{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:47:04Z","timestamp":1792075624848,"version":"4.4.0"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"39","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":225,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1S10 OD020022-1"],"award-info":[{"award-number":["1S10 OD020022-1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM144129"],"award-info":[{"award-number":["GM144129"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000165","name":"Division of Chemistry","doi-asserted-by":"publisher","award":["CHE-1048642"],"award-info":[{"award-number":["CHE-1048642"]}],"id":[{"id":"10.13039\/100000165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    Rigid saturated bioisosteres of arenes can improve the properties of drug candidates, but their synthesis can be challenging. Functionalization of adamantane dicarboxylates provides a tractable entry to a novel class of\n                    <jats:italic>meta<\/jats:italic>\n                    -arene bioisosteres.\n                  <\/jats:p>","DOI":"10.1039\/d6sc04786f","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:03:01Z","timestamp":1786716181000},"page":"18881-18886","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decarboxylative functionalization strategy for rapid assembly of bifunctional adamantane\n                    <i>meta<\/i>\n                    -arene bioisosteres"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-6486","authenticated-orcid":false,"given":"Cade A.","family":"MacAllister","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Wisconsin\u2013Madison, 1101 University Avenue, Madison, WI, 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9910-4055","authenticated-orcid":false,"given":"Omar A.","family":"Solis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Wisconsin\u2013Madison, 1101 University Avenue, Madison, WI, 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3412-3129","authenticated-orcid":false,"given":"Alexander J.","family":"Reif","sequence":"additional","affiliation":[{"name":"Discovery Chemistry, Molecular Modalities Discovery, GSK, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.","family":"Goodwin","sequence":"additional","affiliation":[{"name":"Discovery Chemistry, Molecular Modalities Discovery, GSK, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3934-4973","authenticated-orcid":false,"given":"Tehshik P.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Wisconsin\u2013Madison, 1101 University Avenue, Madison, WI, 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC04786F\/cit1\/1","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1021\/jm901241e","volume":"52","author":"Lovering","year":"2009","journal-title":"J. Med. Chem."},{"key":"D6SC04786F\/cit2\/1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1039\/c2md20347b","volume":"4","author":"Lovering","year":"2013","journal-title":"Med. Chem. Commun."},{"key":"D6SC04786F\/cit3\/1","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1021\/jm1013693","volume":"54","author":"Meanwell","year":"2011","journal-title":"J. Med. Chem."},{"key":"D6SC04786F\/cit4\/1","doi-asserted-by":"crossref","first-page":"14046","DOI":"10.1021\/acs.jmedchem.1c01215","volume":"64","author":"Subbaiah","year":"2021","journal-title":"J. Med. Chem."},{"key":"D6SC04786F\/cit5\/1","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1039\/C8OB02812E","volume":"17","author":"Mykhailiuk","year":"2019","journal-title":"Org. Biomol. Chem."},{"key":"D6SC04786F\/cit6\/1","doi-asserted-by":"crossref","first-page":"11585","DOI":"10.1021\/acs.jmedchem.0c00746","volume":"63","author":"Tse","year":"2020","journal-title":"J. Med. Chem."},{"key":"D6SC04786F\/cit7\/1","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1021\/jm4017625","volume":"57","author":"Taylor","year":"2014","journal-title":"J. Med. Chem."},{"key":"D6SC04786F\/cit8\/1","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1021\/jm300094u","volume":"55","author":"Stepan","year":"2012","journal-title":"J. Med. Chem."},{"key":"D6SC04786F\/cit9\/1","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1021\/acsmedchemlett.0c00195","volume":"11","author":"Pu","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"D6SC04786F\/cit10\/1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41586-020-2060-z","volume":"580","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"D6SC04786F\/cit11\/1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/cmdc.201700082","volume":"12","author":"Auberson","year":"2017","journal-title":"ChemMedChem"},{"key":"D6SC04786F\/cit12\/1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41586-022-05290-z","volume":"611","author":"Frank","year":"2022","journal-title":"Nature"},{"key":"D6SC04786F\/cit13\/1","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.1002\/anie.202000548","volume":"59","author":"Levterov","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04786F\/cit14\/1","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1038\/s41467-022-33827-3","volume":"13","author":"Epplin","year":"2022","journal-title":"Nat. Commun."},{"key":"D6SC04786F\/cit15\/1","doi-asserted-by":"crossref","first-page":"e2108881118","DOI":"10.1073\/pnas.2108881118","volume":"118","author":"Zhao","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D6SC04786F\/cit16\/1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41586-023-06021-8","volume":"618","author":"Wiesenfeldt","year":"2023","journal-title":"Nature"},{"key":"D6SC04786F\/cit17\/1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41586-022-04636-x","volume":"605","author":"Kleinmans","year":"2022","journal-title":"Nature"},{"key":"D6SC04786F\/cit19\/1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1126\/science.144.3620.862","volume":"144","author":"Davies","year":"1964","journal-title":"Science"},{"key":"D6SC04786F\/cit20\/1","doi-asserted-by":"crossref","first-page":"117592","DOI":"10.1016\/j.ejmech.2025.117592","volume":"291","author":"Dane","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D6SC04786F\/cit21\/1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1021\/jm00342a029","volume":"6","author":"Gerzon","year":"1963","journal-title":"J. Med. Chem."},{"key":"D6SC04786F\/cit22\/1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1021\/jm00329a007","volume":"8","author":"Rapala","year":"1965","journal-title":"J. Med. Chem."},{"key":"D6SC04786F\/cit23\/1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1021\/jm00314a014","volume":"10","author":"Gerzon","year":"1967","journal-title":"J. Med. Chem."},{"key":"D6SC04786F\/cit24\/1","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1021\/cr100264t","volume":"113","author":"Wanka","year":"2013","journal-title":"Chem. Rev."},{"key":"D6SC04786F\/cit25\/1","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1039\/c1cs15093f","volume":"40","author":"Rodr\u00edguez","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04786F\/cit26\/1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1007\/s11426-011-4381-0","volume":"54","author":"Shang","year":"2011","journal-title":"Sci. China: Chem."},{"key":"D6SC04786F\/cit27\/1","doi-asserted-by":"crossref","first-page":"11856","DOI":"10.1039\/D4CS01051E","volume":"54","author":"Foubelo","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04786F\/cit28\/1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1021\/acsmedchemlett.2c00286","volume":"13","author":"Laudadio","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"key":"D6SC04786F\/cit29\/1","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1021\/acs.orglett.1c01558","volume":"23","author":"Polites","year":"2021","journal-title":"Org. Lett."},{"key":"D6SC04786F\/cit30\/1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acscatal.1c05076","volume":"12","author":"Mousseau","year":"2022","journal-title":"ACS Catal."},{"key":"D6SC04786F\/cit31\/1","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1021\/acs.orglett.3c03684","volume":"26","author":"Revie","year":"2024","journal-title":"Org. Lett."},{"key":"D6SC04786F\/cit32\/1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41557-021-00834-8","volume":"14","author":"Li","year":"2022","journal-title":"Nat. Chem."},{"key":"D6SC04786F\/cit33\/1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.chempr.2023.05.020","volume":"9","author":"Lutovsky","year":"2023","journal-title":"Chem"},{"key":"D6SC04786F\/cit34\/1","doi-asserted-by":"crossref","first-page":"e202200916","DOI":"10.1002\/cctc.202200916","volume":"14","author":"Juli\u00e1","year":"2022","journal-title":"ChemCatChem"},{"key":"D6SC04786F\/cit35\/1","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1021\/jacs.1c02490","volume":"143","author":"Xu","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04786F\/cit36\/1","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1021\/jacs.2c01630","volume":"144","author":"Dow","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04786F\/cit37\/1","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1246\/bcsj.59.3911","volume":"59","author":"Sugimori","year":"1986","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"D6SC04786F\/cit38\/1","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1021\/acs.orglett.9b01439","volume":"21","author":"Li","year":"2019","journal-title":"Org. Lett."},{"key":"D6SC04786F\/cit39\/1","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1021\/ja01019a018","volume":"90","author":"Kochi","year":"1968","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04786F\/cit40\/1","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1021\/ja00949a033","volume":"87","author":"Kochi","year":"1965","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04786F\/cit41\/1","doi-asserted-by":"crossref","first-page":"10886","DOI":"10.1021\/ja505964r","volume":"136","author":"Chu","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04786F\/cit42\/1","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1021\/acscatal.7b01133","volume":"7","author":"Garza-Sanchez","year":"2017","journal-title":"ACS Catal."},{"key":"D6SC04786F\/cit43\/1","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/cmdc.200900292","volume":"4","author":"Perrone","year":"2009","journal-title":"ChemMedChem"}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC04786F\/0\/D6SC04786F.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC04786F\/0\/D6SC04786F.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:20:41Z","timestamp":1792074041000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D6SC04786F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":42,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2026,10,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d6sc04786f","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}