{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:49:35Z","timestamp":1791002975101,"version":"4.1.0"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"34","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":179,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFA151110"],"award-info":[{"award-number":["2025YFA151110"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22271299"],"award-info":[{"award-number":["22271299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023LFG003"],"award-info":[{"award-number":["ZR2023LFG003"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    The difluoromethylene (\u2013CF\n                    <jats:sub>2<\/jats:sub>\n                    \u2013) motif is highly valuable in pharmaceuticals, agrochemicals, and materials science due to its unique physicochemical properties.\n                  <\/jats:p>","DOI":"10.1039\/d6sc04911g","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:04:19Z","timestamp":1782713059000},"page":"16259-16268","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PhSO\n                    <sub>2<\/sub>\n                    CF\n                    <sub>2<\/sub>\n                    H as a difluoromethylene bridge connecting electrophiles and electronically diverse alkenes"],"prefix":"10.1039","volume":"17","author":[{"given":"Yunlong","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaidi","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanfa","family":"Ni","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3537-0207","authenticated-orcid":false,"given":"Jinbo","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC04911G\/cit1\/1","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1021\/acs.jmedchem.5b00258","volume":"58","author":"Gillis","year":"2015","journal-title":"J. Med. Chem."},{"key":"D6SC04911G\/cit2\/1","doi-asserted-by":"crossref","first-page":"10633","DOI":"10.1021\/acsomega.0c00830","volume":"5","author":"Inoue","year":"2020","journal-title":"ACS Omega"},{"key":"D6SC04911G\/cit3\/1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jfluchem.2014.06.014","volume":"167","author":"Fujiwara","year":"2014","journal-title":"J. Fluorine Chem."},{"key":"D6SC04911G\/cit4\/1","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1039\/b610738a","volume":"36","author":"Hird","year":"2007","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04911G\/cit5\/1","doi-asserted-by":"crossref","first-page":"12431","DOI":"10.1021\/acs.chemrev.3c00350","volume":"123","author":"Zhang","year":"2023","journal-title":"Chem. Rev."},{"key":"D6SC04911G\/cit6\/1","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.1021\/acs.jmedchem.7b01788","volume":"61","author":"Meanwell","year":"2018","journal-title":"J. Med. Chem."},{"key":"D6SC04911G\/cit7\/1","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1039\/D0QO00567C","volume":"7","author":"Dong","year":"2020","journal-title":"Org. Chem. Front."},{"key":"D6SC04911G\/cit8\/1","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1021\/acs.accounts.8b00230","volume":"51","author":"Feng","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"D6SC04911G\/cit9\/1","doi-asserted-by":"crossref","first-page":"7378","DOI":"10.1039\/D0CS00670J","volume":"50","author":"Fu","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04911G\/cit10\/1","doi-asserted-by":"crossref","first-page":"7287","DOI":"10.1021\/acscatal.8b02066","volume":"8","author":"Barata-Vallejo","year":"2018","journal-title":"ACS Catal."},{"key":"D6SC04911G\/cit11\/1","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1021\/acs.accounts.8b00079","volume":"51","author":"Dilman","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"D6SC04911G\/cit12\/1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s41557-023-01236-8","volume":"15","author":"Zeng","year":"2023","journal-title":"Nat. Chem."},{"key":"D6SC04911G\/cit13\/1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1021\/acs.accounts.3c00719","volume":"57","author":"Xie","year":"2024","journal-title":"Acc. Chem. Res."},{"key":"D6SC04911G\/cit14\/1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jfluchem.2009.02.015","volume":"130","author":"Alexandrova","year":"2009","journal-title":"J. Fluorine Chem."},{"key":"D6SC04911G\/cit15\/1","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1021\/ol5002297","volume":"16","author":"Kosobokov","year":"2014","journal-title":"Org. Lett."},{"key":"D6SC04911G\/cit16\/1","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1002\/anie.200352172","volume":"42","author":"Prakash","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04911G\/cit17\/1","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.1021\/acs.orglett.1c02603","volume":"23","author":"Trifonov","year":"2021","journal-title":"Org. Lett."},{"key":"D6SC04911G\/cit18\/1","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1039\/D3SC00027C","volume":"14","author":"Kostromitin","year":"2023","journal-title":"Chem. Sci."},{"key":"D6SC04911G\/cit19\/1","doi-asserted-by":"crossref","first-page":"11546","DOI":"10.1039\/D3SC03951J","volume":"14","author":"Zhang","year":"2023","journal-title":"Chem. Sci."},{"key":"D6SC04911G\/cit20\/1","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1021\/jo0489768","volume":"69","author":"Reutrakul","year":"2004","journal-title":"J. Org. Chem."},{"key":"D6SC04911G\/cit21\/1","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/anie.200604783","volume":"46","author":"Li","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04911G\/cit22\/1","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1021\/jo802794u","volume":"74","author":"Bootwicha","year":"2009","journal-title":"J. Org. Chem."},{"key":"D6SC04911G\/cit23\/1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jfluchem.2011.10.009","volume":"135","author":"Peewasan","year":"2012","journal-title":"J. Fluorine Chem."},{"key":"D6SC04911G\/cit24\/1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1021\/jo5022579","volume":"80","author":"Thaharn","year":"2015","journal-title":"J. Org. Chem."},{"key":"D6SC04911G\/cit25\/1","doi-asserted-by":"crossref","first-page":"15963","DOI":"10.1021\/acs.joc.2c02098","volume":"87","author":"Keereewan","year":"2022","journal-title":"J. Org. Chem."},{"key":"D6SC04911G\/cit26\/1","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.1016\/j.tetlet.2009.09.170","volume":"50","author":"Fourri\u00e8re","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"D6SC04911G\/cit27\/1","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1016\/j.tet.2010.03.079","volume":"66","author":"Fourri\u00e8re","year":"2010","journal-title":"Tetrahedron"},{"key":"D6SC04911G\/cit28\/1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jfluchem.2011.02.015","volume":"134","author":"Fourri\u00e8re","year":"2012","journal-title":"J. Fluorine Chem."},{"key":"D6SC04911G\/cit29\/1","doi-asserted-by":"crossref","first-page":"10148","DOI":"10.1021\/acs.joc.5c01356","volume":"90","author":"Lozhkin","year":"2025","journal-title":"J. Org. Chem."},{"key":"D6SC04911G\/cit30\/1","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1002\/anie.201510533","volume":"55","author":"Rong","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04911G\/cit31\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.6023\/A16080412","volume":"75","author":"Rong","year":"2017","journal-title":"Acta Chim. Sin."},{"key":"D6SC04911G\/cit32\/1","doi-asserted-by":"crossref","first-page":"e202308816","DOI":"10.1002\/anie.202308816","volume":"62","author":"Wei","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04911G\/cit33\/1","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1021\/acs.orglett.5c00102","volume":"27","author":"Xiao","year":"2025","journal-title":"Org. Lett."},{"key":"D6SC04911G\/cit34\/1","doi-asserted-by":"crossref","first-page":"10024","DOI":"10.1039\/D2CC03921D","volume":"58","author":"Wei","year":"2022","journal-title":"Chem. Commun."},{"key":"D6SC04911G\/cit35\/1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/cr5002386","volume":"115","author":"Ni","year":"2015","journal-title":"Chem. Rev."},{"key":"D6SC04911G\/cit36\/1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.jfluchem.2009.05.016","volume":"130","author":"Hu","year":"2009","journal-title":"J. Fluorine Chem."},{"key":"D6SC04911G\/cit37\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0022-1139(00)81636-X","volume":"43","author":"Stahly","year":"1989","journal-title":"J. Fluorine Chem."},{"key":"D6SC04911G\/cit38\/1","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/ejoc.200500101","volume":"2005","author":"Surya Prakash","year":"2005","journal-title":"Eur. J. Org Chem."},{"key":"D6SC04911G\/cit39\/1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jfluchem.2013.05.015","volume":"155","author":"Hu","year":"2013","journal-title":"J. Fluorine Chem."},{"key":"D6SC04911G\/cit40\/1","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1002\/anie.200501769","volume":"44","author":"Li","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04911G\/cit41\/1","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1021\/jo070094w","volume":"72","author":"Liu","year":"2007","journal-title":"J. Org. Chem."},{"key":"D6SC04911G\/cit42\/1","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1002\/anie.200460815","volume":"43","author":"Prakash","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04911G\/cit43\/1","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1021\/ol048166i","volume":"6","author":"Prakash","year":"2004","journal-title":"Org. Lett."},{"key":"D6SC04911G\/cit44\/1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/anie.200603983","volume":"46","author":"Ni","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04911G\/cit45\/1","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1039\/C6CS00351F","volume":"45","author":"Ni","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04911G\/cit46\/1","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1038\/s41467-025-62834-3","volume":"16","author":"Sun","year":"2025","journal-title":"Nat. Commun."},{"key":"D6SC04911G\/cit47\/1","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1002\/chem.201905281","volume":"26","author":"Zhu","year":"2020","journal-title":"Chem.\u2013Eur. J."},{"key":"D6SC04911G\/cit48\/1","doi-asserted-by":"crossref","first-page":"12619","DOI":"10.1002\/anie.201707171","volume":"56","author":"Zhang","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04911G\/cit49\/1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41586-024-07548-0","volume":"631","author":"Jiang","year":"2024","journal-title":"Nature"},{"key":"D6SC04911G\/cit50\/1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/s44160-022-00162-w","volume":"1","author":"Wang","year":"2022","journal-title":"Nat. Synth."},{"key":"D6SC04911G\/cit51\/1","doi-asserted-by":"crossref","first-page":"12710","DOI":"10.1039\/C8CC07344A","volume":"54","author":"Tu","year":"2018","journal-title":"Chem. Commun."},{"key":"D6SC04911G\/cit52\/1","doi-asserted-by":"crossref","first-page":"e202404116","DOI":"10.1002\/chem.202404116","volume":"31","author":"Li","year":"2025","journal-title":"Chem.\u2013Eur. J."},{"key":"D6SC04911G\/cit53\/1","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/cmdc.202000610","volume":"15","author":"Colombano","year":"2020","journal-title":"ChemMedChem"},{"key":"D6SC04911G\/cit54\/1","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1038\/s41467-024-48949-z","volume":"15","author":"Duan","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC04911G\/0\/D6SC04911G.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:30:17Z","timestamp":1788370217000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D6SC04911G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":54,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1039\/d6sc04911g","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6SC04911G\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC04911G\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC04911G\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC04911G\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6SC04911G\/v2\/response1","asserted-by":"object"}]},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}