{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:23:53Z","timestamp":1787135033422,"version":"build-2736575974"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"32","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":160,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22338005"],"award-info":[{"award-number":["22338005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22494701"],"award-info":[{"award-number":["22494701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20619"],"award-info":[{"award-number":["U25A20619"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22574041"],"award-info":[{"award-number":["22574041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["JYB2025XDXM414"],"award-info":[{"award-number":["JYB2025XDXM414"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>Mitochondrial dysfunction and lipid peroxidation converge with caspase1-GSDMD activation to trigger pyroptosis and GPX4\/GSH inactivation-driven ferroptosis, leading to amplified cell death and DAMP release.<\/jats:p>","DOI":"10.1039\/d6sc02492k","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:43:19Z","timestamp":1781091799000},"page":"15420-15431","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Invoking ferroptosis and photon-controlled pyroptosis\n                    <i>via<\/i>\n                    an integrated therapeutic system for triple-pathway tumor therapy"],"prefix":"10.1039","volume":"17","author":[{"given":"Xue","family":"Lou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkai","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering and Environment, Weifang University of Science and Technology, Weifang 262700, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwang","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Henan International Joint Laboratory of Smart Molecules and Identification and Diagnostic Functions, Henan Normal University, Henan 453007, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-5186","authenticated-orcid":false,"given":"Jiangli","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-322X","authenticated-orcid":false,"given":"Xiaojun","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC02492K\/cit1\/1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"key":"D6SC02492K\/cit2\/1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"key":"D6SC02492K\/cit3\/1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41392-022-01110-y","volume":"7","author":"Peng","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"D6SC02492K\/cit4\/1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1515\/jtim-2025-0004","volume":"13","author":"Guo","year":"2025","journal-title":"J. Transl. Intern. Med."},{"key":"D6SC02492K\/cit5\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12943-024-01999-9","volume":"23","author":"Diao","year":"2024","journal-title":"Mol. Cancer"},{"key":"D6SC02492K\/cit6\/1","doi-asserted-by":"crossref","first-page":"2406150","DOI":"10.1002\/adfm.202406150","volume":"34","author":"Du","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D6SC02492K\/cit7\/1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13014-022-02171-7","volume":"17","author":"Chen","year":"2022","journal-title":"Radiat. Oncol."},{"key":"D6SC02492K\/cit8\/1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41571-020-0341-y","volume":"17","author":"Carneiro","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D6SC02492K\/cit9\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13045-021-01184-1","volume":"14","author":"He","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"D6SC02492K\/cit10\/1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s12943-024-02172-y","volume":"23","author":"He","year":"2024","journal-title":"Mol. Cancer"},{"key":"D6SC02492K\/cit11\/1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"D6SC02492K\/cit12\/1","doi-asserted-by":"crossref","first-page":"217272","DOI":"10.1016\/j.canlet.2024.217272","volume":"604","author":"Huang","year":"2024","journal-title":"Cancer Lett."},{"key":"D6SC02492K\/cit13\/1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3390\/cancers14071671","volume":"14","author":"Cetraro","year":"2022","journal-title":"Cancers"},{"key":"D6SC02492K\/cit14\/1","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.3390\/cimb46060322","volume":"46","author":"Mirzayans","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"D6SC02492K\/cit15\/1","doi-asserted-by":"crossref","first-page":"16658","DOI":"10.1021\/jacs.3c04180","volume":"145","author":"Zhang","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC02492K\/cit16\/1","doi-asserted-by":"crossref","first-page":"2407713","DOI":"10.1002\/advs.202407713","volume":"12","author":"Huo","year":"2025","journal-title":"Advanced Science"},{"key":"D6SC02492K\/cit17\/1","doi-asserted-by":"crossref","first-page":"e202415735","DOI":"10.1002\/anie.202415735","volume":"64","author":"Ji","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC02492K\/cit18\/1","doi-asserted-by":"crossref","first-page":"9471","DOI":"10.1126\/sciadv.abi9471","volume":"7","author":"Zhang","year":"2021","journal-title":"Sci. Adv."},{"key":"D6SC02492K\/cit19\/1","doi-asserted-by":"crossref","first-page":"2302961","DOI":"10.1002\/adma.202302961","volume":"35","author":"Xu","year":"2023","journal-title":"Adv. Mater."},{"key":"D6SC02492K\/cit20\/1","doi-asserted-by":"crossref","first-page":"9756","DOI":"10.1039\/D4SC00643G","volume":"15","author":"Ma","year":"2024","journal-title":"Chem. Sci."},{"key":"D6SC02492K\/cit21\/1","doi-asserted-by":"crossref","first-page":"e202419376","DOI":"10.1002\/anie.202419376","volume":"64","author":"Liang","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC02492K\/cit22\/1","doi-asserted-by":"crossref","first-page":"e20240005","DOI":"10.1002\/smo.20240005","volume":"2","author":"Huang","year":"2024","journal-title":"Smart Mol."},{"key":"D6SC02492K\/cit23\/1","doi-asserted-by":"crossref","first-page":"e20250002","DOI":"10.1002\/smo.20250002","volume":"3","author":"Zhao","year":"2025","journal-title":"Smart Mol."},{"key":"D6SC02492K\/cit24\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/cancers9020019","volume":"9","author":"Van","year":"2017","journal-title":"Cancers"},{"key":"D6SC02492K\/cit25\/1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3390\/jcm9020483","volume":"9","author":"Banerjee","year":"2020","journal-title":"J. Clin. Med."},{"key":"D6SC02492K\/cit26\/1","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1021\/jacs.3c01231","volume":"145","author":"Li","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC02492K\/cit27\/1","doi-asserted-by":"crossref","first-page":"e202417899","DOI":"10.1002\/anie.202417899","volume":"64","author":"Zeng","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC02492K\/cit28\/1","first-page":"26140","volume":"18","author":"Peng","year":"2024","journal-title":"ACS Nano"},{"key":"D6SC02492K\/cit29\/1","doi-asserted-by":"crossref","first-page":"2415078","DOI":"10.1002\/adma.202415078","volume":"37","author":"Zhong","year":"2025","journal-title":"Adv. Mater."},{"key":"D6SC02492K\/cit30\/1","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1038\/s41467-025-59307-y","volume":"16","author":"Teng","year":"2025","journal-title":"Nat. Commun."},{"key":"D6SC02492K\/cit31\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cell.2024.11.018","volume":"188","author":"Wright","year":"2025","journal-title":"Cell"},{"key":"D6SC02492K\/cit32\/1","doi-asserted-by":"crossref","first-page":"2306419","DOI":"10.1002\/adma.202306419","volume":"36","author":"Ding","year":"2024","journal-title":"Adv. Mater."},{"key":"D6SC02492K\/cit33\/1","doi-asserted-by":"crossref","first-page":"2415673","DOI":"10.1002\/adma.202415673","volume":"37","author":"Wang","year":"2025","journal-title":"Adv. Mater."},{"key":"D6SC02492K\/cit34\/1","doi-asserted-by":"crossref","first-page":"2210037","DOI":"10.1002\/adma.202210037","volume":"35","author":"Cheng","year":"2023","journal-title":"Adv. Mater."},{"key":"D6SC02492K\/cit35\/1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41467-025-55905-y","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"D6SC02492K\/cit36\/1","doi-asserted-by":"crossref","first-page":"8971","DOI":"10.1038\/s41467-024-53380-5","volume":"15","author":"Xia","year":"2024","journal-title":"Nat. Commun."},{"key":"D6SC02492K\/cit37\/1","doi-asserted-by":"crossref","first-page":"2312316","DOI":"10.1002\/adma.202312316","volume":"36","author":"Wang","year":"2024","journal-title":"Adv. Mater."},{"key":"D6SC02492K\/cit38\/1","doi-asserted-by":"crossref","first-page":"e202400829","DOI":"10.1002\/anie.202400829","volume":"63","author":"Zhao","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC02492K\/cit39\/1","doi-asserted-by":"crossref","first-page":"7945","DOI":"10.1021\/acsnano.3c10133","volume":"18","author":"Liu","year":"2024","journal-title":"ACS Nano"},{"key":"D6SC02492K\/cit40\/1","doi-asserted-by":"crossref","first-page":"28783","DOI":"10.1021\/jacs.4c07785","volume":"146","author":"Wang","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC02492K\/cit41\/1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/d41586-025-01337-z","volume":"642","author":"Lange","year":"2025","journal-title":"Nature"},{"key":"D6SC02492K\/cit42\/1","doi-asserted-by":"crossref","first-page":"2404753","DOI":"10.1002\/advs.202404753","volume":"11","author":"Liang","year":"2024","journal-title":"Adv. Sci."},{"key":"D6SC02492K\/cit43\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41586-023-06269-0","volume":"619","author":"Mishima","year":"2023","journal-title":"Nature"},{"key":"D6SC02492K\/cit44\/1","doi-asserted-by":"crossref","first-page":"12261","DOI":"10.1021\/acsnano.4c00844","volume":"18","author":"Fan","year":"2024","journal-title":"ACS Nano"},{"key":"D6SC02492K\/cit45\/1","doi-asserted-by":"crossref","first-page":"e202501530","DOI":"10.1002\/anie.202501530","volume":"64","author":"Chen","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC02492K\/cit46\/1","doi-asserted-by":"crossref","first-page":"e17616","DOI":"10.1002\/advs.202417616","volume":"12","author":"Liu","year":"2025","journal-title":"Adv. Sci."},{"key":"D6SC02492K\/cit47\/1","doi-asserted-by":"crossref","first-page":"7945","DOI":"10.1021\/acsnano.3c10133","volume":"18","author":"Liu","year":"2024","journal-title":"ACS Nano"},{"key":"D6SC02492K\/cit48\/1","doi-asserted-by":"crossref","first-page":"e71138","DOI":"10.1111\/jcmm.71138","volume":"30","author":"Zhao","year":"2026","journal-title":"J. Cell. Mol. Med."},{"key":"D6SC02492K\/cit49\/1","doi-asserted-by":"crossref","first-page":"11132","DOI":"10.1021\/jacs.4c17268","volume":"147","author":"Yao","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC02492K\/cit50\/1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41392-026-02607-6","volume":"11","author":"Wang","year":"2026","journal-title":"Signal Transduct. Targeted Ther."},{"key":"D6SC02492K\/cit51\/1","doi-asserted-by":"crossref","first-page":"2202085","DOI":"10.1002\/adhm.202202085","volume":"12","author":"Chen","year":"2023","journal-title":"Adv. Healthcare Mater."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC02492K\/0\/D6SC02492K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:25:39Z","timestamp":1787131539000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D6SC02492K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":51,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2026,8,19]]}},"URL":"https:\/\/doi.org\/10.1039\/d6sc02492k","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6SC02492K\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC02492K\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC02492K\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC02492K\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC02492K\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC02492K\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC02492K\/v1\/review1","asserted-by":"object"}]},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}