{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:39:43Z","timestamp":1792589983622,"version":"4.5.0"},"reference-count":92,"publisher":"Royal Society of Chemistry (RSC)","issue":"40","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":232,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2137603"],"award-info":[{"award-number":["2137603"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2138259"],"award-info":[{"award-number":["2138259"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2138286"],"award-info":[{"award-number":["2138286"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2138296"],"award-info":[{"award-number":["2138296"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2138307"],"award-info":[{"award-number":["2138307"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-SC0024174"],"award-info":[{"award-number":["DE-SC0024174"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","award":["\u201cLaboratory for Synthetic Chemistry and Chemical Biology\u201d under the Health@InnoHK Programme"],"award-info":[{"award-number":["\u201cLaboratory for Synthetic Chemistry and Chemical Biology\u201d under the Health@InnoHK Programme"]}],"id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000105","name":"Office of Advanced Cyberinfrastructure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GSC 98\/3"],"award-info":[{"award-number":["GSC 98\/3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    A direct-to-biology approach was used to screen 336 Ir\n                    <jats:sup>3+<\/jats:sup>\n                    complexes against bacteria and cancer cells. High throughput experiments and ML models revealed divergent antibacterial and anticancer chemical space.\n                  <\/jats:p>","DOI":"10.1039\/d6sc04917f","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:22:57Z","timestamp":1787304177000},"page":"19469-19482","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring chemical space for iridium(\n                    <scp>iii<\/scp>\n                    ) complexes: a direct-to-biology (D2B) approach to identifying anticancer and antibacterial agents"],"prefix":"10.1039","volume":"17","author":[{"given":"Timothy","family":"Kench","sequence":"first","affiliation":[{"name":"Department of Chemistry, Imperial College London, White City Campus, W12 0BZ, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Seefeldt","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universit\u00e4tsstrasse 150, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aatikah","family":"Majid","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Imperial College London, White City Campus, W12 0BZ, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Man-Hei Yip","sequence":"additional","affiliation":[{"name":"Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Shum","sequence":"additional","affiliation":[{"name":"Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5360-165X","authenticated-orcid":false,"given":"Gianmarco G.","family":"Terrones","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassin","family":"Antar","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universit\u00e4tsstrasse 150, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt V.","family":"Holbling","sequence":"additional","affiliation":[{"name":"Drug Discovery Hub, Translation & Innovation Hub Building, Imperial College London, White City Campus, W12 0BZ, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-5916","authenticated-orcid":false,"given":"Kenneth","family":"Kam-Wing Lo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8111-9959","authenticated-orcid":false,"given":"Nils","family":"Metzler-Nolte","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr University Bochum, Universit\u00e4tsstrasse 150, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9342-0191","authenticated-orcid":false,"given":"Heather J.","family":"Kulik","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA"},{"name":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-199X","authenticated-orcid":false,"given":"Ramon","family":"Vilar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Imperial College London, White City Campus, W12 0BZ, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC04917F\/cit1\/1","doi-asserted-by":"crossref","first-page":"214899","DOI":"10.1016\/j.ccr.2022.214899","volume":"475","author":"Arakelyan","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04917F\/cit2\/1","doi-asserted-by":"crossref","first-page":"214923","DOI":"10.1016\/j.ccr.2022.214923","volume":"477","author":"Chang","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04917F\/cit3\/1","doi-asserted-by":"crossref","first-page":"e202300061","DOI":"10.1002\/cbdv.202300061","volume":"20","author":"Kumar Singh","year":"2023","journal-title":"Chem. Biodiversity"},{"key":"D6SC04917F\/cit4\/1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.trechm.2021.03.006","volume":"3","author":"Karges","year":"2021","journal-title":"Trends Chem."},{"key":"D6SC04917F\/cit5\/1","doi-asserted-by":"crossref","first-page":"12361","DOI":"10.1021\/jacs.4c16035","volume":"147","author":"Wang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04917F\/cit6\/1","doi-asserted-by":"crossref","first-page":"17025","DOI":"10.1039\/D5DT01963J","volume":"54","author":"Liu","year":"2025","journal-title":"Dalton Trans."},{"key":"D6SC04917F\/cit7\/1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41570-023-00463-4","volume":"7","author":"Frei","year":"2023","journal-title":"Nat. Rev. Chem."},{"key":"D6SC04917F\/cit8\/1","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1039\/C9SC06460E","volume":"11","author":"Frei","year":"2020","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit9\/1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrmicro3028","volume":"11","author":"Lemire","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"D6SC04917F\/cit10\/1","doi-asserted-by":"crossref","first-page":"e202507186","DOI":"10.1002\/anie.202507186","volume":"64","author":"Zheng","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit11\/1","doi-asserted-by":"crossref","first-page":"216779","DOI":"10.1016\/j.ccr.2025.216779","volume":"541","author":"Wang","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04917F\/cit12\/1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D6SC04917F\/cit13\/1","doi-asserted-by":"crossref","first-page":"e202300662","DOI":"10.1002\/anie.202300662","volume":"62","author":"Zhang","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit14\/1","doi-asserted-by":"crossref","first-page":"22266","DOI":"10.1039\/D5SC06387F","volume":"16","author":"Lee","year":"2025","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit15\/1","doi-asserted-by":"crossref","first-page":"e202423335","DOI":"10.1002\/anie.202423335","volume":"64","author":"Shi","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit16\/1","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1039\/D1DT03077A","volume":"51","author":"Chelushkin","year":"2022","journal-title":"Dalton Trans."},{"key":"D6SC04917F\/cit17\/1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1021\/acs.accounts.7b00375","volume":"51","author":"Mills","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"D6SC04917F\/cit18\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ccr.2018.01.010","volume":"360","author":"Zamora","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"D6SC04917F\/cit19\/1","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1021\/acs.accounts.0c00825","volume":"54","author":"Monti","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"D6SC04917F\/cit20\/1","doi-asserted-by":"crossref","first-page":"102925","DOI":"10.1016\/j.bioorg.2019.102925","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorg. Chem."},{"key":"D6SC04917F\/cit21\/1","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. Rev."},{"key":"D6SC04917F\/cit22\/1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1021\/ar100140e","volume":"44","author":"Liu","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"D6SC04917F\/cit23\/1","doi-asserted-by":"crossref","first-page":"116603","DOI":"10.1016\/j.ejmech.2024.116603","volume":"275","author":"Dasmahapatra","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"D6SC04917F\/cit24\/1","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1002\/anie.202015962","volume":"60","author":"Neuditschko","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit25\/1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/acs.chemrev.8b00211","volume":"119","author":"Monro","year":"2018","journal-title":"Chem. Rev."},{"key":"D6SC04917F\/cit26\/1","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1039\/D5SC07715J","volume":"17","author":"McGowan","year":"2026","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit27\/1","first-page":"e5995290","author":"Wang","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit28\/1","doi-asserted-by":"crossref","first-page":"e3918717","DOI":"10.1002\/anie.3918717","volume":"65","author":"Liu","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit29\/1","doi-asserted-by":"crossref","first-page":"10789","DOI":"10.1039\/D6SC02555B","volume":"17","author":"Redrado","year":"2026","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit30\/1","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1021\/acscentsci.5c01381","volume":"11","author":"Park","year":"2025","journal-title":"ACS Cent. Sci."},{"key":"D6SC04917F\/cit31\/1","doi-asserted-by":"crossref","first-page":"7908","DOI":"10.1021\/jacs.4c17966","volume":"147","author":"Chang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04917F\/cit32\/1","doi-asserted-by":"crossref","first-page":"9314","DOI":"10.1002\/anie.202000173","volume":"59","author":"Weng","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit33\/1","doi-asserted-by":"crossref","first-page":"111450","DOI":"10.1016\/j.jinorgbio.2021.111450","volume":"219","author":"Chen","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"D6SC04917F\/cit34\/1","doi-asserted-by":"crossref","first-page":"2100706","DOI":"10.1002\/adhm.202100706","volume":"10","author":"Ho","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"D6SC04917F\/cit35\/1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrd4706","volume":"14","author":"Cooper","year":"2015","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6SC04917F\/cit36\/1","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1038\/s41467-025-67341-z","volume":"16","author":"Husbands","year":"2025","journal-title":"Nat. Commun."},{"key":"D6SC04917F\/cit37\/1","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1039\/D3SC05326A","volume":"15","author":"Scaccaglia","year":"2024","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit38\/1","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1021\/acs.inorgchem.4c05414","volume":"64","author":"Kench","year":"2025","journal-title":"Inorg. Chem."},{"key":"D6SC04917F\/cit39\/1","doi-asserted-by":"crossref","first-page":"2400563","DOI":"10.1002\/smtd.202400563","volume":"8","author":"Lee","year":"2024","journal-title":"Small Methods"},{"key":"D6SC04917F\/cit40\/1","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.3390\/cancers13174447","volume":"13","author":"Algorri","year":"2021","journal-title":"Cancers"},{"key":"D6SC04917F\/cit41\/1","doi-asserted-by":"crossref","first-page":"e202112236","DOI":"10.1002\/anie.202112236","volume":"61","author":"Karges","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit42\/1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/anie.201905171","volume":"59","author":"Imberti","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit43\/1","doi-asserted-by":"crossref","first-page":"13454","DOI":"10.1021\/acs.chemrev.1c00381","volume":"121","author":"Pham","year":"2021","journal-title":"Chem. Rev."},{"key":"D6SC04917F\/cit44\/1","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1039\/D4SC01214C","volume":"15","author":"Feng","year":"2024","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit45\/1","doi-asserted-by":"crossref","first-page":"e202400476","DOI":"10.1002\/anie.202400476","volume":"63","author":"Shi","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit46\/1","doi-asserted-by":"crossref","first-page":"e202410803","DOI":"10.1002\/anie.202410803","volume":"63","author":"Zeng","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit47\/1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41467-023-43890-z","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"D6SC04917F\/cit48\/1","doi-asserted-by":"crossref","first-page":"6376","DOI":"10.1039\/D5SC00156K","volume":"16","author":"Negi","year":"2025","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit49\/1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1021\/acs.inorgchem.4c04282","volume":"64","author":"Zeng","year":"2025","journal-title":"Inorg. Chem."},{"key":"D6SC04917F\/cit50\/1","doi-asserted-by":"crossref","first-page":"20833","DOI":"10.1021\/jacs.5c04471","volume":"147","author":"K\u00f6nig","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04917F\/cit51\/1","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1021\/jacs.1c13137","volume":"144","author":"Kuang","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04917F\/cit52\/1","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1021\/jacs.4c15150","volume":"147","author":"You","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04917F\/cit53\/1","doi-asserted-by":"crossref","first-page":"9927","DOI":"10.1021\/acs.chemrev.1c00347","volume":"121","author":"Nandy","year":"2021","journal-title":"Chem. Rev."},{"key":"D6SC04917F\/cit54\/1","doi-asserted-by":"crossref","first-page":"e202420204","DOI":"10.1002\/anie.202420204","volume":"64","author":"Welsh","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit55\/1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1039\/C9SC05586J","volume":"11","author":"Morrison","year":"2020","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit56\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrd.2017.232","volume":"17","author":"Schneider","year":"2017","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6SC04917F\/cit57\/1","doi-asserted-by":"crossref","first-page":"e202501080","DOI":"10.1002\/cmdc.202501080","volume":"21","author":"H\u00fcbner","year":"2026","journal-title":"ChemMedChem"},{"key":"D6SC04917F\/cit58\/1","doi-asserted-by":"crossref","first-page":"23414","DOI":"10.1002\/anie.201909989","volume":"59","author":"Coley","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit59\/1","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv.15000025\/v4","volume-title":"ChemRxiv","author":"Parmelli","year":"2026","unstructured":"B.Parmelli ,  I.Vanlaeys ,  N. K.Chi ,  O.Blacque ,  P.Mesdom ,  K.Cariou ,  G.Gasser  and  T.Stuyver ,  ChemRxiv ,  2026 , preprint,  10.26434\/chemrxiv.15000025\/v4"},{"key":"D6SC04917F\/cit60\/1","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv-2025-pp32k\/v2","volume-title":"ChemRxiv","author":"Rusanov","year":"2026","unstructured":"D. A.Rusanov ,  E. M.Matnurov ,  D.Dolgov ,  D. Yu.Brezgunov ,  P. A.Ivanov Rostovtsev ,  K.Kriukov ,  B. L.Pashaliev ,  H.-J.Choe ,  M.Yarshova ,  J. H. K.Luk ,  T.Petrovi\u0107 ,  B.Abylova ,  D.Aitkulova ,  S. M.Alfadul ,  G.D'Cruz ,  V. V.Vetrova ,  D.Balcells  and  M. V.Babak ,  ChemRxiv ,  2026 , preprint,  10.26434\/chemrxiv-2025-pp32k\/v2"},{"key":"D6SC04917F\/cit61\/1","doi-asserted-by":"crossref","first-page":"e202317901","DOI":"10.1002\/anie.202317901","volume":"63","author":"Orsi","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit62\/1","doi-asserted-by":"crossref","first-page":"e202401808","DOI":"10.1002\/anie.202401808","volume":"63","author":"Kench","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit63\/1","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1021\/jacs.0c12290","volume":"143","author":"DiLuzio","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04917F\/cit64\/1","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1021\/acs.inorgchem.8b03552","volume":"58","author":"Konkankit","year":"2019","journal-title":"Inorg. Chem."},{"key":"D6SC04917F\/cit65\/1","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1021\/jm500455p","volume":"57","author":"Chow","year":"2014","journal-title":"J. Med. Chem."},{"key":"D6SC04917F\/cit66\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1021\/acscombsci.6b00119","volume":"19","author":"Wachter","year":"2016","journal-title":"ACS Comb. Sci."},{"key":"D6SC04917F\/cit67\/1","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.1039\/c0dt00034e","volume":"39","author":"Mulcahy","year":"2010","journal-title":"Dalton Trans."},{"key":"D6SC04917F\/cit68\/1","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1021\/acs.jmedchem.4c01875","volume":"68","author":"Niemeier","year":"2024","journal-title":"J. Med. Chem."},{"key":"D6SC04917F\/cit69\/1","doi-asserted-by":"crossref","first-page":"14267","DOI":"10.1021\/acs.inorgchem.4c02420","volume":"63","author":"DiLuzio","year":"2024","journal-title":"Inorg. Chem."},{"key":"D6SC04917F\/cit70\/1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s41597-024-03735-w","volume":"11","author":"Krasnov","year":"2024","journal-title":"Sci. Data"},{"key":"D6SC04917F\/cit71\/1","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1021\/ac961242d","volume":"69","author":"Valk\u00f3","year":"1997","journal-title":"Anal. Chem."},{"key":"D6SC04917F\/cit72\/1","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.1002\/ejic.201200798","volume":"2012","author":"Maschke","year":"2012","journal-title":"Eur. J. Inorg. Chem."},{"key":"D6SC04917F\/cit73\/1","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1021\/jm00118a010","volume":"31","author":"Minick","year":"1988","journal-title":"J. Med. Chem."},{"key":"D6SC04917F\/cit74\/1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/cmdc.201402001","volume":"9","author":"Maschke","year":"2014","journal-title":"ChemMedChem"},{"key":"D6SC04917F\/cit75\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41579-022-00820-y","volume":"21","author":"Darby","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"D6SC04917F\/cit76\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s44259-023-00016-1","volume":"1","author":"Saxena","year":"2023","journal-title":"npj Antimicrob. Resist."},{"key":"D6SC04917F\/cit77\/1","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1039\/D0SC06885C","volume":"12","author":"Tan","year":"2021","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit78\/1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1517\/17425255.1.4.655","volume":"1","author":"Chan","year":"2005","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"D6SC04917F\/cit79\/1","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1039\/D4SC08495K","volume":"16","author":"Zou","year":"2025","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit80\/1","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1039\/D1CS00417D","volume":"51","author":"Sen","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"D6SC04917F\/cit81\/1","doi-asserted-by":"crossref","first-page":"e202300662","DOI":"10.1002\/anie.202300662","volume":"62","author":"Zhang","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC04917F\/cit82\/1","doi-asserted-by":"crossref","first-page":"e000337","DOI":"10.1136\/jitc-2019-000337","volume":"8","author":"Galluzzi","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"D6SC04917F\/cit83\/1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrc3380","volume":"12","author":"Krysko","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"D6SC04917F\/cit84\/1","doi-asserted-by":"crossref","first-page":"e001926","DOI":"10.1136\/jitc-2020-001926","volume":"9","author":"Alzeibak","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"D6SC04917F\/cit85\/1","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1021\/acs.jctc.8b01176","volume":"15","author":"Bannwarth","year":"2019","journal-title":"J. Chem. Theory Comput."},{"key":"D6SC04917F\/cit86\/1","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1021\/ja00326a036","volume":"106","author":"Parr","year":"1984","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC04917F\/cit87\/1","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1021\/acs.organomet.6b00371","volume":"35","author":"Falivene","year":"2016","journal-title":"Organometallics"},{"key":"D6SC04917F\/cit88\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0022-2836(73)90011-9","volume":"79","author":"Shrake","year":"1973","journal-title":"J. Mol. Biol."},{"key":"D6SC04917F\/cit89\/1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jcc.540160303","volume":"16","author":"Eisenhaber","year":"1995","journal-title":"J. Comput. Chem."},{"key":"D6SC04917F\/cit90\/1","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1039\/D2SC06150C","volume":"14","author":"Terrones","year":"2023","journal-title":"Chem. Sci."},{"key":"D6SC04917F\/cit91\/1","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1002\/agt2.540","volume":"5","author":"Zhuang","year":"2024","journal-title":"Aggregate"},{"key":"D6SC04917F\/cit92\/1","doi-asserted-by":"crossref","first-page":"8838","DOI":"10.1021\/acs.jmedchem.5c02755","volume":"69","author":"Krasnov","year":"2026","journal-title":"J. Med. Chem."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC04917F\/0\/D6SC04917F.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC04917F\/0\/D6SC04917F.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:49:19Z","timestamp":1792586959000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D6SC04917F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":92,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2026,10,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d6sc04917f","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}