{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:52:48Z","timestamp":1791449568088,"version":"4.3.3"},"reference-count":69,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":270,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["CFI-35833, CFI-4484"],"award-info":[{"award-number":["CFI-35833, CFI-4484"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-03168"],"award-info":[{"award-number":["RGPIN-2021-03168"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2026-0688"],"award-info":[{"award-number":["RGPIN-2026-0688"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005247","name":"University of British Columbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>Sampling the slurry directly, online chiral HPLC detects the unwanted enantiomer within the growing solid and triggers a thermal reset that purges it, enabling five days of autonomous preferential crystallization of both enantiomers.<\/jats:p>","DOI":"10.1039\/d6sc05647d","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:44:28Z","timestamp":1790606668000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Direct-inject liquid-chromatography enables an autonomous continuous preferential crystallization platform"],"prefix":"10.1039","author":[{"given":"Joshua S.","family":"Derasp","sequence":"first","affiliation":[{"name":"Department of Chemistry, The University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada"},{"name":"Acceleration Consortium, The University of Toronto, Toronto, Ontario M5G 1X6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Painsecq","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada"},{"name":"Universit\u00e9 de Rouen Normandie, Place Emile Blondel, 76821 Mont-Saint-Aignan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-6591","authenticated-orcid":false,"given":"Wenyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada"},{"name":"Acceleration Consortium, The University of Toronto, Toronto, Ontario M5G 1X6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Reish","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada"},{"name":"Acceleration Consortium, The University of Toronto, Toronto, Ontario M5G 1X6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4345-3005","authenticated-orcid":false,"given":"Jason E.","family":"Hein","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada"},{"name":"Acceleration Consortium, The University of Toronto, Toronto, Ontario M5G 1X6, Canada"},{"name":"Department of Chemistry, University of Bergen, Bergen N-5020, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6SC05647D\/cit1\/1","volume-title":"Chiral Chemicals Market (2025\u20132030) Size, Share & Trends Analysis Report by Technology, Application and Region, and Segment Forecasts","author":"Grand View Research","unstructured":"Grand View Research ,  Chiral Chemicals Market (2025\u20132030) Size, Share & Trends Analysis Report by Technology, Application and Region, and Segment Forecasts ,  https:\/\/www.grandviewresearch.com\/industry-analysis\/chiral-chemicals-market , accessed June 29, 2026"},{"key":"D6SC05647D\/cit2a\/1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/anie.201302823","volume":"53","author":"Lorenz","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC05647D\/cit2b\/1","doi-asserted-by":"crossref","first-page":"11955","DOI":"10.1039\/D3SC01630G","volume":"14","author":"Sui","year":"2023","journal-title":"Chem. Sci."},{"key":"D6SC05647D\/cit3\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/B978-0-32-390644-9.00088-3","volume-title":"Comprehensive Chirality","volume":"9","author":"Kukor","year":"2024","unstructured":"A. J.Kukor  and  J. E.Hein , in  Comprehensive Chirality ,  Elsevier ,  Amsterdam , 2nd edn,  2024 ,  vol. 9 ,  pp. 81\u2013128"},{"key":"D6SC05647D\/cit4\/1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1021\/acs.oprd.5b00141","volume":"19","author":"Rougeot","year":"2015","journal-title":"Org. Process Res. Dev."},{"key":"D6SC05647D\/cit5\/1","volume-title":"Enantiomers, Racemates, and Resolutions","author":"Jacques","year":"1981","unstructured":"J.Jacques ,  A.Collet  and  S. H.Wilen ,  Enantiomers, Racemates, and Resolutions ,  Wiley ,  New York ,  1981"},{"key":"D6SC05647D\/cit6\/1","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1021\/acs.cgd.6b01088","volume":"16","author":"Otero-de-la-Roza","year":"2016","journal-title":"Cryst. Growth Des."},{"key":"D6SC05647D\/cit7a\/1","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1021\/jacsau.2c00394","volume":"2","author":"Walsh","year":"2022","journal-title":"JACS Au"},{"key":"D6SC05647D\/cit7b\/1","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1021\/acs.cgd.3c00019","volume":"23","author":"Walsh","year":"2023","journal-title":"Cryst. Growth Des."},{"key":"D6SC05647D\/cit8a\/1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/chir.20067","volume":"16","author":"Alvarez Rodrigo","year":"2004","journal-title":"Chirality"},{"key":"D6SC05647D\/cit8b\/1","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1021\/acs.oprd.9b00275","volume":"23","author":"Dunn","year":"2019","journal-title":"Org. Process Res. Dev."},{"key":"D6SC05647D\/cit8c\/1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/acs.oprd.1c00320","volume":"26","author":"Rehman","year":"2022","journal-title":"Org. Process Res. Dev."},{"key":"D6SC05647D\/cit9a\/1","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1002\/anie.202013502","volume":"60","author":"Valenti","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC05647D\/cit9b\/1","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1021\/acs.oprd.4c00091","volume":"28","author":"Oketani","year":"2024","journal-title":"Org. Process Res. Dev."},{"key":"D6SC05647D\/cit9c\/1","doi-asserted-by":"crossref","first-page":"20264","DOI":"10.1002\/anie.202107804","volume":"60","author":"Zhou","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC05647D\/cit9d\/1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1021\/jacs.2c10584","volume":"145","author":"van Dongen","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC05647D\/cit9e\/1","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1039\/D3CC00332A","volume":"59","author":"van Dongen","year":"2023","journal-title":"Chem. Commun."},{"key":"D6SC05647D\/cit9f\/1","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1021\/acs.cgd.1c01010","volume":"21","author":"Sanada","year":"2021","journal-title":"Cryst. Growth Des."},{"key":"D6SC05647D\/cit9g\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1021\/acs.oprd.4c00291","volume":"29","author":"Christian-Tabak","year":"2025","journal-title":"Org. Process Res. Dev."},{"key":"D6SC05647D\/cit10\/1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1021\/acs.molpharmaceut.2c00825","volume":"20","author":"Charpentier","year":"2023","journal-title":"Mol. Pharmaceutics"},{"key":"D6SC05647D\/cit11a\/1","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1039\/D1RE00284H","volume":"6","author":"Kukor","year":"2021","journal-title":"React. Chem. Eng."},{"key":"D6SC05647D\/cit11b\/1","doi-asserted-by":"crossref","first-page":"10765","DOI":"10.1039\/D2SC01825J","volume":"13","author":"Kukor","year":"2022","journal-title":"Chem. Sci."},{"key":"D6SC05647D\/cit11c\/1","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1039\/D3RE00077J","volume":"8","author":"Kukor","year":"2023","journal-title":"React. Chem. Eng."},{"key":"D6SC05647D\/cit12a\/1","doi-asserted-by":"crossref","first-page":"14069","DOI":"10.1021\/acs.joc.1c01098","volume":"86","author":"Sato","year":"2021","journal-title":"J. Org. Chem."},{"key":"D6SC05647D\/cit12b\/1","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1038\/s41467-024-49772-2","volume":"15","author":"Shi","year":"2024","journal-title":"Nat. Commun."},{"key":"D6SC05647D\/cit12c\/1","doi-asserted-by":"crossref","first-page":"12331","DOI":"10.1021\/acscatal.4c03401","volume":"14","author":"Cai","year":"2024","journal-title":"ACS Catal."},{"key":"D6SC05647D\/cit13a\/1","doi-asserted-by":"crossref","first-page":"14276","DOI":"10.1021\/ja4059876","volume":"135","author":"Wadsworth","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC05647D\/cit13b\/1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1021\/cn900037c","volume":"1","author":"Limon","year":"2010","journal-title":"ACS Chem. Neurosci."},{"key":"D6SC05647D\/cit13c\/1","doi-asserted-by":"crossref","first-page":"11219","DOI":"10.1021\/ja8033763","volume":"130","author":"Bowers","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC05647D\/cit13d\/1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1248\/yakushi1947.120.10_935","volume":"120","author":"Tomoda","year":"2000","journal-title":"Yakugaku Zasshi"},{"key":"D6SC05647D\/cit13e\/1","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.7164\/antibiotics.42.1556","volume":"42","author":"Takahashi","year":"1989","journal-title":"J. Antibiot."},{"key":"D6SC05647D\/cit13f\/1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0040-4039(00)98516-2","volume":"26","author":"Takahashi","year":"1985","journal-title":"Tetrahedron Lett."},{"key":"D6SC05647D\/cit14a\/1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1021\/acs.accounts.8b00473","volume":"52","author":"Metrano","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"D6SC05647D\/cit14b\/1","doi-asserted-by":"crossref","first-page":"8756","DOI":"10.1002\/anie.201703919","volume":"56","author":"Macharia","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D6SC05647D\/cit15\/1","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1021\/jm502023y","volume":"58","author":"Bouhlel","year":"2015","journal-title":"J. Med. Chem."},{"key":"D6SC05647D\/cit16a\/1","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1039\/D0CS00102C","volume":"49","author":"Lenci","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"D6SC05647D\/cit16b\/1","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1002\/ejoc.200900599","volume":"2009","author":"Grauer","year":"2009","journal-title":"Eur. J. Org. Chem."},{"key":"D6SC05647D\/cit16c\/1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1248\/cpb.55.349","volume":"55","author":"Tanaka","year":"2007","journal-title":"Chem. Pharm. Bull."},{"key":"D6SC05647D\/cit16d\/1","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1021\/cr000053z","volume":"101","author":"Venkatraman","year":"2001","journal-title":"Chem. Rev."},{"key":"D6SC05647D\/cit17a\/1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.csbj.2019.01.012","volume":"17","author":"Ali","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"D6SC05647D\/cit17b\/1","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.3390\/molecules24203654","volume":"24","author":"Moiola","year":"2019","journal-title":"Molecules"},{"key":"D6SC05647D\/cit17c\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1039\/C4CS00246F","volume":"44","author":"Lau","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"D6SC05647D\/cit17d\/1","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1021\/jm4011675","volume":"57","author":"Walensky","year":"2014","journal-title":"J. Med. Chem."},{"key":"D6SC05647D\/cit18a\/1","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1002\/ejoc.200500434","volume":"2005","author":"Ohfune","year":"2005","journal-title":"Eur. J. Org. Chem."},{"key":"D6SC05647D\/cit18b\/1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1039\/B611091F","volume":"5","author":"Vogt","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"D6SC05647D\/cit18c\/1","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1002\/ejoc.200800225","volume":"2008","author":"Calaza","year":"2008","journal-title":"Eur. J. Org. Chem."},{"key":"D6SC05647D\/cit18d\/1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1055\/s-0031-1289756","volume":"44","author":"Ace\u00f1a","year":"2012","journal-title":"Synthesis"},{"key":"D6SC05647D\/cit18e\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/jo502408z","volume":"80","author":"Metz","year":"2015","journal-title":"J. Org. Chem."},{"key":"D6SC05647D\/cit18f\/1","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/s41467-024-45790-2","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"D6SC05647D\/cit19\/1","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1039\/C9RE00057G","volume":"4","author":"Chung","year":"2019","journal-title":"React. Chem. Eng."},{"key":"D6SC05647D\/cit20\/1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.15227\/orgsyn.083.0170","volume":"83","author":"Sugiura","year":"2006","journal-title":"Org. Synth."},{"key":"D6SC05647D\/cit21\/1","unstructured":"Progressive dissolution experimental details are provided in the SI (Section S8)"},{"key":"D6SC05647D\/cit22\/1","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1021\/ol070764k","volume":"9","author":"Pattarozzi","year":"2007","journal-title":"Org. Lett."},{"key":"D6SC05647D\/cit23\/1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/adsc.200600446","volume":"349","author":"Storcken","year":"2007","journal-title":"Adv. Synth. Catal."},{"key":"D6SC05647D\/cit24\/1","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1021\/jo500707t","volume":"79","author":"Curto","year":"2014","journal-title":"J. Org. Chem."},{"key":"D6SC05647D\/cit25\/1","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1021\/ja000563a","volume":"122","author":"Schafmeister","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"D6SC05647D\/cit26\/1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41573-020-00135-8","volume":"20","author":"Muttenthaler","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D6SC05647D\/cit27\/1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMoa2032183","volume":"384","author":"Wilding","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"D6SC05647D\/cit28\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJMoa2206038","volume":"387","author":"Jastreboff","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"D6SC05647D\/cit29\/1","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1021\/acs.jmedchem.6c00463","volume":"69","author":"Josien","year":"2026","journal-title":"J. Med. Chem."},{"key":"D6SC05647D\/cit30\/1","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jacc.2023.02.018","volume":"81","author":"Ballantyne","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"D6SC05647D\/cit31\/1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.aed8713","volume":"392","author":"Klapars","year":"2026","journal-title":"Science"},{"key":"D6SC05647D\/cit32a\/1","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1016\/S0957-4166(97)00349-2","volume":"8","author":"Ndzi\u00e9","year":"1997","journal-title":"Tetrahedron:Asymmetry"},{"key":"D6SC05647D\/cit32b\/1","first-page":"1","volume":"269","author":"Coquerel","year":"2007","journal-title":"Top. Curr. Chem."},{"key":"D6SC05647D\/cit33\/1","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1002\/chem.200801847","volume":"15","author":"Izumi","year":"2009","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6SC05647D\/cit34\/1","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1002\/chem.200902983","volume":"16","author":"Viedma","year":"2010","journal-title":"Chem. \u2013 Eur. J."},{"key":"D6SC05647D\/cit35\/1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1039\/C6RE00211K","volume":"2","author":"Rougeot","year":"2017","journal-title":"React. Chem. Eng."},{"key":"D6SC05647D\/cit36a\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2572940: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2scc2m","DOI":"10.5517\/ccdc.csd.cc2scc2m"},{"key":"D6SC05647D\/cit36b\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2572941: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2scc3n","DOI":"10.5517\/ccdc.csd.cc2scc3n"}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/SC\/article-pdf\/doi\/10.1039\/D6SC05647D\/0\/D6SC05647D.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:22:11Z","timestamp":1791447731000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/SC\/article-lookup\/doi\/10.1039\/D6SC05647D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":69,"URL":"https:\/\/doi.org\/10.1039\/d6sc05647d","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}