{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:58:08Z","timestamp":1790794688199,"version":"4.1.0"},"reference-count":50,"publisher":"Royal Society of Chemistry (RSC)","issue":"37","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1504303"],"award-info":[{"award-number":["2022YFA1504303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021187","name":"Beijing National Laboratory for Molecular Sciences","doi-asserted-by":"publisher","award":["BNLMS-CXX-202106"],"award-info":[{"award-number":["BNLMS-CXX-202106"]}],"id":[{"id":"10.13039\/501100021187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22193073"],"award-info":[{"award-number":["22193073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22221002"],"award-info":[{"award-number":["22221002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92253305"],"award-info":[{"award-number":["92253305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92256302"],"award-info":[{"award-number":["92256302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["25JCZDJC00670"],"award-info":[{"award-number":["25JCZDJC00670"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>Purification-free, in-plate multicomponent synthesis of tetrahydrotriazines from aldehyde, amines, and hydrazines for direct-to-biology screenings.<\/jats:p>","DOI":"10.1039\/d6sc04848j","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:03:06Z","timestamp":1784127786000},"page":"17729-17737","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modular in-plate synthesis of N-heterocycles for direct-to-biology screening"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9413-4529","authenticated-orcid":false,"given":"Xiaowei","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhantao","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China"},{"name":"School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing 100871, China"},{"name":"Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxi","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beile","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6000-0204","authenticated-orcid":false,"given":"Bilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-3418","authenticated-orcid":false,"given":"Gang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Qiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-8035","authenticated-orcid":false,"given":"Xiaoguang","family":"Lei","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, New Cornerstone Science Laboratory, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-6268","authenticated-orcid":false,"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5067-9889","authenticated-orcid":false,"given":"Gong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China"},{"name":"State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC04848J\/cit1\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41570-018-0025-7","volume":"2","author":"Chow","year":"2018","journal-title":"Nat. Rev. Chem."},{"key":"D6SC04848J\/cit2\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrd.2017.232","volume":"17","author":"Schneider","year":"2018","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6SC04848J\/cit3\/1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrd.2018.116","volume":"17","author":"Bostr\u00f6m","year":"2018","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6SC04848J\/cit4\/1","doi-asserted-by":"crossref","first-page":"eaat0805","DOI":"10.1126\/science.aat0805","volume":"363","author":"Campos","year":"2019","journal-title":"Science"},{"key":"D6SC04848J\/cit5\/1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1126\/science.1259203","volume":"347","author":"Buitrago Santanilla","year":"2015","journal-title":"Science"},{"key":"D6SC04848J\/cit6\/1","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1021\/acs.accounts.7b00428","volume":"50","author":"Krska","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"D6SC04848J\/cit7\/1","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1021\/acs.jmedchem.6b01543","volume":"60","author":"Cernak","year":"2017","journal-title":"J. Med. Chem."},{"key":"D6SC04848J\/cit8\/1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1126\/science.aap9112","volume":"359","author":"Perera","year":"2018","journal-title":"Science"},{"key":"D6SC04848J\/cit9\/1","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1038\/s41467-019-10685-0","volume":"10","author":"Benz","year":"2019","journal-title":"Nat. Commun."},{"key":"D6SC04848J\/cit10\/1","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1021\/acs.accounts.1c00119","volume":"54","author":"Mahjour","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"D6SC04848J\/cit11\/1","doi-asserted-by":"crossref","first-page":"e202506588","DOI":"10.1002\/anie.202506588","volume":"64","author":"Nsouli","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04848J\/cit12\/1","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/cbic.200300724","volume":"4","author":"Brik","year":"2003","journal-title":"ChemBioChem"},{"key":"D6SC04848J\/cit13\/1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41586-018-0056-8","volume":"557","author":"Gesmundo","year":"2018","journal-title":"Nature"},{"key":"D6SC04848J\/cit14\/1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41586-019-1589-1","volume":"574","author":"Meng","year":"2019","journal-title":"Nature"},{"key":"D6SC04848J\/cit15\/1","doi-asserted-by":"crossref","first-page":"10899","DOI":"10.1021\/jacs.9b13652","volume":"142","author":"Kitamura","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04848J\/cit16\/1","doi-asserted-by":"crossref","first-page":"12098","DOI":"10.1039\/D1SC03551G","volume":"12","author":"Thomas","year":"2021","journal-title":"Chem. Sci."},{"key":"D6SC04848J\/cit17\/1","doi-asserted-by":"crossref","first-page":"115567","DOI":"10.1016\/j.ejmech.2023.115567","volume":"258","author":"Li","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D6SC04848J\/cit18\/1","doi-asserted-by":"crossref","first-page":"8437","DOI":"10.1038\/s41467-023-43614-3","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"D6SC04848J\/cit19\/1","doi-asserted-by":"crossref","first-page":"15437","DOI":"10.1021\/acs.jmedchem.3c01604","volume":"66","author":"Stevens","year":"2023","journal-title":"J. Med. Chem."},{"key":"D6SC04848J\/cit20\/1","doi-asserted-by":"crossref","first-page":"2400594","DOI":"10.1002\/advs.202400594","volume":"11","author":"Yan","year":"2024","journal-title":"Adv. Sci."},{"key":"D6SC04848J\/cit21\/1","doi-asserted-by":"crossref","first-page":"e202403792","DOI":"10.1002\/anie.202403792","volume":"63","author":"Meidner","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04848J\/cit22\/1","doi-asserted-by":"crossref","first-page":"e202418314","DOI":"10.1002\/anie.202418314","volume":"64","author":"Wilders","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04848J\/cit23\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/jacs.5c13496","volume":"148","author":"Hu","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04848J\/cit24\/1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.53517\/CMDR.2581-5008.112017173","volume":"1","author":"Kumar","year":"2017","journal-title":"Curr. Med. Drug Res."},{"key":"D6SC04848J\/cit25\/1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2174\/1570193X18666210122154419","volume":"18","author":"Hashem","year":"2021","journal-title":"Mini-Rev. Org. Chem."},{"key":"D6SC04848J\/cit26\/1","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1021\/cr100233r","volume":"112","author":"D\u00f6mling","year":"2012","journal-title":"Chem. Rev."},{"key":"D6SC04848J\/cit27\/1","doi-asserted-by":"crossref","first-page":"8323","DOI":"10.1021\/cr400615v","volume":"114","author":"Rotstein","year":"2014","journal-title":"Chem. Rev."},{"key":"D6SC04848J\/cit28\/1","volume-title":"Multicomponent Reactions towards Heterocycles: Concepts and Applications","author":"Van der Eycken","year":"2021","unstructured":"E. V.Van der Eycken  and  U. K.Sharma ,  Multicomponent Reactions towards Heterocycles: Concepts and Applications ,  Wiley-VCH ,  2021"},{"key":"D6SC04848J\/cit29\/1","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1081\/SCC-120004086","volume":"32","author":"Rostamizadeh","year":"2002","journal-title":"Synth. Commun."},{"key":"D6SC04848J\/cit30\/1","doi-asserted-by":"crossref","first-page":"12377","DOI":"10.1002\/anie.201306300","volume":"52","author":"Tong","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04848J\/cit31\/1","doi-asserted-by":"crossref","first-page":"153303","DOI":"10.1016\/j.tetlet.2021.153303","volume":"79","author":"Wang","year":"2021","journal-title":"Tetrahedron Lett."},{"key":"D6SC04848J\/cit32\/1","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1002\/anie.202016267","volume":"60","author":"Li","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04848J\/cit33\/1","doi-asserted-by":"crossref","first-page":"10080","DOI":"10.1021\/jacs.2c04620","volume":"144","author":"Li","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04848J\/cit34\/1","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1021\/jacs.3c12215","volume":"146","author":"Cai","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04848J\/cit35\/1","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.31635\/ccschem.024.202404848","volume":"7","author":"Wang","year":"2025","journal-title":"CCS Chem."},{"key":"D6SC04848J\/cit36\/1","doi-asserted-by":"crossref","first-page":"0088","DOI":"10.1038\/s41570-017-0088","volume":"1","author":"Colomer","year":"2017","journal-title":"Nat. Rev. Chem."},{"key":"D6SC04848J\/cit37\/1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/tcr.201900020","volume":"20","author":"An","year":"2020","journal-title":"Chem. Rec."},{"key":"D6SC04848J\/cit38\/1","doi-asserted-by":"crossref","first-page":"12544","DOI":"10.1021\/acs.chemrev.1c00749","volume":"122","author":"Motiwala","year":"2022","journal-title":"Chem. Rev."},{"key":"D6SC04848J\/cit39\/1","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1002\/ejoc.200700746","author":"Brehme","year":"2007","journal-title":"Eur. J. Org Chem."},{"key":"D6SC04848J\/cit40\/1","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1021\/cr900067y","volume":"110","author":"Lazny","year":"2010","journal-title":"Chem. Rev."},{"key":"D6SC04848J\/cit41\/1","doi-asserted-by":"crossref","first-page":"13430","DOI":"10.1002\/chem.201602430","volume":"22","author":"de Gracia Retamosa","year":"2016","journal-title":"Chem. Eur. J."},{"key":"D6SC04848J\/cit42\/1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jlac.19576050121","volume":"605","author":"Ried","year":"1957","journal-title":"Liebigs Ann. Chem."},{"key":"D6SC04848J\/cit43\/1","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1039\/b002750m","author":"Atlan","year":"2000","journal-title":"Chem. Commun."},{"key":"D6SC04848J\/cit44\/1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/B306242B","volume":"5","author":"El Ka\u00efm","year":"2003","journal-title":"Green Chem."},{"key":"D6SC04848J\/cit45\/1","doi-asserted-by":"crossref","first-page":"17545","DOI":"10.1021\/acs.jmedchem.1c01017","volume":"64","author":"Fang","year":"2021","journal-title":"J. Med. Chem."},{"key":"D6SC04848J\/cit46\/1","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1021\/jacsau.2c00600","volume":"2","author":"Guo","year":"2022","journal-title":"JACS Au"},{"key":"D6SC04848J\/cit47\/1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0163-7258(00)00092-9","volume":"88","author":"Michelotti","year":"2000","journal-title":"Pharmacol. Ther."},{"key":"D6SC04848J\/cit48\/1","doi-asserted-by":"crossref","first-page":"9489","DOI":"10.1021\/acs.jmedchem.6b01217","volume":"59","author":"Guo","year":"2016","journal-title":"J. Med. Chem."},{"key":"D6SC04848J\/cit49a\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2521695: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2qn10g","DOI":"10.5517\/ccdc.csd.cc2qn10g"},{"key":"D6SC04848J\/cit49b\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2521699: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2qn14l","DOI":"10.5517\/ccdc.csd.cc2qn14l"}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC04848J\/0\/D6SC04848J.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:30:21Z","timestamp":1790793021000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D6SC04848J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":50,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2026,9,30]]}},"URL":"https:\/\/doi.org\/10.1039\/d6sc04848j","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}