{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:16:08Z","timestamp":1788372968502,"version":"build-2803163510"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"34","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024B1515040028"],"award-info":[{"award-number":["2024B1515040028"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22577169"],"award-info":[{"award-number":["22577169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    RGCS@PEG with Cu-doped silica core co-delivers Re3 &amp; GSNO, enabling ROS-responsive release, O\n                    <jats:sub>2<\/jats:sub>\n                    -independent type I PDT (NADH \u2192 \u02d9O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) &amp; NO, producing ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    storm that induces ferroptosis-dominated ICD, CD24 downregulation, and TME remodeling.\n                  <\/jats:p>","DOI":"10.1039\/d6sc04449b","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:34:03Z","timestamp":1784133243000},"page":"16417-16431","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A molecularly engineered rhenium platform triggers a self-enhancing RNS storm to disrupt tumor hypoxia and resultant immunosuppression"],"prefix":"10.1039","volume":"17","author":[{"given":"Long-Bo","family":"Yu","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Hua","family":"Shen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo-Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Xin","family":"Guan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-8367","authenticated-orcid":false,"given":"Cai-Ping","family":"Tan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China"},{"name":"Guangdong Basic Research Center of Excellence for Functional Molecular Engineering, Guangzhou 510006, P. R. China"},{"name":"State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC04449B\/cit1\/1","doi-asserted-by":"crossref","first-page":"7046","DOI":"10.1002\/anie.202015082","volume":"60","author":"Fang","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04449B\/cit2\/1","doi-asserted-by":"crossref","first-page":"2000376","DOI":"10.1002\/adma.202000376","volume":"32","author":"Li","year":"2020","journal-title":"Adv. Mater."},{"key":"D6SC04449B\/cit3\/1","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.cell.2022.06.010","volume":"185","author":"Lundberg","year":"2022","journal-title":"Cell"},{"key":"D6SC04449B\/cit4\/1","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1021\/acsnano.4c16329","volume":"19","author":"Xu","year":"2025","journal-title":"ACS Nano"},{"key":"D6SC04449B\/cit5\/1","doi-asserted-by":"crossref","first-page":"e2306476","DOI":"10.1002\/adma.202306476","volume":"36","author":"Li","year":"2024","journal-title":"Adv. Mater."},{"key":"D6SC04449B\/cit6\/1","doi-asserted-by":"crossref","first-page":"2101935","DOI":"10.1002\/advs.202101935","volume":"9","author":"Kim","year":"2022","journal-title":"Adv. Sci."},{"key":"D6SC04449B\/cit7\/1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12943-022-01657-y","volume":"21","author":"Wu","year":"2022","journal-title":"Mol. Cancer"},{"key":"D6SC04449B\/cit8\/1","doi-asserted-by":"crossref","first-page":"118013","DOI":"10.1016\/j.biopha.2025.118013","volume":"186","author":"Alemu","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"D6SC04449B\/cit9\/1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/s41467-022-35709-0","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"key":"D6SC04449B\/cit10\/1","doi-asserted-by":"crossref","first-page":"2302220","DOI":"10.1002\/adma.202302220","volume":"35","author":"Liu","year":"2023","journal-title":"Adv. Mater."},{"key":"D6SC04449B\/cit11\/1","doi-asserted-by":"crossref","first-page":"154766","DOI":"10.1016\/j.metabol.2021.154766","volume":"119","author":"Hill","year":"2021","journal-title":"Metabolism"},{"key":"D6SC04449B\/cit12\/1","doi-asserted-by":"crossref","first-page":"2410338","DOI":"10.1002\/smll.202410338","volume":"21","author":"Das","year":"2025","journal-title":"Small"},{"key":"D6SC04449B\/cit13\/1","doi-asserted-by":"crossref","first-page":"214462","DOI":"10.1016\/j.ccr.2022.214462","volume":"460","author":"Pete","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04449B\/cit14\/1","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1039\/D1CS01079D","volume":"54","author":"Li","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04449B\/cit15\/1","doi-asserted-by":"crossref","first-page":"2103978","DOI":"10.1002\/adma.202103978","volume":"33","author":"Wan","year":"2021","journal-title":"Adv. Mater."},{"key":"D6SC04449B\/cit16\/1","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1038\/s41467-022-29862-9","volume":"13","author":"An","year":"2022","journal-title":"Nat. Commun."},{"key":"D6SC04449B\/cit17\/1","first-page":"303","volume":"12","author":"Jiang","year":"2022","journal-title":"Bioact. Mater."},{"key":"D6SC04449B\/cit18\/1","first-page":"414","volume":"34","author":"Zou","year":"2024","journal-title":"Bioact. Mater."},{"key":"D6SC04449B\/cit19\/1","doi-asserted-by":"crossref","first-page":"121577","DOI":"10.1016\/j.biomaterials.2022.121577","volume":"286","author":"Zhang","year":"2022","journal-title":"Biomaterials"},{"key":"D6SC04449B\/cit20\/1","doi-asserted-by":"crossref","first-page":"e202115800","DOI":"10.1002\/anie.202115800","volume":"61","author":"Su","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04449B\/cit21\/1","doi-asserted-by":"crossref","first-page":"e202516957","DOI":"10.1002\/anie.202516957","volume":"64","author":"Mak","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04449B\/cit22\/1","doi-asserted-by":"crossref","first-page":"102612","DOI":"10.1016\/j.redox.2023.102612","volume":"60","author":"Zhuge","year":"2023","journal-title":"Redox Biol."},{"key":"D6SC04449B\/cit23\/1","doi-asserted-by":"crossref","first-page":"37735","DOI":"10.1021\/acsami.5c07882","volume":"17","author":"Yue","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6SC04449B\/cit24\/1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1021\/jacs.0c10517","volume":"143","author":"Sun","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04449B\/cit25\/1","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1002\/anie.202013301","volume":"60","author":"Wang","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04449B\/cit26\/1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.cmet.2022.07.005","volume":"34","author":"Wang","year":"2022","journal-title":"Cell Metab."},{"key":"D6SC04449B\/cit27\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41392-023-01365-z","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"D6SC04449B\/cit28\/1","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1038\/s41467-024-49825-6","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"D6SC04449B\/cit29\/1","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1158\/0008-5472.CAN-24-0012","volume":"84","author":"Guo","year":"2024","journal-title":"Cancer Res."},{"key":"D6SC04449B\/cit30\/1","doi-asserted-by":"crossref","first-page":"1174789","DOI":"10.3389\/fimmu.2023.1174789","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"D6SC04449B\/cit31\/1","doi-asserted-by":"crossref","first-page":"e2300288","DOI":"10.1002\/advs.202300288","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci."},{"key":"D6SC04449B\/cit32\/1","doi-asserted-by":"crossref","first-page":"e007068","DOI":"10.1136\/jitc-2023-007068","volume":"11","author":"Shen","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"D6SC04449B\/cit33\/1","doi-asserted-by":"crossref","first-page":"e14256","DOI":"10.1002\/advs.202514256","volume":"13","author":"Yu","year":"2026","journal-title":"Adv. Sci."},{"key":"D6SC04449B\/cit34\/1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ccell.2025.12.005","volume":"44","author":"Galluzzi","year":"2026","journal-title":"Cancer Cell"},{"key":"D6SC04449B\/cit35\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41392-023-01365-z","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"D6SC04449B\/cit36\/1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13045-022-01328-x","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"D6SC04449B\/cit37\/1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41586-019-1456-0","volume":"572","author":"Barkal","year":"2019","journal-title":"Nature"},{"key":"D6SC04449B\/cit38\/1","doi-asserted-by":"crossref","first-page":"20250074","DOI":"10.1002\/EXP.20250074","volume":"6","author":"Wu","year":"2026","journal-title":"Exploration"},{"key":"D6SC04449B\/cit39\/1","doi-asserted-by":"crossref","first-page":"270009","DOI":"10.1002\/EXP.70009","volume":"5","author":"Xia","year":"2025","journal-title":"Exploration"},{"key":"D6SC04449B\/cit40\/1","doi-asserted-by":"crossref","first-page":"171794","DOI":"10.1016\/j.cej.2025.171794","volume":"527","author":"Ling","year":"2026","journal-title":"Chem. Eng. J."},{"key":"D6SC04449B\/cit41\/1","doi-asserted-by":"crossref","first-page":"e16008","DOI":"10.1002\/adma.202516008","volume":"38","author":"Tang","year":"2026","journal-title":"Adv. Mater."},{"key":"D6SC04449B\/cit42\/1","doi-asserted-by":"crossref","first-page":"e06011","DOI":"10.1002\/adma.202506011","volume":"37","author":"Shang","year":"2025","journal-title":"Adv. Mater."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC04449B\/0\/D6SC04449B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:41:13Z","timestamp":1788370873000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D6SC04449B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":42,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1039\/d6sc04449b","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}