{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:37:54Z","timestamp":1791902274268,"version":"4.3.4"},"reference-count":48,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2027,4,16]],"date-time":"2027-04-16T00:00:00Z","timestamp":1807833600000},"content-version":"am","delay-in-days":470,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>Pt-MOF\/Qu\/BV2 can achieve multi-targeted treatment of Alzheimer's disease through synergistic antioxidant effects, chelation of metal ions, inhibition of A\u03b2, and restoration of microglial cell polarization.<\/jats:p>","DOI":"10.1039\/d6tb00201c","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:01:23Z","timestamp":1776308483000},"page":"6034-6049","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A microglia membrane biomimetic platinum-based MOF-loaded quercetin nanodrug delivery system for the treatment of Alzheimer's disease"],"prefix":"10.1039","volume":"14","author":[{"given":"Ruixin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P. R. China"},{"name":"School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengrong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liran","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-779X","authenticated-orcid":false,"given":"Meng","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"2","key":"D6TB00201C\/cit1\/1","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","volume":"7","author":"GBD 2019 Dementia Forecasting Collaborators","year":"2022","journal-title":"Lancet Public Health"},{"issue":"5054","key":"D6TB00201C\/cit2\/1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"issue":"9","key":"D6TB00201C\/cit3\/1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.2174\/0118715273355336250226055826","volume":"24","author":"Puranik","year":"2025","journal-title":"CNS Neurol. Disord.:Drug Targets"},{"issue":"20","key":"D6TB00201C\/cit4\/1","doi-asserted-by":"publisher","first-page":"4388","DOI":"10.1021\/bi900254n","volume":"48","author":"Sarell","year":"2009","journal-title":"Biochemistry"},{"issue":"3","key":"D6TB00201C\/cit5\/1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.0959-9673.2005.00434.x","volume":"86","author":"Maynard","year":"2005","journal-title":"Int. J. Exp. Pathol."},{"key":"D6TB00201C\/cit6\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2025.07.019","volume":"583","author":"Kang","year":"2025","journal-title":"Neuroscience"},{"issue":"1","key":"D6TB00201C\/cit7\/1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13195-020-00688-1","volume":"12","author":"Feng","year":"2020","journal-title":"Alzheimer's Res. Ther."},{"issue":"1","key":"D6TB00201C\/cit8\/1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40035-024-00433-w","volume":"13","author":"Huang","year":"2024","journal-title":"Transl. Neurodegener."},{"issue":"10","key":"D6TB00201C\/cit9\/1","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/s43587-023-00491-1","volume":"3","author":"Lau","year":"2023","journal-title":"Nat. Aging"},{"issue":"1","key":"D6TB00201C\/cit10\/1","doi-asserted-by":"publisher","first-page":"10092","DOI":"10.1038\/s41598-022-13683-3","volume":"12","author":"de la Cueva","year":"2022","journal-title":"Sci. Rep."},{"issue":"22","key":"D6TB00201C\/cit11\/1","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1021\/acs.accounts.4c00458","volume":"57","author":"Kim","year":"2024","journal-title":"Acc. Chem. Res."},{"key":"D6TB00201C\/cit12\/1","doi-asserted-by":"publisher","first-page":"110887","DOI":"10.1016\/j.biopha.2020.110887","volume":"132","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"D6TB00201C\/cit13\/1","doi-asserted-by":"publisher","first-page":"101768","DOI":"10.1016\/j.nantod.2023.101768","volume":"49","author":"Zhang","year":"2023","journal-title":"Nano Today"},{"issue":"Pt D","key":"D6TB00201C\/cit14\/1","doi-asserted-by":"publisher","first-page":"127684","DOI":"10.1016\/j.jhazmat.2021.127684","volume":"424","author":"Ji","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"D6TB00201C\/cit15\/1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jcis.2022.04.085","volume":"621","author":"Gao","year":"2022","journal-title":"J. Colloid Interface Sci."},{"issue":"3","key":"D6TB00201C\/cit16\/1","doi-asserted-by":"publisher","first-page":"e2308393","DOI":"10.1002\/adma.202308393","volume":"36","author":"Yang","year":"2023","journal-title":"Adv. Mater."},{"issue":"11","key":"D6TB00201C\/cit17\/1","doi-asserted-by":"publisher","first-page":"4999","DOI":"10.1002\/ptr.7966","volume":"37","author":"Zhou","year":"2023","journal-title":"Phytother. Res."},{"issue":"05","key":"D6TB00201C\/cit18\/1","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1142\/s0192415x22500537","volume":"50","author":"Wang","year":"2022","journal-title":"Am. J. Chin. Med."},{"issue":"11","key":"D6TB00201C\/cit19\/1","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.2174\/011570159x355614250130100132","volume":"23","author":"Bianchini","year":"2025","journal-title":"Curr. Neuropharmacol."},{"key":"D6TB00201C\/cit20\/1","doi-asserted-by":"publisher","first-page":"102838","DOI":"10.1016\/j.arr.2025.102838","volume":"111","author":"Yang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"D6TB00201C\/cit21\/1","doi-asserted-by":"publisher","first-page":"102010","DOI":"10.1016\/j.redox.2021.102010","volume":"44","author":"Han","year":"2021","journal-title":"Redox Biol."},{"issue":"9","key":"D6TB00201C\/cit22\/1","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1039\/c7tb03053c","volume":"6","author":"Han","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"D6TB00201C\/cit23\/1","doi-asserted-by":"publisher","first-page":"e01809","DOI":"10.1002\/adhm.202501809","author":"Zhuang","year":"2025","journal-title":"Adv. Healthcare Mater."},{"issue":"17","key":"D6TB00201C\/cit24\/1","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.3390\/nano14171379","volume":"14","author":"Nabipour","year":"2024","journal-title":"Nanomaterials"},{"key":"D6TB00201C\/cit25\/1","doi-asserted-by":"publisher","first-page":"125112","DOI":"10.1016\/j.ijpharm.2024.125112","volume":"670","author":"Li","year":"2025","journal-title":"Int. J. Pharm."},{"key":"D6TB00201C\/cit26\/1","doi-asserted-by":"publisher","first-page":"163340","DOI":"10.1016\/j.cej.2025.163340","volume":"514","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"D6TB00201C\/cit27\/1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jconrel.2024.09.009","volume":"375","author":"Li","year":"2024","journal-title":"J. Controlled Release"},{"issue":"6","key":"D6TB00201C\/cit28\/1","doi-asserted-by":"publisher","first-page":"e2303211","DOI":"10.1002\/adhm.202303211","volume":"13","author":"Qi","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"D6TB00201C\/cit29\/1","doi-asserted-by":"publisher","first-page":"125626","DOI":"10.1016\/j.ijpharm.2025.125626","volume":"677","author":"Qian","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"12","key":"D6TB00201C\/cit30\/1","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1039\/d1tb02522h","volume":"10","author":"Li","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"D6TB00201C\/cit31\/1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03572-y","volume":"23","author":"Yuan","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"22","key":"D6TB00201C\/cit32\/1","doi-asserted-by":"publisher","first-page":"14469","DOI":"10.1021\/acsnano.4c01253","volume":"18","author":"Fan","year":"2024","journal-title":"ACS Nano"},{"key":"D6TB00201C\/cit33\/1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/bs.ctm.2020.08.007","volume":"86","author":"Shin","year":"2020","journal-title":"Curr. Top. Membr."},{"issue":"Pt 3","key":"D6TB00201C\/cit34\/1","doi-asserted-by":"publisher","first-page":"135323","DOI":"10.1016\/j.ijbiomac.2024.135323","volume":"279","author":"Muthusamy","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D6TB00201C\/cit35\/1","doi-asserted-by":"publisher","first-page":"174829","DOI":"10.1016\/j.ejphar.2022.174829","volume":"919","author":"Zhang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"D6TB00201C\/cit36\/1","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1038\/s41467-022-30436-y","volume":"13","author":"Dai","year":"2022","journal-title":"Nat. Commun."},{"issue":"11","key":"D6TB00201C\/cit37\/1","doi-asserted-by":"publisher","first-page":"10419","DOI":"10.1021\/acsabm.5c01746","volume":"8","author":"Shen","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"D6TB00201C\/cit38\/1","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12974-015-0343-3","volume":"12","author":"Yu","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"D6TB00201C\/cit39\/1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40035-020-00189-z","volume":"9","author":"Wang","year":"2020","journal-title":"Transl. Neurodegener."},{"issue":"17","key":"D6TB00201C\/cit40\/1","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1021\/acschemneuro.3c00486","volume":"14","author":"Roy","year":"2023","journal-title":"ACS Chem. Neurosci."},{"issue":"6","key":"D6TB00201C\/cit41\/1","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1039\/c5nr08358c","volume":"8","author":"Moglianetti","year":"2016","journal-title":"Nanoscale"},{"issue":"10","key":"D6TB00201C\/cit42\/1","doi-asserted-by":"publisher","first-page":"6282","DOI":"10.1021\/acs.nanolett.6b02590","volume":"16","author":"Yugay","year":"2016","journal-title":"Nano Lett."},{"issue":"23","key":"D6TB00201C\/cit43\/1","doi-asserted-by":"publisher","first-page":"12879","DOI":"10.1021\/acs.jpcc.6b03237","volume":"120","author":"Todaro","year":"2016","journal-title":"J. Phys. Chem. C"},{"issue":"15\u201316","key":"D6TB00201C\/cit44\/1","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/j.ccr.2010.01.007","volume":"254","author":"Riordan","year":"2010","journal-title":"Coord. Chem. Rev."},{"issue":"10","key":"D6TB00201C\/cit45\/1","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1021\/ja0390350","volume":"126","author":"Xiao","year":"2004","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"D6TB00201C\/cit46\/1","doi-asserted-by":"publisher","first-page":"10066","DOI":"10.1038\/s41467-025-63458-3","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"issue":"32","key":"D6TB00201C\/cit47\/1","doi-asserted-by":"publisher","first-page":"10011","DOI":"10.1021\/acs.jafc.2c03411","volume":"70","author":"Wei","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"D6TB00201C\/cit48\/1","doi-asserted-by":"publisher","first-page":"878631","DOI":"10.3389\/fphar.2022.878631","volume":"13","author":"Kang","year":"2022","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/TB\/D6TB00201C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:06:32Z","timestamp":1782943592000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/14\/19\/6034-6049\/1244503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":48,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,5,20]]}},"URL":"https:\/\/doi.org\/10.1039\/d6tb00201c","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6TB00201C\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00201C\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00201C\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00201C\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00201C\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00201C\/v1\/review2","asserted-by":"object"}]},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}