{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:15:46Z","timestamp":1788372946045,"version":"build-2803163510"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"34","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2022-NR070709"],"award-info":[{"award-number":["RS-2022-NR070709"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2026-25482625"],"award-info":[{"award-number":["RS-2026-25482625"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00411134"],"award-info":[{"award-number":["RS-2024-00411134"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-25403620"],"award-info":[{"award-number":["RS-2025-25403620"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00214034"],"award-info":[{"award-number":["RS-2023-00214034"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>Rationally designed metal\u2013organic macrocycles modulate amyloid-\u03b2 aggregation through dual mechanisms involving direct peptide interactions and photoinduced oxidative modifications, resulting in reduced fibrillization and cytotoxicity.<\/jats:p>","DOI":"10.1039\/d6sc04289a","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:03:12Z","timestamp":1784127792000},"page":"16541-16554","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metal\u2013organic macrocycles as molecular modulators of amyloid-\u03b2 aggregation and cytotoxicity"],"prefix":"10.1039","volume":"17","author":[{"given":"Chanju","family":"Na","sequence":"first","affiliation":[{"name":"Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-8288","authenticated-orcid":false,"given":"Gajendra","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Energy and Chemical Engineering, Incheon National University, Incheon 22012, Republic of Korea"},{"name":"Innovation Center for Chemical Engineering, Incheon National University, Incheon 22012, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1609-4008","authenticated-orcid":false,"given":"Mingeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea"},{"name":"Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4992-6724","authenticated-orcid":false,"given":"Yena","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Energy and Chemical Engineering, Incheon National University, Incheon 22012, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5004-7865","authenticated-orcid":false,"given":"Junseong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-9071","authenticated-orcid":false,"given":"Chang Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Energy and Chemical Engineering, Incheon National University, Incheon 22012, Republic of Korea"},{"name":"Innovation Center for Chemical Engineering, Incheon National University, Incheon 22012, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3377-4996","authenticated-orcid":false,"given":"Mi Hee","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC04289A\/cit1\/1","doi-asserted-by":"crossref","first-page":"216107","DOI":"10.1016\/j.ccr.2024.216107","volume":"519","author":"Wu","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04289A\/cit2\/1","doi-asserted-by":"crossref","first-page":"33330","DOI":"10.1021\/jacs.5c09419","volume":"147","author":"Zhang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04289A\/cit3\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41557-023-01387-8","volume":"16","author":"Benchimol","year":"2024","journal-title":"Nat. Chem."},{"key":"D6SC04289A\/cit4\/1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41570-020-00246-1","volume":"5","author":"Zhang","year":"2021","journal-title":"Nat. Rev. Chem."},{"key":"D6SC04289A\/cit5\/1","doi-asserted-by":"crossref","first-page":"2308589","DOI":"10.1002\/adfm.202308589","volume":"34","author":"Wang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D6SC04289A\/cit6\/1","doi-asserted-by":"crossref","first-page":"1230444","DOI":"10.1126\/science.1230444","volume":"341","author":"Furukawa","year":"2013","journal-title":"Science"},{"key":"D6SC04289A\/cit7\/1","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1039\/D3CS00926B","volume":"53","author":"Xu","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04289A\/cit8\/1","doi-asserted-by":"crossref","first-page":"12147","DOI":"10.1021\/jacs.9b06182","volume":"141","author":"Lavendomme","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04289A\/cit9\/1","doi-asserted-by":"crossref","first-page":"14005","DOI":"10.1021\/jacs.9b06222","volume":"141","author":"Sepehrpour","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04289A\/cit10\/1","doi-asserted-by":"crossref","first-page":"8007","DOI":"10.1002\/anie.201900934","volume":"58","author":"Domarco","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04289A\/cit11\/1","doi-asserted-by":"crossref","first-page":"214308","DOI":"10.1016\/j.ccr.2021.214308","volume":"452","author":"Gupta","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04289A\/cit12\/1","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1039\/C6CC00046K","volume":"52","author":"Gupta","year":"2016","journal-title":"Chem. Commun."},{"key":"D6SC04289A\/cit13\/1","doi-asserted-by":"crossref","first-page":"16161","DOI":"10.1002\/chem.202102745","volume":"27","author":"Herasymchuk","year":"2021","journal-title":"Chem.\u2013Eur. J."},{"key":"D6SC04289A\/cit14\/1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41593-018-0235-9","volume":"21","author":"Soto","year":"2018","journal-title":"Nat. Neurosci."},{"key":"D6SC04289A\/cit15\/1","doi-asserted-by":"crossref","first-page":"102276","DOI":"10.1016\/j.arr.2024.102276","volume":"96","author":"Bashir","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"D6SC04289A\/cit16\/1","doi-asserted-by":"crossref","first-page":"9285","DOI":"10.1021\/acsami.5c20362","volume":"18","author":"Na","year":"2026","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6SC04289A\/cit17\/1","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41580-023-00647-2","volume":"24","author":"Louros","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D6SC04289A\/cit18\/1","doi-asserted-by":"crossref","first-page":"e70266","DOI":"10.1002\/agt2.70266","volume":"7","author":"Lu","year":"2026","journal-title":"Aggregate"},{"key":"D6SC04289A\/cit19\/1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1126\/science.aao2825","volume":"358","author":"Gremer","year":"2017","journal-title":"Science"},{"key":"D6SC04289A\/cit20\/1","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1073\/pnas.1237107100","volume":"100","author":"Hoshi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6SC04289A\/cit21\/1","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.bbadis.2014.06.006","volume":"1842","author":"Diociaiuti","year":"2014","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"D6SC04289A\/cit22\/1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1039\/C6CS00731G","volume":"46","author":"Lee","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04289A\/cit23\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"D6SC04289A\/cit24\/1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"D6SC04289A\/cit25\/1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1021\/acs.inorgchem.3c03441","volume":"63","author":"La Manna","year":"2024","journal-title":"Inorg. Chem."},{"key":"D6SC04289A\/cit26\/1","doi-asserted-by":"crossref","first-page":"14258","DOI":"10.1039\/D4DT01691B","volume":"53","author":"Terpstra","year":"2024","journal-title":"Dalton Trans."},{"key":"D6SC04289A\/cit27\/1","doi-asserted-by":"crossref","first-page":"9485","DOI":"10.1039\/D1SC02273C","volume":"12","author":"Chan","year":"2021","journal-title":"Chem. Sci."},{"key":"D6SC04289A\/cit28\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/jacs.5c14323","volume":"148","author":"Na","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04289A\/cit29\/1","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1039\/D3QI02445H","volume":"11","author":"Kim","year":"2024","journal-title":"Inorg. Chem. Front."},{"key":"D6SC04289A\/cit30\/1","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1021\/jacsau.2c00281","volume":"2","author":"Hong","year":"2022","journal-title":"JACS Au"},{"key":"D6SC04289A\/cit31\/1","doi-asserted-by":"crossref","first-page":"112053","DOI":"10.1016\/j.jinorgbio.2022.112053","volume":"238","author":"Kwak","year":"2023","journal-title":"J. Inorg. Biochem."},{"key":"D6SC04289A\/cit32\/1","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1007\/s12274-016-1127-5","volume":"9","author":"Li","year":"2016","journal-title":"Nano Res."},{"key":"D6SC04289A\/cit33\/1","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1039\/c1dt10489f","volume":"40","author":"Barry","year":"2011","journal-title":"Dalton Trans."},{"key":"D6SC04289A\/cit34\/1","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.3390\/ma6115352","volume":"6","author":"Gupta","year":"2013","journal-title":"Materials"},{"key":"D6SC04289A\/cit35\/1","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1021\/ja502477a","volume":"136","author":"Tamgho","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04289A\/cit36\/1","doi-asserted-by":"crossref","first-page":"124197","DOI":"10.1016\/j.ijbiomac.2023.124197","volume":"239","author":"Singh","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"D6SC04289A\/cit37\/1","doi-asserted-by":"crossref","first-page":"14619","DOI":"10.1038\/srep14619","volume":"5","author":"Lu","year":"2015","journal-title":"Sci. Rep."},{"key":"D6SC04289A\/cit38\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0010-8545(02)00312-0","volume":"236","author":"Clarke","year":"2003","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04289A\/cit39\/1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.saa.2019.02.097","volume":"215","author":"Mallah","year":"2019","journal-title":"Spectrochim. Acta, Part A"},{"key":"D6SC04289A\/cit40\/1","doi-asserted-by":"crossref","first-page":"5631","DOI":"10.1039\/D1CS00122A","volume":"50","author":"Bismillah","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04289A\/cit41\/1","doi-asserted-by":"crossref","first-page":"215733","DOI":"10.1016\/j.ccr.2024.215733","volume":"507","author":"Lv","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04289A\/cit42\/1","doi-asserted-by":"crossref","first-page":"110693","DOI":"10.1016\/j.inoche.2023.110693","volume":"152","author":"Lee","year":"2023","journal-title":"Inorg. Chem. Commun."},{"key":"D6SC04289A\/cit43\/1","doi-asserted-by":"crossref","first-page":"6967","DOI":"10.3390\/molecules27206967","volume":"27","author":"Teeuwen","year":"2022","journal-title":"Molecules"},{"key":"D6SC04289A\/cit44\/1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.dyepig.2015.07.002","volume":"122","author":"Karatay","year":"2015","journal-title":"Dyes Pigm."},{"key":"D6SC04289A\/cit45\/1","doi-asserted-by":"crossref","first-page":"216454","DOI":"10.1016\/j.ccr.2025.216454","volume":"530","author":"Sorsche","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04289A\/cit46\/1","doi-asserted-by":"crossref","first-page":"e202401562","DOI":"10.1002\/chem.202401562","volume":"30","author":"Bag","year":"2024","journal-title":"Chem.\u2013Eur. J."},{"key":"D6SC04289A\/cit47\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1039\/C2CS35216H","volume":"42","author":"Kamkaew","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04289A\/cit48\/1","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1039\/c3cs35531d","volume":"42","author":"Zhao","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04289A\/cit49\/1","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/jacs.0c12805","volume":"143","author":"Bilger","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04289A\/cit50\/1","first-page":"1257","volume":"148","author":"Mann","year":"1996","journal-title":"Am. J. Pathol."},{"key":"D6SC04289A\/cit51\/1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3233\/JAD-180582","volume":"66","author":"Baghallab","year":"2018","journal-title":"J. Alzheimer's Dis."},{"key":"D6SC04289A\/cit52\/1","doi-asserted-by":"crossref","first-page":"100168","DOI":"10.1074\/jbc.RA120.015501","volume":"296","author":"Reyes-Ruiz","year":"2021","journal-title":"J. Biol. Chem."},{"key":"D6SC04289A\/cit53\/1","doi-asserted-by":"publisher","DOI":"10.1007\/s12565-025-00915-5","author":"Araki","year":"2026","journal-title":"Anat. Sci. Int."},{"key":"D6SC04289A\/cit54\/1","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1038\/s41467-022-30982-5","volume":"13","author":"Gerken","year":"2022","journal-title":"Nat. Commun."},{"key":"D6SC04289A\/cit55\/1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1021\/ja00367a066","volume":"104","author":"Harbour","year":"1982","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04289A\/cit56\/1","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1039\/D4DT00834K","volume":"53","author":"Belletto","year":"2024","journal-title":"Dalton Trans."},{"key":"D6SC04289A\/cit57\/1","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1021\/acschemneuro.2c00649","volume":"14","author":"Oasa","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"D6SC04289A\/cit58a\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2528127: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2qvqht","DOI":"10.5517\/ccdc.csd.cc2qvqht"},{"key":"D6SC04289A\/cit58b\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2528128: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2qvqjv","DOI":"10.5517\/ccdc.csd.cc2qvqjv"}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC04289A\/0\/D6SC04289A.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:36:55Z","timestamp":1788370615000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D6SC04289A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":59,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1039\/d6sc04289a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6SC04289A\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC04289A\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC04289A\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC04289A\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC04289A\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC04289A\/v1\/review1","asserted-by":"object"}]},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}