{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:47:09Z","timestamp":1782985629014,"version":"3.54.5"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"25","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":133,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>In this work we demonstrate that relaxivity, and by extension image contrast, can be modulated by an AND-logic polymeric gate at a mesoporous silica interface that is responsive to both low pH and hypoxic microenvironments.<\/jats:p>","DOI":"10.1039\/d6sc01039c","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:02:29Z","timestamp":1778760149000},"page":"12589-12596","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AND-logic MRI contrast by water flux modulation"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5917-1106","authenticated-orcid":false,"given":"James P.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6091-2189","authenticated-orcid":false,"given":"Connor M.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-0707","authenticated-orcid":false,"given":"Anna M.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-1709","authenticated-orcid":false,"given":"Jason J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC01039C\/cit1\/1","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1002\/jmri.26211","volume":"49","author":"van Beek","year":"2019","journal-title":"J. Magn. Reson. Imaging"},{"key":"D6SC01039C\/cit2\/1","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1118\/1.3618730","volume":"38","author":"Goerner","year":"2011","journal-title":"Med. Phys."},{"key":"D6SC01039C\/cit3\/1","doi-asserted-by":"crossref","first-page":"17025","DOI":"10.1021\/jacs.9b09149","volume":"141","author":"Li","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC01039C\/cit4\/1","doi-asserted-by":"crossref","first-page":"10727","DOI":"10.1002\/chem.201000499","volume":"16","author":"Carniato","year":"2010","journal-title":"Chem.\u2013Eur. J."},{"key":"D6SC01039C\/cit5\/1","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1021\/ja710193c","volume":"130","author":"Taylor","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC01039C\/cit6\/1","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.3390\/ma13173795","volume":"13","author":"Yuan","year":"2020","journal-title":"Materials"},{"key":"D6SC01039C\/cit7\/1","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.3390\/ma12244096","volume":"12","author":"Ellis","year":"2019","journal-title":"Materials"},{"key":"D6SC01039C\/cit8\/1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1039\/D2CC06255K","volume":"59","author":"Ellis","year":"2023","journal-title":"Chem. Commun."},{"key":"D6SC01039C\/cit9\/1","doi-asserted-by":"crossref","first-page":"e2001091","DOI":"10.1002\/adhm.202001091","volume":"10","author":"Fu","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"D6SC01039C\/cit10\/1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1063\/1.1731684","volume":"34","author":"Bloembergen","year":"1961","journal-title":"J. Chem. Phys."},{"key":"D6SC01039C\/cit11\/1","doi-asserted-by":"crossref","first-page":"8540","DOI":"10.1039\/C9CC03312B","volume":"55","author":"Pellico","year":"2019","journal-title":"Chem. Commun."},{"key":"D6SC01039C\/cit12\/1","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1161\/HYPERTENSIONAHA.109.147066","volume":"55","author":"Zhang","year":"2010","journal-title":"Hypertension"},{"key":"D6SC01039C\/cit13\/1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trecan.2023.10.002","volume":"10","author":"Ge","year":"2024","journal-title":"Trends Cancer"},{"key":"D6SC01039C\/cit14\/1","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1002\/cmdc.201402034","volume":"9","author":"Do","year":"2014","journal-title":"ChemMedChem"},{"key":"D6SC01039C\/cit15\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/ph14010069","volume":"14","author":"Nwasike","year":"2021","journal-title":"Pharmaceuticals"},{"key":"D6SC01039C\/cit16\/1","doi-asserted-by":"crossref","first-page":"9218","DOI":"10.1002\/anie.201503863","volume":"54","author":"Wu","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC01039C\/cit17\/1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0090-9556(25)08391-6","volume":"22","author":"Zbaida","year":"1994","journal-title":"Drug Metab. Dispos."},{"key":"D6SC01039C\/cit18\/1","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1021\/acs.langmuir.8b04268","volume":"35","author":"Santos","year":"2019","journal-title":"Langmuir"},{"key":"D6SC01039C\/cit19\/1","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/0360-3016(85)90217-2","volume":"11","author":"Thistlethwaite","year":"1985","journal-title":"Int. J. Radiat. Oncol., Biol., Phys."},{"key":"D6SC01039C\/cit20\/1","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1039\/C4SM00596A","volume":"10","author":"Besnard","year":"2014","journal-title":"Soft Matter"},{"key":"D6SC01039C\/cit21\/1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2967\/jnumed.109.068981","volume":"51","author":"Zhang","year":"2010","journal-title":"J. Nucl. Med."},{"key":"D6SC01039C\/cit22\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2020.08.011","volume":"312","author":"Lee-Rueckert","year":"2020","journal-title":"Atherosclerosis"},{"key":"D6SC01039C\/cit23\/1","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1039\/D3CC01205K","volume":"59","author":"Yuan","year":"2023","journal-title":"Chem. Commun."},{"key":"D6SC01039C\/cit24\/1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1039\/C2CC37545A","volume":"49","author":"Huang","year":"2013","journal-title":"Chem. Commun."},{"key":"D6SC01039C\/cit25\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.biomaterials.2018.09.020","volume":"185","author":"Eom","year":"2018","journal-title":"Biomaterials"},{"key":"D6SC01039C\/cit26\/1","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1021\/acs.bioconjchem.1c00492","volume":"32","author":"Kanwal","year":"2021","journal-title":"Bioconjugate Chem."},{"key":"D6SC01039C\/cit27\/1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1021\/acs.biomac.5b01614","volume":"17","author":"Sigg","year":"2016","journal-title":"Biomacromolecules"},{"key":"D6SC01039C\/cit28\/1","doi-asserted-by":"crossref","first-page":"9937","DOI":"10.1039\/C6CC03396B","volume":"52","author":"Sigg","year":"2016","journal-title":"Chem. Commun."},{"key":"D6SC01039C\/cit29\/1","doi-asserted-by":"crossref","first-page":"13613","DOI":"10.1038\/s41598-020-70396-1","volume":"10","author":"Piasentin","year":"2020","journal-title":"Sci. Rep."},{"key":"D6SC01039C\/cit30\/1","doi-asserted-by":"crossref","first-page":"114534","DOI":"10.1016\/j.colsurfb.2025.114534","volume":"249","author":"Guo","year":"2025","journal-title":"Colloids Surf., B"},{"key":"D6SC01039C\/cit31\/1","doi-asserted-by":"crossref","first-page":"22848","DOI":"10.1039\/c2jm35116a","volume":"22","author":"Davis","year":"2012","journal-title":"J. Mater. Chem."},{"key":"D6SC01039C\/cit32\/1","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1039\/c1py00173f","volume":"2","author":"Skrabania","year":"2011","journal-title":"Polym. Chem."},{"key":"D6SC01039C\/cit33\/1","doi-asserted-by":"crossref","first-page":"154551","DOI":"10.1016\/j.apsusc.2022.154551","volume":"607","author":"Avval","year":"2023","journal-title":"Appl. Surf. Sci."},{"key":"D6SC01039C\/cit34\/1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1021\/acsmacrolett.9b00089","volume":"8","author":"Li","year":"2019","journal-title":"ACS Macro Lett."},{"key":"D6SC01039C\/cit35\/1","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1039\/C5PY00525F","volume":"6","author":"Wu","year":"2015","journal-title":"Polym. Chem."},{"key":"D6SC01039C\/cit36\/1","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1039\/C4SM02242D","volume":"11","author":"Min","year":"2015","journal-title":"Soft Matter"},{"key":"D6SC01039C\/cit37\/1","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1021\/la063450z","volume":"23","author":"Sanjuan","year":"2007","journal-title":"Langmuir"},{"key":"D6SC01039C\/cit38\/1","doi-asserted-by":"crossref","first-page":"e1626508","DOI":"10.1080\/00268976.2019.1626508","volume":"118","author":"Wahab","year":"2020","journal-title":"Mol. Phys."},{"key":"D6SC01039C\/cit39\/1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1039\/C9QM00450E","volume":"4","author":"Wang","year":"2020","journal-title":"Mater. Chem. Front."},{"key":"D6SC01039C\/cit40\/1","doi-asserted-by":"crossref","first-page":"1044927","DOI":"10.3389\/fbioe.2022.1044927","volume":"10","author":"Purohit","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D6SC01039C\/cit41\/1","doi-asserted-by":"crossref","first-page":"e202400595","DOI":"10.1002\/cctc.202400595","volume":"16","author":"Bilyj","year":"2024","journal-title":"ChemCatChem"},{"key":"D6SC01039C\/cit42\/1","doi-asserted-by":"crossref","first-page":"13902","DOI":"10.1021\/bi0509346","volume":"44","author":"Davydov","year":"2005","journal-title":"Biochemistry"},{"key":"D6SC01039C\/cit43\/1","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1021\/acs.langmuir.1c02224","volume":"38","author":"Salminen","year":"2022","journal-title":"Langmuir"},{"key":"D6SC01039C\/cit44\/1","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/pola.28621","volume":"55","author":"Foster","year":"2017","journal-title":"J. Polym. Sci., Part A: Polym. Chem."},{"key":"D6SC01039C\/cit45\/1","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.biomaterials.2013.11.057","volume":"35","author":"Yang","year":"2014","journal-title":"Biomaterials"},{"key":"D6SC01039C\/cit46\/1","doi-asserted-by":"crossref","first-page":"21335","DOI":"10.1038\/srep21335","volume":"6","author":"Tian","year":"2016","journal-title":"Sci. Rep."},{"key":"D6SC01039C\/cit47\/1","doi-asserted-by":"crossref","first-page":"224901","DOI":"10.1063\/1.2743963","volume":"126","author":"Ju","year":"2007","journal-title":"J. Chem. Phys."},{"key":"D6SC01039C\/cit48\/1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3390\/pr7110805","volume":"7","author":"Nguyen-Thi","year":"2019","journal-title":"Processes"},{"key":"D6SC01039C\/cit49\/1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/s41467-019-09158-1","volume":"10","author":"Fan","year":"2019","journal-title":"Nat. Commun."},{"key":"D6SC01039C\/cit50\/1","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1021\/acsami.6b13876","volume":"9","author":"Li","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6SC01039C\/cit51\/1","doi-asserted-by":"crossref","first-page":"14122","DOI":"10.1039\/C7NJ02804K","volume":"41","author":"Rahman","year":"2017","journal-title":"New J. Chem."},{"key":"D6SC01039C\/cit52\/1","doi-asserted-by":"crossref","first-page":"110543","DOI":"10.1016\/j.micromeso.2020.110543","volume":"309","author":"Nguyen","year":"2020","journal-title":"Microporous Mesoporous Mater."},{"key":"D6SC01039C\/cit53\/1","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1007\/s11696-023-02734-2","volume":"77","author":"Xue","year":"2023","journal-title":"Chem. Pap."},{"key":"D6SC01039C\/cit54\/1","doi-asserted-by":"crossref","first-page":"13937","DOI":"10.1039\/D3SC03466F","volume":"15","author":"Duncan","year":"2024","journal-title":"Chem. Sci."},{"key":"D6SC01039C\/cit55\/1","doi-asserted-by":"crossref","first-page":"6985","DOI":"10.1021\/ic5008928","volume":"53","author":"Boros","year":"2014","journal-title":"Inorg. Chem."},{"key":"D6SC01039C\/cit56\/1","doi-asserted-by":"crossref","first-page":"10897","DOI":"10.1021\/acs.inorgchem.4c00972","volume":"63","author":"Oliveira","year":"2024","journal-title":"Inorg. Chem."},{"key":"D6SC01039C\/cit57\/1","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/jmri.21969","volume":"30","author":"Aime","year":"2009","journal-title":"J. Magn. Reson. Imaging"},{"key":"D6SC01039C\/cit58\/1","doi-asserted-by":"crossref","first-page":"103106","DOI":"10.1016\/j.bioorg.2019.103106","volume":"91","author":"Lei","year":"2019","journal-title":"Bioorg. Chem."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/SC\/D6SC01039C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:29:35Z","timestamp":1782984575000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D6SC01039C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":58,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,7,2]]}},"URL":"https:\/\/doi.org\/10.1039\/d6sc01039c","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}