College University Faisalabad, Faisalabad-38040, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Jabar","sequence":"additional","affiliation":[{"name":"Punjab Institute of Nuclear Medicine (PINUM), Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Minahal","family":"Fatima","sequence":"additional","affiliation":[{"name":"CIMS Dental College, CMH Institute of Medical Sciences, Multan, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Muhammad","family":"Waji-Ul-Hassan","sequence":"additional","affiliation":[{"name":"Allama Iqbal Medical College, Lahore-54550, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayyar","family":"Rubab","sequence":"additional","affiliation":[{"name":"Punjab Institute of Nuclear Medicine (PINUM), Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz Kush","family":"Naseeb Ahmad","sequence":"additional","affiliation":[{"name":"Punjab Institute of Nuclear Medicine (PINUM), Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Fawzy","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouf","family":"Aldawood","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, P.O.Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahani O.","family":"Alkahtani","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz A.","family":"Alshihri","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-5669","authenticated-orcid":false,"given":"Nadeem Ahmad","family":"Lodhi","sequence":"additional","affiliation":[{"name":"Isotope Production Division, Pakistan Institute of Nuclear Science & Technology (PINSTECH), P. O. Nilore, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-9066","authenticated-orcid":false,"given":"Syed Ali","family":"Raza Naqvi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Government College University Faisalabad, Faisalabad-38040, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"7","key":"D6RA08252A\/cit1\/1","doi-asserted-by":"crossref","first-page":"e70262","DOI":"10.1002\/mco2.70262","volume":"6","author":"Song","year":"2025","journal-title":"MedComm"},{"key":"D6RA08252A\/cit2\/1","doi-asserted-by":"crossref","first-page":"7167","DOI":"10.2147\/JIR.S518155","volume":"18","author":"Jiang","year":"2025","journal-title":"J. Inflammation Res."},{"issue":"2","key":"D6RA08252A\/cit3\/1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pharmthera.2012.05.006","volume":"135","author":"Dorward","year":"2012","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"D6RA08252A\/cit4\/1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s12012-020-09576-4","volume":"20","author":"Wei","year":"2020","journal-title":"Cardiovasc. Toxicol."},{"issue":"6","key":"D6RA08252A\/cit5\/1","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1109\/TCBB.2022.3143770","volume":"19","author":"Li","year":"2022","journal-title":"IEEE\/ACM Trans. Comput. Biol. Bioinf."},{"issue":"5","key":"D6RA08252A\/cit6\/1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s00044-026-03570-1","volume":"35","author":"Jia","year":"2026","journal-title":"Med. Chem. Res."},{"issue":"1","key":"D6RA08252A\/cit7\/1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12951-024-02446-z","volume":"22","author":"Wang","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"6","key":"D6RA08252A\/cit8\/1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/08923973.2024.2402338","volume":"46","author":"He","year":"2024","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"7","key":"D6RA08252A\/cit9\/1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/cells14070488","volume":"14","author":"Nishida","year":"2025","journal-title":"Cells"},{"issue":"2","key":"D6RA08252A\/cit10\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/cbdd.13393","volume":"93","author":"Khan","year":"2019","journal-title":"Chem. Biol. Drug Des."},{"issue":"1","key":"D6RA08252A\/cit11\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s44303-025-00126-7","volume":"3","author":"Dvorakova Bendova","year":"2025","journal-title":"npj Imaging"},{"issue":"5","key":"D6RA08252A\/cit12\/1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/RLU.0000000000002525","volume":"44","author":"Usmani","year":"2019","journal-title":"Clin. Nucl. Med."},{"key":"D6RA08252A\/cit13\/1","doi-asserted-by":"crossref","first-page":"1452558","DOI":"10.3389\/fphys.2024.1452558","volume":"15","author":"Guo","year":"2024","journal-title":"Front. Physiol."},{"issue":"9","key":"D6RA08252A\/cit14\/1","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1007\/s00259-024-06732-8","volume":"51","author":"Hess","year":"2024","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"4","key":"D6RA08252A\/cit15\/1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s40336-021-00445-w","volume":"9","author":"Casali","year":"2021","journal-title":"Clin. Transl. Imaging"},{"issue":"7","key":"D6RA08252A\/cit16\/1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2174\/1381612824666171129200611","volume":"24","author":"Vorster","year":"2018","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"D6RA08252A\/cit17\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11307-019-01366-x","volume":"22","author":"Xu","year":"2020","journal-title":"Mol. Imaging Biol."},{"issue":"2","key":"D6RA08252A\/cit18\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1053\/j.semnuclmed.2017.10.003","volume":"48","author":"Salmanoglu","year":"2018","journal-title":"Semin. Nucl. Med."},{"issue":"6","key":"D6RA08252A\/cit19\/1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s40336-013-0041-z","volume":"1","author":"Palestro","year":"2013","journal-title":"Clin. Transl. Imaging"},{"key":"D6RA08252A\/cit20\/1","first-page":"205","volume-title":"Profiles of Drug Substances, Excipients and Related Methodology","author":"Ahmed","year":"2011","unstructured":"M. O.Ahmed  and  A. A.Al-Badr ,  Chapter 6 - Lornoxicam , in  Profiles of Drug Substances, Excipients and Related Methodology , ed.  H. G. Brittain ,  Academic Press ,  2011 .  pp. 205\u2013239"},{"issue":"6","key":"D6RA08252A\/cit21\/1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2165\/00003088-199834060-00001","volume":"34","author":"Skjodt","year":"1998","journal-title":"Clin. Pharmacokinet."},{"issue":"1","key":"D6RA08252A\/cit22\/1","first-page":"8421657","volume":"2020","author":"Pirooznia","year":"2020","journal-title":"Contrast Media Mol. Imaging"},{"issue":"10","key":"D6RA08252A\/cit23\/1","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3390\/ph17101283","volume":"17","author":"Saleem","year":"2024","journal-title":"Pharmaceuticals"},{"key":"D6RA08252A\/cit24\/1","doi-asserted-by":"crossref","first-page":"1020387","DOI":"10.3389\/fchem.2022.1020387","volume":"10","author":"Naqvi","year":"2022","journal-title":"Front. Chem."},{"issue":"1","key":"D6RA08252A\/cit25\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/cbdd.13923","volume":"99","author":"Naqvi","year":"2022","journal-title":"Chem. Biol. Drug Des."},{"issue":"42","key":"D6RA08252A\/cit26\/1","doi-asserted-by":"crossref","first-page":"14452","DOI":"10.1039\/C7DT01189J","volume":"46","author":"Naqvi","year":"2017","journal-title":"Dalton Trans."},{"issue":"11","key":"D6RA08252A\/cit27\/1","first-page":"1041","volume":"23","author":"Jones","year":"1982","journal-title":"J. Nucl. Med."},{"issue":"1","key":"D6RA08252A\/cit28\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ajme.2014.09.004","volume":"51","author":"Qadir","year":"2015","journal-title":"Alexandria J. Med."},{"issue":"8\u20139","key":"D6RA08252A\/cit29\/1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1524\/ract.2012.1964","volume":"100","author":"Carroll","year":"2012","journal-title":"Radiochim. Acta"},{"key":"D6RA08252A\/cit30\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.comptc.2013.09.011","volume":"1023","author":"Nathavad","year":"2013","journal-title":"Comput. Theor. Chem."},{"key":"D6RA08252A\/cit31\/1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.saa.2013.11.069","volume":"122","author":"Mahmoud","year":"2014","journal-title":"Spectrochim. Acta, Part A"},{"issue":"7","key":"D6RA08252A\/cit32\/1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/jlcr.3396","volume":"59","author":"Erfani","year":"2016","journal-title":"J. Labelled Compd. Radiopharm."},{"issue":"3","key":"D6RA08252A\/cit33\/1","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1007\/s11033-019-04762-2","volume":"46","author":"Khan","year":"2019","journal-title":"Mol. Biol. Rep."},{"issue":"24","key":"D6RA08252A\/cit34\/1","doi-asserted-by":"crossref","first-page":"12030","DOI":"10.1021\/acs.chemrev.5c00641","volume":"125","author":"Boros","year":"2025","journal-title":"Chem. Rev."},{"key":"D6RA08252A\/cit35\/1","doi-asserted-by":"crossref","first-page":"121220","DOI":"10.1016\/j.talanta.2020.121220","volume":"219","author":"Moein","year":"2020","journal-title":"Talanta"},{"issue":"2","key":"D6RA08252A\/cit36\/1","first-page":"2442","volume":"17","author":"Papachristou","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"D6RA08252A\/cit37\/1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3390\/inorganics6040130","volume":"6","author":"Klose","year":"2018","journal-title":"Inorganics"},{"issue":"5","key":"D6RA08252A\/cit38\/1","doi-asserted-by":"crossref","first-page":"e00173","DOI":"10.1002\/prp2.173","volume":"3","author":"Harrell","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"issue":"9","key":"D6RA08252A\/cit39\/1","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.3390\/ijms23095023","volume":"23","author":"Cri\u015fan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"D6RA08252A\/cit40\/1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1021\/acsomega.5c08741","volume":"11","author":"Battal-Kaplan","year":"2026","journal-title":"ACS Omega"},{"issue":"2","key":"D6RA08252A\/cit41\/1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02993710","volume":"16","author":"Arano","year":"2002","journal-title":"Ann. Nucl. Med."},{"issue":"17","key":"D6RA08252A\/cit42\/1","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1016\/j.bmcl.2018.07.011","volume":"28","author":"Moon","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"7","key":"D6RA08252A\/cit43\/1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s000110050474","volume":"48","author":"Berg","year":"1999","journal-title":"Inflammation Res."},{"issue":"8","key":"D6RA08252A\/cit44\/1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/03639045.2023.2235009","volume":"49","author":"Durkan","year":"2023","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"3","key":"D6RA08252A\/cit45\/1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10967-009-7483-9","volume":"280","author":"Amin","year":"2009","journal-title":"J. Radioanal. Nucl. Chem."},{"issue":"1","key":"D6RA08252A\/cit46\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10967-005-0880-9","volume":"266","author":"El-Ghany","year":"2005","journal-title":"J. Radioanal. Nucl. Chem."},{"issue":"1","key":"D6RA08252A\/cit47\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/informatics1010072","volume":"1","author":"Eggleston","year":"2014","journal-title":"Informatics"},{"issue":"6","key":"D6RA08252A\/cit48\/1","first-page":"920","volume":"44","author":"Sarda","year":"2003","journal-title":"J.\nNucl. Med."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/RA\/article-pdf\/doi\/10.1039\/D6RA08252A\/0\/D6RA08252A.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:45:08Z","timestamp":1792593908000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/RA\/article-lookup\/doi\/10.1039\/D6RA08252A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":48,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2026,10,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d6ra08252a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6RA08252A\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA08252A\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA08252A\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA08252A\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6RA08252A\/v1\/review1","asserted-by":"object"}]},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}