{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:07:50Z","timestamp":1789657670834,"version":"4.0.1"},"reference-count":41,"publisher":"Royal Society of Chemistry (RSC)","issue":"35","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":194,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22127803"],"award-info":[{"award-number":["22127803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22574128"],"award-info":[{"award-number":["22574128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SY6J007"],"award-info":[{"award-number":["SY6J007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["Q2022203"],"award-info":[{"award-number":["Q2022203"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>SECM was applied to investigate the changes in GSH efflux and membrane permeability of astrocytes under dynamic mechanical-hypoxic microenvironment.<\/jats:p>","DOI":"10.1039\/d6sc03951k","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:23:12Z","timestamp":1784046192000},"page":"16830-16841","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrochemical monitoring of early astrocytic responses underlying the synergistic effect of extracellular matrix softening and hypoxia"],"prefix":"10.1039","volume":"17","author":[{"given":"Siyu","family":"Zhang","sequence":"first","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Liu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingsi","family":"Yan","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Song","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-4025","authenticated-orcid":false,"given":"Kosuke","family":"Ino","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2081-8339","authenticated-orcid":false,"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC03951K\/cit1\/1","doi-asserted-by":"crossref","first-page":"102319","DOI":"10.1016\/j.xcrm.2025.102319","volume":"6","author":"Wang","year":"2025","journal-title":"Cell Rep. Med."},{"key":"D6SC03951K\/cit2\/1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.neuron.2015.02.041","volume":"85","author":"Hemphill","year":"2015","journal-title":"Neuron"},{"key":"D6SC03951K\/cit3\/1","doi-asserted-by":"crossref","first-page":"eadr5300","DOI":"10.1126\/scitranslmed.adr5300","volume":"17","author":"Cui","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"D6SC03951K\/cit4\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41427-021-00304-0","volume":"13","author":"Hu","year":"2021","journal-title":"NPG Asia Mater."},{"key":"D6SC03951K\/cit5\/1","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.7150\/thno.88223","volume":"14","author":"Madai","year":"2024","journal-title":"Theranostics"},{"key":"D6SC03951K\/cit6\/1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.redox.2018.02.010","volume":"16","author":"Fr\u00f8yset","year":"2018","journal-title":"Redox Biol."},{"key":"D6SC03951K\/cit7\/1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41582-023-00792-4","volume":"19","author":"Fontana","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"D6SC03951K\/cit8\/1","doi-asserted-by":"crossref","first-page":"101576","DOI":"10.1016\/j.redox.2020.101576","volume":"34","author":"Huang","year":"2020","journal-title":"Redox Biol."},{"key":"D6SC03951K\/cit9\/1","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.4103\/1673-5374.257520","volume":"14","author":"Linseman","year":"2019","journal-title":"Neural Regener. Res."},{"key":"D6SC03951K\/cit10\/1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.expneurol.2015.03.020","volume":"275","author":"Burda","year":"2016","journal-title":"Exp. Neurol."},{"key":"D6SC03951K\/cit11\/1","doi-asserted-by":"crossref","first-page":"102690","DOI":"10.1016\/j.redox.2023.102690","volume":"62","author":"Sun","year":"2023","journal-title":"Redox Biol."},{"key":"D6SC03951K\/cit12\/1","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1089\/ars.2012.4553","volume":"17","author":"Franco","year":"2012","journal-title":"Antioxid. Redox Signaling"},{"key":"D6SC03951K\/cit13\/1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41423-019-0213-5","volume":"16","author":"Shi","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"D6SC03951K\/cit14\/1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tins.2016.10.007","volume":"40","author":"Van Horn","year":"2017","journal-title":"Trends Neurosci."},{"key":"D6SC03951K\/cit15\/1","doi-asserted-by":"crossref","first-page":"13234","DOI":"10.1021\/acs.chemrev.6b00067","volume":"116","author":"Polcari","year":"2016","journal-title":"Chem. Rev."},{"key":"D6SC03951K\/cit16\/1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1039\/C8AN01490F","volume":"144","author":"Filice","year":"2019","journal-title":"Analyst"},{"key":"D6SC03951K\/cit17\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.aca.2014.06.047","volume":"842","author":"Matsumae","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"D6SC03951K\/cit18\/1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1021\/ac010945e","volume":"74","author":"Cai","year":"2001","journal-title":"Anal. Chem."},{"key":"D6SC03951K\/cit19\/1","doi-asserted-by":"crossref","first-page":"10349","DOI":"10.1039\/D2SC02708A","volume":"13","author":"Kuermanbayi","year":"2022","journal-title":"Chem. Sci."},{"key":"D6SC03951K\/cit20\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1039\/D3SC03504B","volume":"15","author":"Liu","year":"2024","journal-title":"Chem. Sci."},{"key":"D6SC03951K\/cit21\/1","doi-asserted-by":"crossref","first-page":"9249","DOI":"10.1073\/pnas.1214809110","volume":"110","author":"Kuss","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6SC03951K\/cit22\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1750-3639.1994.tb00838.x","volume":"4","author":"Eng","year":"2008","journal-title":"Brain Pathol."},{"key":"D6SC03951K\/cit23\/1","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1038\/s41418-018-0137-0","volume":"25","author":"Yang","year":"2018","journal-title":"Cell Death Differ."},{"key":"D6SC03951K\/cit24\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jneuroim.2006.01.014","volume":"174","author":"Zhang","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"D6SC03951K\/cit25\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCRESAHA.118.313143","volume":"123","author":"Lv","year":"2018","journal-title":"Circ. Res."},{"key":"D6SC03951K\/cit26\/1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.nbd.2011.12.023","volume":"45","author":"Colak","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"D6SC03951K\/cit27\/1","doi-asserted-by":"crossref","first-page":"eabb6260","DOI":"10.1126\/sciadv.abb6260","volume":"7","author":"Li","year":"2021","journal-title":"Sci. Adv."},{"key":"D6SC03951K\/cit28\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"D6SC03951K\/cit29\/1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.celrep.2015.03.053","volume":"11","author":"Endo","year":"2015","journal-title":"Cell Rep."},{"key":"D6SC03951K\/cit30\/1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0301-0082(99)00060-X","volume":"62","author":"Dringen","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"D6SC03951K\/cit31\/1","doi-asserted-by":"crossref","first-page":"20354","DOI":"10.1074\/jbc.273.32.20354","volume":"273","author":"Singh","year":"1998","journal-title":"J. Biol. Chem."},{"key":"D6SC03951K\/cit32\/1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s10571-019-00755-8","volume":"40","author":"Luo","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"D6SC03951K\/cit33\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ces.2018.02.049","volume":"183","author":"Lee","year":"2018","journal-title":"Chem. Eng. Sci."},{"key":"D6SC03951K\/cit34\/1","doi-asserted-by":"crossref","first-page":"12132","DOI":"10.1002\/anie.201705684","volume":"56","author":"Rosales","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC03951K\/cit35\/1","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1021\/acs.analchem.0c05284","volume":"93","author":"Lang","year":"2021","journal-title":"Anal. Chem."},{"key":"D6SC03951K\/cit36\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.aca.2015.12.027","volume":"908","author":"Filice","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"D6SC03951K\/cit37\/1","doi-asserted-by":"crossref","first-page":"9855","DOI":"10.1073\/pnas.97.18.9855","volume":"97","author":"Liu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6SC03951K\/cit38\/1","doi-asserted-by":"crossref","first-page":"2200689","DOI":"10.1002\/smtd.202200689","volume":"6","author":"Zhang","year":"2022","journal-title":"Small Methods"},{"key":"D6SC03951K\/cit39\/1","doi-asserted-by":"crossref","first-page":"e03389","DOI":"10.1002\/advs.202503389","volume":"12","author":"Liu","year":"2025","journal-title":"Adv. Sci."},{"key":"D6SC03951K\/cit40\/1","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1172\/JCI119812","volume":"100","author":"Pahan","year":"1997","journal-title":"J. Clin. Invest."},{"key":"D6SC03951K\/cit41\/1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s10020-024-01025-0","volume":"30","author":"Liu","year":"2024","journal-title":"Mol. Med."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC03951K\/0\/D6SC03951K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:25:51Z","timestamp":1789655151000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D6SC03951K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":41,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d6sc03951k","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}